LOCUS       NM_001008509            3318 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus bromodomain containing 8 (Brd8), transcript
            variant 2, mRNA.
ACCESSION   NM_001008509 XM_226083
VERSION     NM_001008509.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3318)
  AUTHORS   Huang SS, Cao S, Lu CE, Qin YB and Yang JP.
  TITLE     Effects of nicorandil on p120 expression in the spinal cord and
            dorsal root ganglion of rats with chronic postsurgical pain
  JOURNAL   Mol Med Rep 22 (6), 4821-4827 (2020)
   PUBMED   33173987
  REMARK    GeneRIF: Effects of nicorandil on p120 expression in the spinal
            cord and dorsal root ganglion of rats with chronic postsurgical
            pain.
REFERENCE   2  (bases 1 to 3318)
  AUTHORS   Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M,
            Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C and Hamiche
            A.
  TITLE     ANP32E is a histone chaperone that removes H2A.Z from chromatin
  JOURNAL   Nature 505 (7485), 648-653 (2014)
   PUBMED   24463511
REFERENCE   3  (bases 1 to 3318)
  AUTHORS   Watanabe S and Peterson CL.
  TITLE     The INO80 family of chromatin-remodeling enzymes: regulators of
            histone variant dynamics
  JOURNAL   Cold Spring Harb Symp Quant Biol 75, 35-42 (2010)
   PUBMED   21502417
  REMARK    Review article
REFERENCE   4  (bases 1 to 3318)
  AUTHORS   Yamada HY and Rao CV.
  TITLE     BRD8 is a potential chemosensitizing target for spindle poisons in
            colorectal cancer therapy
  JOURNAL   Int J Oncol 35 (5), 1101-1109 (2009)
   PUBMED   19787264
  REMARK    GeneRIF: BRD8 expression is associated with tumor progression
            toward advanced stages
REFERENCE   5  (bases 1 to 3318)
  AUTHORS   Yoshino M, Mizutani T, Yamada K, Yazawa T, Ogata-Kawata H,
            Sekiguchi T, Kajitani T and Miyamoto K.
  TITLE     Co-activator p120 is increased by gonadotropins in the rat ovary
            and enhances progesterone receptor activity
  JOURNAL   Reprod Biol Endocrinol 4, 50 (2006)
   PUBMED   17014737
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3318)
  AUTHORS   Doyon Y, Selleck W, Lane WS, Tan S and C J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB180485.1.
            
            On Dec 16, 2004 this sequence version replaced XM_226083.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB180485.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3318
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3318
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /note="bromodomain containing 8"
                     /db_xref="GeneID:291691"
                     /db_xref="RGD:1307003"
     exon            1..209
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2949
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bromodomain-containing protein 8"
                     /codon_start=1
                     /product="bromodomain-containing protein 8 isoform 2"
                     /protein_id="NP_001008509.1"
                     /db_xref="GeneID:291691"
                     /db_xref="RGD:1307003"
                     /translation="MLLQRVNLCSVSGTPEVWPLWGLSTVISFRVVPGSNSGCRAFRT
                     RVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVI
                     VRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCSDIAMKKKLEEE
                     EAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEAT
                     SGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPL
                     LSELLKKGSLLPTSPRLVNESEMPVPSGHLSSTGVLLEVGGVLPMIHGGDIQPATSAV
                     AASPAASGAPTLSRLLEAGPTQFSTPLPSFTTVASEPPVKLVPPPVESVSQATIVMMP
                     ALPAPSSAPAVSTPESVAPVSQPEPCVPLEAVGDPQTVTVSMDSSEISMIINSIKEEC
                     FRSGVAEAPGGSKAPSIDGKEDLDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDD
                     HPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDF
                     EESETKGIHELVDIRDSGVEIKVEPTEPEPGMSGAEIVAGVGPVPSLEPPELRSQDLD
                     EEPRSSAAGEMGEADVSSGKGEERPLPAVKTEASPESMLSPSHGSNPIEDPLEAETQH
                     KFEMSDSLKEESGTIFGSQIKDAPGEEEEEDGVSEAASLEEPKEEDQGEGYLSEMDNE
                     PPVSESDDGFSIHNATLQSHTLGDSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLV
                     WRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIM
                     LMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDS
                     TRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK"
     exon            210..279
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            280..329
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            330..452
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            453..533
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            534..598
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            599..735
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            736..954
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1099
