LOCUS       NM_001401243            2343 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus bromodomain containing 7 (Brd7), transcript
            variant 2, mRNA.
ACCESSION   NM_001401243 XM_006255267
VERSION     NM_001401243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Wang,X.M., Wang,Y.C., Liu,X.J., Wang,Q., Zhang,C.M., Zhang,L.P.,
            Liu,H., Zhang,X.Y., Mao,Y. and Ge,Z.M.
  TITLE     BRD7 mediates hyperglycaemia-induced myocardial apoptosis via
            endoplasmic reticulum stress signalling pathway
  JOURNAL   J Cell Mol Med 21 (6), 1094-1105 (2017)
   PUBMED   27957794
  REMARK    GeneRIF: down-regulation of BRD7 attenuated HG-induced expression
            of CHOP via inhibiting nuclear translocation of XBP-1s without
            affecting the total expression of XBP-1s. In conclusion, inhibition
            of BRD7 appeared to protect against hyperglycaemia-induced
            cardiomyocyte apoptosis by inhibiting ER stress signalling pathway.
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Sanchez,R., Meslamani,J. and Zhou,M.M.
  TITLE     The bromodomain: from epigenome reader to druggable target
  JOURNAL   Biochim Biophys Acta 1839 (8), 676-685 (2014)
   PUBMED   24686119
  REMARK    Review article
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Singh,A.P. and Archer,T.K.
  TITLE     Analysis of the SWI/SNF chromatin-remodeling complex during early
            heart development and BAF250a repression cardiac gene transcription
            during P19 cell differentiation
  JOURNAL   Nucleic Acids Res 42 (5), 2958-2975 (2014)
   PUBMED   24335282
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Park,Y.A., Lee,J.W., Kim,H.S., Lee,Y.Y., Kim,T.J., Choi,C.H.,
            Choi,J.J., Jeon,H.K., Cho,Y.J., Ryu,J.Y., Kim,B.G. and Bae,D.S.
  TITLE     Tumor suppressive effects of bromodomain-containing protein 7
            (BRD7) in epithelial ovarian carcinoma
  JOURNAL   Clin Cancer Res 20 (3), 565-575 (2014)
   PUBMED   24198243
REFERENCE   5  (bases 1 to 2343)
  AUTHORS   Tang,H., Wang,Z., Liu,Q., Liu,X., Wu,M. and Li,G.
  TITLE     Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma
            growth by directly targeting LRRC4
  JOURNAL   PLoS One 9 (1), e84146 (2014)
   PUBMED   24404152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2343)
  AUTHORS   Tang,X.Y., Liu,F., Peng,Y., Xiang,B., Wang,C.H., Yao,C.J. and
            Shen,S.R.
  TITLE     [Expression and SNP analysis of BRD7 gene in acute leukemia cells]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 33 (8), 645-650 (2008)
   PUBMED   18772500
REFERENCE   7  (bases 1 to 2343)
  AUTHORS   Peng,C., Zhou,J., Liu,H.Y., Zhou,M., Wang,L.L., Zhang,Q.H.,
            Yang,Y.X., Xiong,W., Shen,S.R., Li,X.L. and Li,G.Y.
  TITLE     The transcriptional regulation role of BRD7 by binding to
            acetylated histone through bromodomain
  JOURNAL   J Cell Biochem 97 (4), 882-892 (2006)
   PUBMED   16265664
REFERENCE   8  (bases 1 to 2343)
  AUTHORS   Kzhyshkowska,J., Rusch,A., Wolf,H. and Dobner,T.
  TITLE     Regulation of transcription by the heterogeneous nuclear
            ribonucleoprotein E1B-AP5 is mediated by complex formation with the
            novel bromodomain-containing protein BRD7
  JOURNAL   Biochem J 371 (Pt 2), 385-393 (2003)
   PUBMED   12489984
REFERENCE   9  (bases 1 to 2343)
  AUTHORS   Staal,A., Enserink,J.M., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Molecular characterization of celtix-1, a bromodomain protein
            interacting with the transcription factor interferon regulatory
            factor 2
  JOURNAL   J Cell Physiol 185 (2), 269-279 (2000)
   PUBMED   11025449
REFERENCE   10 (bases 1 to 2343)
  AUTHORS   Cuppen,E., van Ham,M., Pepers,B., Wieringa,B. and Hendriks,W.
