LOCUS       NM_001399505            5279 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus BRF1 general transcription factor IIIB subunit
            (Brf1), mRNA.
ACCESSION   NM_001399505 XM_006240658
VERSION     NM_001399505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5279)
  AUTHORS   Vannini,A.
  TITLE     A structural perspective on RNA polymerase I and RNA polymerase III
            transcription machineries
  JOURNAL   Biochim Biophys Acta 1829 (3-4), 258-264 (2013)
   PUBMED   23031840
  REMARK    Review article
REFERENCE   2  (bases 1 to 5279)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   3  (bases 1 to 5279)
  AUTHORS   Dumay-Odelot,H., Durrieu-Gaillard,S., Da Silva,D., Roeder,R.G. and
            Teichmann,M.
  TITLE     Cell growth- and differentiation-dependent regulation of RNA
            polymerase III transcription
  JOURNAL   Cell Cycle 9 (18), 3687-3699 (2010)
   PUBMED   20890107
  REMARK    Review article
REFERENCE   4  (bases 1 to 5279)
  AUTHORS   Johnson,S.A., Dubeau,L. and Johnson,D.L.
  TITLE     Enhanced RNA polymerase III-dependent transcription is required for
            oncogenic transformation
  JOURNAL   J Biol Chem 283 (28), 19184-19191 (2008)
   PUBMED   18456653
REFERENCE   5  (bases 1 to 5279)
  AUTHORS   Angelis,E., Garcia,A., Chan,S.S., Schenke-Layland,K., Ren,S.,
            Goodfellow,S.J., Jordan,M.C., Roos,K.P., White,R.J. and
            MacLellan,W.R.
  TITLE     A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA
            polymerase III after biomechanical stress in adult myocardium
  JOURNAL   Circ Res 102 (10), 1222-1229 (2008)
   PUBMED   18420946
REFERENCE   6  (bases 1 to 5279)
  AUTHORS   Ernens,I., Goodfellow,S.J., Innes,F., Kenneth,N.S., Derblay,L.E.,
            White,R.J. and Scott,P.H.
  TITLE     Hypoxic stress suppresses RNA polymerase III recruitment and tRNA
            gene transcription in cardiomyocytes
  JOURNAL   Nucleic Acids Res 34 (1), 286-294 (2006)
   PUBMED   16407335
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5279)
  AUTHORS   Raineri,I., Wegmueller,D., Gross,B., Certa,U. and Moroni,C.
  TITLE     Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover
            studied by RNA interference
  JOURNAL   Nucleic Acids Res 32 (4), 1279-1288 (2004)
   PUBMED   14976220
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006240658.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.197867.1,
                                           SRR26360181.2450058.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               JAXUCZ010000006.1  137902124-137902386 c
            264-344             JAXUCZ010000006.1  137896218-137896298 c
            345-518             JAXUCZ010000006.1  137891218-137891391 c
            519-550             JAXUCZ010000006.1  137885944-137885975 c
            551-623             JAXUCZ010000006.1  137882560-137882632 c
            624-773             JAXUCZ010000006.1  137875497-137875646 c
            774-867             JAXUCZ010000006.1  137874208-137874301 c
            868-994             JAXUCZ010000006.1  137872166-137872292 c
            995-1034            JAXUCZ010000006.1  137871544-137871583 c
            1035-1127           JAXUCZ010000006.1  137871367-137871459 c
            1128-1391           JAXUCZ010000006.1  137867190-137867453 c
            1392-1453           JAXUCZ010000006.1  137865841-137865902 c
