LOCUS       NP_001388172             652 aa            linear   ROD 31-MAR-2024
DEFINITION  bromodomain-containing protein 7 isoform 2 [Rattus norvegicus].
ACCESSION   NP_001388172 XP_006255329
VERSION     NP_001388172.1
DBSOURCE    REFSEQ: accession NM_001401243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 652)
  AUTHORS   Wang,X.M., Wang,Y.C., Liu,X.J., Wang,Q., Zhang,C.M., Zhang,L.P.,
            Liu,H., Zhang,X.Y., Mao,Y. and Ge,Z.M.
  TITLE     BRD7 mediates hyperglycaemia-induced myocardial apoptosis via
            endoplasmic reticulum stress signalling pathway
  JOURNAL   J Cell Mol Med 21 (6), 1094-1105 (2017)
   PUBMED   27957794
  REMARK    GeneRIF: down-regulation of BRD7 attenuated HG-induced expression
            of CHOP via inhibiting nuclear translocation of XBP-1s without
            affecting the total expression of XBP-1s. In conclusion, inhibition
            of BRD7 appeared to protect against hyperglycaemia-induced
            cardiomyocyte apoptosis by inhibiting ER stress signalling pathway.
REFERENCE   2  (residues 1 to 652)
  AUTHORS   Sanchez,R., Meslamani,J. and Zhou,M.M.
  TITLE     The bromodomain: from epigenome reader to druggable target
  JOURNAL   Biochim Biophys Acta 1839 (8), 676-685 (2014)
   PUBMED   24686119
  REMARK    Review article
REFERENCE   3  (residues 1 to 652)
  AUTHORS   Singh,A.P. and Archer,T.K.
  TITLE     Analysis of the SWI/SNF chromatin-remodeling complex during early
            heart development and BAF250a repression cardiac gene transcription
            during P19 cell differentiation
  JOURNAL   Nucleic Acids Res 42 (5), 2958-2975 (2014)
   PUBMED   24335282
REFERENCE   4  (residues 1 to 652)
  AUTHORS   Park,Y.A., Lee,J.W., Kim,H.S., Lee,Y.Y., Kim,T.J., Choi,C.H.,
            Choi,J.J., Jeon,H.K., Cho,Y.J., Ryu,J.Y., Kim,B.G. and Bae,D.S.
  TITLE     Tumor suppressive effects of bromodomain-containing protein 7
            (BRD7) in epithelial ovarian carcinoma
  JOURNAL   Clin Cancer Res 20 (3), 565-575 (2014)
   PUBMED   24198243
REFERENCE   5  (residues 1 to 652)
  AUTHORS   Tang,H., Wang,Z., Liu,Q., Liu,X., Wu,M. and Li,G.
  TITLE     Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma
            growth by directly targeting LRRC4
  JOURNAL   PLoS One 9 (1), e84146 (2014)
   PUBMED   24404152
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 652)
  AUTHORS   Tang,X.Y., Liu,F., Peng,Y., Xiang,B., Wang,C.H., Yao,C.J. and
            Shen,S.R.
  TITLE     [Expression and SNP analysis of BRD7 gene in acute leukemia cells]
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 33 (8), 645-650 (2008)
   PUBMED   18772500
REFERENCE   7  (residues 1 to 652)
  AUTHORS   Peng,C., Zhou,J., Liu,H.Y., Zhou,M., Wang,L.L., Zhang,Q.H.,
            Yang,Y.X., Xiong,W., Shen,S.R., Li,X.L. and Li,G.Y.
  TITLE     The transcriptional regulation role of BRD7 by binding to
            acetylated histone through bromodomain
  JOURNAL   J Cell Biochem 97 (4), 882-892 (2006)
   PUBMED   16265664
REFERENCE   8  (residues 1 to 652)
  AUTHORS   Kzhyshkowska,J., Rusch,A., Wolf,H. and Dobner,T.
  TITLE     Regulation of transcription by the heterogeneous nuclear
            ribonucleoprotein E1B-AP5 is mediated by complex formation with the
            novel bromodomain-containing protein BRD7
  JOURNAL   Biochem J 371 (Pt 2), 385-393 (2003)
   PUBMED   12489984
REFERENCE   9  (residues 1 to 652)
  AUTHORS   Staal,A., Enserink,J.M., Stein,J.L., Stein,G.S. and van Wijnen,A.J.
  TITLE     Molecular characterization of celtix-1, a bromodomain protein
            interacting with the transcription factor interferon regulatory
            factor 2
  JOURNAL   J Cell Physiol 185 (2), 269-279 (2000)
   PUBMED   11025449
REFERENCE   10 (residues 1 to 652)
  AUTHORS   Cuppen,E., van Ham,M., Pepers,B., Wieringa,B. and Hendriks,W.
  TITLE     Identification and molecular characterization of BP75, a novel
            bromodomain-containing protein
  JOURNAL   FEBS Lett 459 (3), 291-298 (1999)
   PUBMED   10526152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Feb 4, 2022 this sequence version replaced XP_006255329.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.75475.1,
                                           SRR26360172.1903065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..652
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     Protein         1..652
                     /product="bromodomain-containing protein 7 isoform 2"
                     /note="bromodomain-containing protein 7"
                     /calculated_mol_wt=73814
     Region          135..232
                     /region_name="Bromo_brd7_like"
                     /note="Bromodomain, brd7_like subgroup. The BRD7 gene
                     encodes a nuclear protein that has been shown to inhibit
                     cell growth and the progression of the cell cycle by
                     regulating cell-cycle genes at the transcriptional level.
                     BRD7 has been identified as a gene...; cd05513"
                     /db_xref="CDD:99945"
     Site            order(160,165,168,207,211,217)
                     /site_type="active"
                     /note="acetyllysine binding site [active]"
                     /db_xref="CDD:99945"
     Region          311..485
                     /region_name="DUF3512"
                     /note="Domain of unknown function (DUF3512); pfam12024"
                     /db_xref="CDD:463436"
     CDS             1..652
                     /gene="Brd7"
                     /coded_by="NM_001401243.1:211..2169"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:361374"
                     /db_xref="RGD:1309891"
ORIGIN      
        1 mgkkhkkhks drhfyeeyve kplklvlkvg gsevtelstg ssghdsslfe drsdhdkhkd
       61 rkrkkrkkge kqapgeekgr krrrvkedkk krdrdrvene adkdlqchvp irldlppekp
      121 ltsslakqee veqtplqeal nqlmrqlqrk dpsaffsfpv tdfiapgysm iikhpmdfst
      181 mkekiknndy qsieelkdnf klmctnamiy nkpetiyyka akkllhsgmk ilsqeriqsl
      241 kqsidfmadl qktrkqkdra dacqggedsg cwqreredsg daetqafksp tkdnkkkdkd
      301 vledkwrssn sereheqier vvqesggklt rrlancqcef errkpdgttt lgllhpvdpi
      361 vgepgycpvr lgmttgrlqs gvntlqgfke dkrnrvtpvl ylnygpyssy aphydstfan
      421 iskddsdliy stygedsdlp nnfsisefla tcqdypyvma dslldvltkg ghsrslqdld
      481 mpspedegqt raldvakeae qvahiepagr lessgqdrlt alqavtnfga paevfdseea
      541 evfqrkldet trllrelqea qnerlstrpp pnmicllgps yremylaeqv tnnlkeltqq
      601 vtpgdvvsih gvrkamgisv pspimghslv dlteecedpk etstaesgpa as
//
