LOCUS       NM_001012171            1965 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus BSCL2 lipid droplet biogenesis associated, seipin
            (Bscl2), mRNA.
ACCESSION   NM_001012171 XM_039084125 XM_342013
VERSION     NM_001012171.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1965)
  AUTHORS   Zhu,X., An,X., Chen,M., Guo,D., Xie,P., Wang,B., Huang,Z. and Yu,W.
  TITLE     Seipin overexpression attenuates cerebral ischemia-reperfusion
            injury via preventing apoptosis and autophagy
  JOURNAL   Brain Behav 13 (12), e3195 (2023)
   PUBMED   37897134
  REMARK    GeneRIF: Seipin overexpression attenuates cerebral
            ischemia-reperfusion injury via preventing apoptosis and autophagy.
REFERENCE   2  (bases 1 to 1965)
  AUTHORS   Ren,Z., Xie,P., Lv,J., Hu,Y., Guan,Z., Chen,L. and Yu,W.
  TITLE     miR-187-3p inhibitor attenuates cerebral ischemia/reperfusion
            injury by regulating Seipin-mediated autophagic flux
  JOURNAL   Int J Mol Med 46 (3), 1051-1062 (2020)
   PUBMED   32705147
  REMARK    GeneRIF: miR1873p inhibitor attenuates cerebral
            ischemia/reperfusion injury by regulating Seipinmediated autophagic
            flux.
REFERENCE   3  (bases 1 to 1965)
  AUTHORS   Chung,J., Wu,X., Lambert,T.J., Lai,Z.W., Walther,T.C. and
            Farese,R.V. Jr.
  TITLE     LDAF1 and Seipin Form a Lipid Droplet Assembly Complex
  JOURNAL   Dev Cell 51 (5), 551-563 (2019)
   PUBMED   31708432
REFERENCE   4  (bases 1 to 1965)
  AUTHORS   Salo,V.T., Li,S., Vihinen,H., Holtta-Vuori,M., Szkalisity,A.,
            Horvath,P., Belevich,I., Peranen,J., Thiele,C., Somerharju,P.,
            Zhao,H., Santinho,A., Thiam,A.R., Jokitalo,E. and Ikonen,E.
  TITLE     Seipin Facilitates Triglyceride Flow to Lipid Droplet and
            Counteracts Droplet Ripening via Endoplasmic Reticulum Contact
  JOURNAL   Dev Cell 50 (4), 478-493 (2019)
   PUBMED   31178403
REFERENCE   5  (bases 1 to 1965)
  AUTHORS   Li,D., Zhao,Y.G., Li,D., Zhao,H., Huang,J., Miao,G., Feng,D.,
            Liu,P., Li,D. and Zhang,H.
  TITLE     The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact
            Formation
  JOURNAL   Cell Rep 27 (2), 343-358 (2019)
   PUBMED   30970241
REFERENCE   6  (bases 1 to 1965)
  AUTHORS   Ito,D., Fujisawa,T., Iida,H. and Suzuki,N.
  TITLE     Characterization of seipin/BSCL2, a protein associated with spastic
            paraplegia 17
  JOURNAL   Neurobiol Dis 31 (2), 266-277 (2008)
   PUBMED   18585921
REFERENCE   7  (bases 1 to 1965)
  AUTHORS   Windpassinger,C., Auer-Grumbach,M., Irobi,J., Patel,H., Petek,E.,
            Horl,G., Malli,R., Reed,J.A., Dierick,I., Verpoorten,N.,
            Warner,T.T., Proukakis,C., Van den Bergh,P., Verellen,C., Van
            Maldergem,L., Merlini,L., De Jonghe,P., Timmerman,V., Crosby,A.H.
            and Wagner,K.
  TITLE     Heterozygous missense mutations in BSCL2 are associated with distal
            hereditary motor neuropathy and Silver syndrome
  JOURNAL   Nat Genet 36 (3), 271-276 (2004)
   PUBMED   14981520
REFERENCE   8  (bases 1 to 1965)
  AUTHORS   Windpassinger,C., Wagner,K., Petek,E., Fischer,R. and
            Auer-Grumbach,M.