            1454-1535           JAXUCZ010000006.1  137865136-137865217 c
            1536-1591           JAXUCZ010000006.1  137865003-137865058 c
            1592-1848           JAXUCZ010000006.1  137863986-137864242 c
            1849-1900           JAXUCZ010000006.1  137859783-137859834 c
            1901-2072           JAXUCZ010000006.1  137859176-137859347 c
            2073-5279           JAXUCZ010000006.1  137855449-137858655 c
FEATURES             Location/Qualifiers
     source          1..5279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5279
                     /gene="Brf1"
                     /note="BRF1 general transcription factor IIIB subunit"
                     /db_xref="GeneID:299347"
                     /db_xref="RGD:1311158"
     exon            1..263
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2110
                     /gene="Brf1"
                     /note="BRF1 homolog, subunit of RNA polymerase III
                     transcription initiation factor IIIB; BRF1, RNA polymerase
                     III transcription initiation factor 90 subunit; BRF1, RNA
                     polymerase III transcription initiation factor subunit"
                     /codon_start=1
                     /product="transcription factor IIIB 90 kDa subunit"
                     /protein_id="NP_001386434.1"
                     /db_xref="GeneID:299347"
                     /db_xref="RGD:1311158"
                     /translation="MTGRVCRGCGGTDIELDAARGDAVCTGCGSVLEDNIIVSEVQFV
                     ENSGGGSSAVGQFVSLDGAGKTPTLGGGFHVNLGKESRAQTLQNGRRHIHHLGSQLQL
                     NQHCLDTAFNFFKMAVSKHLTRGRKMAHVIAACLYLVCRTEGTPHMLLDLSDLLQVNV
                     YVLGKTFLLLARELCINAPAIDPCLYIPRFAHLLEFGEKNHEVSMTALRLLQRMKRDW
                     MHTGRRPSGLCGAALLVAARMHDFRRTVKEVISVVKVCESTLRKRLTEFEDTPTSQLT
                     IDEFMKIDLEEECDPPSYTAGQRKLRMKQLEQVLSKKLEEVEGEISTYQDAIEIELEN
                     SRPKAKGALANLSKDGSGEDATSSPFCEEDTEDEELEAAASHMNKDFYRELLGADGGS
                     EAAEDADGGSRPLALESLLGPLPTAASLGISDSIRECISSPSGDPKDSSGDGELDLSG
                     IDDLEIDRYILNESEARVKAELWMRENAEYLREQKEKEARIAKEKELGIYKEHKPKKS
                     CKRREPILASTAGEAIEKMLEQKKISSKINYSVLRDLNSKGGGSPPRDDSQPPEHTST
                     KKLSRRKRAATRNSADPGTSMGKRLRPLVSAQPAKKAAVGEALLLNSPALGAEPVKPS
                     AVLVESGPVSYHPEEDADEEDAEEEDGEPCVSALQMMGGNDYGCDGDEDDGY"
     exon            264..344
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            345..518
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..550
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..623
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..773
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..867
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..994
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1034
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1127
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1391
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1453
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1535
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1591
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1848
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1900
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2072
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..5279
