LOCUS       NM_152845               1380 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus bombesin receptor subtype 3 (Brs3), mRNA.
ACCESSION   NM_152845
VERSION     NM_152845.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1380)
  AUTHORS   Moreno-Villegas,Z., Martin-Duce,A., Aparicio,C., Portal-Nunez,S.,
            Sanz,R., Mantey,S.A., Jensen,R.T., Lorenzo,O., Egido,J. and
            Gonzalez,N.
  TITLE     Activation of bombesin receptor Subtype-3 by
            [D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin6-14 increased glucose
            uptake and lipogenesis in human and rat adipocytes
  JOURNAL   Mol Cell Endocrinol 474, 10-19 (2018)
   PUBMED   29402494
  REMARK    GeneRIF: BRS-3 protein levels were decreased in diabetic rat and in
            obese and diabetic human fat pieces.
REFERENCE   2  (bases 1 to 1380)
  AUTHORS   Zhang,L., Parks,G.S., Wang,Z., Wang,L., Lew,M. and Civelli,O.
  TITLE     Anatomical characterization of bombesin receptor subtype-3 mRNA
            expression in the rodent central nervous system
  JOURNAL   J Comp Neurol 521 (5), 1020-1039 (2013)
   PUBMED   22911445
  REMARK    GeneRIF: This sstudy demonistrated comprehensive mapping of BRS-3
            mRNA in the rat brain and double in situ hybridization was
            performed to determine whether BRS-3 colocalizes with other
            neurotransmitters or neuropeptides.
REFERENCE   3  (bases 1 to 1380)
  AUTHORS   Porcher,C., Juhem,A., Peinnequin,A. and Bonaz,B.
  TITLE     Bombesin receptor subtype-3 is expressed by the enteric nervous
            system and by interstitial cells of Cajal in the rat
            gastrointestinal tract
  JOURNAL   Cell Tissue Res 320 (1), 21-31 (2005)
   PUBMED   15726424
  REMARK    GeneRIF: Brs3 is expressed by the enteric nervous system and by
            interstitial cells of Cajal in the gastrointestinal tract.
REFERENCE   4  (bases 1 to 1380)
  AUTHORS   Dumesny,C., Whitley,J.C., Baldwin,G.S., Giraud,A.S. and Shulkes,A.
  TITLE     Developmental expression and biological activity of
            gastrin-releasing peptide and its receptors in the kidney
  JOURNAL   Am J Physiol Renal Physiol 287 (3), F578-F585 (2004)
   PUBMED   15140764
  REMARK    GeneRIF: bombesin receptor subtype-3 (BRS-3) was detected in the
            rat adult and fetal kidney.
REFERENCE   5  (bases 1 to 1380)
  AUTHORS   Jennings,C.A., Harrison,D.C., Maycox,P.R., Crook,B., Smart,D. and
            Hervieu,G.J.
  TITLE     The distribution of the orphan bombesin receptor subtype-3 in the
            rat CNS
  JOURNAL   Neuroscience 120 (2), 309-324 (2003)
   PUBMED   12890504
REFERENCE   6  (bases 1 to 1380)
  AUTHORS   Liu,J., Lao,Z.J., Zhang,J., Schaeffer,M.T., Jiang,M.M., Guan,X.M.,
            Van der Ploeg,L.H. and Fong,T.M.
  TITLE     Molecular basis of the pharmacological difference between rat and
            human bombesin receptor subtype-3 (BRS-3)
  JOURNAL   Biochemistry 41 (28), 8954-8960 (2002)
   PUBMED   12102638
  REMARK    GeneRIF: results indicate that the sequence variation in the E3
            loop is responsible for the species difference between rat and
            human BRS-3, and multiple residues in the E3 loop are involved in
            interactions with the agonist dY-bombesin
REFERENCE   7  (bases 1 to 1380)
  AUTHORS   Ohki-Hamazaki,H., Watase,K., Yamamoto,K., Ogura,H., Yamano,M.,
            Yamada,K., Maeno,H., Imaki,J., Kikuyama,S., Wada,E. and Wada,K.
