LOCUS       NM_001402393            3980 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus bromodomain testis associated (Brdt), transcript
            variant 1, mRNA.
ACCESSION   NM_001402393
VERSION     NM_001402393.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3980)
  AUTHORS   Li,L., Sha,Y., Wang,X., Li,P., Wang,J., Kee,K. and Wang,B.
  TITLE     Whole-exome sequencing identified a homozygous BRDT mutation in a
            patient with acephalic spermatozoa
  JOURNAL   Oncotarget 8 (12), 19914-19922 (2017)
   PUBMED   28199965
REFERENCE   2  (bases 1 to 3980)
  AUTHORS   Sanchez,R., Meslamani,J. and Zhou,M.M.
  TITLE     The bromodomain: from epigenome reader to druggable target
  JOURNAL   Biochim Biophys Acta 1839 (8), 676-685 (2014)
   PUBMED   24686119
  REMARK    Review article
REFERENCE   3  (bases 1 to 3980)
  AUTHORS   Gaucher,J., Boussouar,F., Montellier,E., Curtet,S., Buchou,T.,
            Bertrand,S., Hery,P., Jounier,S., Depaux,A., Vitte,A.L.,
            Guardiola,P., Pernet,K., Debernardi,A., Lopez,F., Holota,H.,
            Imbert,J., Wolgemuth,D.J., Gerard,M., Rousseaux,S. and Khochbin,S.
  TITLE     Bromodomain-dependent stage-specific male genome programming by
            Brdt
  JOURNAL   EMBO J 31 (19), 3809-3820 (2012)
   PUBMED   22922464
REFERENCE   4  (bases 1 to 3980)
  AUTHORS   Berkovits,B.D., Wang,L., Guarnieri,P. and Wolgemuth,D.J.
  TITLE     The testis-specific double bromodomain-containing protein BRDT
            forms a complex with multiple spliceosome components and is
            required for mRNA splicing and 3'-UTR truncation in round
            spermatids
  JOURNAL   Nucleic Acids Res 40 (15), 7162-7175 (2012)
   PUBMED   22570411
REFERENCE   5  (bases 1 to 3980)
  AUTHORS   Plaseski,T., Noveski,P., Popeska,Z., Efremov,G.D. and
            Plaseska-Karanfilska,D.
  TITLE     Association study of single-nucleotide polymorphisms in FASLG,
            JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 genes with
            male infertility
  JOURNAL   J Androl 33 (4), 675-683 (2012)
   PUBMED   22016351
REFERENCE   6  (bases 1 to 3980)
  AUTHORS   Filippakopoulos,P., Picaud,S., Mangos,M., Keates,T., Lambert,J.P.,
            Barsyte-Lovejoy,D., Felletar,I., Volkmer,R., Muller,S., Pawson,T.,
            Gingras,A.C., Arrowsmith,C.H. and Knapp,S.
  TITLE     Histone recognition and large-scale structural analysis of the
            human bromodomain family
  JOURNAL   Cell 149 (1), 214-231 (2012)
   PUBMED   22464331
REFERENCE   7  (bases 1 to 3980)
  AUTHORS   Barda,S., Paz,G., Yogev,L., Yavetz,H., Lehavi,O., Hauser,R.,
            Botchan,A., Breitbart,H. and Kleiman,S.E.
  TITLE     Expression of BET genes in testis of men with different
            spermatogenic impairments
  JOURNAL   Fertil Steril 97 (1), 46-52 (2012)
   PUBMED   22035730
REFERENCE   8  (bases 1 to 3980)
  AUTHORS   Moriniere,J., Rousseaux,S., Steuerwald,U., Soler-Lopez,M.,
            Curtet,S., Vitte,A.L., Govin,J., Gaucher,J., Sadoul,K., Hart,D.J.,
            Krijgsveld,J., Khochbin,S., Muller,C.W. and Petosa,C.
  TITLE     Cooperative binding of two acetylation marks on a histone tail by a
            single bromodomain
  JOURNAL   Nature 461 (7264), 664-668 (2009)
   PUBMED   19794495
REFERENCE   9  (bases 1 to 3980)
  AUTHORS   Shang,E., Nickerson,H.D., Wen,D., Wang,X. and Wolgemuth,D.J.
