LOCUS       NM_173115               4127 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus BMP/retinoic acid inducible neural specific 2
            (Brinp2), mRNA.
ACCESSION   NM_173115
VERSION     NM_173115.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4127)
  AUTHORS   Cowley,A.W. Jr., Moreno,C., Jacob,H.J., Peterson,C.B., Stingo,F.C.,
            Ahn,K.W., Liu,P., Vannucci,M., Laud,P.W., Reddy,P., Lazar,J.,
            Evans,L., Yang,C., Kurth,T. and Liang,M.
  TITLE     Characterization of biological pathways associated with a 1.37 Mbp
            genomic region protective of hypertension in Dahl S rats
  JOURNAL   Physiol Genomics 46 (11), 398-410 (2014)
   PUBMED   24714719
REFERENCE   2  (bases 1 to 4127)
  AUTHORS   Cha,J.D., Kim,H.J. and Cha,I.H.
  TITLE     Genetic alterations in oral squamous cell carcinoma progression
            detected by combining array-based comparative genomic hybridization
            and multiplex ligation-dependent probe amplification
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111 (5), 594-607
            (2011)
   PUBMED   21334929
REFERENCE   3  (bases 1 to 4127)
  AUTHORS   Terashima,M., Kobayashi,M., Motomiya,M., Inoue,N., Yoshida,T.,
            Okano,H., Iwasaki,N., Minami,A. and Matsuoka,I.
  TITLE     Analysis of the expression and function of BRINP family genes
            during neuronal differentiation in mouse embryonic stem
            cell-derived neural stem cells
  JOURNAL   J Neurosci Res 88 (7), 1387-1393 (2010)
   PUBMED   20025061
REFERENCE   4  (bases 1 to 4127)
  AUTHORS   Kawano,H., Nakatani,T., Mori,T., Ueno,S., Fukaya,M., Abe,A.,
            Kobayashi,M., Toda,F., Watanabe,M. and Matsuoka,I.
  TITLE     Identification and characterization of novel developmentally
            regulated neural-specific proteins, BRINP family
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 60-75 (2004)
   PUBMED   15193423
  REMARK    GeneRIF: Results describe BRINP1, 2, and 3 genes, which have
            distinct regulatory mechanisms of expression within the nervous
            system and which suppress the cell cycle progression in nonneuronal
            cells.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_173115.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB077853.1, SRR26360186.488132.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-812               JAXUCZ010000013.1  73064483-73065294   c
            813-1157            JAXUCZ010000013.1  73012223-73012567   c
            1158-1348           JAXUCZ010000013.1  72986026-72986216   c
            1349-1557           JAXUCZ010000013.1  72984633-72984841   c
            1558-1663           JAXUCZ010000013.1  72973661-72973766   c
            1664-1900           JAXUCZ010000013.1  72970045-72970281   c
            1901-2123           JAXUCZ010000013.1  72968107-72968329   c
            2124-4127           JAXUCZ010000013.1  72964502-72966505   c
FEATURES             Location/Qualifiers
     source          1..4127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..4127
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /note="BMP/retinoic acid inducible neural specific 2"
                     /db_xref="GeneID:286895"
                     /db_xref="RGD:708419"
     exon            1..812
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1157
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             889..3240
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /note="BMP/retinoic acid-inducible neural-specific protein
                     2; protein FAM5B; family with sequence similarity 5,
                     member B; bone morphogenetic protein/retinoic acid