  TITLE     Refinement of the Silver syndrome locus on chromosome 11q12-q14 in
            four families and exclusion of eight candidate genes
  JOURNAL   Hum Genet 114 (1), 99-109 (2003)
   PUBMED   13680364
REFERENCE   9  (bases 1 to 1965)
  AUTHORS   Kaisaki,P.J., Sebag-Montefiore,L.M., Brown,J.H., Magre,J.,
            Lathrop,M., Capeau,J. and Gauguier,D.
  TITLE     Localization, cDNA sequence and genomic organization of the rat
            seipin gene (Bscl2) and sequence analysis in inbred rat models of
            Type 2 diabetes mellitus
  JOURNAL   Cytogenet Genome Res 98 (1), 71-74 (2002)
   PUBMED   12584444
  REMARK    GeneRIF: Localization, cDNA sequence and genomic organization of
            the rat and sequence analysis in inbred rat models of Type 2
            diabetes mellitus.
REFERENCE   10 (bases 1 to 1965)
  AUTHORS   Magre,J., Delepine,M., Khallouf,E., Gedde-Dahl,T. Jr., Van
            Maldergem,L., Sobel,E., Papp,J., Meier,M., Megarbane,A., Bachy,A.,
            Verloes,A., d'Abronzo,F.H., Seemanova,E., Assan,R., Baudic,N.,
            Bourut,C., Czernichow,P., Huet,F., Grigorescu,F., de Kerdanet,M.,
            Lacombe,D., Labrune,P., Lanza,M., Loret,H., Matsuda,F., Navarro,J.,
            Nivelon-Chevalier,A., Polak,M., Robert,J.J., Tric,P.,
            Tubiana-Rufi,N., Vigouroux,C., Weissenbach,J., Savasta,S.,
            Maassen,J.A., Trygstad,O., Bogalho,P., Freitas,P., Medina,J.L.,
            Bonnicci,F., Joffe,B.I., Loyson,G., Panz,V.R., Raal,F.J.,
            O'Rahilly,S., Stephenson,T., Kahn,C.R., Lathrop,M. and Capeau,J.
  CONSRTM   BSCL Working Group
  TITLE     Identification of the gene altered in Berardinelli-Seip congenital
            lipodystrophy on chromosome 11q13
  JOURNAL   Nat Genet 28 (4), 365-370 (2001)
   PUBMED   11479539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, BC089942.1 and BF393055.1.
            
            On or before Mar 4, 2021 this sequence version replaced
            XM_039084125.1, NM_001012171.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1460123.1,
                                           SRR26360176.1213527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-406               JAXUCZ010000001.1  215160943-215161348
            407-621             JAXUCZ010000001.1  215163056-215163270
            622-938             JAXUCZ010000001.1  215164663-215164979
            939-979             JAXUCZ010000001.1  215166514-215166554
            980-1957            BC089942.1         643-1620
            1958-1965           BF393055.1         16-23               c
FEATURES             Location/Qualifiers
     source          1..1965
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1965
                     /gene="Bscl2"
                     /note="BSCL2 lipid droplet biogenesis associated, seipin"
                     /db_xref="GeneID:361722"
                     /db_xref="RGD:1308135"
     exon            1..406
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..621
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             547..1860
                     /gene="Bscl2"
                     /note="bernardinelli-Seip congenital lipodystrophy type 2
                     protein homolog; Berardinelli-Seip congenital
                     lipodystrophy 2 (seipin); BSCL2, seipin lipid droplet
                     biogenesis associated"
                     /codon_start=1
                     /product="seipin"
                     /protein_id="NP_001012171.2"
                     /db_xref="GeneID:361722"
                     /db_xref="RGD:1308135"
                     /translation="MIHHRREAGGKETCRDPVKGSDKEEEPSAALPHGQVYRPSGRPA
