LOCUS       NP_058954                171 aa            linear   ROD 15-JUN-2024
DEFINITION  protein BTG1 [Rattus norvegicus].
ACCESSION   NP_058954
VERSION     NP_058954.1
DBSOURCE    REFSEQ: accession NM_017258.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 171)
  AUTHORS   Velayutham,N., Calderon,M.U., Alfieri,C.M., Padula,S.L., van
            Leeuwen,F.N., Scheijen,B. and Yutzey,K.E.
  TITLE     Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle arrest
  JOURNAL   J Mol Cell Cardiol 179, 30-41 (2023)
   PUBMED   37062247
  REMARK    GeneRIF: Btg1 and Btg2 regulate neonatal cardiomyocyte cell cycle
            arrest.
REFERENCE   2  (residues 1 to 171)
  AUTHORS   Li,F., Liu,J., Park,E.S., Jo,M. and Curry,T.E. Jr.
  TITLE     The B cell translocation gene (BTG) family in the rat ovary:
            hormonal induction, regulation, and impact on cell cycle kinetics
  JOURNAL   Endocrinology 150 (8), 3894-3902 (2009)
   PUBMED   19359386
  REMARK    GeneRIF: Overexpression of BTG1 or BTG2 arrested granulosa cells at
            the G0/G1 phase of the cell cycle and decreased cell apoptosis.
REFERENCE   3  (residues 1 to 171)
  AUTHORS   Urzua,U., Roby,K.F., Gangi,L.M., Cherry,J.M., Powell,J.I. and
            Munroe,D.J.
  TITLE     Transcriptomic analysis of an in vitro murine model of ovarian
            carcinoma: functional similarity to the human disease and
            identification of prospective tumoral markers and targets
  JOURNAL   J Cell Physiol 206 (3), 594-602 (2006)
   PUBMED   16245302
REFERENCE   4  (residues 1 to 171)
  AUTHORS   Cho,J.W., Kim,J.J., Park,S.G., Lee,D.H., Lee,S.C., Kim,H.J.,
            Park,B.C. and Cho,S.
  TITLE     Identification of B-cell translocation gene 1 as a biomarker for
            monitoring the remission of acute myeloid leukemia
  JOURNAL   Proteomics 4 (11), 3456-3463 (2004)
   PUBMED   15449376
REFERENCE   5  (residues 1 to 171)
  AUTHORS   Iwai,K., Hirata,K., Ishida,T., Takeuchi,S., Hirase,T., Rikitake,Y.,
            Kojima,Y., Inoue,N., Kawashima,S. and Yokoyama,M.
  TITLE     An anti-proliferative gene BTG1 regulates angiogenesis in vitro
  JOURNAL   Biochem Biophys Res Commun 316 (3), 628-635 (2004)
   PUBMED   15033446
REFERENCE   6  (residues 1 to 171)
  AUTHORS   Corjay,M.H., Kearney,M.A., Munzer,D.A., Diamond,S.M. and
            Stoltenborg,J.K.
  TITLE     Antiproliferative gene BTG1 is highly expressed in apoptotic cells
            in macrophage-rich areas of advanced lesions in Watanabe heritable
            hyperlipidemic rabbit and human
  JOURNAL   Lab Invest 78 (7), 847-858 (1998)
   PUBMED   9690562
REFERENCE   7  (residues 1 to 171)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   8  (residues 1 to 171)
  AUTHORS   Raburn,D.J., Hamil,K.G., Tsuruta,J.K., O'Brien,D.A. and Hall,S.H.
  TITLE     Stage-specific expression of B cell translocation gene 1 in rat
            testis
  JOURNAL   Endocrinology 136 (12), 5769-5777 (1995)
   PUBMED   7588335
REFERENCE   9  (residues 1 to 171)
  AUTHORS   Hamil,K.G. and Hall,S.H.
  TITLE     Cloning of rat Sertoli cell follicle-stimulating hormone primary
            response complementary deoxyribonucleic acid: regulation of TSC-22
            gene expression
  JOURNAL   Endocrinology 134 (3), 1205-1212 (1994)
   PUBMED   8161377
REFERENCE   10 (residues 1 to 171)
  AUTHORS   Rouault,J.P., Rimokh,R., Tessa,C., Paranhos,G., Ffrench,M.,
            Duret,L., Garoccio,M., Germain,D., Samarut,J. and Magaud,J.P.
  TITLE     BTG1, a member of a new family of antiproliferative genes
  JOURNAL   EMBO J 11 (4), 1663-1670 (1992)
   PUBMED   1373383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26268.1, CF111001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..171
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     Protein         1..171
                     /product="protein BTG1"
                     /note="anti-proliferative factor; B-cell translocation
                     gene 1 protein; B-cell translocation gene 1,
                     anti-proliferative"
                     /calculated_mol_wt=19064
     Region          11..118
                     /region_name="btg1"
                     /note="tob/btg1 family; smart00099"
                     /db_xref="CDD:128410"
     Site            159
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P62324; propagated from
                     UniProtKB/Swiss-Prot (Q63073.1)"
     CDS             1..171
                     /gene="Btg1"
                     /coded_by="NM_017258.2:1..516"
                     /db_xref="GeneID:29618"
                     /db_xref="RGD:2224"
ORIGIN      
        1 mhpfytraat migeiaaavs fiskflrtkg ltserqlqtf sqslqellae hykhhwfpek
       61 pckgsgyrci rinhkmdpli gqaaqrigls sqelfrllps eltlwvdpye vsyrigedgs
      121 icvlyeaspa ggssqnstnv qmvdsrisck eelllgrtsp sknynmmtvs g
//
