LOCUS       NM_001399401            2614 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus BTB domain containing 10 (Btbd10), transcript
            variant 1, mRNA.
ACCESSION   NM_001399401 XM_006230034
VERSION     NM_001399401.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Wang,X., Gong,Y., Zheng,M., Xie,Q., Tang,H., Wang,D. and Chen,X.
  TITLE     Early changes in GMRP1 after intracerebral hemorrhage: involvement
            in brain damage and cell apoptosis
  JOURNAL   Acta Neurochir Suppl 118, 163-167 (2013)
   PUBMED   23564125
  REMARK    GeneRIF: The results of this study showed that a decreased
            GMRP1-mediated Akt pathway contributed to cell apoptosis on the
            hemorrhagic side, suggesting that GMRP1 plays an important role in
            brain damage after intracerebral hemorrhage in rat model.
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   Zheng,M., Zhu,H., Gong,Y., Wang,D., Xie,Q., Tang,H., Yang,Z.,
            Lu,B., Chen,X. and Wang,X.
  TITLE     Involvement of GMRP1, a novel mediator of Akt pathway, in brain
            damage after intracerebral hemorrhage
  JOURNAL   Int J Clin Exp Pathol 6 (2), 224-229 (2013)
   PUBMED   23330007
  REMARK    GeneRIF: Decreased GMRP1(BTBD10)-mediated Akt pathway contributed
            to cell apoptosis in hemorrhagic side, suggesting that GMRP1 played
            an important role in brain damage after intracerebral hemorrhage.
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Wang,X., Liu,Y., Yang,Z., Zhang,Z., Zhou,W., Ye,Z., Zhang,W.,
            Zhang,S., Yang,Z., Feng,X., Chen,F. and Hu,R.
  TITLE     Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic
            beta cell proliferation and apoptosis via activation of Akt
            signalling pathway in rats and mice
  JOURNAL   Diabetologia 54 (4), 852-863 (2011)
   PUBMED   21267538
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Nawa,M., Kanekura,K., Hashimoto,Y., Aiso,S. and Matsuoka,M.
  TITLE     A novel Akt/PKB-interacting protein promotes cell adhesion and
            inhibits familial amyotrophic lateral sclerosis-linked mutant
            SOD1-induced neuronal death via inhibition of PP2A-mediated
            dephosphorylation of Akt/PKB
  JOURNAL   Cell Signal 20 (3), 493-505 (2008)
   PUBMED   18160256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 7, 2022 this sequence version replaced XM_006230034.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.3216.1,
                                           SRR26360194.1052139.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000001.1  176923478-176923663 c
            187-273             JAXUCZ010000001.1  176923139-176923225 c
            274-338             JAXUCZ010000001.1  176919211-176919275 c
            339-496             JAXUCZ010000001.1  176900569-176900726 c
            497-693             JAXUCZ010000001.1  176884494-176884690 c
            694-979             JAXUCZ010000001.1  176881918-176882203 c
            980-1082            JAXUCZ010000001.1  176878993-176879095 c
            1083-1203           JAXUCZ010000001.1  176878252-176878372 c
            1204-1401           JAXUCZ010000001.1  176875953-176876150 c
            1402-1512           JAXUCZ010000001.1  176873117-176873227 c
            1513-2614           JAXUCZ010000001.1  176865817-176866918 c
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..2614
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /note="BTB domain containing 10"
                     /db_xref="GeneID:308890"
                     /db_xref="RGD:1306301"
     exon            1..186
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            187..273
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            274..338
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            339..496
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..1823
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /note="isoform a is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein 10; K+ channel
                     tetramerization protein; BTB (POZ) domain containing 10"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 10 isoform a"
                     /protein_id="NP_001386330.1"
                     /db_xref="GeneID:308890"
                     /db_xref="RGD:1306301"
                     /translation="MAGRPHPYDSNSSDPENWDRKLHSRPRKLYKHSSTASRVAKGGV