                     RNSRPETGARSPAVPIMVNDPPVPALLWAQEVGHVLAGRARRLMLQFGVLFCTILLLL
                     WVSVFLYGSFYYSYMPTVSHLSPVHFYYRTDCDSSTASLCSFPVANVSLTKSGRDRVL
                     MYGQPYRVTLELELPESPVNQDLGMFLVTVSCYTRGGRIISTSSRSVMLHYRSQLLQM
                     LDTLVFSSLLLFGFAEQKQLLEVELYSDYRENSYVPTTGAIIEVHSKRVQMYGAYLRI
                     HAHFTGLRYLLYNFPMTCAFVGVASNFTFLSVIALFSYMQWVWGAVWPRHRFSLQVNI
                     RQRDNSGHGAQRRISRHQPGQASTQQSDVTEDGESPEDPSGTEGQLSEEEKPEKQPLN
                     GEGEQEPEASDGSWEDAALLTEASTSALAPETLGSLRQRQTCSSS"
     exon            622..938
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1020
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1164
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1299
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1397
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1539
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1606
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1675
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1756
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1965
                     /gene="Bscl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgggtac aaacaggcag ccgccatctt ggacattggc tgcaggcgct gagtcgccct
       61 gtcccgccct acggcccctc aggccacctc cacccggggc tgctgtccct gggcccacgg
      121 aaacccaccc tactggccct tgccgctttc attgcacgct cgtttgaatg ctccgccgct
      181 tttgagcgct cattttaaca aacccccact gggggcgctc gggcgcctta tactccgtga
      241 tctccaatcc ttacgatgtc taaccggctc gactggccct gttccctgaa tatggcaagt
      301 gtatcgacta aggatcctct ttcccaagaa cgctaacaca ggcgttgtcc tctgaggctc
      361 tgaatgactt tattcttcaa atgcctttac cttttcgtag ctccagtgac cctccattct
      421 tcagatctag gaagatgtga cactctacag gtgatcagct tctagatcac cactttgtac
      481 ccacaagtga tttgagttgg ggatccaggg gcagcagagg taaccatcag gaagatattt
      541 aaagaaatga tacatcacag acgagaagct ggggggaaag agacatgcag agacccggtc
      601 aaaggatcag acaaagagga ggaaccttca gctgccctac cccatggcca agtgtatcgt
      661 cccagtggaa gaccagccag gaactcaagg cctgaaactg gggccagatc ccctgctgtc
      721 cccatcatgg tcaatgaccc accagtccct gccttgctgt gggcccagga agtgggccat
      781 gtgttggcag gccgcgcccg caggctgatg ctgcagtttg gggtgctctt ttgtaccatc
      841 ctccttttgc tttgggtgtc tgtgttcctc tacggttctt tctactactc ctacatgccg
      901 accgtcagcc acctcagccc tgtgcatttc tattacagga cagactgtga ttcctctact
      961 gcttcgctct gctctttccc tgttgccaat gtctcgctga ctaagagtgg acgtgaccgg
     1021 gtgctgatgt atggacagcc atatcgagtc accttagagc ttgagctgcc agaatcccct
     1081 gtgaatcaag acttgggcat gttcttagtc accgtttcgt gctataccag aggtggccga
     1141 atcatctcca cttcttcacg ctcggtgatg cttcattacc gctctcagct gctacagatg
     1201 ctcgacacgc tggtgttctc cagcctgctg ctgtttggct ttgcagaaca gaagcagctc
     1261 ctggaagtag aactctactc tgactatagg gagaattcgt atgtaccaac aactggggca
     1321 attatcgaag tccacagcaa gcgtgtccag atgtatggag cttacctccg catccatgcc
     1381 cacttcactg gactcaggta cctgctatac aacttcccca tgacctgcgc cttcgtgggt
     1441 gtggccagca acttcacatt cctcagtgtc atcgcgctct tcagctatat gcagtgggtg
     1501 tggggtgctg tctggccccg acaccgcttc tctttgcagg ttaatatccg acaaagggat
     1561 aattcaggac acggggccca gcgtcggatc tctcgccatc agccaggtca ggcgtctacc
     1621 cagcagtcag atgtgacaga ggatggcgag agccctgagg atccctcagg aacagagggt
     1681 cagctgtctg aggaagagaa accagagaag cagcctctga atggagaagg ggagcaggag
     1741 ccagaggcta gtgacggctc ctgggaagat gctgctttgc tgaccgaagc ctcaacgtct
     1801 gccctcgccc ctgagactct gggcagcctc aggcaacgcc agacctgctc cagttcctga
     1861 acaaaagggt ggagtcttca cattccagca ctttcccata gggcacctct tcccttgttc
     1921 ccttaataaa ctattttgtg tcagctgcta gtatggacat cagag
//
