LOCUS       NM_001191572            4572 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus bromodomain and PHD finger containing, 1 (Brpf1),
            transcript variant 1, mRNA.
ACCESSION   NM_001191572 XM_002729422
VERSION     NM_001191572.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   Yan,K., Rousseau,J., Littlejohn,R.O., Kiss,C., Lehman,A.,
            Rosenfeld,J.A., Stumpel,C.T.R., Stegmann,A.P.A., Robak,L.,
            Scaglia,F., Nguyen,T.T.M., Fu,H., Ajeawung,N.F., Camurri,M.V.,
            Li,L., Gardham,A., Panis,B., Almannai,M., Sacoto,M.J.G., Baskin,B.,
            Ruivenkamp,C., Xia,F., Bi,W., Cho,M.T., Potjer,T.P., Santen,G.W.E.,
            Parker,M.J., Canham,N., McKinnon,M., Potocki,L., MacKenzie,J.J.,
            Roeder,E.R., Campeau,P.M. and Yang,X.J.
  CONSRTM   DDD Study; CAUSES Study
  TITLE     Mutations in the Chromatin Regulator Gene BRPF1 Cause Syndromic
            Intellectual Disability and Deficient Histone Acetylation
  JOURNAL   Am J Hum Genet 100 (1), 91-104 (2017)
   PUBMED   27939640
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Liu,L. and Pilch,P.F.
  TITLE     PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in
            response to metabolic challenges
  JOURNAL   Elife 5, e17508 (2016)
   PUBMED   27528195
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4572)
  AUTHORS   Lalonde,M.E., Avvakumov,N., Glass,K.C., Joncas,F.H., Saksouk,N.,
            Holliday,M., Paquet,E., Yan,K., Tong,Q., Klein,B.J., Tan,S.,
            Yang,X.J., Kutateladze,T.G. and Cote,J.
  TITLE     Exchange of associated factors directs a switch in HBO1
            acetyltransferase histone tail specificity
  JOURNAL   Genes Dev 27 (18), 2009-2024 (2013)
   PUBMED   24065767
REFERENCE   4  (bases 1 to 4572)
  AUTHORS   Ullah,M., Pelletier,N., Xiao,L., Zhao,S.P., Wang,K., Degerny,C.,
            Tahmasebi,S., Cayrou,C., Doyon,Y., Goh,S.L., Champagne,N., Cote,J.
            and Yang,X.J.
  TITLE     Molecular architecture of quartet MOZ/MORF histone
            acetyltransferase complexes
  JOURNAL   Mol Cell Biol 28 (22), 6828-6843 (2008)
   PUBMED   18794358
  REMARK    Erratum:[Mol Cell Biol. 2009 Feb;29(3):942]
REFERENCE   5  (bases 1 to 4572)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_002729422.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN13663624
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JAXUCZ010000004.1  148011996-148012135
            141-746             JAXUCZ010000004.1  148014243-148014848
            747-1706            JAXUCZ010000004.1  148018204-148019163
            1707-1869           JAXUCZ010000004.1  148020195-148020357
            1870-2001           JAXUCZ010000004.1  148020723-148020854
            2002-2130           JAXUCZ010000004.1  148021214-148021342
            2131-2440           JAXUCZ010000004.1  148022034-148022343
            2441-2761           JAXUCZ010000004.1  148022660-148022980
            2762-3046           JAXUCZ010000004.1  148023285-148023569
            3047-3194           JAXUCZ010000004.1  148024049-148024196
