LOCUS       NM_019290               1225 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus BTG anti-proliferation factor 3 (Btg3), mRNA.
ACCESSION   NM_019290 XM_346415
VERSION     NM_019290.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Kee,H.J., Park,S., Kwon,J.S., Choe,N., Ahn,Y., Kook,H. and
            Jeong,M.H.
  TITLE     B cell translocation gene, a direct target of miR-142-5p, inhibits
            vascular smooth muscle cell proliferation by down-regulating cell
            cycle progression
  JOURNAL   FEBS Lett 587 (15), 2385-2392 (2013)
   PUBMED   23770100
  REMARK    GeneRIF: BTG3, a novel, direct target of miR-142-5p, negatively
            regulates VSMC proliferation
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Li,F., Liu,J., Park,E.S., Jo,M. and Curry,T.E. Jr.
  TITLE     The B cell translocation gene (BTG) family in the rat ovary:
            hormonal induction, regulation, and impact on cell cycle kinetics
  JOURNAL   Endocrinology 150 (8), 3894-3902 (2009)
   PUBMED   19359386
  REMARK    GeneRIF: Fndings suggest that the induction of the Btg3 may be
            important for theca and granulosa cell differentiation into luteal
            cells by arresting cell cycle progression.
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Rahmani,Z.
  TITLE     APRO4 negatively regulates Src tyrosine kinase activity in PC12
            cells
  JOURNAL   J Cell Sci 119 (Pt 4), 646-658 (2006)
   PUBMED   16434477
  REMARK    GeneRIF: by controlling the basal threshold of Src activity,
            constitutes an important negative regulatory mechanism for
            Src-mediated signalling.
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Seo,M.S., Lee,M.S. and Lim,I.K.
  TITLE     Expression of rat BTG(3) gene, Rbtg3, is regulated by redox changes
  JOURNAL   Gene 240 (1), 165-173 (1999)
   PUBMED   10564823
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Yoshida,Y., Matsuda,S., Ikematsu,N., Kawamura-Tsuzuku,J.,
            Inazawa,J., Umemori,H. and Yamamoto,T.
  TITLE     ANA, a novel member of Tob/BTG1 family, is expressed in the
            ventricular zone of the developing central nervous system
  JOURNAL   Oncogene 16 (20), 2687-2693 (1998)
   PUBMED   9632145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Nov 26, 2020 this sequence version replaced NM_019290.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087037.1, BC127498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                JAXUCZ010000011.1  30532953-30532981   c
            30-209              JAXUCZ010000011.1  30529745-30529924   c
            210-347             JAXUCZ010000011.1  30525416-30525553   c
            348-555             JAXUCZ010000011.1  30521547-30521754   c
            556-1225            JAXUCZ010000011.1  30517068-30517737   c
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..1225
                     /gene="Btg3"
                     /note="BTG anti-proliferation factor 3"
                     /db_xref="GeneID:54230"
                     /db_xref="RGD:2226"
     exon            1..29
                     /gene="Btg3"
                     /inference="alignment:Splign:2.1.0"
     exon            30..209
                     /gene="Btg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..795
                     /gene="Btg3"
                     /note="B-cell translocation gene 3; rBTG3; BTG family,
                     member 3"
                     /codon_start=1
                     /product="protein BTG3"
                     /protein_id="NP_062163.2"
                     /db_xref="GeneID:54230"
                     /db_xref="RGD:2226"
                     /translation="MKNEIAAVVFFFTRLVRKHDKLKKEAVERFAEKLTQILQEKYKN
                     HWYPEKPSKGQAYRCIRVNKFQRVDPDVLKACENSCILYSDLGLPKELTLWVDPCEVC
                     CRYGEKNNAFIVASFENEDENKDEISKKVSRALDKVTSDYHSGSSSSDEDTSKEVEVK
                     PSAVATTPSPVYQISELIFPPLPMWHPLPRKKPGMYRGGGHQSHYPPPVPFAYPSPGR
                     KNKAFRPIPVTWVPPPGMHCDRNHWINPHMLAPH"
     exon            210..347
                     /gene="Btg3"
                     /inference="alignment:Splign:2.1.0"
     exon            348..555
                     /gene="Btg3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1225
                     /gene="Btg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagggtg cagccccgga gcggcggcgg ggcaaaatga agaacgaaat tgctgctgtt
       61 gtcttctttt tcacaaggct ggttcgaaag catgataagt tgaaaaaaga agcagttgag
      121 aggtttgctg agaaattgac tcaaatactt caagagaaat acaaaaatca ctggtatcca
      181 gaaaaaccct caaaaggaca agcctacaga tgcattcgtg tcaataagtt tcagagagtt
      241 gatcccgacg tcctgaaagc ctgtgagaac agctgcatcc tgtacagtga cctgggcttg
      301 ccaaaggagc ttacactctg ggtggatccg tgtgaggtgt gctgccggta tggagagaaa
      361 aacaatgcat tcattgttgc cagctttgaa aatgaggatg agaacaagga tgagatctcc
      421 aagaaagtta gcagggctct tgataaggtg acctctgatt atcattcagg gtcctcctcc
      481 tcagatgaag acacaagcaa ggaagtagaa gtgaaaccga gtgcagtggc tacaacgcca
      541 agccccgtgt accagatttc agaactgata ttcccacctc ttccaatgtg gcaccctttg
      601 cccagaaaaa agccaggaat gtaccgaggg ggtggccatc agagtcacta ccctcctcct
      661 gttccatttg cttatccaag tccaggaagg aagaataaag cgttccgccc aattccagtg
      721 acatgggtac ctcctcctgg aatgcattgt gaccggaatc actggattaa tcctcacatg
      781 ttagcacctc actagctcat ttgattgtgc tgatgttatg ttgatagaaa ggaagaaata
      841 ccttcctaga tactaagagt tcatacttgt agtgaagtca gatggacaaa accatcaggc
      901 ttatttttat agaaaagcta ttgagaataa tctttcttaa agtatatata tatatgcact
      961 ttagatatat tgatatagtt tgagaaactt tattaaagtt agtcaagtgc ctgagttttt
     1021 aatattggac ttgagtattt atatattgtg cattgactct gttggataca aaacactgta
     1081 ggagggcgat atgttctagc acctttgagc atttacttta tggagaatat gtaagttatt
     1141 tatacagaag gacatctatt ttatgtcaca tagaagaatt gtgtgaaatc atgtagttgc
     1201 aaataaaaag tagtttgagg catga
//
