LOCUS       NM_001195476            1102 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus BRICK1 subunit of SCAR/WAVE actin nucleating
            complex (Brk1), mRNA.
ACCESSION   NM_001195476 XM_001055004 XM_002726399
VERSION     NM_001195476.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   Chen,Z., Borek,D., Padrick,S.B., Gomez,T.S., Metlagel,Z.,
            Ismail,A.M., Umetani,J., Billadeau,D.D., Otwinowski,Z. and
            Rosen,M.K.
  TITLE     Structure and control of the actin regulatory WAVE complex
  JOURNAL   Nature 468 (7323), 533-538 (2010)
   PUBMED   21107423
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Escobar,B., de Carcer,G., Fernandez-Miranda,G., Cascon,A.,
            Bravo-Cordero,J.J., Montoya,M.C., Robledo,M., Canamero,M. and
            Malumbres,M.
  TITLE     Brick1 is an essential regulator of actin cytoskeleton required for
            embryonic development and cell transformation
  JOURNAL   Cancer Res 70 (22), 9349-9359 (2010)
   PUBMED   20861187
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Derivery,E., Fink,J., Martin,D., Houdusse,A., Piel,M.,
            Stradal,T.E., Louvard,D. and Gautreau,A.
  TITLE     Free Brick1 is a trimeric precursor in the assembly of a functional
            wave complex
  JOURNAL   PLoS One 3 (6), e2462 (2008)
   PUBMED   18560548
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1 and FM063685.1.
            
            On or before Sep 16, 2010 this sequence version replaced
            XM_001055004.2, XM_002726399.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214114.1, FQ213578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                JAXUCZ010000004.1  148306436-148306447
            13-612              FM063685.1         1-600
            613-1102            JAXUCZ010000004.1  148321179-148321668
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1102
                     /gene="Brk1"
                     /note="BRICK1 subunit of SCAR/WAVE actin nucleating
                     complex"
                     /db_xref="GeneID:679934"
                     /db_xref="RGD:1598136"
     exon            1..139
                     /gene="Brk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..249
                     /gene="Brk1"
                     /note="probable protein BRICK1; BRICK1, SCAR/WAVE
                     actin-nucleating complex subunit"
                     /codon_start=1
                     /product="protein BRICK1"
                     /protein_id="NP_001182405.1"
                     /db_xref="GeneID:679934"
                     /db_xref="RGD:1598136"
                     /translation="MAGQEDPVQREIHQDWANREYIEIITSSIKKISDFLNSFDMSCR
                     SRLATLNEKLTALERRIEYIEARVTKGETLT"
     exon            140..222
                     /gene="Brk1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..1102
                     /gene="Brk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcttcctc aggctgccgc catggcggga caagaggatc cggtgcagcg agagattcac
       61 caggactggg cgaaccggga gtacattgag atcatcacca gcagcatcaa gaaaatctcg
      121 gactttctca actctttcga tatgtcttgt cgttcaagac tcgcaacact gaatgagaaa
      181 ttgacagccc ttgaacggag aatagagtac attgaagcga gggtgacaaa gggtgagact
      241 ctcacctaga actgtgccac gccgctgctg ggaagttgct gtacagaaca ctggccatgt
      301 gggaaaggcc cagcagcctt ctgctcctcc tcctctcctt acagagcgac agggcttttt
      361 cttgtttttc tttttcaaaa gtggcctttg ggctctgctg tgtgccctgg ggtgtgatgt
      421 ggcatggggg agcaagcagt ccaggggacc tcttggaaac agcattaggc tttttccttt
      481 tcagtaacat tgtgtggaac tattgtcaat gtgcttgagg tgttgagggg ccaaagctgg
      541 gactctctaa ggtcctcccc acctctcagt ctctttctct cagactttcc ttccctacag
      601 ctcccatggc ctctgcactg atttctatcc acagtcagcc ttctccctgc ctgtgagagg
      661 tgggggcagt cctggctgag actcgtgccc tgcagtgtgg ttgccagaaa atgttgttgc
      721 taacacacca gtttcttgtt ctgggaggtc aaagccaggc ccccagttga agggacattt
      781 tcagttttct ttgtgtcact tggggtatca gtggctctca tgcttcccta ataaactcaa
      841 ctttgtctga ctgctgactg tggtggcaag actagctgga gagggactcg ctgttcacag
      901 agtcattgtg taggaatgct ctcccacaga ggatcctgca gctctagctg ttcaaagcct
      961 aggcagctcc agtcagagtg ttcctgtctg gacacttgaa ccagctcagc ctggaattat
     1021 ttggtctttc agcagatact accaaggact tttactttat aggtgtgtta gactctaata
     1081 aaagatacag tattgaatca ga
//
