LOCUS       NP_001406455            1749 aa            linear   ROD 10-APR-2024
DEFINITION  bTB/POZ domain-containing protein 8 [Rattus norvegicus].
ACCESSION   NP_001406455 XP_006250658
VERSION     NP_001406455.1
DBSOURCE    REFSEQ: accession NM_001419526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1749)
  AUTHORS   Piccini,A., Castroflorio,E., Valente,P., Guarnieri,F.C., Aprile,D.,
            Michetti,C., Bramini,M., Giansante,G., Pinto,B., Savardi,A.,
            Cesca,F., Bachi,A., Cattaneo,A., Wren,J.D., Fassio,A., Valtorta,F.,
            Benfenati,F. and Giovedi,S.
  TITLE     APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle
            Trafficking and Neuronal Development
  JOURNAL   Cell Rep 21 (12), 3596-3611 (2017)
   PUBMED   29262337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Apr 7, 2023 this sequence version replaced XP_006250658.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..1749
                     /product="bTB/POZ domain-containing protein 8"
                     /note="BTB (POZ) domain containing 8; APache;
                     AP2-interacting clathrin-endocytosis protein"
                     /calculated_mol_wt=189802
     Region          1..36
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          43..146
                     /region_name="BTB1_POZ_BTBD8"
                     /note="first BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 8 (BTBD8); cd18285"
                     /db_xref="CDD:349594"
     Region          189..308
                     /region_name="BTB2_POZ_BTBD8"
                     /note="second BTB (Broad-Complex, Tramtrack and Bric a
                     brac)/POZ (poxvirus and zinc finger) domain found in
                     BTB/POZ domain-containing protein 8 (BTBD8); cd18286"
                     /db_xref="CDD:349595"
     Region          316..377
                     /region_name="BACK_BTBD8"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     BTB/POZ domain-containing protein 8 (BTBD8); cd18490"
                     /db_xref="CDD:350565"
     Region          526..638
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          658..680
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          697..749
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          771..1034
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          1060..1095
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          1108..1387
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          1402..1434
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          1453..1591
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          1628..1647
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D4A0X3.4)"
     Region          1705..1749
                     /region_name="DUF4596"
                     /note="Domain of unknown function (DUF4596); pfam15363"
                     /db_xref="CDD:464673"
     CDS             1..1749
                     /gene="Btbd8"
                     /coded_by="NM_001419526.1:69..5318"
                     /db_xref="GeneID:100364240"
                     /db_xref="RGD:2321418"
ORIGIN      
        1 mahcgaggaa paglprspgl grkglprkgs gerrrlkavv seqlsrdvlr llreemhtdm
       61 vlsvsgslfk vhravllara pgfhshitgh tsrgltdeli pvdsveasef kaflqivyss
      121 nksvknyeee ilqkmqvgnv mpekgldvsf lqcrtssdcf lgkheipadv tsggdsfisk
      181 ddcdlepvse lgadllklyl sqdyhdidic vdgksfkahr ailsarssyf aamlsgcwae
      241 ssqecitlqg ithvemsvmm hfiyggtldf pekanvgqil nvadmygleg lrevaiyvlr
      301 rdycnffqkp vprtwasile clviahsvgv eslfadcmnc iishfarfws ersfanvppe
      361 iqktclsmqi qslnhgnaal llmesdklit glprvkwtea alsmasqlqg ecvtfivqnf
      421 sqvmesasft lllqsqamss tahlldkifk aiedsitaen scsllmaldt llksdsaeem
      481 gftcriqavr dklwtflvqs fyavrhtesw klmhiddqqk iqaaaldkgd drrlgrkpvl
      541 sssqqrrqgs dvikikpwtg nnkklcrasp stnekmrsdg lgasghasgt hrnsvnkvsk
      601 hgegtkvskv ttevktgath vpgkpkttik pqtennahtk lesisstvvg rparmaatgr
      661 kdlahgkgiq nqegettgar pkvltanlnt qarakplqtv kgkdngcsat vgpssrsans
      721 smerlastgs vdetkengsv edkscdkkpy vsaspgqmvy ngvtstvavk srpvsrvtsg
      781 tsskksfihe qgpsvtssvi kkgrgsskgl ndsapqtaak rggssngyaa aqprtksapp
      841 tlaqtqgsqg esphsvkssi ssrqsdesvt rlrhgtdkqm pkrkvvkqgh atlqkvnakp
      901 tpknpsqstk ggtmtskdsk qkvlpgqvtl qsqasqrpsn peaattqrsv lhgvndnrsq
      961 vfkqrppesl vnlasdtngp easpspcrpq pqsplgnqek trqerehqdg stlgdsvkhe
     1021 lrseltsieq shtpaykvss qcsanpncgc iaslkpvtsn psenwinsnt antdqvcvsd
     1081 rerqtgrkgt drepsvncva rkaalpsvpa gmsgtlksaq ddrklpfhre elsaqghlph
     1141 dcatedskca tptsavssrc llgqpsekgy knmeasgtse sheapeapfm gpwdlntsat
     1201 hqrespesdt gsattssddi kprsedydag gsqddegshd rgvskcstal chdflgrsss
     1261 dtstpeelkv hegdlrtevr vrkpgggdlp lhsasddetp rkkpdpwsrs tivhprekgs
     1321 aprgsvpsaq evdqvsssad etederseae nvrehsspsn sgtqhvqgii nlafedgteh
     1381 esrefsatkk frrsvllsvd eceevgsdeg eghtplqpsl dslspsdvfd gvsyehhgrt
     1441 gysrffkene attaehkysr gndghknegf llsprsrdfp rqgkqcvstg ektrldvppk
     1501 asqqpfpesk dmtskrevah glqqhgtltd gdtrsqerpc hlelhqreps stipkissar
     1561 sldscpsqvl pqdgqvtath ptppkranna vfsgdiddcd tmaqttmydh rpsktlspih
     1621 emsltaaceq keesgthvad rasedeqpfa kqdwtllkql lseqdanlnv tsslpedlsl
     1681 aqylinqtll lardsskpqg sahadtwnrw selssplddl tasattvsvs stdcspqgew
     1741 tileletqh
//
