LOCUS       NM_022256                611 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus betacellulin (Btc), mRNA.
ACCESSION   NM_022256
VERSION     NM_022256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Gezginci-Oktayoglu S, Karatug A and Bolkent S.
  TITLE     Nerve growth factor neutralization suppresses beta-cell
            proliferation through activin A and betacellulin
  JOURNAL   Pancreas 44 (2), 243-249 (2015)
   PUBMED   25401376
  REMARK    GeneRIF: Suggest that beta-cell proliferation decreased through NGF
            neutralization is possibly related to decreased betacellulin and
            increased activin-A secretion from beta cells of hyperglycemic
            rats.
REFERENCE   2  (bases 1 to 611)
  AUTHORS   Yechoor V, Liu V, Paul A, Lee J, Buras E, Ozer K, Samson S and Chan
            L.
  TITLE     Gene therapy with neurogenin 3 and betacellulin reverses major
            metabolic problems in insulin-deficient diabetic mice
  JOURNAL   Endocrinology 150 (11), 4863-4873 (2009)
   PUBMED   19819964
REFERENCE   3  (bases 1 to 611)
  AUTHORS   Dahlhoff M, Horst D, Gerhard M, Kolligs FT, Wolf E and Schneider
            MR.
  TITLE     Betacellulin stimulates growth of the mouse intestinal epithelium
            and increases adenoma multiplicity in Apc+/Min mice
  JOURNAL   FEBS Lett 582 (19), 2911-2915 (2008)
   PUBMED   18656477
REFERENCE   4  (bases 1 to 611)
  AUTHORS   Li L, Li F, Qi H, Feng G, Yuan K, Deng H and Zhou H.
  TITLE     Coexpression of Pdx1 and betacellulin in mesenchymal stem cells
            could promote the differentiation of nestin-positive
            epithelium-like progenitors and pancreatic islet-like spheroids
  JOURNAL   Stem Cells Dev 17 (4), 815-823 (2008)
   PUBMED   18439098
  REMARK    GeneRIF: Coexpression of Pdx1 and betacellulin in mesenchymal stem
            cells could promote the differentiation of nestin-positive
            epithelium-like progenitors and pancreatic islet-like spheroids
REFERENCE   5  (bases 1 to 611)
  AUTHORS   Shin S, Li N, Kobayashi N, Yoon JW and Jun HS.
  TITLE     Remission of diabetes by beta-cell regeneration in diabetic mice
            treated with a recombinant adenovirus expressing betacellulin
  JOURNAL   Mol Ther 16 (5), 854-861 (2008)
   PUBMED   18388935
  REMARK    Erratum:[Mol Ther. 2008 Jul;16(7):1347]
REFERENCE   6  (bases 1 to 611)
  AUTHORS   Lawson J, Wheldrake JF and Dunbar AJ.
  TITLE     Genomic structure and promoter characterization of the gene
            encoding the ErbB ligand betacellulin
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 183-190 (2002)
   PUBMED   12031500
REFERENCE   7  (bases 1 to 611)
  AUTHORS   Dunbar AJ, Priebe IK, Sanderson MP and Goddard C.
  TITLE     Purification and molecular characterization of recombinant rat
            betacellulin
  JOURNAL   J Mol Endocrinol 27 (2), 239-247 (2001)
   PUBMED   11564606
REFERENCE   8  (bases 1 to 611)
  AUTHORS   Tada H, Seno M, Yamada H, Sasada R and Igarashi K.
  TITLE     Molecular cloning and expression of rat betacellulin cDNA
  JOURNAL   Biochim Biophys Acta 1492 (1), 285-288 (2000)
   PUBMED   11004502
REFERENCE   9  (bases 1 to 611)
  AUTHORS   Kallincos NC, Xian CJ, Dunbar AJ, Couper RT and Read LC.
  TITLE     Cloning of rat betacellulin and characterization of its expression
            in the gastrointestinal tract
  JOURNAL   Growth Factors 18 (3), 203-213 (2000)
   PUBMED   11334056
REFERENCE   10 (bases 1 to 611)
  AUTHORS   Miyagawa J, Hanafusa O, Sasada R, Yamamoto K, Igarashi K, Yamamori
            K, Seno M, Tada H, Nammo T, Li M, Yamagata K, Nakajima H, Namba M,
            Kuwajima M and Matsuzawa Y.
  TITLE     Immunohistochemical localization of betacellulin, a new member of
            the EGF family, in normal human pancreas and islet tumor cells
  JOURNAL   Endocr J 46 (6), 755-764 (1999)
   PUBMED   10724350
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB028862.1.
            
            On Feb 21, 2013 this sequence version replaced NM_022256.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028862.1, SRR8487226.123402.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-611               AB028862.1         1-611
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..611
                     /gene="Btc"
                     /note="betacellulin"
                     /db_xref="GeneID:64022"
                     /db_xref="RGD:620275"
     exon            1..112
                     /gene="Btc"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..582
                     /gene="Btc"
                     /note="probetacellulin"
                     /codon_start=1
                     /product="probetacellulin precursor"
                     /protein_id="NP_071592.1"
                     /db_xref="GeneID:64022"
                     /db_xref="RGD:620275"
                     /translation="MDSTAPGSGVSSLPLLLALVLGLVILQCVVADGNTTRTPETNGS
                     LCGAPGENCTGTTPRQKSKTHFSRCPKQYKHYCIHGRCRFVMDEQTPSCICEKGYFGA
                     RCEQVDLFYLQQDRGQILVVCLIGVMVLFIILVIGVCTCCHPLRKHRKKKKEEKMETL
                     SKDKTPISEDIQETNIA"
     exon            113..211
                     /gene="Btc"
                     /inference="alignment:Splign:2.1.0"
     exon            212..329
                     /gene="Btc"
                     /inference="alignment:Splign:2.1.0"
     exon            330..476
                     /gene="Btc"
                     /inference="alignment:Splign:2.1.0"
     exon            477..589
                     /gene="Btc"
                     /inference="alignment:Splign:2.1.0"
     exon            590..611
                     /gene="Btc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgagagaga ctcgttcagg ggctgccctg ccccacacag cacggttgat ggactcgact
       61 gccccaggca gcggtgtcag ctccctgccg ctgctcctgg cccttgtcct gggtcttgtg
      121 attctccagt gcgtggtggc agatgggaac acaaccagaa cccctgaaac caatggctct
      181 ctttgtggag ctcctgggga aaactgcaca ggtaccaccc ctagacagaa atcgaaaacc
      241 cacttctctc ggtgccccaa gcaatacaag cattactgca tccatgggag atgccgcttc
      301 gtgatggacg aacaaactcc ctcctgcatc tgtgagaaag gctactttgg ggcccggtgt
      361 gagcaggtgg acctgtttta tctccagcag gacagggggc agatcctggt ggtctgcttg
      421 ataggcgtca tggtgctgtt catcatttta gtcattggcg tctgcacctg ctgtcatcct
      481 cttcggaaac atcgcaaaaa gaagaaggaa gagaaaatgg aaactttgag taaagataaa
      541 actcccataa gtgaagatat tcaagagacc aatattgctt aacttaatga ttataaagtt
      601 accacaagct g
//
