LOCUS       NM_001419526            6985 bp    mRNA    linear   ROD 10-APR-2024
DEFINITION  Rattus norvegicus BTB domain containing 8 (Btbd8), mRNA.
ACCESSION   NM_001419526 XM_006250596
VERSION     NM_001419526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6985)
  AUTHORS   Piccini,A., Castroflorio,E., Valente,P., Guarnieri,F.C., Aprile,D.,
            Michetti,C., Bramini,M., Giansante,G., Pinto,B., Savardi,A.,
            Cesca,F., Bachi,A., Cattaneo,A., Wren,J.D., Fassio,A., Valtorta,F.,
            Benfenati,F. and Giovedi,S.
  TITLE     APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle
            Trafficking and Neuronal Development
  JOURNAL   Cell Rep 21 (12), 3596-3611 (2017)
   PUBMED   29262337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Apr 7, 2023 this sequence version replaced XM_006250596.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               JAXUCZ010000014.1  2478986-2479202     c
            218-412             JAXUCZ010000014.1  2472045-2472239     c
            413-609             JAXUCZ010000014.1  2467190-2467386     c
            610-727             JAXUCZ010000014.1  2459540-2459657     c
            728-817             JAXUCZ010000014.1  2449268-2449357     c
            818-898             JAXUCZ010000014.1  2440704-2440784     c
            899-995             JAXUCZ010000014.1  2439991-2440087     c
            996-1084            JAXUCZ010000014.1  2434443-2434531     c
            1085-1187           JAXUCZ010000014.1  2431927-2432029     c
            1188-1370           JAXUCZ010000014.1  2427675-2427857     c
            1371-1508           JAXUCZ010000014.1  2426683-2426820     c
            1509-1638           JAXUCZ010000014.1  2425712-2425841     c
            1639-1700           JAXUCZ010000014.1  2423557-2423618     c
            1701-2370           JAXUCZ010000014.1  2420115-2420784     c
            2371-2461           JAXUCZ010000014.1  2419506-2419596     c
            2462-2607           JAXUCZ010000014.1  2418968-2419113     c
            2608-4848           JAXUCZ010000014.1  2413448-2415688     c
            4849-6985           JAXUCZ010000014.1  2410093-2412229     c
FEATURES             Location/Qualifiers
     source          1..6985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..6985
                     /gene="Btbd8"
                     /note="BTB domain containing 8"
                     /db_xref="GeneID:100364240"
                     /db_xref="RGD:2321418"
     exon            1..217
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..5318
                     /gene="Btbd8"
                     /note="BTB (POZ) domain containing 8; APache;
                     AP2-interacting clathrin-endocytosis protein"
                     /codon_start=1
                     /product="bTB/POZ domain-containing protein 8"
                     /protein_id="NP_001406455.1"
                     /db_xref="GeneID:100364240"
                     /db_xref="RGD:2321418"
                     /translation="MAHCGAGGAAPAGLPRSPGLGRKGLPRKGSGERRRLKAVVSEQL
