LOCUS       NM_001100903            7037 bp    mRNA    linear   ROD 24-APR-2024
DEFINITION  Rattus norvegicus bromodomain containing 4 (Brd4), mRNA.
ACCESSION   NM_001100903 XM_001065925 XM_001066148 XM_001077931 XM_343175
VERSION     NM_001100903.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7037)
  AUTHORS   Li,X., Yang,Q., Jiang,P., Wen,J., Chen,Y., Huang,J., Tian,M.,
            Ren,J. and Yang,Q.
  TITLE     Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves
            Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation
  JOURNAL   Neurochem Res 49 (5), 1254-1267 (2024)
   PUBMED   38381246
  REMARK    GeneRIF: Inhibition of CK2 Diminishes Fibrotic Scar Formation and
            Improves Outcomes After Ischemic Stroke via Reducing BRD4
            Phosphorylation.
REFERENCE   2  (bases 1 to 7037)
  AUTHORS   Jia,X., Ju,J., Li,Z., Peng,X., Wang,J. and Gao,F.
  TITLE     Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia
            polarization via STING-IRF3 pathway in morphine-tolerant rats
  JOURNAL   Eur J Pharmacol 969, 176428 (2024)
   PUBMED   38432572
  REMARK    GeneRIF: Inhibition of spinal BRD4 alleviates pyroptosis and M1
            microglia polarization via STING-IRF3 pathway in morphine-tolerant
            rats.
REFERENCE   3  (bases 1 to 7037)
  AUTHORS   Sun,J., Wang,X.H., Song,F.H., Li,D.Y., Gao,S.J., Zhang,L.Q.,
            Wu,J.Y., Liu,D.Q., Wang,L.W., Zhou,Y.Q. and Mei,W.
  TITLE     Inhibition of Brd4 alleviates osteoarthritis pain via suppression
            of neuroinflammation and activation of Nrf2-mediated antioxidant
            signalling
  JOURNAL   Br J Pharmacol 180 (24), 3194-3214 (2023)
   PUBMED   37485568
  REMARK    GeneRIF: Inhibition of Brd4 alleviates osteoarthritis pain via
            suppression of neuroinflammation and activation of Nrf2-mediated
            antioxidant signalling.
REFERENCE   4  (bases 1 to 7037)
  AUTHORS   Wang,D., Zhu,Z., Fu,Y., Zhang,Q., Zhang,Y., Wang,T., Weng,Y.,
            Wen,Y., Cao,W., Tao,G. and Wang,Y.
  TITLE     Bromodomain-containing protein 4 activates androgen receptor
            transcription and promotes ovarian fibrosis in PCOS
  JOURNAL   Cell Rep 42 (9), 113090 (2023)
   PUBMED   37669164
  REMARK    GeneRIF: Bromodomain-containing protein 4 activates androgen
            receptor transcription and promotes ovarian fibrosis in PCOS.
REFERENCE   5  (bases 1 to 7037)
  AUTHORS   Zhu,Y., Ni,H., Chen,Q., Qian,H., Fang,Y., Gao,R. and Liu,B.
  TITLE     Inhibition of BRD4 expression attenuates the inflammatory response
            and apoptosis by downregulating the HMGB-1/NF-kappaB signaling
            pathway following traumatic brain injury in rats
  JOURNAL   Neurosci Lett 812, 137385 (2023)
   PUBMED   37423465
  REMARK    GeneRIF: Inhibition of BRD4 expression attenuates the inflammatory
            response and apoptosis by downregulating the HMGB-1/NF-kappaB
            signaling pathway following traumatic brain injury in rats.
REFERENCE   6  (bases 1 to 7037)
  AUTHORS   Yang,Z., He,N. and Zhou,Q.
  TITLE     Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1
            gene expression and cell cycle progression
  JOURNAL   Mol Cell Biol 28 (3), 967-976 (2008)
   PUBMED   18039861
REFERENCE   7  (bases 1 to 7037)
  AUTHORS   Nishiyama,A., Dey,A., Miyazaki,J. and Ozato,K.
  TITLE     Brd4 is required for recovery from antimicrotubule drug-induced
            mitotic arrest: preservation of acetylated chromatin
  JOURNAL   Mol Biol Cell 17 (2), 814-823 (2006)
   PUBMED   16339075
REFERENCE   8  (bases 1 to 7037)
  AUTHORS   Jang,M.K., Mochizuki,K., Zhou,M., Jeong,H.S., Brady,J.N. and
            Ozato,K.
