LOCUS       NM_017259               2519 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus BTG anti-proliferation factor 2 (Btg2), mRNA.
ACCESSION   NM_017259
VERSION     NM_017259.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2519)
  AUTHORS   Ruan,Y., Meng,S., Jia,R., Cao,X. and Jin,Z.
  TITLE     MicroRNA-322-5p protects against myocardial infarction through
            targeting BTG2
  JOURNAL   Am J Med Sci 367 (6), 397-405 (2024)
   PUBMED   38437946
  REMARK    GeneRIF: MicroRNA-322-5p protects against myocardial infarction
            through targeting BTG2.
REFERENCE   2  (bases 1 to 2519)
  AUTHORS   Wu,F., Zhang,P. and Zhou,G.
  TITLE     The involvement of EGR1 in neuron apoptosis in the in vitro model
            of spinal cord injury via BTG2 up-regulation
  JOURNAL   Neurol Res 45 (7), 646-654 (2023)
   PUBMED   36759943
  REMARK    GeneRIF: The involvement of EGR1 in neuron apoptosis in the in
            vitro model of spinal cord injury via BTG2 up-regulation.
REFERENCE   3  (bases 1 to 2519)
  AUTHORS   Velayutham,N., Calderon,M.U., Alfieri,C.M., Padula,S.L., van
            Leeuwen,F.N., Scheijen,B. and Yutzey,K.E.
  TITLE     Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest
  JOURNAL   J Mol Cell Cardiol 179, 30-41 (2023)
   PUBMED   37062247
  REMARK    GeneRIF: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle
            arrest.
REFERENCE   4  (bases 1 to 2519)
  AUTHORS   Hoffman,M.J., Takizawa,A., Jensen,E.S., Schilling,R.,
            Grzybowski,M., Geurts,A.M. and Dwinell,M.R.
  TITLE     Btg2 mutation induces renal injury and impairs blood pressure
            control in female rats
  JOURNAL   Physiol Genomics 54 (7), 231-241 (2022)
   PUBMED   35503009
  REMARK    GeneRIF: Btg2 mutation induces renal injury and impairs blood
            pressure control in female rats.
REFERENCE   5  (bases 1 to 2519)
  AUTHORS   Hu,D., Gu,Y., Wu,D., Zhang,J., Li,Q., Luo,J., Li,S., Yuan,Z. and
            Zhu,B.
  TITLE     Icariside II protects cardiomyocytes from hypoxia-induced injury by
            upregulating the miR-7-5p/BTG2 axis and activating the PI3K/Akt
            signaling pathway
  JOURNAL   Int J Mol Med 46 (4), 1453-1465 (2020)
   PUBMED   32945347
  REMARK    GeneRIF: Icariside II protects cardiomyocytes from hypoxiainduced
            injury by upregulating the miR75p/BTG2 axis and activating the
            PI3K/Akt signaling pathway.
REFERENCE   6  (bases 1 to 2519)
  AUTHORS   Iacopetti,P., Barsacchi,G., Tirone,F., Maffei,L. and Cremisi,F.
  TITLE     Developmental expression of PC3 gene is correlated with neuronal
            cell birthday
  JOURNAL   Mech Dev 47 (2), 127-137 (1994)
   PUBMED   7811636
REFERENCE   7  (bases 1 to 2519)
  AUTHORS   Gubits,R.M., Burke,R.E., Casey-McIntosh,G., Bandele,A. and
            Munell,F.
  TITLE     Immediate early gene induction after neonatal hypoxia-ischemia
  JOURNAL   Brain Res Mol Brain Res 18 (3), 228-238 (1993)
   PUBMED   7684483
REFERENCE   8  (bases 1 to 2519)
  AUTHORS   Bradbury,A., Possenti,R., Shooter,E.M. and Tirone,F.
  TITLE     Molecular cloning of PC3, a putatively secreted protein whose mRNA
            is induced by nerve growth factor and depolarization
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3353-3357 (1991)
   PUBMED   1849653
REFERENCE   9  (bases 1 to 2519)
  AUTHORS   Altin,J.G., Kujubu,D.A., Raffioni,S., Eveleth,D.D., Herschman,H.R.
            and Bradshaw,R.A.
  TITLE     Differential induction of primary-response (TIS) genes in PC12
            pheochromocytoma cells and the unresponsive variant PC12nnr5
  JOURNAL   J Biol Chem 266 (9), 5401-5406 (1991)
   PUBMED   2005087
REFERENCE   10 (bases 1 to 2519)
  AUTHORS   Stephenson,S.P., Morley,R.C. and Butcher,G.W.