                     SRDVLRLLREEMHTDMVLSVSGSLFKVHRAVLLARAPGFHSHITGHTSRGLTDELIPV
                     DSVEASEFKAFLQIVYSSNKSVKNYEEEILQKMQVGNVMPEKGLDVSFLQCRTSSDCF
                     LGKHEIPADVTSGGDSFISKDDCDLEPVSELGADLLKLYLSQDYHDIDICVDGKSFKA
                     HRAILSARSSYFAAMLSGCWAESSQECITLQGITHVEMSVMMHFIYGGTLDFPEKANV
                     GQILNVADMYGLEGLREVAIYVLRRDYCNFFQKPVPRTWASILECLVIAHSVGVESLF
                     ADCMNCIISHFARFWSERSFANVPPEIQKTCLSMQIQSLNHGNAALLLMESDKLITGL
                     PRVKWTEAALSMASQLQGECVTFIVQNFSQVMESASFTLLLQSQAMSSTAHLLDKIFK
                     AIEDSITAENSCSLLMALDTLLKSDSAEEMGFTCRIQAVRDKLWTFLVQSFYAVRHTE
                     SWKLMHIDDQQKIQAAALDKGDDRRLGRKPVLSSSQQRRQGSDVIKIKPWTGNNKKLC
                     RASPSTNEKMRSDGLGASGHASGTHRNSVNKVSKHGEGTKVSKVTTEVKTGATHVPGK
                     PKTTIKPQTENNAHTKLESISSTVVGRPARMAATGRKDLAHGKGIQNQEGETTGARPK
                     VLTANLNTQARAKPLQTVKGKDNGCSATVGPSSRSANSSMERLASTGSVDETKENGSV
                     EDKSCDKKPYVSASPGQMVYNGVTSTVAVKSRPVSRVTSGTSSKKSFIHEQGPSVTSS
                     VIKKGRGSSKGLNDSAPQTAAKRGGSSNGYAAAQPRTKSAPPTLAQTQGSQGESPHSV
                     KSSISSRQSDESVTRLRHGTDKQMPKRKVVKQGHATLQKVNAKPTPKNPSQSTKGGTM
                     TSKDSKQKVLPGQVTLQSQASQRPSNPEAATTQRSVLHGVNDNRSQVFKQRPPESLVN
                     LASDTNGPEASPSPCRPQPQSPLGNQEKTRQEREHQDGSTLGDSVKHELRSELTSIEQ
                     SHTPAYKVSSQCSANPNCGCIASLKPVTSNPSENWINSNTANTDQVCVSDRERQTGRK
                     GTDREPSVNCVARKAALPSVPAGMSGTLKSAQDDRKLPFHREELSAQGHLPHDCATED
                     SKCATPTSAVSSRCLLGQPSEKGYKNMEASGTSESHEAPEAPFMGPWDLNTSATHQRE
                     SPESDTGSATTSSDDIKPRSEDYDAGGSQDDEGSHDRGVSKCSTALCHDFLGRSSSDT
                     STPEELKVHEGDLRTEVRVRKPGGGDLPLHSASDDETPRKKPDPWSRSTIVHPREKGS
                     APRGSVPSAQEVDQVSSSADETEDERSEAENVREHSSPSNSGTQHVQGIINLAFEDGT
                     EHESREFSATKKFRRSVLLSVDECEEVGSDEGEGHTPLQPSLDSLSPSDVFDGVSYEH
                     HGRTGYSRFFKENEATTAEHKYSRGNDGHKNEGFLLSPRSRDFPRQGKQCVSTGEKTR
                     LDVPPKASQQPFPESKDMTSKREVAHGLQQHGTLTDGDTRSQERPCHLELHQREPSST
                     IPKISSARSLDSCPSQVLPQDGQVTATHPTPPKRANNAVFSGDIDDCDTMAQTTMYDH
                     RPSKTLSPIHEMSLTAACEQKEESGTHVADRASEDEQPFAKQDWTLLKQLLSEQDANL
                     NVTSSLPEDLSLAQYLINQTLLLARDSSKPQGSAHADTWNRWSELSSPLDDLTASATT
                     VSVSSTDCSPQGEWTILELETQH"
     exon            218..412
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            413..609
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            610..727
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            728..817
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            818..898
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            899..995
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1084
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1187
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1370
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1508
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1638
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1700