  TITLE     The first bromodomain of Brdt, a testis-specific member of the BET
            sub-family of double-bromodomain-containing proteins, is essential
            for male germ cell differentiation
  JOURNAL   Development 134 (19), 3507-3515 (2007)
   PUBMED   17728347
REFERENCE   10 (bases 1 to 3980)
  AUTHORS   Pivot-Pajot,C., Caron,C., Govin,J., Vion,A., Rousseaux,S. and
            Khochbin,S.
  TITLE     Acetylation-dependent chromatin reorganization by BRDT, a
            testis-specific bromodomain-containing protein
  JOURNAL   Mol Cell Biol 23 (15), 5354-5365 (2003)
   PUBMED   12861021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000014.1  2590617-2590760     c
            145-284             JAXUCZ010000014.1  2575364-2575503     c
            285-524             JAXUCZ010000014.1  2574546-2574785     c
            525-662             JAXUCZ010000014.1  2572259-2572396     c
            663-777             JAXUCZ010000014.1  2570994-2571108     c
            778-950             JAXUCZ010000014.1  2567899-2568071     c
            951-1301            JAXUCZ010000014.1  2566314-2566664     c
            1302-1430           JAXUCZ010000014.1  2560310-2560438     c
            1431-1619           JAXUCZ010000014.1  2559323-2559511     c
            1620-1789           JAXUCZ010000014.1  2557811-2557980     c
            1790-2070           JAXUCZ010000014.1  2557316-2557596     c
            2071-2196           JAXUCZ010000014.1  2557073-2557198     c
            2197-2379           JAXUCZ010000014.1  2556824-2557006     c
            2380-2441           JAXUCZ010000014.1  2547548-2547609     c
            2442-2616           JAXUCZ010000014.1  2546669-2546843     c
            2617-2714           JAXUCZ010000014.1  2539160-2539257     c
            2715-2920           JAXUCZ010000014.1  2538319-2538524     c
            2921-3110           JAXUCZ010000014.1  2537430-2537619     c
            3111-3218           JAXUCZ010000014.1  2533450-2533557     c
            3219-3980           JAXUCZ010000014.1  2532275-2533036     c
FEATURES             Location/Qualifiers
     source          1..3980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3980
                     /gene="Brdt"
                     /note="bromodomain testis associated"
                     /db_xref="GeneID:305123"
                     /db_xref="RGD:1306678"
     exon            1..144
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            145..284
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            285..524
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..3179
                     /gene="Brdt"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bromodomain testis-specific protein; bromodomain,
                     testis-specific"
                     /codon_start=1
                     /product="bromodomain testis-specific protein isoform 1"
                     /protein_id="NP_001389322.1"
                     /db_xref="GeneID:305123"
                     /db_xref="RGD:1306678"
                     /translation="MSLPSRQMAIVNPPPPEYINAKKTGRLTNQLQFLQRVVLKALWK
                     HSFSWPFQQPVDAAKLKLPDYYTIIETPMDLSTIKKRLENRYYEKASECVGDFNTMFS
                     NCYLYNKPGDDIVVMAQALEKLFMQKLSQMPQEEQIVGGKERMKKDIQQKTAVSSAKE
                     QTPSKSAENVFKRQEIPAGFPDVCLSPLNMAQEAPPTCDSQTVVQITKGVKRRADTTT
                     PTTSSAKASSESPPPLREAKPANAPVKENTVKSVLPDSQQQHRVLKTVKVTEQLKHCS
                     EILKEMLAKKHLPYAWPFYNPVDVDALGLHNYYDIVKNPMDLGTIKGKMDKQEYKDAC