                     /gene="Brf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccttgcg ggctgagggc cgcgggcgga gagcgggttg gtgagcggca gggggccggt
       61 ggggccccgc ggctccaaca tgacgggccg cgtctgccgc ggttgcggcg gcacggacat
      121 cgagttggat gcggcgcgcg gcgacgcggt gtgcacgggc tgcggttcgg tgctcgagga
      181 caacatcatc gtgtccgagg tgcagttcgt ggagaacagc ggcggcggct cgtcggcagt
      241 cggccagttc gtgtcgctgg acggtgcggg gaaaacccca accctaggcg gcggctttca
      301 tgtgaacttg ggaaaggaat caagagcaca gaccctacag aatgggcggc gccacatcca
      361 ccacctgggg agccagttgc aactgaacca gcactgcctg gacacagcct tcaacttctt
      421 caagatggct gtaagcaagc atcttacccg aggacggaaa atggcccatg tgattgctgc
      481 ctgcctctac ttggtttgcc gaacggaagg cacacctcac atgctcctcg acctcagcga
      541 cctgctccag gttaacgtgt atgtgctggg aaagaccttc ctgctcttgg cgagggagct
      601 ttgcatcaac gcaccagcta tagacccatg cttgtacatt ccacgatttg cgcatctact
      661 ggaatttggg gagaagaacc atgaggtatc catgacggcc ctgaggcttc tgcagaggat
      721 gaaaagggat tggatgcaca caggccggcg cccctctggc ctctgtggag cagcacttct
      781 ggttgcagcc agaatgcatg acttccggag aaccgtcaaa gaagtcatca gcgtggtcaa
      841 agtatgtgag tccacattgc ggaagaggct cacagaattt gaagacactc caaccagtca
      901 gctcactatt gacgagttta tgaagattga cctggaggag gagtgtgacc cgccctcata
      961 caccgctgga cagaggaagc tgcgcatgaa gcagctggaa caggtcctgt ccaaaaagct
     1021 agaagaagtt gaaggtgaga tatccactta ccaagatgcc attgaaattg agctagaaaa
     1081 cagtcggcca aaggctaaag gggctctcgc caacttgtca aaggatggct ccggtgagga
     1141 cgccacatcc agcccgttct gtgaggaaga cactgaggat gaggagctcg aggctgctgc
     1201 cagccacatg aacaaggact tttaccgaga gctcctgggg gctgatggcg gctcggaggc
     1261 agcagaagac gctgatgggg gcagcagacc cctcgccctg gagtccctgc ttggtcccct
     1321 gcccacagca gccagcctgg gtatctcaga ctccatccga gagtgcatct cctcccccag
     1381 tggagacccc aaagactctt caggggatgg ggagctggac ctcagcggca tcgatgacct
     1441 tgagattgac agatacatcc tgaacgagtc agaagcccgg gtaaaggctg agttgtggat
     1501 gcgggagaat gctgagtacc tgcgggaaca gaaagagaaa gaagcaagaa tagcgaagga
     1561 gaaggagctt ggcatctata aggagcacaa gcccaagaag tcttgcaaac gccgggagcc
     1621 aatcctagcc agcacagccg gggaggccat tgagaagatg ctggaacaga agaaaatctc
     1681 cagcaagatc aactacagtg tgctgcggga ccttaacagc aagggtgggg gcagcccgcc
     1741 cagggacgac tcacagcctc cagagcacac cagcaccaag aagctgtcac ggaggaaaag
     1801 agcagctacc aggaacagtg ctgatcctgg gacaagcatg gggaagaggt tgaggccttt
     1861 ggtgtctgct cagcccgcta agaaggcagc tgtgggagag gccttgctct taaattcccc
     1921 tgccttggga gctgagcctg tcaagccatc ggcagtcttg gtggagagtg gccctgtgtc
     1981 ataccatcct gaggaggatg cagatgagga ggacgccgag gaagaggatg gagagccctg
     2041 cgtcagtgct ctgcagatga tgggaggcaa tgattatggc tgtgatggtg acgaggatga
     2101 tggctactga gtggaactca agaccaggca gcatcccggt gctggactcc aagtgtatct
     2161 gtttataggt gtcagatggg ccttgggcca cggctcacag gcatgatttc tgagactcga
     2221 ccagtcaagc actgccccac ttatttgaag ctctcttccc atggccgcac tgtggaccat
     2281 tgtacttact attgggaatc atgttttgag caatgcaagg gatatttttt gccctgcaag
     2341 ggaaacgagc tgtgtgttat gtgtaatgaa acatggtcag agagtagccg ggtctggaac
     2401 cacgtcatgc ctcacctact agtcactgtt taccagggat cctcaggcag accctgtgcc
     2461 ctctagtcat agggagattg aagcacaaga gcctcagtgt agaagagccc tgctctgaac
     2521 ctgctgtttg ttctctgccc tgtccttgcc tgagacgtgt cagtcattgc tctatactag