            3195-3552           JAXUCZ010000004.1  148025280-148025637
            3553-3707           JAXUCZ010000004.1  148026035-148026189
            3708-4572           JAXUCZ010000004.1  148027567-148028431
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..4572
                     /gene="Brpf1"
                     /note="bromodomain and PHD finger containing, 1"
                     /db_xref="GeneID:679713"
                     /db_xref="RGD:1584828"
     exon            1..140
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            141..746
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..3891
                     /gene="Brpf1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peregrin"
                     /codon_start=1
                     /product="peregrin isoform 1"
                     /protein_id="NP_001178501.1"
                     /db_xref="GeneID:679713"
                     /db_xref="RGD:1584828"
                     /translation="MGVDFDVKTFCHNLRATKPPYECPVETCRKVYKSYSGIEYHLYH
                     YDHDSPPPPQQTPLRKHKKKGRQSRPANKQSPSPSEVSQSPGREVMSYAQAQRMVEVD
                     LHGRVHRISIFDNLDVVSEDEEAPEEAPENGSNKENTETPAATPKSGKHKNKEKRKDS
                     NHHHHSAPASAAPKLPEVVYRELDQDTPDAPPRPTSYYRYIEKSAEELDEEVEYDMDE
                     EDYIWLDIMNERRKTEGVSPIPQEIFEYLMDRLEKESYFESHNKGDPNALVDEDAVCC
                     ICNDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRRCLQSPSRAVDCALCPN
                     KGGAFKQTDDGRWAHVVCALWIPEVCFANTVFLEPIDSIEHIPPARWKLTCYICKQRG
                     SGACIQCHKANCYTAFHVTCAQQAGLYMKMEPVRETGANGTSFSVRKTAYCDIHTPPG
                     SARRLPALSHSEGEEEEDEEEDEGKSWSSEKVKKAKAKSRIKMKKARKILAEKRAAAP
                     VVSVPCIPPHRLSKITNRLTIQRKSQFMQRLHSYWTLKRQSRNGVPLLRRLQTHLQSQ
                     RNCDQVGRDSEDKNWALKEQLKSWQRLRHDLERARLLVELIRKREKLKRETIKIQQIA
                     MEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMKQNLE
                     AYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVLRQARRQAEKMGI
                     DFETGMHIPHNLAGDEVSHHTEDVEEERLVLLENQKHLPVEEQLKLLLERLDEVNASK
                     QSVGRSRRAKMIKKEMTALRRKLAHQRETGRDGPERHGPSGRGNLTPHPAACDKDGQT
                     DSAAEESSSQETSKGLGPNMSSTPAHEVGRRTSVLFSKKNPKTAGPPKRPGRPPKNRE
                     SQMTPSHGGSPVGPPQLPIMGSLRQRKRGRSPRPSSSSDSDSDKSTEDPPMDLPANGF
                     SSGNQPVKKSFLVYRNDCNLPRSSSDSESSSSSSSSAASDRTSTTPSKQGRGKPSFSR
                     GTFPEDSSEDTSGTENEAYSVGTGRGVGHSSKYPHPKSGVLGTQFQSLASPPAADPSP
                     LSRSCEVVRKSLGRGAGWLSEDEDSPLDALDLVWAKCRGYPSYPALIIDPKMPREGMF
                     HHGVPIPVPPLEVLKLGEQMTQEAREHLYLVLFFDNKRTWQWLPRTKLVPLGVNQDLD
                     KEKMLEGRKSNIRKSVQIAYHRALQHRSKVQGEQSSETSDSD"
     exon            747..1706
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1869
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2001
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2130
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2440
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2761