                     inducible neural-specific 2; bone morphogenic
                     protein/retinoic acid inducible neural-specific 2"
                     /codon_start=1
                     /product="BMP/retinoic acid-inducible neural-specific
                     protein 2 precursor"
                     /protein_id="NP_775138.1"
                     /db_xref="GeneID:286895"
                     /db_xref="RGD:708419"
                     /translation="MRWPCSSRFRGLWPEAAPWAVLLALGVPGWVLAVSATVAAVVPE
                     QHVSSAGQAPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLAL
                     ERKDFFSLPLPLAPEFVRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLGGEESLTI
                     FVDKRKLSRKSETLGGVPVVGGTGNSSAVSLETLHQLAASYFIDRESTLRRLHHIQIA
                     TGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQLLGLQVLLPEHLRERFVAAA
                     LSYITCSSEGELVCRENDCWCKCSPTFPECNCPDADIQAMEDSLLQIQDSWATHNRQF
                     EESEEFQTLLKRLPSDRFLNSTAISQYWTMDANLQHRYQQLGASLKVLLKKMHRIVRR
                     LFNLCKRCHRQPRFRLPKERSLSFWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYDQS
                     SCQGPIPCALGEGPACAHCASDNTTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETD
                     LQDLELKYLLQKRDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHV
                     MLALSLQICLTKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGSFPDWERTNVDAAAQC
                     QNWTITLGNRWKTFFETVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINT
                     LQVFGYSLPFDPDAIRDLILQLDYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDL
                     FSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNPVEYETGKLCS"
     exon            1158..1348
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1557
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1663
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1900
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2123
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..4127
                     /gene="Brinp2"
                     /gene_synonym="Fam5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagggcag cattgttatc ttaagacact catctggtgt ctgagtctgc aggtgacact
       61 ggttaggtac ggagcgtgaa gtcggagtgg ggacgcaccg ggctgcagct ctaggatgga
      121 atccgcctgc ctgccaagcg gctcgcggct caacccgcag cgcctcctct gagctcggcg
      181 ggttccggag gacttgggaa atgcacctgc cgcgcgctca gaggacacca gcaggtcctc
      241 aggcagccga aggagcccag acgcccgagg aaccgtttct gaccacgtac aaggcacaga
      301 tttcggatga cagggcgggt gagtctcttt agagttgggg gaaaaaaagg caagatcttt
      361 ggtttcacct cggtcgaggg acaggggact tctcagttgg cctcccactt tcctcacctc
      421 tcccacgccg cgtgcgaccc agcctagcgc tgatcccact tcacagatgc tgtgggtgcc
      481 tgggatgctc gctgctccgt ggcaaggcag caggcaagtg gtctaaacgc cgccgccgcc
      541 gccgccgcca ccgccgccgc cgcggcaaca gcaaagccca gaacaggaga atttgaaaag
      601 agacatccgt tccctctcac aagctgaggg ggggaggcat tcgcatttcc ccaaaggaga
      661 aagagccaca agaaatcatg aagtaaaaac tttggaaggc tgccactgga gatgttgcac
      721 aaaaactggg cgtcttttag gagtctcctc gcagtccttg gtgttttggg gagcagctga
      781 tacagcaaga agggctctta caaggattca agtttggagc cctggaggag cagcacggag
      841 tgggagagct tggcgagaga atgaagacac taaccgcctg ggagaagcat gaggtggccg
      901 tgcagctctc ggtttagagg gctttggccg gaggccgccc catgggcagt cctgctggca
      961 ctaggcgtgc ccgggtgggt gctggctgtc tcggccacgg tggccgctgt ggtcccggaa
     1021 cagcatgtct cctcggctgg tcaggctccc ctggactggc tgctcacaga ccgaggcccc
     1081 ttccaccgtg cccaggagta tgctgatttc atggagcgtt accgccaggg gttcactacc
     1141 agatacagga tctacaggga gtttgcccga tggaaagtga acaacttggc cctagaaagg