  TITLE     The bromodomain protein Brd4 is a positive regulatory component of
            P-TEFb and stimulates RNA polymerase II-dependent transcription
  JOURNAL   Mol Cell 19 (4), 523-534 (2005)
   PUBMED   16109376
REFERENCE   9  (bases 1 to 7037)
  AUTHORS   Houzelstein,D., Bullock,S.L., Lynch,D.E., Grigorieva,E.F.,
            Wilson,V.A. and Beddington,R.S.
  TITLE     Growth and early postimplantation defects in mice deficient for the
            bromodomain-containing protein Brd4
  JOURNAL   Mol Cell Biol 22 (11), 3794-3802 (2002)
   PUBMED   11997514
REFERENCE   10 (bases 1 to 7037)
  AUTHORS   Dey,A., Ellenberg,J., Farina,A., Coleman,A.E., Maruyama,T.,
            Sciortino,S., Lippincott-Schwartz,J. and Ozato,K.
  TITLE     A bromodomain protein, MCAP, associates with mitotic chromosomes
            and affects G(2)-to-M transition
  JOURNAL   Mol Cell Biol 20 (17), 6537-6549 (2000)
   PUBMED   10938129
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Nov 21, 2008 this sequence version replaced
            XM_343175.3, XM_001066148.1, XM_001065925.1, XM_001077931.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000007.1  11946463-11946575   c
            114-432             JAXUCZ010000007.1  11900803-11901121   c
            433-570             JAXUCZ010000007.1  11897392-11897529   c
            571-706             JAXUCZ010000007.1  11895897-11896032   c
            707-999             JAXUCZ010000007.1  11893383-11893675   c
            1000-1362           JAXUCZ010000007.1  11892653-11893015   c
            1363-1491           JAXUCZ010000007.1  11891703-11891831   c
            1492-1701           JAXUCZ010000007.1  11886989-11887198   c
            1702-1901           JAXUCZ010000007.1  11885948-11886147   c
            1902-2197           JAXUCZ010000007.1  11885131-11885426   c
            2198-2308           JAXUCZ010000007.1  11884064-11884174   c
            2309-2361           JAXUCZ010000007.1  11875377-11875429   c
            2362-2746           JAXUCZ010000007.1  11874858-11875242   c
            2747-3337           JAXUCZ010000007.1  11873660-11874250   c
            3338-3712           JAXUCZ010000007.1  11870898-11871272   c
            3713-3843           JAXUCZ010000007.1  11870673-11870803   c
            3844-4049           JAXUCZ010000007.1  11870333-11870538   c
            4050-4290           JAXUCZ010000007.1  11870010-11870250   c
            4291-7037           JAXUCZ010000007.1  11866997-11869743   c
FEATURES             Location/Qualifiers
     source          1..7037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..7037
                     /gene="Brd4"
                     /note="bromodomain containing 4"
                     /db_xref="GeneID:362844"
                     /db_xref="RGD:1307282"
     exon            1..113
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            114..432
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..4359
                     /gene="Brd4"
                     /codon_start=1
                     /product="bromodomain-containing protein 4"
                     /protein_id="NP_001094373.1"
                     /db_xref="GeneID:362844"
                     /db_xref="RGD:1307282"
                     /translation="MSTESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQSANAASTN
                     PPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIK
                     TPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQK
