LOCUS       NM_001127337            2442 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus BR serine/threonine kinase 1 (Brsk1), mRNA.
ACCESSION   NM_001127337 XM_001071463 XM_574355
VERSION     NM_001127337.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Watabe,A.M., Nagase,M., Hagiwara,A., Hida,Y., Tsuji,M., Ochiai,T.,
            Kato,F. and Ohtsuka,T.
  TITLE     SAD-B kinase regulates pre-synaptic vesicular dynamics at
            hippocampal Schaffer collateral synapses and affects contextual
            fear memory
  JOURNAL   J Neurochem 136 (1), 36-47 (2016)
   PUBMED   26444684
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Sample,V., Ramamurthy,S., Gorshkov,K., Ronnett,G.V. and Zhang,J.
  TITLE     Polarized activities of AMPK and BRSK in primary hippocampal
            neurons
  JOURNAL   Mol Biol Cell 26 (10), 1935-1946 (2015)
   PUBMED   25788287
  REMARK    GeneRIF: The activities of both AMPK and BRSK are polarized in
            developing hippocampal neurons, with high levels in the distal
            region of extended axons.
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Yoshida,H. and Goedert,M.
  TITLE     Phosphorylation of microtubule-associated protein tau by
            AMPK-related kinases
  JOURNAL   J Neurochem 120 (1), 165-176 (2012)
   PUBMED   21985311
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Muller,M., Lutter,D. and Puschel,A.W.
  TITLE     Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and
            SadB-deficient neurons disrupts neuronal polarity
  JOURNAL   J Cell Sci 123 (Pt 2), 286-294 (2010)
   PUBMED   20026642
  REMARK    GeneRIF: The regulation of Wee1 by SadA and SadB kinases is
            essential for the differentiation of polarized neurons.
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Alvarado-Kristensson,M., Rodriguez,M.J., Silio,V., Valpuesta,J.M.
            and Carrera,A.C.
  TITLE     SADB phosphorylation of gamma-tubulin regulates centrosome
            duplication
  JOURNAL   Nat Cell Biol 11 (9), 1081-1092 (2009)
   PUBMED   19648910
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Barnes,A.P., Lilley,B.N., Pan,Y.A., Plummer,L.J., Powell,A.W.,
            Raines,A.N., Sanes,J.R. and Polleux,F.
  TITLE     LKB1 and SAD kinases define a pathway required for the polarization
            of cortical neurons
  JOURNAL   Cell 129 (3), 549-563 (2007)
   PUBMED   17482548
REFERENCE   7  (bases 1 to 2442)
  AUTHORS   Inoue,E., Mochida,S., Takagi,H., Higa,S., Deguchi-Tawarada,M.,
            Takao-Rikitsu,E., Inoue,M., Yao,I., Takeuchi,K., Kitajima,I.,
            Setou,M., Ohtsuka,T. and Takai,Y.
  TITLE     SAD: a presynaptic kinase associated with synaptic vesicles and the
            active zone cytomatrix that regulates neurotransmitter release
  JOURNAL   Neuron 50 (2), 261-275 (2006)
   PUBMED   16630837
REFERENCE   8  (bases 1 to 2442)
  AUTHORS   Kishi,M., Pan,Y.A., Crump,J.G. and Sanes,J.R.
  TITLE     Mammalian SAD kinases are required for neuronal polarization
  JOURNAL   Science 307 (5711), 929-932 (2005)
   PUBMED   15705853
REFERENCE   9  (bases 1 to 2442)
  AUTHORS   Lu,R., Niida,H. and Nakanishi,M.
  TITLE     Human SAD1 kinase is involved in UV-induced DNA damage checkpoint
            function
  JOURNAL   J Biol Chem 279 (30), 31164-31170 (2004)
   PUBMED   15150265
REFERENCE   10 (bases 1 to 2442)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB365521.1.
