LOCUS       NM_138979               2720 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus barttin CLCNK type accessory subunit beta (Bsnd),
            mRNA.
ACCESSION   NM_138979
VERSION     NM_138979.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2720)
  AUTHORS   Uetsuka,S., Ogata,G., Nagamori,S., Isozumi,N., Nin,F., Yoshida,T.,
            Komune,S., Kitahara,T., Kikkawa,Y., Inohara,H., Kanai,Y. and
            Hibino,H.
  TITLE     Molecular architecture of the stria vascularis membrane transport
            system, which is essential for physiological functions of the
            mammalian cochlea
  JOURNAL   Eur J Neurosci 42 (3), 1984-2002 (2015)
   PUBMED   26060893
REFERENCE   2  (bases 1 to 2720)
  AUTHORS   Wolf,K., Meier-Meitinger,M., Bergler,T., Castrop,H., Vitzthum,H.,
            Riegger,G.A., Kurtz,A. and Kramer,B.K.
  TITLE     Parallel down-regulation of chloride channel CLC-K1 and barttin
            mRNA in the thin ascending limb of the rat nephron by furosemide
  JOURNAL   Pflugers Arch 446 (6), 665-671 (2003)
   PUBMED   12759757
REFERENCE   3  (bases 1 to 2720)
  AUTHORS   Waldegger,S., Jeck,N., Barth,P., Peters,M., Vitzthum,H., Wolf,K.,
            Kurtz,A., Konrad,M. and Seyberth,H.W.
  TITLE     Barttin increases surface expression and changes current properties
            of ClC-K channels
  JOURNAL   Pflugers Arch 444 (3), 411-418 (2002)
   PUBMED   12111250
REFERENCE   4  (bases 1 to 2720)
  AUTHORS   Estevez,R., Boettger,T., Stein,V., Birkenhager,R., Otto,E.,
            Hildebrandt,F. and Jentsch,T.J.
  TITLE     Barttin is a Cl- channel beta-subunit crucial for renal Cl-
            reabsorption and inner ear K+ secretion
  JOURNAL   Nature 414 (6863), 558-561 (2001)
   PUBMED   11734858
REFERENCE   5  (bases 1 to 2720)
  AUTHORS   Birkenhager,R., Otto,E., Schurmann,M.J., Vollmer,M., Ruf,E.M.,
            Maier-Lutz,I., Beekmann,F., Fekete,A., Omran,H., Feldmann,D.,
            Milford,D.V., Jeck,N., Konrad,M., Landau,D., Knoers,N.V.,
            Antignac,C., Sudbrak,R., Kispert,A. and Hildebrandt,F.
  TITLE     Mutation of BSND causes Bartter syndrome with sensorineural
            deafness and kidney failure
  JOURNAL   Nat Genet 29 (3), 310-314 (2001)
   PUBMED   11687798
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081725.1.
            
            On Sep 16, 2004 this sequence version replaced NM_138979.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081725.1, AJ421029.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760389
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2720
                     /gene="Bsnd"
                     /note="barttin CLCNK type accessory subunit beta"
                     /db_xref="GeneID:192675"
                     /db_xref="RGD:621139"
     exon            1..376
                     /gene="Bsnd"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1126
                     /gene="Bsnd"
                     /note="Bartter syndrome, infantile, with sensorineural
                     deafness (Barttin); barttin CLCNK-type chloride channel
                     accessory beta subunit; barttin CLCNK type accessory beta
                     subunit"
                     /codon_start=1
                     /product="barttin"
                     /protein_id="NP_620435.1"
                     /db_xref="GeneID:192675"
                     /db_xref="RGD:621139"
                     /translation="MADEKTFRIGFIVLGLFLLSLGTFLMSHDRPQVYGTFYAMGSIM
                     VIGGVLWSMCQCYPKITFVPADSDFQGMLSPKALSLLETGLSEVKSPQPPYVRLWEEA
                     AYDQSLPDFTHIQMKVMGYSEDPRPLLAPELKTGTSSAKEGEPHSAQTWMEAAVVVHR
                     ELDEKEGEKSRSQSSPPACSQGSAPLASFHDDLDVGSSEGRSPQPSPPDRDEAHLQVP
                     WASRGPLDRFGDFALIDDTPISEDMGLEGQAQEEALPSKQPWSLRMKEETVQAGAEEP