                     EFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFEMHFAKIPDEPVESMRACHLTTNS
                     AKALSRESSSEASSGDCSSEDSEDERVQRLAKLQEQLNAVHQQLQVLSQVPLRKLKKK
                     NEKSKRAPKRKKVNRDENPKKKAKQMKQKEKAKSNQPKKKKPLLKLEEEDNAKPMNYD
                     EKRQLSLDINKLPGDKLGRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYV
                     LACLRKRSLKPHAKKVVRSKEELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKL
                     PPPPPPPPELASGSRLSDSSSSSSSSGSGSSSSSSSSSGSGSSSSDSSSSDSSDSEPE
                     ISPKFTGVKQNDLPSKENTKQIQCSVPDITSAETALVQQSTGPCGAPGKPPQQMPGCQ
                     VPHHLQATESTASVQTQPLAGDCKRVLHGPPVVHASAESHTVLELQCHAPVQKDIKIK
                     NADSWKSLGKPVKASSVLKSSDELFNQFRKAAIEKEVKARTQEQIRKHLEHSAKDPKV
                     SQESQREFGSGFTPESSSNKVQGRSHGEEQSEQQQLPSPSETQDISKLWLLKDRNLAR
                     EKEQERRRREAMAGTIDMTLQSDIMTMFENNFD"
     exon            525..662
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            663..777
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            778..950
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1301
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1430
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1619
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1789
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2070
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2196
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2379
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2441
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2616
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2714
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2920
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3110
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3218
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3980
                     /gene="Brdt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaaggcgc cagtcgctgg ctgctgacag ccgccatccg ggcgagagct ggcggccacc
       61 ggtggagagc cgggagcgag ggccctgcac tgcttcatct agtgcaaacg gagagggtga
      121 ttggataagg tcccttccta agaggaattt gtagacttcc tgctaaggcc tcaatttgta
      181 tttttgaaga acagaaagaa attctgtgaa gtgttgaaac catttaaacc atctaagacc
      241 aagacatacc tactgaaaca atgcacagta tttgtgtaaa aaaggacata ttctcgtaga
      301 caccttgaag ataccaggat ctgaagtagt tgagaatgtc tctgccaagt cgacaaatgg
      361 ctattgttaa cccccctcca ccagagtaca taaatgctaa gaaaactggg cggttgacca
      421 accagctgca gttcctgcag agagtcgtcc tgaaggcgct gtggaaacac agtttctcct
      481 ggccgtttca acagcctgtg gatgccgcga agctcaagct gcctgactat tacaccatca
      541 tagagacgcc aatggattta agtacaatta agaagcggct ggaaaacagg tactacgaga
      601 aggcttccga atgcgtggga gacttcaaca cgatgttctc aaactgctac ttatacaaca
      661 agcctggaga tgacattgtg gttatggccc aagctctgga gaagttattt atgcagaagc
      721 tgtctcagat gccacaggaa gagcagattg tgggtggcaa ggagagaatg aagaaagata
      781 tccaacaaaa gacagccgtt tcctctgcta aggaacaaac tccctccaaa tcggcagaaa
      841 atgtgtttaa gcgacaagaa attcctgctg ggtttcctga tgtctgtctc tctcccttaa
      901 acatggcaca agaggctccc ccgacctgcg actcacagac tgtggtccaa attacaaagg
      961 gtgtgaagag gagggcggac acaacaactc ctaccacttc ctcagctaaa gcaagtagtg
     1021 aatcccctcc gccactgaga gaagcgaagc cggcgaatgc gccagtgaag gaaaacacag
     1081 tgaagagcgt cctgccagac tctcagcagc aacacagggt tttaaaaacg gtcaaagtaa
     1141 cggagcagtt gaagcactgc agcgagattc ttaaagaaat gcttgccaag aagcatctgc
