LOCUS       NM_001109882            1681 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus basigin (Bsg), transcript variant 1, mRNA.
ACCESSION   NM_001109882
VERSION     NM_001109882.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Zhu,X., Tang,Z., Li,W., Li,X., Iwakiri,Y. and Liu,F.
  TITLE     S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP
            activity in liver fibrosis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1640-1649 (2023)
   PUBMED   37700592
  REMARK    GeneRIF: S-nitrosylation of EMMPRIN influences the migration of
            HSCs and MMP activity in liver fibrosis.
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Chen,Y., Luan,J., Jiang,T., Cai,D., Sun,C., Wang,X., Zhao,X. and
            Gou,X.
  TITLE     Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits
            Tumor Growth and Decreases Cancer-Induced Bone Destruction and Pain
  JOURNAL   Cancer Res Treat 53 (2), 576-583 (2021)
   PUBMED   33138345
  REMARK    GeneRIF: Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells
            Inhibits Tumor Growth and Decreases Cancer-Induced Bone Destruction
            and Pain.
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Wang,Q., Xu,B., Fan,K., Wu,J. and Wang,T.
  TITLE     Inflammation suppression by dexamethasone via inhibition of
            CD147-mediated NF-kappaB pathway in collagen-induced arthritis rats
  JOURNAL   Mol Cell Biochem 473 (1-2), 63-76 (2020)
   PUBMED   32594339
  REMARK    GeneRIF: Inflammation suppression by dexamethasone via inhibition
            of CD147-mediated NF-kappaB pathway in collagen-induced arthritis
            rats.
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Wang,Q., Xu,B., Fan,K., Wu,J. and Wang,T.
  TITLE     CypB-CD147 Signaling Is Involved in Crosstalk between Cartilage and
            FLS in Collagen-Induced Arthritis
  JOURNAL   Mediators Inflamm 2020, 6473858 (2020)
   PUBMED   32908452
  REMARK    GeneRIF: CypB-CD147 Signaling Is Involved in Crosstalk between
            Cartilage and FLS in Collagen-Induced Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Forero-Quintero,L.S., Ames,S., Schneider,H.P., Thyssen,A.,
            Boone,C.D., Andring,J.T., McKenna,R., Casey,J.R., Deitmer,J.W. and
            Becker,H.M.
  TITLE     Membrane-anchored carbonic anhydrase IV interacts with
            monocarboxylate transporters via their chaperones CD147 and GP70
  JOURNAL   J Biol Chem 294 (2), 593-607 (2019)
   PUBMED   30446621
  REMARK    GeneRIF: This study analyzed the direct interaction between CAIV
            and the two Monocarboxylate transporters (MCTs) chaperones basigin
            (CD147) and embigin (GP70). In rat CD147, binding of CAIV was
            mediated by by the positively charged Lys-73.
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Kuno,N., Kadomatsu,K., Fan,Q.W., Hagihara,M., Senda,T., Mizutani,S.
            and Muramatsu,T.
  TITLE     Female sterility in mice lacking the basigin gene, which encodes a
            transmembrane glycoprotein belonging to the immunoglobulin
            superfamily
  JOURNAL   FEBS Lett 425 (2), 191-194 (1998)
   PUBMED   9559645
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Naruhashi,K., Kadomatsu,K., Igakura,T., Fan,Q.W., Kuno,N.,
            Muramatsu,H., Miyauchi,T., Hasegawa,T., Itoh,A., Muramatsu,T. and
            Nabeshima,T.
  TITLE     Abnormalities of sensory and memory functions in mice lacking Bsg
            gene
  JOURNAL   Biochem Biophys Res Commun 236 (3), 733-737 (1997)
   PUBMED   9245724
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Polette,M., Gilles,C., Marchand,V., Lorenzato,M., Toole,B.,
            Tournier,J.M., Zucker,S. and Birembaut,P.
  TITLE     Tumor collagenase stimulatory factor (TCSF) expression and
            localization in human lung and breast cancers
  JOURNAL   J Histochem Cytochem 45 (5), 703-709 (1997)
   PUBMED   9154157
REFERENCE   9  (bases 1 to 1681)
  AUTHORS   Nehme,C.L., Cesario,M.M., Myles,D.G., Koppel,D.E. and Bartles,J.R.
  TITLE     Breaching the diffusion barrier that compartmentalizes the
            transmembrane glycoprotein CE9 to the posterior-tail plasma
            membrane domain of the rat spermatozoon
  JOURNAL   J Cell Biol 120 (3), 687-694 (1993)
   PUBMED   8425897
REFERENCE   10 (bases 1 to 1681)
  AUTHORS   Fossum,S., Mallett,S. and Barclay,A.N.
