LOCUS       NM_001025669            3365 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus BRO1 domain and CAAX motif containing (Brox),
            mRNA.
ACCESSION   NM_001025669 XM_223020
VERSION     NM_001025669.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3365)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   2  (bases 1 to 3365)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097348.1.
            
            On Jul 22, 2005 this sequence version replaced XM_223020.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097348.1, SRR8487231.79949.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3365
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3365
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /note="BRO1 domain and CAAX motif containing"
                     /db_xref="GeneID:305031"
                     /db_xref="RGD:1307161"
     exon            1..63
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            64..180
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1315
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /note="BRO1 domain- and CAAX motif-containing protein"
                     /codon_start=1
                     /product="BRO1 domain-containing protein BROX"
                     /protein_id="NP_001020840.1"
                     /db_xref="GeneID:305031"
                     /db_xref="RGD:1307161"
                     /translation="MTHWFHRNPLKATAPVSFNYYGMITGPPASKICNDLRSARTRLL
                     ELFTDLSCNPETMKNAADLYFSLLQGFINSVGDSTQESKLRYIQNFKWTDTLQGHVPS
                     AQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKES
                     HIPKLLTPAEKGRDLEARLIDAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETAS
                     FYQKADHTLSSLEPAHSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQE
                     AEKLYAEAEALCKEYGETKGPGPTAKPSGHLFFRKLGSLVKNTLDKCQRENGFIYFQK
                     IPTEAPQLELKANYGLVEPVPFEFPPMSALWTPEALAAFDLTKRPKDDSIKPKPEEEV
                     KPVKEPDIKPQKDTGCSVS"
     exon            181..287
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            288..384
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            385..480
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            481..553
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            554..659
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            660..749
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            750..835
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            836..917
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1068
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1228
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..3341
                     /gene="Brox"
                     /gene_synonym="RGD1307161"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgtccca ccttcccttt ccttcagcag gaagagtggg ccttacggac tctgaggtct
       61 ccgagcacat cgcgtgaaga tgacccactg gtttcatagg aacccattaa aagctacagc
      121 tcctgtgtcc ttcaactact atggcatgat cactgggcct cctgcttcaa agatttgcaa
      181 tgatttgaga tccgccagga ctcggctcct cgaattgttc actgatttga gctgtaatcc
      241 agaaacgatg aagaatgccg cagacctgta tttctctctt ttacaaggtt tcataaattc
      301 agtgggtgac tccacccagg aaagcaaatt acgatacatt cagaatttca aatggactga
      361 tacattacaa ggacatgttc cgagtgccca gcaggatgct gttttcgaac tgatttccat
      421 gggatttaat gtagcgctgt ggtatacaaa atatgcttca agattggctg gaaaagaaaa
      481 cataacagaa gatgaagcaa aagaagttca ccgaagccta aaaattgcag ctgggatttt