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2762..3046
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3194
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3552
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3707
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..4572
                     /gene="Brpf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccgccgc tgccacagcc tttgccgcca cggtctcgcc gccgctgtcc ctgtgccgcc
       61 tccaggagcc ccctctcccc attgtcccgg cggcaccggg ttcccaggcc agaagatcca
      121 aaagctcggg aaacgcgagg atgtgacagc atgggggtgg actttgatgt gaagaccttc
      181 tgccacaact tgcgggcaac taagccacca tatgagtgcc ctgtggagac ttgccgcaag
      241 gtttacaaga gttacagtgg tatcgagtac cacctgtacc actatgacca cgacagccca
      301 ccacccccac agcagactcc gctgcgcaag cacaaaaaga aagggcgcca gtcacgacca
      361 gccaacaagc agtcacccag cccctctgag gtctcacagt cacctggccg agaggtgatg
      421 agctatgctc aggcccagcg catggtagaa gtggaccttc atggccgtgt ccaccgaatc
      481 agcatctttg acaacttgga tgtggtgtcg gaggatgagg aggcccctga ggaggcccct
      541 gagaatggca gcaacaagga aaacactgag acacctgcag ctacacctaa gtcaggcaag
      601 cataagaata aggaaaaacg aaaggactcc aaccaccacc atcacagcgc tcctgccagt
      661 gctgctccca aactgcctga ggtggtgtat cgtgagctag atcaagatac ccctgatgca
      721 ccgccccggc ctacttccta ctaccggtac atcgagaagt ctgcagagga gctggatgag
      781 gaggtggagt atgatatgga tgaagaggac tacatctggc tggatatcat gaacgagcgg
      841 cggaagactg agggtgtaag tcccattcca caagagatct ttgagtactt aatggaccgg
      901 ttggagaagg agtcgtactt tgagagtcac aataaaggtg accccaatgc actagtggat
      961 gaagatgctg tgtgctgtat ctgcaatgat ggcgagtgcc agaacagcaa tgttatcctc
     1021 ttctgtgaca tgtgcaactt ggctgtgcac caggagtgct acggtgtccc ctatatccct
     1081 gaaggccagt ggctgtgccg ccgttgcctg cagtcacctt ctcgtgcagt ggactgtgct
     1141 ctgtgcccca ataagggcgg tgccttcaag cagacagatg atggccgctg ggcccacgtg
     1201 gtgtgtgcct tgtggatccc tgaggtctgc tttgccaaca cagtcttcct agaacctatc
     1261 gatagcattg agcacatccc accagctcgg tggaagctca cctgctacat ttgtaaacag
     1321 cggggctccg gagcctgcat ccagtgccat aaggccaatt gctacacagc cttccatgtg
     1381 acatgtgccc aacaggctgg cctttacatg aagatggagc ctgtgcgtga aacaggtgcc
     1441 aatggtacct cctttagtgt ccgcaagaca gcctactgtg acatccacac acccccaggt
     1501 tctgctcgtc gcctgcctgc tttatcccac agtgaaggtg aggaagaaga ggatgaagaa
     1561 gaagatgagg gtaagagctg gagctcagag aaggtcaaga aggccaaggc taagtcccgg
     1621 attaagatga agaaagctcg aaagatcttg gcagaaaaga gggcagcagc acctgtggtg
     1681 tccgtgccct gcatcccacc acacaggctc agtaagatca ccaaccgcct gaccatccag
     1741 aggaagagcc agttcatgca gaggctacat agctactgga ctctgaaacg acaatcacgg
     1801 aatggggtcc cactactccg gcgcctgcaa acacaccttc agtctcagag gaactgtgat
     1861 caagttggga gagattctga agataagaac tgggctctca aagaacagct caagtcctgg
     1921 cagagactcc ggcatgacct ggagcgagct cggctactgg tggagttgat ccgaaagcga
     1981 gagaaactga aaagggagac gatcaagatc cagcagattg ccatggaaat gcagctgacc
     2041 cctttcctca tcctcctccg aaaaaccttg gaacagctcc aagagaagga cacaggcaac
     2101 atcttcagcg agccggtccc tctgtctgag gtacctgact acctagacca catcaaaaaa