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..2370
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2461
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2607
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..4848
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
     exon            4849..6985
                     /gene="Btbd8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctgggt tcgggaacgc ccccgtccgg gtcccgcgcg gcctggcacc cgggctcttg
       61 agcctgatat ggcccactgt ggagcaggcg gcgcggcccc ggcgggcctt ccgaggtccc
      121 cggggcttgg caggaagggg ctgcccagga aggggtccgg ggagcggcgc cggctgaagg
      181 cggtggtgtc ggagcagctc agccgcgacg tgctcaggct tttaagggaa gagatgcaca
      241 cagacatggt tctttctgtc agtggctcgc tgttcaaagt gcacagggca gtcttgttag
      301 ccagagcccc tggctttcac tcccacatca ctggacacac gtcaaggggc ctaacagatg
      361 agctcattcc tgtggacagc gttgaagctt cggaatttaa agcgttttta cagattgtgt
      421 attcatcaaa caaaagtgta aaaaactatg aagaggaaat tcttcaaaaa atgcaagtgg
      481 gaaacgtaat gccagaaaag gggctggacg tcagcttcct gcagtgtaga acttcatctg
      541 actgctttct tgggaaacac gaaatcccag cggatgttac cagtggaggt gacagtttta
      601 tttccaagga tgattgtgac ctggaaccgg tgtctgaatt aggagcagat ttgctgaagc
      661 tttacctgag tcaggattat cacgacattg acatttgtgt tgatgggaaa agcttcaaag
      721 ctcacagggc cattttaagt gccaggtcga gttactttgc tgcaatgctg agtggctgct
      781 gggctgaaag ctcccaagag tgcattactc ttcaaggtat aacccatgtg gaaatgagtg
      841 ttatgatgca ctttatatat ggagggactt tggattttcc agaaaaggct aatgttggtc
      901 agatactgaa cgtggctgat atgtatggac tggaaggatt aagagaagta gcaatctatg
      961 ttttaagaag agattactgt aatttctttc agaagcctgt tcccagaacg tgggcatcta
     1021 ttctagaatg cttagtcatt gctcattcgg tcggagtgga aagccttttt gctgactgca
     1081 tgaactgcat tataagccat tttgcaaggt tttggtcgga aagaagcttt gcaaatgttc
     1141 ctcctgagat tcagaaaacg tgtctcagta tgcagattca gtccttaaac catgggaatg
     1201 ccgccttgct tctgatggaa agtgataagc taatcacggg tctgcccagg gtgaagtgga
     1261 cagaagcagc cctgtcgatg gcatctcagc tccaaggaga gtgtgtgacg ttcattgtac
     1321 aaaacttctc ccaggtcatg gagagtgcga gcttcactct tctcctgcag tcacaagcaa
     1381 tgagcagcac agctcatctg ttggacaaaa tttttaaagc aattgaagac agtatcaccg
     1441 ctgagaatag ctgctctctg ctcatggctc tggacacatt actgaagtct gacagtgcag
     1501 aggaaatggg ctttacgtgc aggatccaag ccgtacgtga taagctgtgg accttcctgg
     1561 ttcagtcgtt ctatgctgtc cgtcacacag agagctggaa gctgatgcac atagatgatc
     1621 agcagaaaat ccaagcagcc gcacttgaca agggtgatga ccgcaggctt ggcaggaagc
     1681 ccgtgctctc cagctcccag caaaggagac aaggctctga tgttataaaa ataaaacctt
     1741 ggacgggaaa taacaaaaaa ctgtgtcggg cgtctccctc tactaatgag aagatgagat
     1801 ctgatggact aggagcgtca gggcatgcat caggcactca cagaaacagt gtgaacaaag
     1861 tgtccaagca tggcgagggc accaaagtgt ccaaggtgac cacagaggtg aaaaccgggg
     1921 caacacatgt ccctggcaag cctaaaacta caataaagcc ccaaacagaa aacaatgctc
     1981 acacaaagtt agaaagtata tcatccacag ttgtgggaag accagcaaga atggcagcga
     2041 ctggacggaa ggacctggca catggaaaag ggatccagaa ccaagaaggg gagaccacag