                     INELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTSPQTQMPQQNPPPP
                     VQATTHPFPAVTPDLIAQPPVMTMVPPQPLQTPSPVPPQPPPPPAPVPQPVQSHPPII
                     ATTPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLAPEPKTAKLGPRRESSRPVKPPKK
                     DVPDSQQHPGPEKSSKISEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYC
                     DIIKHPMDMSTIKSKLESREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV
                     FEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEER
                     AQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKKKEEMEENKKSKA
                     KELPPKKTKKNNSSNSNVSKKEPAPTKTKPPPTYESEEEDKCKPMSYEEKRQLSLDIN
                     KLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKP
                     QAEKVDVIAGSSKMKGFSSSESESTSESSSSDSEDSETEMAPKSKKKGHTGRDQKKHH
                     HHHHPQMQPAPAPVPQQPPPPPQQPPPPPPPQQQQQQQQQQPPPPPPPPSMPQQTAPA
                     MKSSPPPFITAQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPH
                     LNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALAQPPLLPQPPMAQP
                     PQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSV
                     QQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLPSMPFSAHIQQPPPPTGQQPTHPP
                     PGQQPPPPQPAKPQQVIQHHPSPRHHKSDPYSAGHLREAPSPLMIHSPQMPQFQSLTH
                     QSPPQQNVQPKKQVKGRAEPQPPGPVMGRGQGCPPASPAAVPMLSQELRPPSVVQPQP
                     LVVVKEEKIHSPIIRSEPFSTSLRPEPPKHPENMKAPVHLPQRPEMKPVDVGRPVIRP
                     PEQSAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSD
                     SFEHFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEAR
                     RRQEQQQQQQRQEQQQQQQQQAAAVAAASAPQAQSSQPQSMLDQQRELARKREQERRR
                     REAMAATIDMNFQSDLLSIFEENLF"
     exon            433..570
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..706
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..999
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1362
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1491
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1701
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1901
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2197
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2308
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2361
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2746
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..3337
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3712
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3843
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4049
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4290
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..7037
                     /gene="Brd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcaggcaa gcggggcctg tgagcgcagc ggcgcagcag gcgcggcgga cgggccccgg
       61 cttggcgcag gcgtcccgga cagcgtgcgg cggcgtgcgg cctagcgtct cagagtgcct
      121 ggtgaagaat gtgatgggat cactagcatg tctacggaga gcggccctgg gacaagattg
      181 agaaatctgc cagtaatggg ggatggacta gaaacctccc aaatgtctac aacgcaggcc
      241 caggcccaac cccagtcagc aaatgcagcc agcaccaatc ctccaccccc agagacctcc
      301 aaccctaaca agcccaagag gcagaccaac caactgcaat atctgctcag agtggtgctc
      361 aagacactat ggaaacacca gtttgcgtgg cctttccagc agcctgtgga tgccgtcaag
      421 ctgaacctcc ctgattacta taagattatt aaaacaccca tggatatggg aacaataaag
      481 aagcgcttgg aaaacaacta ttactggaat gctcaggaat gtatccagga cttcaacact
