LOCUS       NM_001191995             869 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus brain specific homeobox (Bsx), mRNA.
ACCESSION   NM_001191995 XM_576393
VERSION     NM_001191995.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Carstensen,M.B., Hertz,H., Bering,T., Moller,M., Rohde,K.,
            Klein,D.C., Coon,S.L. and Rath,M.F.
  TITLE     Circadian regulation and molecular role of the Bsx homeobox gene in
            the adult pineal gland
  JOURNAL   J Pineal Res 68 (2), e12629 (2020)
   PUBMED   31808568
  REMARK    GeneRIF: Circadian regulation and molecular role of the Bsx
            homeobox gene in the adult pineal gland.
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Lage,R., Vazquez,M.J., Varela,L., Saha,A.K., Vidal-Puig,A.,
            Nogueiras,R., Dieguez,C. and Lopez,M.
  TITLE     Ghrelin effects on neuropeptides in the rat hypothalamus depend on
            fatty acid metabolism actions on BSX but not on gender
  JOURNAL   FASEB J 24 (8), 2670-2679 (2010)
   PUBMED   20335227
  REMARK    GeneRIF: Ghrelin-induced changes in the AMPK-CPT1 pathway are
            associated with increased levels of AgRP and NPY mRNA expression
            through modulation of BSX, pCREB, and FoxO1 in a gender-independent
            manner.
REFERENCE   3  (bases 1 to 869)
  AUTHORS   McArthur,T. and Ohtoshi,A.
  TITLE     A brain-specific homeobox gene, Bsx, is essential for proper
            postnatal growth and nursing
  JOURNAL   Mol Cell Biol 27 (14), 5120-5127 (2007)
   PUBMED   17485440
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Sakkou,M., Wiedmer,P., Anlag,K., Hamm,A., Seuntjens,E.,
            Ettwiller,L., Tschop,M.H. and Treier,M.
  TITLE     A role for brain-specific homeobox factor Bsx in the control of
            hyperphagia and locomotory behavior
  JOURNAL   Cell Metab 5 (6), 450-463 (2007)
   PUBMED   17550780
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Chu,H.Y. and Ohtoshi,A.
  TITLE     Cloning and functional analysis of hypothalamic homeobox gene Bsx1a
            and its isoform, Bsx1b
  JOURNAL   Mol Cell Biol 27 (10), 3743-3749 (2007)
   PUBMED   17353277
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_576393.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1055232.1,
                                           SRR26360194.373306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050746, SAMN17050764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               JAXUCZ010000008.1  50151204-50151510
            308-504             JAXUCZ010000008.1  50153396-50153592
            505-869             JAXUCZ010000008.1  50154596-50154960
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..869
                     /gene="Bsx"
                     /gene_synonym="RGD1565120"
                     /note="brain specific homeobox"
                     /db_xref="GeneID:500982"
                     /db_xref="RGD:1565120"
     exon            1..307
                     /gene="Bsx"
                     /gene_synonym="RGD1565120"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..744
                     /gene="Bsx"
                     /gene_synonym="RGD1565120"
                     /codon_start=1
                     /product="brain-specific homeobox protein homolog"
                     /protein_id="NP_001178924.1"
                     /db_xref="GeneID:500982"
                     /db_xref="RGD:1565120"
                     /translation="MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASS
                     LASRVPLLDYGYPLMPTPTLLTPHTHHPLHKGEHHHPYFLATSGMPVPALFPHPQHAE
                     LPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQN
                     RRMKHKKQLRKSQDEPKAADGPESPEGSPRAPEGAPADARLSLPAGAFVLTEPEDEVD
                     IGDEGELSSGPHVL"
     exon            308..504
                     /gene="Bsx"
                     /gene_synonym="RGD1565120"
                     /inference="alignment:Splign:2.1.0"
     exon            505..869
                     /gene="Bsx"
                     /gene_synonym="RGD1565120"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcactttg tccgggccct cgccccgtgc caggcgctct gcaagatgaa tctcaacttc
       61 acttcccctc tccatccagc atcttctcag aggcccacgt cgtttttcat cgaggacatt
      121 ctgctacaca agcccaagcc gttgagggaa gtggcccctg accactttgc cagctctctg
      181 gcctctaggg tgcctttgct agactatggc taccccctta tgcccacacc caccctcctc
      241 acccctcaca ctcatcatcc tctgcataag ggggagcatc atcaccctta tttcctggcc
      301 acctcaggga tgccggtccc ggctctgttc ccgcacccgc agcatgcaga gctacccggg
      361 aagcactgcc gccgccgcaa agctcgcacg gtgttttctg actcgcagct ctccggcctg
      421 gagaaaaggt tcgaaatcca gcgctacctg tcgacaccag agcgtgtgga gctggccact
      481 gctctcagcc tctctgagac tcaggtgaaa acgtggttcc agaaccggcg gatgaagcat
      541 aaaaaacagc tgaggaaaag tcaagacgaa cccaaagccg cagacgggcc tgagagccca
      601 gagggcagcc ctcgtgctcc cgagggcgcg cccgccgacg ctcggctgag tttgccggcc
      661 ggtgccttcg tgcttacaga gccggaggac gaggtggaca ttggggacga aggcgagctc
      721 agctcagggc cgcacgtgct ctgagtggcc aggctgggaa gggagacccg ggcgaggagg
      781 ctgtggggcc agacccggtt ctttccgggc gagaagactc gcggagactc tagactgttc
      841 ctgcggcctg gactggaaga aagaaaggc
//
