LOCUS       NM_017258               1462 bp    mRNA    linear   ROD 15-JUN-2024
DEFINITION  Rattus norvegicus BTG anti-proliferation factor 1 (Btg1), mRNA.
ACCESSION   NM_017258
VERSION     NM_017258.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Velayutham,N., Calderon,M.U., Alfieri,C.M., Padula,S.L., van
            Leeuwen,F.N., Scheijen,B. and Yutzey,K.E.
  TITLE     Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest
  JOURNAL   J Mol Cell Cardiol 179, 30-41 (2023)
   PUBMED   37062247
  REMARK    GeneRIF: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle
            arrest.
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Li,F., Liu,J., Park,E.S., Jo,M. and Curry,T.E. Jr.
  TITLE     The B cell translocation gene (BTG) family in the rat ovary:
            hormonal induction, regulation, and impact on cell cycle kinetics
  JOURNAL   Endocrinology 150 (8), 3894-3902 (2009)
   PUBMED   19359386
  REMARK    GeneRIF: Overexpression of BTG1 or BTG2 arrested granulosa cells at
            the G0/G1 phase of the cell cycle and decreased cell apoptosis.
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Urzua,U., Roby,K.F., Gangi,L.M., Cherry,J.M., Powell,J.I. and
            Munroe,D.J.
  TITLE     Transcriptomic analysis of an in vitro murine model of ovarian
            carcinoma: functional similarity to the human disease and
            identification of prospective tumoral markers and targets
  JOURNAL   J Cell Physiol 206 (3), 594-602 (2006)
   PUBMED   16245302
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Cho,J.W., Kim,J.J., Park,S.G., Lee,D.H., Lee,S.C., Kim,H.J.,
            Park,B.C. and Cho,S.
  TITLE     Identification of B-cell translocation gene 1 as a biomarker for
            monitoring the remission of acute myeloid leukemia
  JOURNAL   Proteomics 4 (11), 3456-3463 (2004)
   PUBMED   15449376
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Iwai,K., Hirata,K., Ishida,T., Takeuchi,S., Hirase,T., Rikitake,Y.,
            Kojima,Y., Inoue,N., Kawashima,S. and Yokoyama,M.
  TITLE     An anti-proliferative gene BTG1 regulates angiogenesis in vitro
  JOURNAL   Biochem Biophys Res Commun 316 (3), 628-635 (2004)
   PUBMED   15033446
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Corjay,M.H., Kearney,M.A., Munzer,D.A., Diamond,S.M. and
            Stoltenborg,J.K.
  TITLE     Antiproliferative gene BTG1 is highly expressed in apoptotic cells
            in macrophage-rich areas of advanced lesions in Watanabe heritable
            hyperlipidemic rabbit and human
  JOURNAL   Lab Invest 78 (7), 847-858 (1998)
   PUBMED   9690562
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Raburn,D.J., Hamil,K.G., Tsuruta,J.K., O'Brien,D.A. and Hall,S.H.
  TITLE     Stage-specific expression of B cell translocation gene 1 in rat
            testis
  JOURNAL   Endocrinology 136 (12), 5769-5777 (1995)
   PUBMED   7588335
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Hamil,K.G. and Hall,S.H.
  TITLE     Cloning of rat Sertoli cell follicle-stimulating hormone primary
            response complementary deoxyribonucleic acid: regulation of TSC-22
            gene expression
  JOURNAL   Endocrinology 134 (3), 1205-1212 (1994)
   PUBMED   8161377
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Rouault,J.P., Rimokh,R., Tessa,C., Paranhos,G., Ffrench,M.,
            Duret,L., Garoccio,M., Germain,D., Samarut,J. and Magaud,J.P.
  TITLE     BTG1, a member of a new family of antiproliferative genes
  JOURNAL   EMBO J 11 (4), 1663-1670 (1992)
   PUBMED   1373383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017258.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26268.1, CF111001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               JAXUCZ010000007.1  33228149-33228296
            149-1462            JAXUCZ010000007.1  33229093-33230406
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..1462
                     /gene="Btg1"
                     /note="BTG anti-proliferation factor 1"
                     /db_xref="GeneID:29618"
                     /db_xref="RGD:2224"
     CDS             1..516
                     /gene="Btg1"
                     /note="anti-proliferative factor; B-cell translocation
                     gene 1 protein; B-cell translocation gene 1,
                     anti-proliferative"
                     /codon_start=1
                     /product="protein BTG1"
                     /protein_id="NP_058954.1"
                     /db_xref="GeneID:29618"
                     /db_xref="RGD:2224"
                     /translation="MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSL
                     QELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSEL
                     TLWVDPYEVSYRIGEDGSICVLYEASPAGGSSQNSTNVQMVDSRISCKEELLLGRTSP
                     SKNYNMMTVSG"
     exon            1..148
                     /gene="Btg1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..1462
                     /gene="Btg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcatccct tctacactcg ggccgccacc atgataggcg agatcgccgc cgcggtgtcc
       61 ttcatctcca agttcctccg caccaagggg ctcacgagcg agcgacagct gcagactttc
      121 agccagagcc tgcaggaact gctggcagag cattacaaac atcactggtt cccagaaaag
      181 ccgtgcaagg gatcaggtta ccgttgtatt cgcatcaacc ataagatgga tcctctgatt
      241 ggacaggcag cccagcggat tggactgagc agtcaagagt tgttcaggct tctcccaagt
      301 gaactcacac tctgggttga cccctacgaa gtgtcctaca ggattggaga ggatggctcc
      361 atctgtgtgc tgtatgaagc ctcaccagcg ggaggtagct ctcaaaacag caccaacgtg
      421 caaatggtag acagcagaat cagctgtaag gaggaacttc tcttgggcag aacaagccct
      481 tccaaaaact acaatatgat gactgtatca ggttaagata tagtctatgg atggatcatc
      541 ttataatgga tggatagatt tgattttttg ctttgggtgg gctcctcttg gggatggatt
      601 atggaataac catgtcacag ctgtgaagat ctggcacaag atagagtggt aataattttt
      661 ttttttaaag tgacagtgcc atagtttgga cagtaccttt aagtgattta agtagcctgt
      721 gagtccaagt aaaggatcac tttatttggt agggagtgaa gtcgcagggt ggtttcagtt
      781 tctcccagac cttataccca atttgtcaca ccagtccctt taaggaaatt ctgtatttca
      841 aagaaccctc ttttgcagtc agtcaacctt gcaggggaat ttgcactatt tacacttgaa
      901 agttaccagt aacttttttt tggcagctca ataggaaagc tcaatgttct aagcatggta
      961 gtactggaaa tattacacgg agacttttac ctagcactta aaaatgtata aatgtacata
     1021 aagacactta gtacgcatga cctgggggaa atggtcagac cttgtgtttt tggctttgag
     1081 agtagcaagt gaccggaatc tgccatgaca acaggctttt aagaccctta caaagacact
     1141 gtctcaactg tggttagcac cagccagctc tctgtacatt cgcttgtagt tttctaagat
     1201 tgagtgagta aacttcttat ttttagaaag tggaggtctg gtttgtaact ttccttgtac
     1261 tcaattgggt aagagtcttt ttccacaaac cgccatctat tttgtgaact ttgttagtca
     1321 tcttttattt ggtaaattat gaactggtgt aaatttgtac agttcatgta tattgattgt
     1381 ggcaaagttg tacagatttc tatattttgg atgagaaatt tttcttctct ctataataaa
     1441 ttgtttctta tcttggcatt tt
//
