LOCUS       NM_001012047            1974 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus biotinidase (Btd), mRNA.
ACCESSION   NM_001012047 XM_224619
VERSION     NM_001012047.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1974)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 1974)
  AUTHORS   Pindolia,K., Jordan,M., Guo,C., Matthews,N., Mock,D.M., Strovel,E.,
            Blitzer,M. and Wolf,B.
  TITLE     Development and characterization of a mouse with profound
            biotinidase deficiency: a biotin-responsive neurocutaneous disorder
  JOURNAL   Mol Genet Metab 102 (2), 161-169 (2011)
   PUBMED   21051254
REFERENCE   3  (bases 1 to 1974)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 1974)
  AUTHORS   Brumwell,C.L., Hossain,W.A., Morest,D.K. and Wolf,B.
  TITLE     Biotinidase reveals the morphogenetic sequence in cochlea and
            cochlear nucleus of mice
  JOURNAL   Hear Res 209 (1-2), 104-121 (2005)
   PUBMED   16107307
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001012047.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090017.1, CO572952.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000016.1  6871931-6872020
            91-349              JAXUCZ010000016.1  6894275-6894533
            350-499             JAXUCZ010000016.1  6898222-6898371
            500-1974            JAXUCZ010000016.1  6899237-6900711
FEATURES             Location/Qualifiers
     source          1..1974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..1974
                     /gene="Btd"
                     /note="biotinidase"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
     exon            1..90
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            91..349
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1672
                     /gene="Btd"
                     /EC_number="3.5.1.12"
                     /note="biotinase"
                     /codon_start=1
                     /product="biotinidase precursor"
                     /protein_id="NP_001012047.1"
                     /db_xref="GeneID:306262"
                     /db_xref="RGD:1305316"
                     /translation="MSGARTAHALVFLLGCSALALGVCSASLEHGEAEYYVAAVYEHR
                     SVLSPNPLELSSRQQALELMKQNLDVYEQQVMAAAQKGAHIIVFPEDGIHGFNFTRTS
                     IYPFLDLMPSPRLVSWNPCLEPFRFNDTEVLQRLSCMAIKGKMFLVANLGTKQPCLGS
                     DPGCPQDGRYQFNTNVAFSDNGTLVGRYRKHNLYFEEAFDSPADVDLTTFDTPFAGKF
                     GMFTCFDILFFDPAVRLLRDFEVKHIAYPTAWMNQLPLLAAIEIQKAFATAFGVTVLA
                     ANIHHPTLGMTGSGIHTPLKSFWYHNMDDPEGHLIIARVATNPQGLVGTENTTSEMDP
                     SHRKFLKVLSGDPYCEKDAQEVRCDEAAKWNLNAPPTFHSEMMYDNFTLVPVWGKEGH
                     LQVCSNSLCCHLLFERPALSKELYALGVFDGLHTVHGTYYVQACALVKCGGAGFETCG
                     QEISEAEGLFDFHLWGNFSTLYVFPLFLTSGMTLDTPDQLGWESDHYFLRKRGLSSGL
                     VTAALYGRLYERN"
     exon            350..499
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1974
                     /gene="Btd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagatttct catgcagccc aggccctcca gcactggtta atagtcatct tcattcgtcc
       61 ctcgaagacg tgcccacaga ccagcccaac atttacggtc tgcattatgt ctggagcccg
      121 cactgcgcat gcgctcgtct tcctcctcgg ctgttctgcg cttgcgttgg gcgtctgctc
      181 agcctccctg gagcacggcg aggctgagta ctacgtggct gccgtgtacg aacaccgatc
      241 ggtcctgagc ccaaaccccc tggagctcag cagccgccag caggccctgg agctcatgaa
      301 gcagaacctc gacgtctatg aacagcaagt gatggctgca gcccagaagg gtgcgcacat
      361 tatagtgttc ccagaagacg gtatccacgg attcaacttc acaagaacat ccatttaccc
      421 attcttggac ttgatgccat ctcccaggct ggtcagttgg aacccgtgtc tggagccctt
      481 tcgcttcaat gacacggagg tcctccagcg cctgagttgc atggccatca agggaaagat
      541 gttcttggtg gccaatcttg ggacaaaaca gccttgcctc ggcagcgacc ctgggtgccc
      601 gcaggacggg agataccagt ttaacacaaa cgtcgcgttc agtgacaacg gaaccctcgt
      661 cggccgctac cgtaagcaca acctgtactt tgaggaagcc ttcgatagcc ctgctgacgt
      721 ggacctcacc acctttgata cgccgttcgc gggcaagttc ggtatgttca cttgctttga
      781 tatcctgttc tttgaccccg cggtccggct cctcagagac tttgaggtaa agcacattgc
      841 gtaccctacg gcctggatga accagctgcc gctcttggca gccattgaaa tccagaaagc
      901 attcgccacc gccttcggcg tcaccgttct ggcagctaac atccaccacc cgactctggg
      961 gatgacgggc agtggcatac acacccctct gaagtccttt tggtaccata acatggacga
     1021 ccccgaaggt caccttataa ttgcccgggt agccacaaac ccacagggcc tcgttgggac
     1081 agagaataca actagtgaaa tggatccgtc ccataggaag ttcttaaaag tcttgtctgg
     1141 ggatccgtac tgtgagaagg atgcccagga agtgcgctgc gacgaggctg ccaagtggaa
     1201 cctgaacgca ccacctacct tccactcgga gatgatgtat gacaatttca ccctggtccc
     1261 cgtctgggga aaggaaggcc acctccaggt gtgctccaac agtctctgtt gccacttact
     1321 tttcgagagg cccgccctgt ccaaagagct atatgccctg ggtgtctttg acggactcca
     1381 cacagtgcac ggtacctact acgttcaagc ctgtgccctg gtcaagtgcg ggggcgctgg
     1441 ctttgaaacc tgcgggcagg agatctcgga ggccgagggc ttgtttgact ttcatctgtg
     1501 ggggaacttc agcaccttgt atgtcttccc tttatttctc acctcgggga tgaccctaga
     1561 cacccctgac cagctcgggt gggagagcga ccactatttc ttgaggaaga ggggactgtc
     1621 ctccggcctg gtgacggcag ctctctatgg gcggttgtat gagaggaatt aggaaaactg
     1681 tggtcagcag gttgggctct gcaggctggc cttgccttcc cacggcccac agatcccaaa
     1741 cactgggaaa accgccccgc ccctgtggca ctggatccca ccctggggaa ctgtaagaag
     1801 atgggagagg cagttcctcc ttcctttcta cataatgact gagatatttt ctggtatttt
     1861 ctattcacat tattcttttt caagccacac cctcttacca ctactacaca attggtttta
     1921 aagactaagc caaaaaaaaa aaaaaaaaat aaacatcagc tgccattcta caaa
//