     2101 gggccaggcc caaggttctc actgcaaacc tgaacacaca agccagagcc aagcctttgc
     2161 aaacagtgaa agggaaagat aatgggtgct ccgccactgt ggggccctcc agtagatctg
     2221 caaattccag catggaacgt ttggcttcca caggctctgt ggatgagaca aaagaaaacg
     2281 gatcagtaga agacaagtct tgtgacaaga agccatacgt tagtgcttcc ccgggacaga
     2341 tggtgtacaa tggagtaacg tcaactgtag cagtgaagtc tcgaccagtt tcaagagtta
     2401 ccagtggaac atccagcaag aaaagcttta ttcatgagca aggcccttct gtgactagca
     2461 gtgtaataaa gaaagggaga gggagcagca aaggacttaa cgattcagca ccacagacag
     2521 cggccaagag aggagggagc agcaatggat atgcagcagc tcagcctcgg acaaagagcg
     2581 cccctcccac cctggctcag acccaaggat cgcaaggaga gtcgccacac tcagtaaaat
     2641 cttccatatc ttcaaggcag tctgatgaaa gcgtaacaag gttgaggcac ggaacggaca
     2701 aacagatgcc taagagaaaa gttgtcaagc aaggacacgc aactttgcag aaggttaatg
     2761 caaagccaac acctaaaaac ccaagtcagt ccacgaaagg tggaaccatg accagtaaag
     2821 actcaaaaca aaaagtgctt cctggacaag ttacgctgca aagtcaggct tctcaacggc
     2881 cttccaaccc cgaagcagcc accacacaga gaagcgtgct tcatggtgtg aatgacaaca
     2941 ggagccaggt ctttaaacag aggcctcctg agtccctggt taaccttgct agtgacacca
     3001 atggtcctga agcatccccg tcaccctgca gacctcaacc acaaagtccg ttaggcaatc
     3061 aggagaaaac gagacaggag cgagaacacc aagatgggtc aaccctgggt gattcagtaa
     3121 aacatgagct gaggtcagaa ctgaccagta tagagcaaag ccacacaccc gcttacaagg
     3181 tctcaagtca gtgcagtgca aacccaaact gtgggtgcat cgcttctctg aaacccgtga
     3241 cttcaaatcc aagtgaaaac tggatcaact ccaacacagc aaatacagac caagtctgtg
     3301 tatcagacag agagagacaa acggggagaa aaggcacaga tcgtgaacca agtgtgaact
     3361 gtgtggccag gaaagcagct ttaccgagtg ttcctgcagg gatgagtggt accctaaagt
     3421 ctgctcagga cgacagaaaa ctcccatttc acagagaaga actctcagct caaggccact
     3481 tacctcatga ctgtgccaca gaggacagta aatgtgctac acccacctca gctgtttcct
     3541 ccagatgtct cttgggacaa ccatctgaaa aaggttataa aaatatggaa gcatcaggaa
     3601 cctcagagag ccatgaagct ccggaagctc cattcatggg tccctgggat ttgaacacca
     3661 gtgccacaca tcagagagag agtccagaat ccgacactgg cagcgctacc acatcctcag
     3721 acgacataaa gccccgctcc gaagactatg acgctggggg gtctcaggat gacgagggct
     3781 cccatgacag aggcgtctcc aagtgcagca cggcgctgtg ccatgacttc cttgggagaa
     3841 gcagcagcga caccagcacc cctgaggagt tgaaggtgca tgaaggtgac ctcagaaccg
     3901 aagtcagagt gagaaagccg ggtgggggag acctcccgct ccactcggca agtgatgatg
     3961 agacccctag gaagaagcca gatccctggt ctcgatctac gatagtccac cccagggaga
     4021 agggaagtgc tccacggggc agtgtcccat ctgctcagga agtagaccag gtttcttctt
     4081 cagcagatga gacagaagat gaaagatctg aagcagaaaa cgttagggaa cactcctctc
     4141 cgtccaactc aggtactcag cacgttcagg ggataattaa cttagctttt gaagatggaa
     4201 ctgaacatga aagtcgtgag ttttctgcga ctaagaagtt tagaaggtca gtgttgctct
     4261 cggtagatga gtgtgaagaa gtggggtctg acgaaggcga aggccatacc cccctccagc
     4321 cctccctaga ttctctttca ccttctgatg tttttgatgg tgtttcctat gagcatcatg
     4381 gaaggacagg ctactccagg tttttcaaag aaaatgaagc gactactgca gagcacaaat
     4441 acagtagagg caacgatggg cataaaaatg aaggttttct cctgagccct aggagcagag
     4501 acttcccaag acaaggtaag cagtgtgtct caacaggtga gaagaccagg ttagatgtcc