  TITLE     Genetics of the rat CT system: its apparent complexity is a
            consequence of cross-reactivity between the distinct MHC class I
            antigens RT1.C and RT1.A
  JOURNAL   J Immunogenet 12 (2), 101-114 (1985)
   PUBMED   3878378
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017259.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60921.1, SRR26643429.44303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840111, SAMN12840130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000013.1  48087485-48087690   c
            207-2519            JAXUCZ010000013.1  48083931-48086243   c
FEATURES             Location/Qualifiers
     source          1..2519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2519
                     /gene="Btg2"
                     /gene_synonym="Agl; An; an-1; Pc3; Tis21"
                     /note="BTG anti-proliferation factor 2"
                     /db_xref="GeneID:29619"
                     /db_xref="RGD:2225"
     exon            1..206
                     /gene="Btg2"
                     /gene_synonym="Agl; An; an-1; Pc3; Tis21"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..541
                     /gene="Btg2"
                     /gene_synonym="Agl; An; an-1; Pc3; Tis21"
                     /note="B-cell translocation gene 2, anti-proliferative;
                     cell surface alloantigen; NGF-inducible anti-proliferative
                     protein PC3; NGF-inducible anti-proliferative putative
                     secreted protein; Early induced gene B-cell translocation
                     gene 2; BTG family, member 2"
                     /codon_start=1
                     /product="protein BTG2"
                     /protein_id="NP_058955.1"
                     /db_xref="GeneID:29619"
                     /db_xref="RGD:2225"
                     /translation="MSHGKRTDMLPEIAAAVGFLTSLLRTRGCVSEQRLKVFSRALQD
                     ALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHQLLPSELTL
                     WVDPYEVSYRIGEDGSICVLYEEAPVATSYGLLTCKNQMMLGRSSPSKNYVMTVSS"
     exon            207..2519
                     /gene="Btg2"
                     /gene_synonym="Agl; An; an-1; Pc3; Tis21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccgtg aggcggccgg accatcatcg tcctgctaat acagctactt cctcaaccac
       61 cggtatgagc cacgggaaga gaaccgacat gctcccggag atcgccgccg ccgtaggttt
      121 cctcaccagt ctcctgagga ctcggggctg cgtgagcgag cagagactca aggttttcag
      181 tagggcgctc caggacgcac tgaccgatca ttacaaacac cactggtttc cagaaaagcc
      241 atccaagggc tccggctatc gctgtatccg catcaaccac aagatggacc ccatcatcag
      301 caaggtggcc agccagatcg gactcagcca gccccagctg caccagctcc tgcccagcga
      361 gctgaccctg tgggtcgatc cctacgaagt gtcctaccgc atcggggaag atggatccat
      421 ctgcgtgctg tatgaggagg cgccggtggc cacctcctac gggctcctca cctgcaagaa
      481 ccagatgatg ctgggcagga gcagtccatc gaagaactac gtgatgactg tctccagcta
      541 gagaggagcc gccccgccct ggcactctac tgttctcatg ctgccctgac aacaggccac
      601 cgtatacctc aacctgggga actgtatttt taaagtgaag agctatttat acatgttatt
      661 tttttttttt aagaaaagag gaggaaaaaa ccaaaagttt ttttttaaaa aaacaaaaaa
      721 gaaaaaacaa ttcgttaacg ggagctgctt ggaagtggtc tccccaggtg cctttggaga
      781 gaactgttct tgattgagtc tatgagccag tgtttgccta ggggagtggg ttggggattg
      841 gcctagccaa ggtaaaaggg gattcttggc tgatccccca ggaggtggtg gaagggagca
      901 aggttagcaa ctgtgaacga gaggggtcag ggtctgctct gggttaccgt ccccgctggg
      961 atgcctgtat tcctggtccc tctcttactc aggggcattc aagcctggtc tcaaataata
     1021 ctacattgcc taatcttctc ttttgttttt ctgctgagat cctgggcaca cggaaaggcc
     1081 tctcctgtcc cttccgtctg agcagagttt cttgaaactg tgtctcgttt ctgatcctac
     1141 cctcggggtc ctgaagaggt ggtttcccgg cctggaatct atctaaacgt ttttggaggg
     1201 tgggctataa ggcagatata atggagggga accgcacaaa ccctttgctt tgctctgtgc
     1261 tgctttgtat ggatggatgg ttaataactt agggatgatt tgcaatggaa ttttgggacc
     1321 caaagagtat ccaatggggg tgggtgtttt ggacctaagc cctccttttg ggaaccacgt
     1381 gacagtctga atgctgctac cattattcct ttgagaggtg gctcaaagct ccagggaact
     1441 ccaggtcctt tcttactgcc ttctcttcaa gagcaacctc ccccatttct tttccctctt
     1501 tcctgcggtt gggtcctgga gggccccatt tcctaggaca agagttctca atcactgtgc
     1561 aatagtccca ggaagctctg gaactgggcc tcccagcccc tcctgattcc tggtgggttt
     1621 taggaccccg ccttccccgt tcttctgact ggctggtggg ccttgaggag atctccctcg
     1681 gctgcaggga gggcacctgt gcactgcagg actacctggt actcctgtgg ggctgccacg
     1741 gagagccaaa ccttaggcat agctttgtct cctcggtgct cagagcacct gcagggggag
     1801 gttgcccccc tcagtaaaaa tccaaattta tttgtagatg tgtgcaatat ttactgttct
     1861 gggttggaga aaatcgggaa acactgggaa gaagtggcct tccttcaggt tcagtgacac
     1921 tgatgagggc ttctcagaag gcctcgagtc tctcaaacca aaggacagag ctagagccag
     1981 ccagtcaccc ttagtgagga tccccttccc catgtctctc cactgccgtg gcatcccatg
     2041 tcctggattt ctcaattcct cagtttctac tcaaaggtgc tacttaccaa acactctgcc
     2101 cgtcccgctc tccccagctt cgcacagccg tcccaggtgg cttcgtctct cctgctttaa
     2161 agttaacttt gggcccacag acccgagagc tgtgggttga agcaaagctg tgaatcgctc
     2221 cagatggtcc ctgtgttctg tccacacaca ggtccccgcc tttttagaag cagcctcctg
     2281 gtctcatgct taaatctgtt cctcactgcc cgtgttcact ttagaaatgg cagaaccaca
     2341 gagctggact gttgagcagg cctgtctctc tcattaaata aaaataagta agtttgtaag
     2401 ctattccgac agaagagaca aaggttactg attgtacaat agcgctttta tatggaagac
     2461 tgtacagctt tatggacaaa tgtaaaactt ttttgttttt aataaaaatg tagcagacc
//