                     EQEEEDLYYGLPDSPGDPLPDKELGFEPDVQG"
     exon            377..468
                     /gene="Bsnd"
                     /inference="alignment:Splign:2.1.0"
     exon            469..723
                     /gene="Bsnd"
                     /inference="alignment:Splign:2.1.0"
     exon            724..2694
                     /gene="Bsnd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgggccca ctgaagcgtg tcacctgccc tgcagaactg ctgggcccag ggctgcgagc
       61 tggatgcgtg gggatcattc ctggctctgt gcattacgct gtggttctca gccatctact
      121 gtgtcatcgc tccttgcaag cctgctcaac gtttgagtag gattgtgggc agctctctgc
      181 tggtggccgg ttagccacca tggctgacga gaagaccttc cgaatcggtt tcatcgtgct
      241 gggccttttc ctgctatccc tgggcacatt ccttatgagc cacgatcgac cccaagtcta
      301 cggcaccttc tatgccatgg gcagcatcat ggtgattggg ggtgtcctct ggagcatgtg
      361 ccaatgctat cctaagatca cctttgtgcc ggcagactct gacttccaag gcatgttgtc
      421 cccaaaggcc ctgagcctgc tggagactgg gctttcagaa gtaaagagcc cccagccccc
      481 ctacgtcagg ctgtgggaag aagccgctta tgaccagagc ctcccagact tcactcacat
      541 ccaaatgaag gtcatgggct acagtgagga ccccaggcca ctgctggccc ccgaactgaa
      601 gacaggaacc agcagtgcca aggaaggcga gcctcattct gctcagacct ggatggaggc
      661 tgcggtggtc gtccatagag agttggatga gaaggaggga gagaaatctc gttctcagag
      721 cagccctcca gcgtgttccc aaggctctgc acccttggcg tcatttcacg atgacttgga
      781 cgtgggttct agcgaaggcc gcagccccca gccatcccca cctgacagag atgaggcaca
      841 cctgcaggtg ccctgggcca gcagaggtcc actggatcgc ttcggtgact ttgctctgat
      901 tgatgacacc cctatatcag aggacatggg cctggagggg caggcacagg aggaagctct
      961 acccagcaag caaccatggt ccctgaggat gaaggaggag actgtccagg caggtgcaga
     1021 agaaccagag caggaggagg aagatctgta ctacgggctg cccgacagcc ctggggaccc
     1081 cctccctgac aaagagttgg gctttgagcc tgatgtccag ggttgagatg aaactgcttc
     1141 ctgggtctag cctgacagca ctgctctctt catgtgaccc ctcaagggct cagttttcca
     1201 agtccaaata ggattgtatg gagggtcgag tgaggcagtg aactgaagca tcttgggaac
     1261 tgaagcaaac acacatgggg ggcagccatc ctcctcccag tgagccacgt acttctggtt
     1321 gtagcttgtt ctgctgacct gcaggtagag tggggttttc tgaggtcctg tgttatagcc
     1381 agaccctcag aagccctttc tatctctggg gtctgatggg cctcctgtgg tgctacccag
     1441 gcccccaaga gcccactgtg ttttgatcct ctgatgaatg tttgattcac cccacagcgg
     1501 atgctgtctc tcggctccat gtcttcagca ggtcccctgt tctgggatct atgactctgg
     1561 ctgacctctg ctgacctgac ctgacgtctg gatatctctc tggtccctcc tgttcctgca
     1621 gttgccccta gcccttgctt gagctgtgtt cttcagggtc ccttgtgctg agtgaattcc
     1681 cacccattcc tatacgcctg tgaatgtgac ctttcttctg ctagttttcc tggcatccca
     1741 actcctaggt gagaatttct ctccgggact tgggcatcca tttctgtgac tgatgcttgc
     1801 cactgccctg ggacaacatc ttggcctcat tcaccatagt tcccaggaga tccttggcat
     1861 gtgcagatct cagtagagct gggaaccttt gcagatagtg tcaccctccc atttgacaag
     1921 taatggactc ttagtctctg acacccactt ttcaaaatgg cttctagaca gtcataaaaa
     1981 tcaggcaaaa agctaccaga agcagctcac agagcacact tgcattgact tagaaatgga
     2041 caaaatccgg ctgttgaatt aattccactt gatgcccttg gcttttactg agcatctgct
     2101 aggatccagg cactcagctt gggaaatagt cactggtccc tgacccctct aagggctcac
     2161 agtcccagct tgctgtcttg taagttggga acatagcatg gggcagaaga tggggtggtg
     2221 tcagagccac ccccatctgc agatcttact accctctgtt ttcagtcaac atggagggag
     2281 ccatacggag ggtgttgcta ccttccccag ccaggtccac acaacttaga tctgttctga
     2341 gaaggttagg ggtctctttg gagggaagga gatccagctg gtgctcagtg agaacatacc
     2401 acaatcctcc ccgcttctgg ggcatgtcta cctcttcagt gaagatgcct cctccaggca
     2461 cctcctctct ggtcaccgga ccaggtgtcc tttgttcatg tcgcagctgc tgtgtactgc
     2521 tggcccaggc agggaggact gtgacccaca tcagacagag cagagccagc accaagggct
     2581 aaaataaaaa aaaaagtttt tgacattgaa gggtcacctt tactcgcctg caaattcttt
     2641 tctgtaaaac tgcccattcc gctcggggca gaataaaatg agacttcacg cctgaaaaaa
     2701 aaaaaaaaaa aaaaaaaaaa
//