      541 atgtttacaa attgttacat ctataacaag cctggagatg acatcgtctt aatggcagaa
      601 gctctggaga agctcttctt gcagaaaatc aatgaactgc ctacagaaga aaccgagatc
      661 atgatagtcc aggcaaaggg acgaggacga gggaggaaag aaacagggac agcaaagcct
      721 ggtgtatcca cggtaccaaa cacaactcaa gcatcaactt ctccgcagac ccagatgcct
      781 cagcagaacc ctcctccacc tgtgcaggcc acaactcacc cctttcctgc tgtcacccca
      841 gacctcattg cccagcctcc tgtcatgaca atggtgcccc cccagccact tcagactcct
      901 tcaccggtac cccctcagcc accaccccca cctgctccag ttccacagcc tgtgcagagt
      961 caccctccca tcattgcgac caccccacag cctgtgaaga caaagaaagg ggtgaagagg
     1021 aaagcagata ccaccacccc caccaccatc gaccccattc atgagccgcc ctcactggcc
     1081 ccggagccca agaccgccaa gctgggtcct cggcgggaga gcagcagacc tgtgaagccc
     1141 ccaaagaagg atgtaccaga ctcccagcag cacccagggc cagagaagag cagcaagatc
     1201 tctgagcagc tgaagtgctg cagtggcatc ctcaaggaga tgtttgctaa gaaacatgct
     1261 gcctatgcct ggcctttcta caagcccgtg gatgtggagg cactgggtct gcacgactac
     1321 tgtgacatca ttaaacaccc catggacatg agcacaatca agtctaaact agagtcccgg
     1381 gagtacagag atgcccagga gtttggtgct gatgtccgat tgatgttttc caactgctac
     1441 aagtacaatc cccctgacca tgaagtggta gccatggctc gaaaactcca ggatgtgttt
     1501 gaaatgcgct ttgccaagat gcctgatgag cctgaagagc cagttgttac ggtgtcctcc
     1561 cctgcagtgc caccccctac aaaggtggta gccccaccct catctagtga cagcagcagt
     1621 gatagttcct ctgacagtga cagttccact gacgactctg aggaagagcg agcccagcgg
     1681 ctggctgagc tccaggagca gctcaaagcc gtgcatgagc agcttgcagc cctctcacag
     1741 ccccaacaga acaaaccaaa gaaaaaggag aaggacaaga aggaaaagaa aaaggaaaag
     1801 cacaaaaaga aagaagaaat ggaggaaaat aaaaaaagca aagccaagga acttcctccc
     1861 aaaaagacaa agaaaaataa cagcagcaac agcaatgtga gcaagaagga accagcaccc
     1921 acgaagacca agccgcctcc cacatatgaa tcagaagaag aggacaagtg taagcctatg
     1981 tcttatgagg agaagcgaca gctaagtcta gatatcaaca aacttcctgg tgagaagcta
     2041 ggccgtgtag tacacataat tcagtcgagg gaaccatcac ttaaaaactc caaccctgat
     2101 gagattgaga ttgattttga gaccctgaag ccatctacac tacgagagtt ggagcgatat
     2161 gtcacctcct gtttgcggaa gaaaaggaaa cctcaagctg aaaaagttga tgtgattgct
     2221 ggttcttcca agatgaaggg cttctcatcc tctgagtcgg agagcaccag cgaatctagc
     2281 tcctctgaca gtgaagactc tgaaacagag atggctccca agtcaaaaaa gaaggggcac
     2341 actgggaggg accagaaaaa gcatcatcac catcaccacc cacagatgca gccagcccca
     2401 gctcctgtgc cccagcagcc gccgccacct ccacagcagc ctcctccacc cccacctcct
     2461 cagcagcagc agcagcagca gcagcagcag cccccacccc caccacctcc gccctccatg
     2521 ccacagcaga ctgccccagc gatgaagtcc tcgcccccac ccttcatcac tgcccaggta
     2581 cccgtcctgg aaccacagct accaggcagt gtctttgacc ctattggcca cttcacccag
     2641 cccatcttgc acctgccgca gccagagctg cctcctcacc tgccccagcc accggagcac
     2701 agcactccac cccatctcaa ccagcatgct gtggtctctc ctccagcttt gcacaatgcg
     2761 ctgccccaac aaccatctcg gcccagcaac cgagctgctg ctctgccccc aaagcctgcc
     2821 cgacccccag ctgtgtcccc tgccttggcc cagccccccc tgctcccaca gccacctatg
     2881 gctcagcccc cccaagtgct gctggaggat gaagagccgc ctgccccacc cctcacctcc
     2941 atgcagatgc agttgtacct acagcagctg cagaaggtgc agcctcccac accactactc
     3001 ccttccgtga aggtgcagtc ccaaccccca ccacctttgc cgcctccacc ccacccttct
     3061 gtgcagcaac agcagctcca gcagcagcca ccaccacccc cacctcctca gccacagcca
     3121 ccaccccagc aacaacacca gcccccacca cgaccagttc acttgccatc catgcccttc
     3181 tctgctcaca ttcagcagcc cccaccaccc acaggacagc aacccaccca cccaccccca
     3241 ggacagcagc cacccccacc acagcctgcc aagcctcagc aagtcatcca gcatcaccct
     3301 tcaccccggc accacaagtc agacccctac tcagctggtc atcttcgtga agccccttct