     4561 cgcccaaagc gagccaacag ccttttccag aaagtaaaga catgactagt aaacgtgagg
     4621 tggctcacgg cttgcagcag cacggcacgc tcacggacgg ggacaccaga tctcaagaac
     4681 ggccatgtca tttggaactc caccagagag aacccagctc caccatacca aagatcagct
     4741 cagcgagatc tctcgactcc tgtcccagcc aggtgctgcc tcaggacggt caagtgacag
     4801 ccacccaccc cacacctccc aagagagcta ataatgctgt gttttcagga gacatagatg
     4861 attgtgatac aatggcacaa accaccatgt atgaccaccg gccttcaaaa accctctctc
     4921 caatacatga gatgtctcta acagcagcgt gtgagcagaa agaggagtca ggaacccatg
     4981 ttgcagacag ggcctctgag gatgagcagc cctttgcaaa gcaggactgg acactgctga
     5041 agcagctgct ttctgaacaa gacgcaaact taaatgtgac cagctctctg cctgaagacc
     5101 tgagcctagc ccagtattta atcaaccaga cactcctttt agcccgagat agttcgaaac
     5161 ctcagggttc agcacacgct gacacttgga acaggtggag tgaactgtcg tccccacttg
     5221 acgatttgac agcaagtgcc accacggtta gtgtttcttc cacagattgt tcgcctcaag
     5281 gggagtggac aatcctggaa ctggaaaccc agcattagga gtttcacagt cgggagagat
     5341 ttagactatg ccacccctgt ttttttgatg cctatttata tttaaattat aatttagtta
     5401 gccaaatata gactgtcctt aaaattgatg gagtctttta atttattgag gtaaatataa
     5461 cttatttatt aatactatgt ctcatatttt gaaaatgttt ttctaaattt atgagcatgt
     5521 tttctacatc cattagatta gaagactgaa gaaagccctg gctgcagttt tcttccctac
     5581 ctaatgattt gttcgtttat tcaagaattt ccatgtcagt atccaaatac atcaacccct
     5641 tactcactct tgacttactc ttgactctgc atacggtacc ataataattt accaataaac
     5701 ttactgtgtg agtgtgcact atacagaatc agtctgtgac tcacatttgg actcaggctg
     5761 agtgttgcgg ctggggagac agagggaccc cagatttccc agcatttcag gactaggaca
     5821 tgaagaggta gcgtacttca ggtttcagcc ataccgctaa taaactaaga ggagtttggc
     5881 ttttctaggt atgtaaggat aggcatttga cccttcgaag gcgtgtggaa actgtcctgt
     5941 ctgtgtggct ccagcagtca ctccctcttg catgccatgg gagaaatatt ttggaactgc
     6001 actgctccaa actatcacag cattaaccaa aatgagtgca tgaggcagct gactgagtcc
     6061 tagtgcgggc atgtgcttcc tctcgtctgt ttccttcctt tgtcagactt ctctcagtct
     6121 gtagctttgt aggaaaacag ataatcgatg ctccgaaagt aagcgatagg atcttagatg
     6181 ctaacgagga tccctttaag gggatgggga cgtaacaacc aggttaatac agagttattt
     6241 atcccaaaac agcactactg tttccattca agtacgaatc tattatacca taaaaccttt
     6301 tcatgacttt aaaaaaggtt ttacattttt ttatattaat tcgttcggtg ggtgtttacg
     6361 tgggtaggcg cgtgtgtgtg tgtaacagca catacatgga agtcagtgga caacctgtga
     6421 gagtcagttc tctccttcct tccaccacag gagtcggagg gattgaactc agatcatcag
     6481 gcttggtggc aagttccttt acccactgag ccacccctgc cctgccctga tcctggttct
     6541 atgccttttt aaaaagctag gcactcttgc aggaccactc atttaggcct aattatccta
     6601 ctgagcccaa tgggtaactg aatggacttt gcgctcatgt gtgaaggtga gtagagtaag
     6661 taagaagttc agtttctagt gcagtgcagg aggatgtaag gaaaacactg aaatcggagc
     6721 acagatgtta aagctgggta gaaatgtaaa gatttaatgg taaatcttta agtggtaaag
     6781 gaaggctttt gtgaccataa gaattaaaag atcctacagc taacttgtgg ggtagaatac
     6841 acaacttctt aattccaact tgctgttgtt tcttccacac aaaacacttc attttcccat
     6901 gaagctgtga ccaagcattg acaagtagtt tgtagtgtga aaccgtttat gtgatcgcaa
     6961 ttaaagcgca ccttcgttcc ccaga
//