     2161 cccatggact ttttcaccat gaagcagaac ttggaggctt accgctactt gaactttgat
     2221 gattttgagg aggacttcaa cctcattgtc agcaactgcc taaagtataa tgccaaggac
     2281 accatcttct acagggcagc agtgcgactc cgtgagcagg gtggtgctgt cctccgtcaa
     2341 gcccggcgcc aggcagaaaa aatgggcatt gactttgaga cgggcatgca tatccctcac
     2401 aacttggccg gagatgaggt ctcacaccac actgaagatg tagaggaaga gcgtctggtc
     2461 ctgctggaga accagaaaca cctgccagta gaagaacagc tgaagttgtt gctggagcgg
     2521 ctggacgaag tcaatgccag caagcagagt gtgggccgct cccggcgtgc aaaaatgatc
     2581 aagaaggaga tgacagcact gcggcgaaag cttgctcatc agcgggagac tggccgggat
     2641 gggcctgagc gtcatggtcc ctcaggtcgg ggcaatctga caccccaccc agcagcctgt
     2701 gacaaggatg gacagactga cagtgctgca gaagagagca gcagccagga aacaagcaaa
     2761 ggcctgggtc ccaacatgtc ctcaaccccc gcacatgagg tgggcaggag aacctcagtt
     2821 ctgttctcca aaaagaaccc gaagacagct ggaccgccca agaggccggg ccggccccca
     2881 aaaaaccggg agagccagat gacccccagc catggaggca gtcctgtggg gccccctcag
     2941 ctccccatca tgggctccct acgtcagcgc aagcggggta ggagtccccg gcccagttca
     3001 agctcagaca gcgacagtga taaatccaca gaagatcccc caatggactt accagccaat
     3061 ggcttcagca gtgggaacca gccagtgaag aagagtttct tggtgtaccg taatgactgc
     3121 aaccttcccc ggagtagctc agactctgag tccagcagca gcagcagcag cagtgcggcc
     3181 tcagaccgga ccagcacaac accctcaaag caaggccggg gcaagccctc cttctctcgg
     3241 ggcacattcc cagaggacag cagtgaagat acctcaggca ctgagaatga ggcctactcc
     3301 gtgggcactg gccgcggcgt gggccacagc agtaagtacc ctcacccaaa gtcaggggtg
     3361 ctggggaccc agtttcaaag ccttgccagc cccccagctg ctgatccgtc ccctctctcc
     3421 cgttcctgtg aagtggtaag aaagagtctg ggtcgaggag ctggctggct gtcagaggat
     3481 gaagactccc cattggatgc tctggacctt gtgtgggcca aatgccgagg ctatccatca
     3541 tacccagctc tgatcattga tccaaagatg ccccgagaag gtatgttcca ccatggggtt
     3601 cccatccctg taccaccact ggaggttctg aaacttgggg aacagatgac acaggaagcc
     3661 cgagagcatc tctacctcgt tctcttcttt gacaacaaac gaacctggca gtggctgccc
     3721 cggactaaac tcgttcctct gggtgtgaac caggatctag acaaagagaa gatgctggag
     3781 ggtcgcaagt ccaacatccg aaagtcagtg caaattgcct accacagggc tctgcagcac
     3841 cgaagcaagg tgcagggtga gcagagcagc gagaccagcg atagcgactg atactgtcag
     3901 aggccagtgg tactctgtga tggctctcct tccctttgct cattgtcctg gagtgatgcc
     3961 gccctctgca ctgatcaatt cctggtcttg gggccagtct caggggaagt tgggtagggg
     4021 aggtccctcc tgccctgagt gcagctggac tgtacaaaac actccaaggg cccatggcca
     4081 ctcagtgcaa ggagaggaga ggtctcacag gtctaaagag ttcaagaact catggcattg
     4141 tagggtaggg tggtgggcct caattcgaat actgtaaaaa acaggccata ccacccttac
     4201 ctgctcatgc taggggaatt cataactgcc tagaggcctg aggcccttgc aggtggtaag
     4261 gtaaatcagc atcttcccag cctagcagtg ggattgatgt ctgtctagcc tggaagaggg
     4321 gcactaggtg acccctcccc tgctgttgta aatactgtaa ttattggaga atttaaatta
     4381 ttctcatttg taactgcgtt tccgggtcgc gccagagtca tttggtacta aaaaaaagaa
     4441 aaagaaaaaa aaaaaaaaag aatggagctt gtctctactt cctttctttt tcccatagag
     4501 tccccctcta cctttcaaac tggtttgtat ttatttcaaa ggaagaaaat atattgattc
     4561 ttagaaaata aa
//
