LOCUS       NM_001395085            2384 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus bromodomain containing 9 (Brd9), transcript
            variant 2, mRNA.
ACCESSION   NM_001395085 XM_006227786
VERSION     NM_001395085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Deng,Z., Zhang,Y., Zhu,Y., Zhu,J., Li,S., Huang,Z., Qin,T., Wu,J.,
            Zhang,C., Chen,W., Huang,D. and Ye,W.
  TITLE     BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in
            Nucleus Pulposus by Modulating the NOX1/ROS/NF-kappaB axis
  JOURNAL   Inflammation 46 (3), 1002-1021 (2023)
   PUBMED   36801999
  REMARK    GeneRIF: BRD9 Inhibition Attenuates Matrix Degradation and
            Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-kappaB
            axis.
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Alpsoy,A. and Dykhuizen,E.C.
  TITLE     Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its
            paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes
  JOURNAL   J Biol Chem 293 (11), 3892-3903 (2018)
   PUBMED   29374058
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Filippakopoulos,P., Picaud,S., Mangos,M., Keates,T., Lambert,J.P.,
            Barsyte-Lovejoy,D., Felletar,I., Volkmer,R., Muller,S., Pawson,T.,
            Gingras,A.C., Arrowsmith,C.H. and Knapp,S.
  TITLE     Histone recognition and large-scale structural analysis of the
            human bromodomain family
  JOURNAL   Cell 149 (1), 214-231 (2012)
   PUBMED   22464331
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Hargreaves,D.C. and Crabtree,G.R.
  TITLE     ATP-dependent chromatin remodeling: genetics, genomics and
            mechanisms
  JOURNAL   Cell Res 21 (3), 396-420 (2011)
   PUBMED   21358755
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 3, 2021 this sequence version replaced XM_006227786.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.148113.1,
                                           SRR26360194.1713716.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               JAXUCZ010000001.1  31185443-31185581   c
            140-354             JAXUCZ010000001.1  31184697-31184911   c
            355-487             JAXUCZ010000001.1  31184342-31184474   c
            488-548             JAXUCZ010000001.1  31183025-31183085   c
            549-693             JAXUCZ010000001.1  31182523-31182667   c
            694-804             JAXUCZ010000001.1  31181104-31181214   c
            805-920             JAXUCZ010000001.1  31180353-31180468   c
            921-1053            JAXUCZ010000001.1  31178222-31178354   c
            1054-1129           JAXUCZ010000001.1  31175462-31175537   c
            1130-1225           JAXUCZ010000001.1  31173760-31173855   c
            1226-1358           JAXUCZ010000001.1  31171149-31171281   c
            1359-1470           JAXUCZ010000001.1  31169563-31169674   c
            1471-1509           JAXUCZ010000001.1  31166993-31167031   c
            1510-1612           JAXUCZ010000001.1  31166039-31166141   c
            1613-1780           JAXUCZ010000001.1  31162105-31162272   c
            1781-2384           JAXUCZ010000001.1  31158546-31159149   c
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..2384
                     /gene="Brd9"
                     /note="bromodomain containing 9"
                     /db_xref="GeneID:308067"
                     /db_xref="RGD:1307359"
     exon            1..139
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1881
                     /gene="Brd9"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bromodomain-containing protein 9"
                     /codon_start=1
                     /product="bromodomain-containing protein 9 isoform 2"
                     /protein_id="NP_001382014.1"
                     /db_xref="GeneID:308067"
                     /db_xref="RGD:1307359"
                     /translation="MGKKHKKHKAEWRSSYEDYTDTPLEKPLKLVLKVGGSEVTELSG
                     SGHDSSYYDDRSDHERERHREKKKKKKKKSEKEKHLDEEERRKRKEEKKRKREKEHCD
                     SEGEADAFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGF
                     FAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRP
                     DTVYYKLAKKILHAGFKMMSKQAALLGSEDPAVEEPVPEVVPVQVETTKKSKKPSREV
                     ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKKLGDGSL