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1309
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1590
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2043
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2137
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2184
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2399
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2492
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2561
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2739
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2844
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2889
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3298
                     /gene="Brd8"
                     /gene_synonym="p120"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttttgggt tcgaggttgc ctctccctgc gtggatgagc aaccccatgt acatggatta
       61 aaaacttaca ccctcatgct gttgcagcgt gtcaatctct gctctgtgag tggcactcct
      121 gaggtatggc cactatgggg tctttcaaca gtaatatctt tccgtgtggt tcctggatca
      181 aactcaggtt gtagggcttt tagaacaagg gtatcagtta gcagagcaat caagcccttt
      241 gctgaacctg gccggcctcc agactggttc tctcaaaaac attgtgcttc tcagtattct
      301 gagctcttag agactactga gactccaaaa cgaaaacggg gtgaaaaggg agaagtggta
      361 gaaactgttg aagatgttat tgttcgcaaa ctgactgctg agagagttga ggaactgaag
      421 aaagtcataa aggagacaca ggagagatac aggcgtctga aaagagatgc agaactaatt
      481 caagccgggc acatggacag cagactggat gagctctgca gtgacattgc aatgaaaaag
      541 aaattggagg aggaagaggc tgaagtaaaa aggaaggcca cagatgctgc ataccaggct
      601 cggcaagcag tgaaaacacc tcctcgaagg ttgccaactg tgatggtccg ctcccctata
      661 gactccgcct ccccaggagg tgattatcca cttggagact tgactccaac cactatggaa
      721 gaggctacct ctggagtaac ccctgggact ttgccgagta ccccagtcac ctcgtttcct
      781 gggattcctg acacccttcc tccaggctct gcacccttag aagcccccat gaccccagta
      841 acagatgatt caccccagaa aaagatgctt ggacagaaag caactccacc cccctcccct
      901 ctgctgtcag agctcttgaa gaagggcagc ctcctgccta ctagccccag actggtgaat
      961 gagagtgaaa tgcccgtgcc ctctggccat ctgagcagca caggggttct cctggaggta
     1021 ggcggggttc ttcccatgat ccatggtggg gacatacagc cagcaaccag tgcagtggca
     1081 gcctcccccg ctgcctcagg tgctcccact ctctcccggc ttttagaagc tggtcccaca
     1141 cagttctcca ctcctcttcc ttccttcact actgttgcca gtgagcctcc agttaagctt
     1201 gtgccacccc ctgtagagtc tgtgtcccag gctaccattg tcatgatgcc tgcgctgcca
     1261 gcaccgtcct ctgctccggc tgtctccact cctgaaagtg tagctccagt gagccagcct
     1321 gagccctgtg ttcccctgga agccgtgggg gatccacaga ctgtgactgt ttccatggat
     1381 agcagtgaaa tctccatgat cattaattcc atcaaagaag agtgtttccg ctcaggagta
     1441 gcagaggctc ctggtggatc aaaggctcca agcatagatg ggaaggaaga tttagatctg
     1501 gctgaaaaga tggatattgc tgtgtcttac acaggtgaag agttggactt tgaaacagtt
     1561 ggagacatca ttgccatcat tgaggacaag gtggatgacc accctgaagt gctggatgtg
     1621 gcagctgtag aagcagcatt gtcgttctgt gaagaaaatg atgatcctca gtccctgcct
     1681 ggcccttggg agcaccctat ccagcaggag cgggacaagc cagtgcctct tccagcacca
     1741 gagatgacag tcaaacaaga gaggctagac ttcgaggagt cagaaaccaa agggatccat
     1801 gaactggtgg acatcaggga ttcaggtgtt gagataaagg tggaacctac agagccagag
     1861 ccaggcatgt ccggggctga gatcgtagct ggagttggtc cagtcccaag tttggagcca
     1921 ccagaactca ggagtcaaga cttagatgag gaacctagaa gttctgcagc tggagagatg
     1981 ggtgaggcag acgtttccag tgggaaaggc gaggaaaggc cacttccggc tgtgaagaca
     2041 gaggcgtccc ctgaaagcat gttgtctcca tcacatggct caaatcctat tgaagatcct
     2101 ttagaggcag agactcaaca caagtttgaa atgtcagact cattgaaaga agaatcaggg
     2161 actatttttg gaagccagat aaaggacgct ccaggtgagg aggaggagga ggatggagtc
     2221 agtgaagcag ctagcctgga ggagcctaag gaggaggatc aaggcgaagg ctatttgtct
     2281 gagatggaca acgagccccc tgtgagcgaa agcgatgatg gctttagtat acataatgcc
     2341 acactgcagt cacacactct gggcgactcc atcccgagca gccccgcctc ctcgcagttt
     2401 tccgtgtgca gtgaagatca agaagcaatt caggctcaga aaatatggaa gaaagccatc
     2461 atgcttgtat ggagagctgc agccaaccat cggtatgcca atgtgttcct gcagcctgtc
     2521 acagacgaca tagctcctgg ctaccacagc attgtgcaga ggcctatgga tttgtcaact
     2581 ataaagaaaa acattgaaaa cggactgatc cgcagcacag ccgagtttca gcgtgatatc
     2641 atgctgatgt tccagaacgc tgttatgtac aatagctcag accatgatgt ctaccacatg
     2701 gcagtggaga tgcagagaga cgtcttggaa cagatccagc aattcttggc cacacagttg
     2761 attatgcaaa catctgagtc tggaatcagt gctaaaagtc tccgggggag agactctacc
     2821 cgaaaacaag atgcttcaga gaaggacagt gtccccatgg gctctcctgc cttccttctc
     2881 tctctgtttg atgggggaac caggggccgc cgctgtgcca tcgaagcgga tatgaagatg
     2941 aagaagtgaa cgcccgccct ctgagctgag cctgaagtag aaatgaggtg tggatagcct
     3001 gagccccggc tcagttccac acttgatctt agtcaaaagg ctgaggagca gtgagtccag
     3061 aagcggagtt acagaagagg aggctcccaa gccacatgac atgagttgag aaaatctctc
     3121 ttcagagagt tggagtagcg cagttgcctg ttttagggca gaaatcatgg gctgtgttaa
     3181 tgccctaacg tgtaactagc agattgtagc taatttgtac tgtcttgtga agtgtacaga
     3241 ttttttttaa ataataataa acctgtgaag tgtgtgtata taacaatcag aaggaaaaaa
     3301 aaaaaaaaaa aaaaaaaa
//