            
            On or before May 14, 2008 this sequence version replaced
            XM_001071463.1, XM_574355.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB365521.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2442
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /note="BR serine/threonine kinase 1"
                     /db_xref="GeneID:499073"
                     /db_xref="RGD:1563268"
     CDS             1..2337
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="BR serine/threonine-protein kinase 1;
                     serine/threonine-protein kinase SAD-B; brain-specific
                     serine/threonine-protein kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase BRSK1"
                     /protein_id="NP_001120809.1"
                     /db_xref="GeneID:499073"
                     /db_xref="RGD:1563268"
                     /translation="MSSGSKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQ
                     TGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYEN
                     KKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPE
                     NLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCG
                     VILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSL
                     EQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRER
                     LHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGK
                     RRPERKSMEVLSITDAGSGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRS
                     PVFSFSPEPGVGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGS
                     PRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRF
                     HRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADI
                     VHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGS
                     SGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTP
                     PRSLQPPPGRPDPDLSSSPRRGPSKDKKLLATNGTPLP"
     exon            1..136
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            137..231
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            232..317
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            318..458
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            459..575
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            576..609
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            610..678
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            679..825
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            826..857
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1028
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1126
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1286
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1347
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1717
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1766
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1890
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2089
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2179
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2442
                     /gene="Brsk1"
                     /gene_synonym="RGD1563268; Sad-b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcgtccg ggtccaagga aggtggcggg ggctcccccg cctaccacct cccacaccca
       61 cacccacacc caccccagca cgcccaatat gtgggcccct atcggctgga gaagacgctg
      121 ggcaaaggac agacaggtct agttaaactt ggggtccact gcatcacggg tcagaaggtc
      181 gctgtcaaga tcgtgaacag ggagaagctg tcggaatctg tgctgatgaa ggtggagagg
      241 gaaatcgcca ttctaaagct cattgaacac ccgcatgtgc tcaagctcca cgacgtctac
      301 gagaacaaga aatatttata cttggtgctt gagcatgttt ctggtggtga gctgttcgac
      361 tacctggtaa aaaaagggag actgacaccc aaggaggccc gaaagttctt ccgccagatt
      421 gtgtcagcgc tggacttctg ccatagctac tccatctgtc acagggacct gaagccagag
      481 aacctgctgc tggatgagaa aaacaacatc cgcatcgcag actttggcat ggcgtccctg
      541 caggtggggg acagcctcct ggagaccagc tgtgggtccc cccattacgc atgtccagag
      601 gtgatcaagg gggagaagta tgatggccgc cgggcagaca tgtggagctg tggagtcatc
      661 ctgtttgccc tgcttgtggg ggcgctgccc ttcgatgatg acaacctacg acagctacta
      721 gagaaggtga aacgtggtgt cttccacatg ccgcacttca tccctccaga ctgccagagc
      781 ctcctgagag ggatgattga agtggagccc gagaaaaggc tcagtctgga gcaaattcag
      841 aaacatcctt ggtatctggg cgggaaacac gaaccagacc cttgcctgga gccagcccca
      901 ggccgcagag tagctatgcg gagcctgcct tccaatggcg agctggaccc tgacgttctg
      961 gaaagcatgg cgtctctggg ctgcttcaga gaccgcgagc ggctacacag agaactgcga
     1021 agtgaggagg aaaaccaaga aaagatgatc tattatttgc ttttggatcg gaaagagcgg
     1081 taccctagct gtgaagacca ggacctgcct cctcggaatg atgttgaccc acctcggaag
     1141 cgtgtggatt cccccatgct gagcagacac gggaaacgga ggccagagcg gaagtccatg
     1201 gaagtcctca gcatcacaga tgctgggagt ggtggctctc cagtgcctac cagaagggcc
     1261 ttggagatgg cccagcacag tcagagatcc cgcagcgtca gtggagcatc cactggtctg
     1321 tcctccagcc ctctaagcag cccaaggagt ccggtctttt ccttctcacc ggagccaggc
     1381 gttggagatg aggctagagg tggaggctcc ccaacttcca aaacacagac gctgccttct
     1441 cggggcccca gaggtggggg cgctggagag cagccaccac ctcccagtgc ccgttccacg
     1501 cccttgcctg gaccaccagg ctccccgcgc tcctccggcg gaaccccctt gcactcacct
     1561 ctgcacacgc ctcgagccag ccctaccggg actccaggaa ctacaccacc tcccagccca
     1621 ggcggtggcg tcgggggagc cgcctggaga agtcgtctca actccatccg caacagcttc
     1681 ctgggctccc ctcgcttcca ccggcgcaag atgcaggtcc ctaccgctga ggagatgtcc
     1741 agtttgacac cagaatcctc tccagagctg gcaaaacgct cctggttcgg gaatttcatc
     1801 tccttggaca aagaagaaca aatattcctc gtgctaaagg acaaacctct cagcagcatc
     1861 aaagcggaca ttgtccatgc ctttctgtcg atccctagcc tgagtcacag tgtgctgtca
     1921 cagaccagct tcagggccga atacaaggcc agcggtggcc cctctgtctt ccagaagcct
     1981 gtccgcttcc aggtggacat cagctcctct gagggtccag aaccctcacc ccgaagagat
     2041 ggtagcagtg gaggtggcat ctactcagtc accttcactc tcatctccgg tcctagccgt
     2101 cggttcaagc gtgtggtaga gaccatccag gcacagttgc tgagtactca tgaccagccc
     2161 tccgtgcagg ccttggcaga tgagaagaat ggagcccaga cccggcctgc tggtacccca
     2221 ccccgaagcc tgcagcctcc accaggccgc cctgaccctg atctgagtag ctctccccgc
     2281 cgaggaccct ctaaggacaa gaagctcctg gccaccaatg gaacccctct accctgaccc
     2341 cagggggcca gggaaggagg ggaaccccct ccaccccctt ccctgccccc ctactgtgaa
     2401 tctgtatata aggcccaagg agtatgttgg gaggggggga ca
//