  TITLE     Mice lacking bombesin receptor subtype-3 develop metabolic defects
            and obesity
  JOURNAL   Nature 390 (6656), 165-169 (1997)
   PUBMED   9367152
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF510984.1.
            
            [WARNING] On Oct 15, 2024 this sequence was replaced by
            NM_152845.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF510984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1380
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..1380
                     /gene="Brs3"
                     /note="bombesin receptor subtype 3"
                     /db_xref="GeneID:260319"
                     /db_xref="RGD:628645"
     exon            1..554
                     /gene="Brs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1320
                     /gene="Brs3"
                     /note="BRS-3; bombesin-like receptor 3"
                     /codon_start=1
                     /product="bombesin receptor subtype-3"
                     /protein_id="NP_690058.1"
                     /db_xref="GeneID:260319"
                     /db_xref="RGD:628645"
                     /translation="MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGI
                     EALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVP
                     VDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNA
                     ILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHS
                     LLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVL
                     VALFALCWLPNHLLYLYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLS
                     KTFQKHFKAQLCCFKAEQPEPPLGDTPLNNLTVMGRVPATGSAHVSEISVTLFSGSTA
                     KKGEDKV"
     exon            555..906
                     /gene="Brs3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1380
                     /gene="Brs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgttctg ttctgttctc ctgactcctc ctcattgcta gacgtaggca ctagacgtga
       61 cagtcaacta catctgaact gagcagagaa gaggtagtga aggcagagtg tgcaggagac
      121 atgtctcaaa ggcagcctca gtcacctaat cagactttaa tttccattac aaatgacaca
      181 gaaacatcaa gctctgccgt ctccaacgat actacaccta aaggatggac cggagacaac
      241 tctccaggaa tagaagcact gtgtgccatc tatatcactt atgctgtgat catttcagtg
      301 ggcatcctcg gaaatgctat cctcatcaaa gtctttttca agactaaatc catgcaaaca
      361 gttccaaata ttttcatcac cagcctggct tttggagatc tgttactcct gctgacttgt
      421 gtgccagtgg atgcaaccca ctacctggca gagggatggc tgtttggaaa ggtcggttgt
      481 aaagtgcttt ccttcatccg gctcacttct gtcggtgtat cagtgttcac gctgacaatt
      541 ctcagcgctg acagatacaa agcagtcgtg aagccacttg aacgacagcc ctccaatgcc
      601 attctgaaga cctgtgccaa agctggtggc atctggatca tggctatgat atttgctctg
      661 ccagaggcta tattctcaaa tgtatacact ttccaagatc ctaacagaaa cgtaacattt
      721 gaatcctgta actcctaccc tatctctgag aggcttttgc aggaaataca ttctctgttg
      781 tgtttcttgg tgttctacat tatcccgctc tcgattatct ctgtctatta ttctttgatt
      841 gccaggactc tttacaaaag caccttgaac ataccgactg aggaacaaag ccatgcccga
      901 aagcagattg aatcccggaa gagaattgcc aaaacggtac tggtgctggt ggctctgttc
      961 gcactctgct ggttgccgaa tcacctcctg tatctctatc actcattcac ttatgaaagc
     1021 tacgcagagc cttctgatgt ccctttcgtt gtcaccattt tctctcgggt gctggctttc
     1081 agtaattcct gcgtgaaccc ctttgctctg tattggctga gcaagacctt ccagaagcat
     1141 tttaaggctc agctctgctg cttcaaggca gagcagcctg aacctcctct tggtgacacc
     1201 ccccttaaca acctcactgt gatggggcgg gttccagcta ctgggagtgc acacgtctct
     1261 gaaattagcg tgaccctgtt tagtggcagt actgccaaga aaggagagga caaagtttag
     1321 atgttccatt taaaatgatt ttaagtctca ctgtgtgtat ccagctttaa gctgtgcata
//