     1201 aaagacttct tcagtttgcc cctgcctctc gccccagagt ttgtccgcaa catccgcctc
     1261 cttggaagga gacccaacct gcagcaggtc actgaaaacc tcatcaaaaa gtacggcact
     1321 catttcttac tttctgccac tcttggagga gaagagtccc tgaccatttt tgtggacaag
     1381 aggaaactaa gcagaaagtc agaaacacta ggaggtgttc ctgtagtggg gggcactggg
     1441 aacagctctg ctgtgtctct ggaaaccctg caccagctgg cagcctccta cttcattgac
     1501 agagagagca cactgcgaag acttcaccat atccaaatag ccacaggggc cataaaggtc
     1561 acagagacca ggaccggtcc actgggctgc agcaactatg acaatctgga ctctgtcagc
     1621 tctgtcctgg ttcagagtcc agagaacaaa gtgcagttat tgggcctgca ggtgctgctc
     1681 cctgaacacc tgcgtgagcg gtttgtggct gcagcactca gctacatcac atgcagctct
     1741 gagggtgagc ttgtctgcag ggagaatgac tgctggtgca agtgcagccc cacgttccca
     1801 gaatgcaact gtcctgatgc tgacattcaa gctatggaag acagcttgct gcagatccaa
     1861 gactcctggg ccactcacaa caggcagttt gaagagtcag aagaattcca gaccctgctg
     1921 aagaggctcc ccagcgaccg attcctgaac tccacagcca tctcccagta ctggaccatg
     1981 gacgccaacc tccagcaccg ttatcagcag ctgggagcca gcttgaaagt cctgttaaag
     2041 aagatgcacc ggatcgtccg ccgcctcttc aatctctgca agcgctgcca tcggcagcct
     2101 cgcttccgcc tgcccaagga gagatccttg tctttctggt ggaaccgaat ccagtccctt
     2161 ctctactgtg gagaaagcac cttccctggg acattcctgg aacagagcca cagctgcacc
     2221 tgtccctatg accaatcttc ctgccagggc cccattccat gtgccctggg ggaagggcct
     2281 gcatgtgccc actgtgcttc agacaatacc acgcgctgtg ggagttgtaa ccctggttat
     2341 gtgctagccc agggactgtg ccggccagag gtagccgagt ccctggagaa ctttcttggg
     2401 ctggagacag acctgcagga ccttgagctg aagtacctgc tgcagaagcg agatagccgc
     2461 attgaggtgc actccatctt tatcagcaat gacatgcgtc tgggcagctg gtttgaccct
     2521 tcctggagga agcggatgct cctcactttg aagagtaaca agtacaagcc gggcctggtg
     2581 catgtgatgt tagccttgtc cttgcagatc tgcctcacta agaacagcac cctggagccc
     2641 gtcatggcca tctatgtgaa ccccttcggg ggcagccact ctgagagctg gttcatgcct
     2701 gtaaacgagg gcagctttcc agactgggaa aggactaacg tggatgcagc tgcccagtgc
     2761 caaaactgga ctatcacttt ggggaacagg tggaagactt tttttgagac agtccatgtt
     2821 tacctacgga gccgaatcaa gtccctggat gacagctcca acgagacaat ctactatgag
     2881 cccctggaga tgactgatcc ctccaagaat ttgggctaca tgaaaatcaa cactttgcag
     2941 gtctttggct acagcctgcc ctttgacccg gatgctatcc gagacttaat tctccagctg
     3001 gactacccgt acactcaagg ttcccaggac tctgcactct tacaactcat tgagcttaga
     3061 gaccgggtga accaactctc tccccctggc aaagtccggc ttgatctttt ctcctgcttg
     3121 ctccgccata ggctcaagct ggccaacaac gaggtgggca ggatccagtc ctccctgaga
     3181 gctttcaatt ccaagctgcc aaatcctgtg gagtatgaga caggcaaact ctgtagctaa
     3241 tgggggaact accccagtgc tggtcagaga gttgatccac acattcaggg tgcaaagata
     3301 atccaagccc tcacctcagt gccaacagag tgcttctaag agacttttag cacctgggag
     3361 ataggagctc aaggcttgga ctgaagcagg cgaaaaacaa tgaaacagcc actgcacaca
     3421 tgcacaagtg catataacac cctaccacac acactcacag ggaggccaca gcccagccac
     3481 ctcgaatctg taaagttggt gctctctaaa atgaatgcag ttgaagaaga accaaggaag
     3541 agataaaaga gctggctaaa ccaggaaaga aatgactgaa aaaaatacat ttcaaagtga
     3601 ttcttgtcat ctaggatagc aagagggaca gaagtgggag ggacaggaga cctcccctct
     3661 gtggagtcac ttttgtattc tttttaacca gatttcttaa aatgtcattg ttctgtgact
     3721 ccctgcactg cttcttactc tgtacagtgc ctccctgcac cctggaggcc ttggtgtcct
     3781 tggaaagtgt gtgcagtgct aaagcagagg agctcacgct aagggcaggt cacggcctct
     3841 ttgctccctc ccccacttct tcctcctgcc agctccctca ctttcttggc ctccccagtt
     3901 tcagagtttt gacttgttcc aagagcccct cacagttcat ccagagccct cttcccacag
     3961 cacccatctg ttcaaggaag cagttttgtc aagttagaga gacaacatat atggaaatgt
     4021 tctttttaaa aaaaaacaac aaaacaaaaa atatttattt tgtgattgtt ttcttgtcaa
     4081 cctgctccag tcacatgaac ctctgagtaa agttttactt ggtttaa
//