                     DHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERAESQLTPCIRNVTSPTRQHHIERE
                     KDHSSSRPSSPRPQRASPNGSISSAGNSSRNSSQSSSDGSCKASGEMVFVYENAKEGA
                     RSVRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAE
                     GIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHEL
                     SNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYS
                     QIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVI
                     YNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVD
                     ELDSLPSHPASGNNDLDPDAQNPML"
     exon            497..693
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            694..979
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1082
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1203
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1401
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1512
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..2614
                     /gene="Btbd10"
                     /gene_synonym="RGD1306301"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagcagc taaagagccg gcctgcaacc tgcccgggcg gctctggtag gcgcagccgg
       61 tggagctgcc gccttacacc tagtaccgga gggatccggt tgagtaggcg gagggagcgg
      121 agcgtcgctc gctcgctctt gtagctcttc tcctcaactc tcggtggacg tctcaagggc
      181 cggcagggca gagtaaccca gtgccccgcc cctttcctgt catctttggg tcaccgcagc
      241 gacaacccta aggaggcgca tcacaatagg gcggtttatc tgagcaggct ggacctctgt
      301 gagggagaag gaaatggaac acctacattt ctaactgggt tatgggtgct acatgtgtgc
      361 tttcagagca gtagtgtgag gaaacttgaa gtgggatggc aggacggccg catccctatg
      421 acagtaactc cagtgatcca gagaattggg atcggaaatt gcatagtaga cctcgtaaac
      481 tttataaaca ttcaagcact gcctcacgtg ttgctaaggg aggagttgac cacaccaaaa
      541 tgagtctgca tggtgctagt gggggacatg agagatcaag agatagacga aggtcaagtg
      601 acagatcacg agattcatct cacgagagag cagagtctca gctcactcct tgtattcgaa
      661 atgtgacttc accaacaagg cagcatcata ttgaacgaga aaaagaccat agttcatctc
      721 gtccaagcag tcctcgtcct caaagagcat ccccaaatgg ctccattagt agtgctggga
      781 acagcagcag gaacagcagc cagtcaagct cagatggaag ctgtaaggcg tccggggaga
      841 tggtgtttgt gtatgagaat gcaaaagaag gggctcgcag tgtgaggaca tctgagcgag
      901 tgaccctgat agtggataac accagatttg ttgtggaccc gtccattttt actgcacagc
      961 caaatacaat gttgggcagg atgtttggat ctggccggga acataatttc acacgtccca
     1021 atgagaaggg agaatatgag gtggcagagg gaattggttc tactgtgttt cgagctattt
     1081 tggattacta taagacagga atcatccgct gtcctgatgg catctctatt cctgaactga
     1141 gagaagcgtg cgattacctt tgtatctctt ttgaatacag cacaattaaa tgtagagatc
     1201 tcagtgccct tatgcatgag ttatcaaatg atggtgctcg tagacaattt gaattttatc
     1261 tggaagaaat gatcctccct cttatggtag caagtgccca gagtggagag cgagagtgcc
     1321 atattgtagt gcttacagat gatgatgtag ttgattggga tgaggagtat ccacctcaga
     1381 tgggagagga atattcacag attatttata gcacaaaatt atatagattt ttcaagtaca
     1441 ttgaaaacag agatgtggcc aaatcagttt tgaaggagag gggtcttaag aagattagat
     1501 tgggaataga aggctaccct acctacaaag aaaaagtaaa gaaaaggcca gggggccgtc
     1561 cagaagtcat ttacaactat gtccaaagac ccttcattcg aatgtcctgg gagaaggagg
     1621 aaggaaagag ccggcacgta gacttccagt gtgtaaagag caaatctatc accaacctgg
     1681 cagcagctgc tgcagacatt ccccaggacc agctggtagt catgcacccc actccccagg
     1741 tggatgagct ggatagcctt cccagccacc ctgcctcagg caacaatgac ctcgatcctg
     1801 acgcacagaa tccaatgctg tgatgctgat gttcctgaaa ccatagcatg ctactctcca
     1861 cagtgacgtc gtactcctca ttctgcactg cgaagccact tttcttcatt gtgagatgca
     1921 cacgtttagg atactgcagt gtaggctttt ttaaagacca aaggtagctg aatggttttt
     1981 taacgagtac aactttagca tcctggttcc agttctataa atgtatttgt ttaccagtag
     2041 gtttgtgaaa ttggttcttt gtatggggac agtccttttt cacacatcca gaagtgggaa
     2101 tttggcagct ggggtacttt cagtgtagat tgaccctcat gccccaggta agatgcagaa
     2161 tattacagag ttgcacttta tagatggtgg ttaaatggag ctgctgaagc cattttagag
     2221 ctgtgatgca cagcataacg taagtgcttc taccagagta ctcctcagca cagtatgtat
     2281 agttggccca caacaagcaa aaacatattt atcttgggtt tatttaaaca attaggatga
     2341 actttgatgc ttatagtgtt ggttcactca tctccagagc cctgcagtcc ttttagagtg
     2401 agtcacatgc agggagggtg aacgtcaaga ggtggtttac tgtccagtct gccttatcct
     2461 taatccgttc atatatttat ttactaatgc tttttttctt aagagttatg ggataggaaa
     2521 atgaactgtt tgctcttcat ttactaaatg attgtaaact cgagtttttc atcaaaataa
     2581 aatttcattg ttttaatgtt tctgaccaac ttta
//