      541 taaacattta aaggaaagtc atattcccaa acttctgaca ccagcagaaa aggggcggga
      601 tttagaggcg cggctcatcg atgcgtacat catccagtgc caggccgagg ctcaggaagt
      661 gaccatcgcc cgagcaatcg agctgaagca cgctccgggg ctgatcgcgg cactcgcgta
      721 cgaaacagcc agcttctatc agaaagcaga tcatactttg tccagtttgg agcctgcaca
      781 ctctgctaag tggagaaaat accttcacct gaagatgtgc ttctacacgg cttatgcgta
      841 ctgctaccat ggccagactc tgttggcgag cgataaatgt ggagaagcaa tcagatctct
      901 ccaagaagca gaaaaattgt acgcagaggc agaagccctg tgcaaagagt acggggagac
      961 caaagggcca gggccaacgg ccaagccatc aggacacttg ttctttcgga agctcggaag
     1021 ccttgtgaag aacaccctgg acaagtgtca gagggaaaat ggcttcattt actttcaaaa
     1081 aattccaaca gaagccccac aactggaact gaaagcgaac tatggcctgg tagagcctgt
     1141 gccttttgaa tttcctccta tgagtgctct ctggacacca gaagccttgg ctgcatttga
     1201 tctcaccaag agacccaagg atgacagtat caaacccaaa ccggaagagg aagtgaaacc
     1261 tgtaaaagaa ccagatatca aacctcagaa agacactggg tgctccgtct cataagaatg
     1321 ccactcactt agaaatctct gctggtccat aagagaaacc tcgggacttc agttcacctt
     1381 tttgattcct ctgaagccca ttggatgatt gtcagcttta gagggacttg gcctttagtt
     1441 tatttattct tggtttttaa catagaggca tttcatgctt ttgtttcggg ctctgcttta
     1501 caatgaggac atttggatgg gttggttttt atgcctctaa cgagcgtcta tggggtgggg
     1561 ggtggaactt ttttgaactc tagatagtaa gtttcatgtt aatgtttttc tactttcaca
     1621 aaaacgttta ttcttcttgc ttgataccag aagaatgctt tgaaaagaga tgagttcgcc
     1681 tctcctcacc aacttgtcag atctgactct agctcagtct tctggtaggg aaactgaatt
     1741 gcagttaaat cagaaaacct cagaccaaat tctttcctta tacttaacca gagtctataa
     1801 ttactagaaa tcagtgtctt caagaacgtg taaggttctt ggaaatcggc agtatgggcc
     1861 tgtgcccctc agcctgcttc ccagcttagt ccgtgctgtt cctgccaccc tcagtactga
     1921 gacagtggtt tgttttggtt tttattagta ccttttctaa tggatttttt acttaagggg
     1981 taaagctttg tactagcatt tagagtgctt ctgtgtagag agagaaaaag aatggacgtg
     2041 tgttttaaag aagtaaaatg ttgcatgttg taaagaaagt ctttgcaaac tcaaccaaga
     2101 caggttgtcc tggatcgcac tggtaatttc tttgttagaa gtgtttaaga aaatgccttt
     2161 gttacctgat ttgggtgtac attgtgtttt taacatggtt ttcttccata tgtatcctat
     2221 cagaattgtt tggcattagg ccaaaggcca tagcaacaga aggttaggat atagacactc
     2281 aaactatgat ctttaaagtg ggttgtatca cttaaaggac ttggttatat ccataaactg
     2341 ggaatggtgg ctgtgtgata cttcatcaag taacagatgt gggtgtatcc tacttggtta
     2401 ctctcctggg atgttaactt ccttttctag gtgacagatt tcttcacata ataggaataa
     2461 taatgtatgt gagaacttac tctgtgccag gcagtgtgta ggcacataca cagaccactg
     2521 catcccctta gcagccctgt gagaacacat cggtctgcat aaagcattga aacaggaata
     2581 tgcatctcgt gatgaggaat gatcgattat acctatcaat taagataaat caataaatca
     2641 tataccatag tttatatgcc tttgaaaagc tacatataat cactaagggt tttttcttaa
     2701 taagttaaaa tgttagttac agcctgcagt gtctaacatt tgaggctgca gctttcagaa
     2761 cacttggagt aactactgaa tgggcattga gctttctttt gctgcctata ggaaaacagt
     2821 accttattaa gttttaccct tcctacagtc acttgttaaa tggcagttac tgacaaaact
     2881 ttaacaagta cttgctgctg cctgtctacg ctctccctgc ctaaaggacc tgttccatgc
     2941 actaatcctc attaacctag gtagtctcag tgtggtttct gtggactaaa ctgccattca
     3001 tgaaatggga acacatactg tgtccggcgc ttctgtaagg ggcagtaaat gctggtgtta
     3061 aaacccatac ttggcagtgt tcacatgatc gcatgagcag tcacagttga ctgcagaagt
     3121 aacaccagaa gcctatcccg taacgtgagg tttggaagag gtaccgggag tctggggaga
     3181 caccaaaaag gagcactgca cgaaggctgt ggagagatga aaccggacat tgatgatgca
     3241 tgtatttcag accaggcaag gacagctcac atgctacttc tgtacagtgt ttatatgatt
     3301 tatcttttta tttatgataa taaattttac ttacatattc aaaaaaaaaa aaaaaaaaaa
     3361 aaaaa
//