                     LYSVVNATEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSASTALSM
                     QNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKMVDDLLDQITGG
                     DHSRMIFQLKQRRSIPMRPADEMKVGDPLGDSGGPVLDFMSMKQYPDVSLDVSMLSSL
                     GKVKKELDHEDSHLNLDETARLLQDLHEAQAERGGSRPSSNLSSLSTASEREQHPPGS
                     PSRLSVGEQPDVTHDPYEFLQSPEPAAPAKN"
     exon            140..354
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            355..487
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            488..548
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            549..693
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            694..804
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            805..920
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1053
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1129
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1225
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1358
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1470
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1509
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1612
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1780
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2384
                     /gene="Brd9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggggggt ggcgaaggaa cacttccgac tggcgcaggt cgggctacgg gcagccgctt
       61 ctcaccggat cccgtgctac ctcagccatg ggcaagaagc acaagaagca caaggcagaa
      121 tggcgctcgt cgtacgaaga ttatacagac acaccactgg agaagcctct gaagctggtg
      181 ctcaaggtgg gaggaagtga agtgacagag ctctcaggat ctggtcacga ctccagctac
      241 tatgatgacc ggtcagacca tgagcgggaa agacataggg aaaagaagaa gaaaaagaag
      301 aagaagtcag agaaggaaaa gcaccttgat gaggaggaga ggaggaagag gaaggaagag
      361 aagaaacgga agcgggagaa ggaacattgt gactcagagg gggaggctga tgcctttgac
      421 cctgggaaga aggtggaggt ggaaccaccc ccagatcgac cagtgagagc ctgccgaaca
      481 cagccagctg agaatgagag cacacccatc cagaggcttc tggagcactt cctccgccag
      541 ctacagagaa aagatcctca tggatttttt gcttttcctg ttacggatgc aattgctcct
      601 gggtattcaa tgataataaa acatcccatg gactttggca cgatgaaaga caagattgta
      661 gctaatgaat ataaatcagt cacagaattt aaggcagatt tcaaattaat gtgtgataat
      721 gcgatgacgt acaatagacc agacaccgtg tactacaaat tagccaagaa gatcctgcac
      781 gcgggcttta agatgatgag caaacaggca gctctcttgg gcagtgaaga ccccgcagtt
      841 gaggaacctg ttcctgaggt tgtcccagtg caagtagaaa ctaccaagaa atccaaaaag
      901 ccgagtagag aagtcatcag ctgcatgttt gagcctgaag ggaatgcctg cagcctgaca
      961 gacagcacag cagaggagca tgtgctagcc ctggtagagc acgcagctga tgaggctcgg
     1021 gacaggatta accggtttct cccaggtggc aagatggggt acctgaagaa gcttggagat
     1081 ggaagtctac tctacagtgt ggtgaatgca actgagcctg atgctgatga ggaggagaca
     1141 caccctgtgg acctgagttc actgtccagc aagttgctcc caggttttac aacattgggt
     1201 ttcaaagatg aaagaagaaa taaagtcaca ttcctctcca gtgccagcac tgcactttca
     1261 atgcagaaca actctgtgtt tggggacttg aagtcggatg agatggagct tctgtattct
     1321 gcctatggag atgagactgg tgtgcagtgc gcactgagcc tgcaggaatt cgtgaaggat
     1381 gctggaagct acagcaagaa aatggtagat gacctcctgg accaaatcac aggtggcgat
     1441 cactcaagga tgatcttcca gctgaagcag aggaggagca tccccatgag acctgcagat
     1501 gagatgaagg ttggggaccc actgggagat agtggtggcc ctgttctgga cttcatgtca
     1561 atgaaacagt atcctgatgt ctccctggat gtgtccatgc tcagctctct tgggaaagtg
     1621 aagaaggagc tggaccatga ggatagccac ttgaacttgg acgagacagc caggctcctg
     1681 caggacttac atgaagcaca agcagagcga ggaggctccc ggccatcctc caaccttagc
     1741 tctctgtcca ctgcctctga gagggagcag catcctccag gaagtccttc tcgccttagt
     1801 gttggggaac agccggatgt cacccatgac ccttacgaat tccttcaatc tccagaacct
     1861 gcagctcctg ccaagaacta gctcgtgggt tttccagatg ttttatttta tttttctaca
     1921 ttttatttga tacggttttt gtcacaagac agaaactttt gtctcatcct ctctggcttg
     1981 tagcagcctg aggagatggt ggcttgtctg tactgtcatg tctgcagcag aggcccagtt
     2041 gcccgaacgg tgtcagtaag ttctgagcag tggaatagaa catagatggg ttgcagtcag
     2101 atggctcaac tctgtctccc gagctccagc agccaagcct gtctgatagc gtgcacatag
     2161 tcattctaca cgcagtctca aaggggcctc agcacaggcc tgcacagaca gtaccttctg
     2221 gtttctacct gtcactgagc cagaggaggg agctgtctcc ttgacaaata atgaaccacc
     2281 ccaccttgta gaatgaagta ttcagagtca taaaatgtct caaaactgga tgtatttgca
     2341 aaatacacaa aaataggtcc taataaagag atgcctaagg gtaa
//