  TITLE     The MRC OX-47 antigen is a member of the immunoglobulin superfamily
            with an unusual transmembrane sequence
  JOURNAL   Eur J Immunol 21 (3), 671-679 (1991)
   PUBMED   2009910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV119278.1, AY120888.1 and BQ199464.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY120888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676808 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                CV119278.1         1-81
            82-1657             AY120888.1         1-1576
            1658-1681           BQ199464.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1681
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /note="basigin"
                     /db_xref="GeneID:25246"
                     /db_xref="RGD:2220"
     exon            1..158
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1258
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; OX-47 antigen; glycoprotein CE9; neurothelin;
                     basigin (Ok blood group); Basigin (Ox47 antigen or CE-9)
                     (EMMPRIN in human) (neurothelin HT7 or 5A11 in avian);
                     Basignin (Ox47 antigen or CE-9) (EMMPRIN in human)
                     (neurothelin HT7 or 5A11 in avian)"
                     /codon_start=1
                     /product="basigin isoform 1 precursor"
                     /protein_id="NP_001103352.1"
                     /db_xref="GeneID:25246"
                     /db_xref="RGD:2220"
                     /translation="MAAALLLALAFTFLSGQGACAAAGFLKAPMSQEQWAGGSVVLHC
                     EAVGSPMPEIQWWFEGNEPNDSCSQLWDGARLDRVHIHATYRQHAASTLSVDGLAAED
                     TGTYECRASSDPDRNHLTRPPRVKWVRAQASVVVLEPGTIVTSVQEVDSKTQLTCFLN
                     SSGIDIVGHRWMRGGKVLQEDTLPDLQMKYTVDADDRSGEYSCIFLPEPVGRGNINVE
                     GPPRIKVGKKSEHASEGEFVKLICKSEASHPPVDEWVWFKTSDTGDQTISNGTEANSK
                     YVIISTPELSELIISDLDMNVDPGTYVCNATNSQGSARETISLRVRSRLAALWPFLGI
                     VAEVLVLVTIIFIYEKRRKPDQTLDEDDPGAAPLKGSGSHLNDKDKNVRQRNAT"
     exon            159..506
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     exon            507..663
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     exon            664..746
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     exon            747..886
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1169
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1194
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1664
                     /gene="Bsg"
                     /gene_synonym="5A11; basignin; CE9; EMMPRIN; HT7; Ox47R"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccccgcg acgccgcgtg cgtacgtgct gcgtgcgcgc gccccaccct tcttatagag
       61 ccgcagtggg gctgctcttg gacgaggcga catggcggcg gcgctgctgc tggcgctggc
      121 cttcacgttc ctgagtggcc aaggcgcctg cgcggcggct ggctttctca aggcgccaat
      181 gtcccaggag cagtgggcgg ggggcagcgt ggtcctgcac tgtgaggctg tgggcagccc
      241 catgccggag atccagtggt ggtttgaagg gaatgaacca aacgacagct gctcccagct
      301 ctgggatggc gcccggctgg accgtgttca catccatgcc acctaccgcc agcatgcagc
      361 cagcacgctg tctgttgatg ggctcgccgc agaggacaca ggcacttatg aatgccgggc
      421 cagcagtgac cctgaccgca accacctgac ccggccaccc agggtcaagt gggttcgtgc
      481 ccaggcgagc gtggtggtcc ttgaaccggg caccatcgta acctctgtcc aggaagttga
      541 ctccaagaca cagcttacct gctttttgaa cagcagtggc attgacatcg ttggccaccg
      601 ctggatgaga ggtggcaagg tactgcagga agacacgctg cccgatctac agatgaagta
      661 cacggtggat gcagatgacc gctctggaga atattcctgc atcttccttc ctgagcctgt
      721 gggcagaggc aacatcaatg tggaggggcc acccaggatc aaggtgggaa agaaatcgga
      781 acacgccagt gagggagagt ttgtgaagct gatctgcaag tctgaggcgt cccaccctcc
      841 tgtggatgag tgggtctggt ttaagacctc tgacactggg gaccagacta tctccaacgg
      901 cactgaggcc aatagcaagt acgtcattat atccacgcct gagctgtcag agctgatcat
      961 cagcgacctg gacatgaacg tggaccctgg cacctacgtg tgcaatgcca ccaactccca
     1021 gggcagtgct cgggagacca tctcactgcg tgtgcgcagc cgcctggcag ccctctggcc
     1081 cttcctgggc attgtggccg aggtcctggt gttggtcacc atcatcttca tctacgagaa
     1141 gaggcggaag ccggaccaga ccctggacga ggatgatcct ggcgccgccc cactgaaggg
     1201 cagcgggtct cacctgaatg acaaggacaa gaatgtgcgc cagaggaacg ccacctgagc
     1261 ggcggggcag gcggggaggg gaggtgccag ggcacttgac cccagcccag cgtctgcctc
     1321 cactcctgtg tcccatcctg tcccgacctg agcctgccca acccaacttc ttatcccagc
     1381 ccaagtgaag acagagcctt accttacaga aaacccatct gggagaagca ggccacttgc
     1441 agtacccctg tttctagttt aaactgaatg aggtttctat gcagacaatc cattccttag
     1501 ggctacgttt ttattttcct tcccttctga agtatgtcac tacagccctg tggagtgggg
     1561 gagtggggtc atgagggaaa ggccagggca cacatgctct gactttaccc tgttggaggg
     1621 ggctgggcct gctgggaccc cacaaataaa gacctacacc accaaaaaaa aaaaaaaaaa
     1681 a
//
