LOCUS       NM_080482               2420 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus BMP/retinoic acid inducible neural specific 1
            (Brinp1), mRNA.
ACCESSION   NM_080482
VERSION     NM_080482.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Berkowicz,S.R., Featherby,T.J., Qu,Z., Giousoh,A., Borg,N.A.,
            Heng,J.I., Whisstock,J.C. and Bird,P.I.
  TITLE     Brinp1(-/-) mice exhibit autism-like behaviour, altered memory,
            hyperactivity and increased parvalbumin-positive cortical
            interneuron density
  JOURNAL   Mol Autism 7, 22 (2016)
   PUBMED   27042284
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2420)
  AUTHORS   Kobayashi,M., Nakatani,T., Koda,T., Matsumoto,K., Ozaki,R.,
            Mochida,N., Takao,K., Miyakawa,T. and Matsuoka,I.
  TITLE     Absence of BRINP1 in mice causes increase of hippocampal
            neurogenesis and behavioral alterations relevant to human
            psychiatric disorders
  JOURNAL   Mol Brain 7, 12 (2014)
   PUBMED   24528488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2420)
  AUTHORS   de Rivero Vaccari,J.P., Minkiewicz,J., Wang,X., De Rivero
            Vaccari,J.C., German,R., Marcillo,A.E., Dietrich,W.D. and
            Keane,R.W.
  TITLE     Astrogliosis involves activation of retinoic acid-inducible
            gene-like signaling in the innate immune response after spinal cord
            injury
  JOURNAL   Glia 60 (3), 414-421 (2012)
   PUBMED   22161971
  REMARK    GeneRIF: The findings of this study identify a role for RLR
            signaling and type I IFN in regulating astrocyte innate immune
            responses after SCI. (c) 2011 Wiley Periodicals, Inc.
REFERENCE   4  (bases 1 to 2420)
  AUTHORS   Terashima,M., Kobayashi,M., Motomiya,M., Inoue,N., Yoshida,T.,
            Okano,H., Iwasaki,N., Minami,A. and Matsuoka,I.
  TITLE     Analysis of the expression and function of BRINP family genes
            during neuronal differentiation in mouse embryonic stem
            cell-derived neural stem cells
  JOURNAL   J Neurosci Res 88 (7), 1387-1393 (2010)
   PUBMED   20025061
REFERENCE   5  (bases 1 to 2420)
  AUTHORS   Kawano,H., Nakatani,T., Mori,T., Ueno,S., Fukaya,M., Abe,A.,
            Kobayashi,M., Toda,F., Watanabe,M. and Matsuoka,I.
  TITLE     Identification and characterization of novel developmentally
            regulated neural-specific proteins, BRINP family
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 60-75 (2004)
   PUBMED   15193423
REFERENCE   6  (bases 1 to 2420)
  AUTHORS   Wright,K.O., Messing,E.M. and Reeder,J.E.
  TITLE     DBCCR1 mediates death in cultured bladder tumor cells
  JOURNAL   Oncogene 23 (1), 82-90 (2004)
   PUBMED   14712213
REFERENCE   7  (bases 1 to 2420)
  AUTHORS   Nishiyama,H., Gill,J.H., Pitt,E., Kennedy,W. and Knowles,M.A.
  TITLE     Negative regulation of G(1)/S transition by the candidate bladder
            tumour suppressor gene DBCCR1
  JOURNAL   Oncogene 20 (23), 2956-2964 (2001)
   PUBMED   11420708
REFERENCE   8  (bases 1 to 2420)
  AUTHORS   Nishiyama,H., Takahashi,T., Kakehi,Y., Habuchi,T. and Knowles,M.A.
  TITLE     Homozygous deletion at the 9q32-33 candidate tumor suppressor locus
            in primary human bladder cancer
  JOURNAL   Genes Chromosomes Cancer 26 (2), 171-175 (1999)
   PUBMED   10469456
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB051356.1.
            
            [WARNING] On Nov 13, 2024 this sequence was replaced by
            NM_080482.3.