  TITLE     Identification and molecular characterization of BP75, a novel
            bromodomain-containing protein
  JOURNAL   FEBS Lett 459 (3), 291-298 (1999)
   PUBMED   10526152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Feb 4, 2022 this sequence version replaced XM_006255267.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.75475.1,
                                           SRR26360172.1903065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000019.1  34882304-34882562
            260-468             JAXUCZ010000019.1  34882754-34882962
            469-598             JAXUCZ010000019.1  34886779-34886908
            599-656             JAXUCZ010000019.1  34887210-34887267
            657-801             JAXUCZ010000019.1  34889967-34890111
            802-912             JAXUCZ010000019.1  34893576-34893686
            913-1097            JAXUCZ010000019.1  34898129-34898313
            1098-1221           JAXUCZ010000019.1  34899047-34899170
            1222-1297           JAXUCZ010000019.1  34899839-34899914
            1298-1405           JAXUCZ010000019.1  34901457-34901564
            1406-1541           JAXUCZ010000019.1  34902060-34902195
            1542-1653           JAXUCZ010000019.1  34905065-34905176
            1654-1710           JAXUCZ010000019.1  34907171-34907227
            1711-1825           JAXUCZ010000019.1  34909003-34909117
            1826-1969           JAXUCZ010000019.1  34909324-34909467
            1970-2113           JAXUCZ010000019.1  34910240-34910383
            2114-2343           JAXUCZ010000019.1  34910715-34910944
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..2343
                     /gene="Brd7"
                     /note="bromodomain containing 7"
                     /db_xref="GeneID:361374"
                     /db_xref="RGD:1309891"
     exon            1..259
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..2169
                     /gene="Brd7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bromodomain-containing protein 7"
                     /codon_start=1
                     /product="bromodomain-containing protein 7 isoform 2"
                     /protein_id="NP_001388172.1"
                     /db_xref="GeneID:361374"
                     /db_xref="RGD:1309891"
                     /translation="MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGH
                     DSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRVENEAD
                     KDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPV
                     TDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYY
                     KAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDRADACQGGEDSGCWQRER
                     EDSGDAETQAFKSPTKDNKKKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLA
                     NCQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDK
                     RNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLA
                     TCQDYPYVMADSLLDVLTKGGHSRSLQDLDMPSPEDEGQTRALDVAKEAEQVAHIEPA
                     GRLESSGQDRLTALQAVTNFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLS
                     TRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPI
                     MGHSLVDLTEECEDPKETSTAESGPAAS"
     exon            260..468
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            469..598
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            599..656
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            657..801
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            802..912
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1097
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1221
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1297
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1405
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1541
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1653
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1710
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1825
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1969
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2113
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2343
                     /gene="Brd7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccgccac tgctttcgcg cttctgccgc gtcccgcgcg tggtcttctc gtgagggacc
       61 tcgcgccgcc gggcgcgtgc cgtccccctg cctcgcggcg cggggtctcg cgggccccgc
      121 tcccgccctc cgctcgcctg gcccggaccg gaagcggcgc cgcacggcct gggcctggcg
      181 cggggggcgg gctctggggc ccggtgggac atgggcaaga agcacaagaa gcacaagtcg
      241 gaccgacact tctacgagga gtacgtggag aagcccctga agctagtcct caaagtggga
      301 gggagcgaag tcactgagct ctccacgggc agctccgggc acgactccag cctcttcgaa
      361 gacagaagcg accatgacaa acacaaggac agaaaacgga aaaagaggaa gaaaggagag
      421 aagcaggctc cgggggaaga gaaggggaga aaacggagga gagtcaagga ggataaaaag
      481 aagcgggatc gagaccgtgt ggagaacgag gcagacaaag atctccagtg tcatgtccct
      541 ataagattag acttacctcc tgagaagcct ctcacaagct ctttagccaa acaagaagaa
      601 gtagagcaga caccccttca ggaagctttg aatcaactca tgagacaact gcaaagaaaa
      661 gacccaagtg ctttcttttc atttcctgtg acggatttta ttgctcctgg ctactccatg
      721 attattaaac acccaatgga ttttagtact atgaaagaaa agatcaagaa taacgactac
      781 cagtccatag aagagctaaa ggataacttc aagctaatgt gtactaatgc aatgatttac
      841 aataagccag agaccattta ttataaagct gcaaagaagc tgttgcactc agggatgaaa
      901 attctcagtc aggagagaat tcagagcctg aagcagagta tagacttcat ggcagacttg
      961 cagaaaactc ggaagcagaa agacagagca gatgcctgtc aaggtggaga ggacagtggc
     1021 tgctggcaga gagaacggga ggactctgga gatgctgaaa cacaggcctt caaaagcccc
     1081 accaaggaca ataaaaagaa agacaaagat gtgcttgaag acaaatggag aagcagcaac
     1141 tcagaaaggg agcatgagca gattgagcgc gttgtccagg agtcgggggg caagctaaca
     1201 cggcggctgg caaactgtca gtgtgaattt gaaagaagaa aaccagatgg aacaacaaca
     1261 ctggggcttc tccatcctgt ggaccccatt gtgggagaac caggctactg ccctgtgaga
     1321 ctggggatga caactggaag actgcagtct ggagtgaaca ccctgcaggg gttcaaagag
     1381 gataaaagga acagagtgac cccagtatta tacttgaatt atggacccta cagctcttat
     1441 gccccacatt atgactctac atttgccaat atcagcaaag atgattctga cttaatctac
     1501 tcaacatatg gggaagactc tgaccttcca aacaatttta gcatctctga gtttttggcc
     1561 acatgccaag attacccgta tgttatggca gatagtttac tggatgttct aacaaaagga
     1621 ggacattcca ggagcctgca ggacttggac atgccgtcac ctgaagatga aggccagacc
     1681 agagcactgg atgttgccaa agaagcagag caggttgcgc acatagagcc agcggggcgt
     1741 ttggagtcca gcggtcagga caggctcaca gcactgcaag cagtgacgaa cttcggtgct
     1801 ccggctgaag tcttcgactc ggaagaggct gaggtgttcc agaggaagct tgatgaaacg
     1861 acaagattgc tcagggagct ccaggaggca cagaacgagc ggctgagcac taggcctcct
     1921 cccaatatga tctgtctctt gggtccttct tacagagaaa tgtaccttgc tgaacaagtg
     1981 accaataacc ttaaagaact cacacagcaa gtgactcccg gcgatgttgt aagcatacac
     2041 ggagtccgaa aagcaatggg gatttctgtt ccttccccca tcatgggaca cagcctcgta
     2101 gatttgacag aagagtgcga agaccctaag gagaccagta ctgccgagag tgggcccgcc
     2161 gcgagctgaa ctcgcctgct atttgatata ttatgtacat atttttcatt ccgaacttgg
     2221 aggtgctttc agaagatagt aactatttgt aaattgtgtt ttaattaagc tttggaacag
     2281 ttccttttaa tgttccaaag attggacttg tattaggaaa taaagctgaa cctgggactg
     2341 tga
//