     2581 gccaccacag tctgcagtct ctgcctttaa cctcaacacc agcttcctgc gggcaggatg
     2641 ctccccacca ttccagtgtc cactccctgt cttggaccac caggagcatc gtaggcctca
     2701 gcctcctgcc taggactcgt ccttgaggca cccagtagct tgttagtcag atttatctgc
     2761 agcacccaga aagcgaagac cagcagacca tgtgctccat cacttaaaat ggacctttcg
     2821 tactcctgaa cagaaccctc tgcaaagaag cctgcaagct atctcctggc ctcttcatga
     2881 gagggcccac agagttccct ccgttcattt aactccagcc tccctggatg caaccctgga
     2941 tgcagactac ttggctttca gatcaagagg tgggggccag gcttggggtg atgagttggg
     3001 gcagctacag atgagggaat gagtcggaca ggtaggaagt gatttgatga aagactgcaa
     3061 gatgctttgg gactctatgt cccaaagggg agtgtggaac catggtcaga gcatggaagg
     3121 gaaagtattt taggatgttt ttatacagca agacttgcct gtgtcgtgga gagagtacag
     3181 agtgaagggt gagaagagga ggactgtgac ctgctcccta gctgtgtgtc ttgtctgccc
     3241 aggaggagag cccagtgctg ggaaatgagc aggggccagg aaggctggag tgctcctgtg
     3301 aggtaattga gttagttgct cactaccgtg gatagcaggt agcggatagg aaagcaggat
     3361 aggatggctg tagaaagctg aggtggaggg cggtggacag tactgagtga ggatgatccc
     3421 tagaagatag ggaagtagcc aagtcagggt gaggggttgt cttgaaatgt gggtcacatg
     3481 gttggagacc caggtgctga ggaggatggt cccagtaggg ggcagccgtg aagtgggcaa
     3541 gatgcttctg agctgagctc acagccttgt gtctgagcta ccagcagcac tagtgtgagg
     3601 ctcaaagagg cactgggtct gtatgacccc gctgtgcttg taattagtcc gtttctatgc
     3661 gcttttttct gactgggatt atcacagcag aatctgcctg cctggggtct tctcagaggg
     3721 tagagcagca gaaccagccc tcaccacact ggaccttagg aaagggaagg aggggacgag
     3781 ggagtccact ggatcctgca ttttagactg agaccctgtg tggtatgcac acttgcatgc
     3841 tgagcagaca ggatagcaca cttcagtctc ctctgccttc tgtcttcctg ccagggagag
     3901 ggaggtccag ggacactaca tgcaggatgc accatccaag tttcttgcca gccatctaaa
     3961 ctgaggaacc taatacttag tggttgccac catcctctgc aaactgggtg atcactgggg
     4021 aatacagtag cagtcagcaa ggttcctgat aaacctagac atttgaggct tggcagagtg
     4081 tgtgcctggc tttagaggta accaggggat gctttcagga gctggaccac agaatgaggt
     4141 tatagccatg caaggctgtc aggcactgtt tccgctttag ctgttcctcc tgagcaattg
     4201 tgcccattga gaagcttctc cagccaaccc tgggccccgg ttttctgatt caggtgctct
     4261 ctcctgccat atactacggg tgaagtaagc ccttccctat gcctagttag actgcggaga
     4321 ccaaggtttg gccatgtcct tcgctcagta cctgtcgagg acccagggga cggatacacc
     4381 ttggcagtgg gagaggatac atgggatggg tatgggtcca gctgggtaga tgtttgcctg
     4441 tttgaagtac ctgtcaccac gtttagctag atggcaggta ccctacaaga aactccagag
     4501 accaaagaag cagggcctcc atgggtgtta atgagggagt agagtagtgg ggtatgtgca
     4561 tcttagaata cctgttagac ccagcgtttc tctctggcct cccttctaag aggtatagaa
     4621 caggagttaa gtaaagaacg gggattggag gagactggtg ggtaccccct ggaggttgct
     4681 tctgcatgat ggataacctg ggttctgatt gctctcttct cagcagagag cagtagatct
     4741 ctgagtgctc aggtgtgcac gccagacagg gtgccagcct agaatgcagg atccaagggt
     4801 ttgagacagt agctggacct gggtctaggg tggttttgtg ggagtccttc cagtctaggg
     4861 agccaagcct gggccagccc ctggaaagcc tgacttcagt gaagagatgc atcagctcct
     4921 agaccccact ggattgctgc ggtcagaact tgctgcaggc taccaccctg caggcccgca
     4981 gcccctccac aatccttata agctctgggc ctaccccagc atcttatctc agtcagtgta
     5041 gaggggagtt tctgacttca tttgcccaag ccttgaggtg gaacccaaat cttgggcctt
     5101 ttttgggcac agaggaagct ttatgattcc tggcaccaaa cccctgcctg gctttcccca
     5161 gcccagccag tttctgtggc tgctggggtg gatggcacca aggaagtctg taccccatga
     5221 gtgagggtgg ctgcaccgga gtgtggcggc atacatgcag tacaggttag tgttgcata
//