     1201 cgtacgcatg gcccttctac aaccctgtgg acgtggatgc tttgggactc cacaactact
     1261 atgacattgt caaaaacccc atggatcttg gaacgatcaa ggggaaaatg gacaagcaag
     1321 agtataagga tgcgtgtgaa tttgctgcag atgtcaggct gatgtttatg aattgctaca
     1381 agtacaaccc tcctgatcat gaagttgtga ccatggccag gatgcttcag gacgtttttg
     1441 aaatgcattt tgccaagatt cctgatgaac ctgttgagag tatgcgtgca tgtcacctta
     1501 caacaaacag tgcaaaagcc ctcagtagag aaagcagcag cgaggcctcc tcgggggact
     1561 gctcttccga agactctgag gacgagcgag tacagcgtct tgccaagctt caggagcagc
     1621 ttaatgctgt tcatcagcaa ctacaagttc tgtcccaagt tccattacgt aagctgaaga
     1681 aaaagaatga gaagtctaaa agggcaccca aaaggaaaaa ggttaacaga gacgagaacc
     1741 caaagaaaaa ggctaagcaa atgaagcaaa aggagaaggc caagagcaat caaccaaaga
     1801 agaagaagcc acttttgaaa ttggaagagg aagacaatgc gaagcctatg aactacgatg
     1861 agaaaaggca gctgagcttg gacataaaca aactgcctgg agacaagctt ggtcgaatag
     1921 ttcatataat acagtcaagg gagccttccc tgaggaactc caacccagat gagatcgaga
     1981 tcgactttga gactctgaag gcatccacac ttagagaact ggagaagtac gtcctggcct
     2041 gtctgaggaa gaggtcgctg aagccccacg cgaagaaggt tgtcaggtct aaagaggagc
     2101 tccattctga aaaaaagctg gagctggaga ggcggttgct ggacgtcaac aatcagctga
     2161 attgtaggaa acggcaaacg aaacgtccag caaaagtgga gaagctgccc ccgcccccgc
     2221 cgccgccccc ggagctggcg agtgggtccc gcctgagcga cagcagcagc agcagcagca
     2281 gcagcggcag tggcagcagc agtagcagta gcagcagctc ggggtccggg agcagcagca
     2341 gtgactcgag ctcctccgac agcagcgatt cagaaccaga aatatctcct aaatttactg
     2401 gagtaaaaca gaatgatttg ccttcaaaag aaaatacaaa gcagatacag tgttctgtgc
     2461 ccgacataac ctctgctgaa actgcccttg ttcagcagag cacagggcca tgtggagctc
     2521 cagggaagcc tccccagcag atgcctggtt gccaagtgcc acaccatctt caggccacag
     2581 agagcactgc gtctgtgcag actcagcccc ttgcaggtga ttgcaagcga gtactgcacg
     2641 ggccccctgt ggtgcacgcc tctgctgaga gccacacagt gctggagctg caatgccatg
     2701 ctcctgtgca gaaggatata aagattaaga atgcagactc ttggaaaagt cttgggaagc
     2761 cagtgaaagc atcaagtgtg ctgaaatctt cagacgagct tttcaaccag tttagaaaag
     2821 ctgcgataga gaaagaagtg aaggctcgga cacaggagca gattcgcaaa cacctggaac
     2881 acagcgcaaa ggacccgaaa gtgtctcaag agagccagag ggagtttgga agcggattca
     2941 ctccagaatc ttcatcaaat aaagtgcaag gcaggtctca cggagaagag cagagtgaac
     3001 agcagcagct gccgtcccca tcggaaactc aagacataag caagctctgg cttctcaaag
     3061 accggaattt ggcgagggag aaagagcaag agcgtaggag aagagaagca atggcgggta
     3121 ccattgacat gactcttcaa agtgacatta tgacaatgtt tgaaaataac tttgattaaa
     3181 actcagtttg taaattaact ctcaacttta aatgaaagct ctcaagtgct ggactccaga
     3241 aatgtgtcat cgtgcctgga tgagttttct acttttccaa gagatatatg tctactgtca
     3301 gaattctcac agcttctaac aagtaatatc tggtttccat gtgcatcacg gtgtgtcagg
     3361 ttctctgctg gtcccatgtt taaactccac actgcctttt gttttaaagt gtattagcta
     3421 tgatttgaaa ggtgttaaat tttaaacaaa gtaatagtaa atattgtgta tgcaagcttc
     3481 tataggaatg agtcagacat ttctagaaat gtgtagggga tagcaataaa tatttgccta
     3541 attaggggaa attgcagcct atggaatgtt ttgccatttc tcaaactgca ttcatgtcta
     3601 agccgtgtgt ctttttaaat tttaaacctt tgaacatttg aaatataacc tgattaaggc
     3661 aatgctgtga tattatctaa agtacaaact caaagtgtgt gcagacaggg cagtgcacag
     3721 ctgctgtaat cccaatactg ggggcagagg tagagaaaga ggcactgctg atgactcgag
     3781 gccagcctgg ctcacatggc aggattcagc ttctggtcac agccagacct cgatcgagaa
     3841 gaaccaagag agagacaggg acagggacag ggacagagaa taagaagatg gtattgcttt
     3901 tatgaaacag ccagaattaa agtgatagct attttattgt gcctatttct actttttaat
     3961 taaaaatttt atacaataca
//