            
            On Aug 31, 2012 this sequence version replaced NM_080482.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2420              AB051356.1         2-2421
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..2420
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /note="BMP/retinoic acid inducible neural specific 1"
                     /db_xref="GeneID:140610"
                     /db_xref="RGD:708519"
     exon            1..274
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..2339
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /note="deleted in bladder cancer protein 1 homolog;
                     BMP/retinoic acid-inducible neural-specific protein 1;
                     deleted in bladder cancer 1; bone morphogenic
                     protein/retinoic acid inducible neural-specific 1; deleted
                     in bladder cancer chromosome region candidate 1; bone
                     morphogenetic protein/retinoic acid inducible
                     neural-specific 1"
                     /codon_start=1
                     /product="BMP/retinoic acid-inducible neural-specific
                     protein 1 precursor"
                     /protein_id="NP_536730.1"
                     /db_xref="GeneID:140610"
                     /db_xref="RGD:708519"
                     /translation="MNWRFVELLYFLFVWGRISVQPSHQEPAGTDQHVSKEFDWLISD
                     RGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQ
                     RSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQS
                     VEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGLLGCNSYDNLDSVSSVLL
                     QSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYVCQNSQCRCQCAEEFPQC
                     NCPITDIQIMEFTLANMAKAWTEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGN
                     DWDLQSRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQ
                     SLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCIIGGNNSCAMCSLANISLCGSC
                     NKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISN
                     EIRLDTFFDLRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNP
                     FSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTR
                     LPTLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQG
                     GQFYSSSSVMLLMLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNHA
                     LDLYNTEILKQSDQMTAKLC"
     exon            275..465
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..635
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..741
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..978
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1201
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..2406
                     /gene="Brinp1"
                     /gene_synonym="Dbc1; Dbccr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccaggact ccacagaatg gagcaagaat gagaggaaaa aggccggcag aaaagcatga
       61 actggaggtt tgttgagctc ctctacttcc tgtttgtatg gggccgtatc tcagtgcagc
      121 cctcccacca ggagccagct gggacagacc aacatgtctc caaggaattt gattggctta
      181 tttcagacag ggggcctttc caccactcca ggagctacct atcctttgtg gaaagacacc
      241 ggcaaggatt tacaaccaga tataaaatat acagggagtt tgcccgttgg aaggtgagga
      301 acacagccat agaaaggaga gatctggtcc gtcatccagt gcccctcatg ccggagtttc
      361 aaaggagcat tcgtctgctt ggcaggagac ccaccaccca gcagttcatt gataccatca
      421 tcaaaaagta cggcacacac ctgctcatct ctgctacatt gggaggagag gaggctttga
      481 ccatgtacat ggacaaaagt cgcctcgacc ggaagtcagg aaatgctacc caaagtgttg
      541 aagctttgca ccagcttgca tcatcctact ttgtcgaccg tgatggcacc atgagaaggc
      601 tccatgagat ccagatttca actggagcaa tcaaggtcac agagacacgc actgggcttc
      661 tgggctgtaa cagctatgac aatctggact ctgtgagttc tgtccttctg caaagcacgg
      721 agagcaaact gcaccttcaa ggtctacaga taatcttccc gcagtatctg caagagaagt
      781 ttgtacagtc agccttgagt tacatcatgt gcaatggcga gggagagtat gtctgtcaga
      841 acagccagtg tcgctgccag tgtgctgagg agttcccaca gtgcaactgc cctatcaccg
      901 acatccagat catggaattt acactggcta acatggccaa ggcctggact gaagcttata
      961 aggacctgga gaattcagat gagttcaagt catttatgaa gcgtctccca agcaaccact
     1021 tcctgaccat tggcagcatc caccagcact ggggcaatga ctgggacctg cagagccgtt
     1081 acaagctcct acagagtgcc actgaggctc agaggcagaa aatccagagg accgcccgca
     1141 agctctttgg cctcagtgtg cgctgccgcc acaatcccaa ccaccagctg cctagagaga
     1201 ggacaattca acagtggctt gcaagggtcc agtcacttct ctattgcaat gagaatgggt
     1261 tctggggaac cttcctggaa agccagagga gttgtgtgtg ccatggtagc accacactgt
     1321 gccagcgccc tatcccatgt atcataggtg ggaacaacag ctgtgccatg tgcagcctgg
     1381 ccaacatctc actctgtggc tcctgcaata agggctacaa gctgtataga ggccgctgtg
     1441 aaccacaaaa cgtggactct gagcggagtg agcagttcat cagctttgag accgacctgg
     1501 acttccagga cttggaactg aagtacctgt tgcagaagat ggattcacgc ctctatgtcc
     1561 acactacctt catcagcaat gagattcgcc tggatacgtt ctttgacctt cggtggcgca
     1621 agcgcatgtc cctcactctc aagagcaaca agaaccgcat ggactttatc catatggtga
     1681 tcggcatgtc catgcgaatc tgccagatgc gaaacagcag cctggaccct atgttctttg
     1741 tctatgtcaa tcccttcagt gggagccatt cagaaggctg gaacatgccc tttggggaat
     1801 ttggctaccc acgttgggag aagatccgtc tgcaaaacag ccaatgctac aactggactc
     1861 tcttgttggg caatcggtgg aaaacttttt tcgagactgt ccatatctac ctacgtagtc
     1921 ggactcggct acccacccta cgcaatgaga ctggccaggg ccccgtggac ctgtcagatc
     1981 cctccaaaag gcaattctac atcaagatct ccgatgtgca ggtgttcggg tatagcctga
     2041 ggttcaatgc tgacctctta cgaagtgccg tgcaacaggt taatcaatcc tatacacagg
     2101 gtggccagtt ctattcctcc tcatccgtga tgcttctcat gttggacatt cgggaccgaa
     2161 ttaaccgcct ggcccctcct gtggccccag gaaaacccca gctggacttg ttttcctgta
     2221 tgctgaagca ccgcctgaag ctgaccaaca gtgagattat cagggtgaat catgccttgg
     2281 acctctacaa cactgagatc ctcaaacagt ctgaccagat gacagccaaa ctctgctaac
     2341 ccgggaccct ttgccatgga ctttcccttc tgttgtacaa atacaacaga ataaaacaaa
     2401 gtaaaaaaaa aaaaaaaaaa
//