     3361 ccgcttatga tacattcccc tcaaatgcca cagttccaga gcctgaccca tcagtctcca
     3421 ccccagcaaa acgtccagcc caagaagcag gtaaagggca gggctgagcc acagccccca
     3481 gggccagtca tgggccgagg ccagggatgc ccacctgcct caccggctgc cgtacctatg
     3541 ctgtcccagg agctgcgccc accgtcagtc gtccagcccc agcccctggt ggtagtgaag
     3601 gaggagaaga ttcactcacc aatcatccgc agtgagcctt ttagcacctc acttcgccca
     3661 gagccgccca agcacccaga gaacatgaag gccccagtcc acctgcctca gcggcctgag
     3721 atgaagcctg tagatgtagg gaggcctgtg atccggcctc cagagcagag tgcaccccca
     3781 ccaggggccc ctgacaagga caaacagaaa caggagccaa aaacaccagt ggcgcccaaa
     3841 aaggacctga aaattaagaa catgggctcc tgggccagcc tggtacagaa gcatccgacc
     3901 accccatcct ccacagccaa gtcctcaagc gacagctttg agcatttccg ccgcgctgct
     3961 cgggagaagg aggagcggga aaaggccctg aaggctcagg ctgagcacgc agagaaggag
     4021 aaggagcggc tgaggcagga gcgcatgagg agccgagagg atgaggatgc gctggaacag
     4081 gcacgtcgag cccatgagga ggcacgacgg cgccaggagc agcagcagca gcagcagaga
     4141 caggagcagc agcagcagca gcaacagcag gcagctgctg tggccgctgc ctccgccccc
     4201 caggcccaga gctcccagcc ccagtctatg ctggaccagc agagggagtt ggcccgaaag
     4261 cgagaacagg agcggaggcg cagggaggca atggcagcta caattgacat gaatttccag
     4321 agtgatcttt tgtcaatatt tgaagaaaat cttttttgag agcacccagg tgacttctga
     4381 cttttctggc aaaaatgttg actctccata gtgttagggg cggcagtgga agcagtagca
     4441 gcagccaggg atgtctctgg gcctggctct cctgcatgct atgcccgggg caggcctgac
     4501 gggcagctga ggatcgcaga gcccatctgc cttacagcca gccggacaga cgtcctacca
     4561 catgccaccc gctcagtgga cgtcagttca gagcacgtct cagtatattg agtcaagtgc
     4621 cggctggacc tgaggcctgc ttccccgcgt gcggggcaga ggcccttctc tgcgccaaat
     4681 gtctacacag tatacacagg acattgttgc tgccgccacc gtgactgatt ttctgtccct
     4741 gagaacatga cgtttgtgac gtcctaccca ttgggagtcc ttcacacccc agccatcgct
     4801 gcccactccc aggaggccag ggcaagcctg tgtggactgg agcagcaagg cactggccca
     4861 ccccttgctg gcactgactt tgccttgaac agaccctctc ccctcccccc acaagccttt
     4921 aattgagagc cgctctctat aagtgttcgc ttgtgcaaaa gggaatagtg ccgtggaagt
     4981 gtgtgtgccc atggcagttt ggacagaggt gactgttcac atgtgtggat aggcctcgcc
     5041 tggggagtaa ggccaccaac caaagtcagt ccttcccacc tgtgtttctg attttatttt
     5101 ttttcctata tatatatttt tttgttgttg ttgaattcta ttttattttt aactctctct
     5161 tctcctcaga cacagtggca ctgcttatct ccaaatggtg tgaccgtctc ctcatgagcg
     5221 gcagctccct cccccccccg ctgtgggtag tgtatgactg tggctgtact gtatagtgaa
     5281 catagttggc atatctttgt ttgaagtttg ttggtgactc caccaaactg gtgtaaaaaa
     5341 caaaaacaga caaaaaaccc ccacaaacca cccaacacac acacagaaag tcctgcttgt
     5401 attcagtttc aaactttatt agtcttattt ttaattataa aaccagaaag ctgcaatttc
     5461 ttttccctct accccttgtt tgttggcttc tttgtttttt aatgtcaaat ctgtttgttt
     5521 ttaccaagaa agggagagcc tggggagggc tccaggccct ggtgggctgc aaactgaggc
     5581 agaggtccca tgcgcacctg gtcagaccag tgcgctgggc cttccttcct tcccattagc
     5641 atttttgttt tgttttgttt tgtttttaaa ttggagcccc tggtgaggtt acatgtgcca
     5701 tgagaaccca gtctacacca cagtgctggt gcctcggtgt tggccaaact ctggagtcac
     5761 tgactggttt gactttcatg tggtgaatat gcatttggtc tgtactgatc atggaataaa
     5821 cacatctctc ttttttaatg ctggtgtctc cctgaaattt ctttgtgaac caactaggta
     5881 ttctagtttg tttaggctag gcccaggttc ccaggcacct ttgtgtaaga tttaccaaca
     5941 gtggacacag ctactctcca ttggccagtc ctgcctttcc tgggcaggag ctgcctgggc
     6001 tcagagtgcc cccaccccaa gctgaagttc taatagggag ccagacaccc tgtaactgcc
     6061 tggactgggt ggtgatgagg ctcactgaaa cttggcttat ccagaccaca ttcttcctga
     6121 aggtcctgat catcctagtc ccttcttcac aaaggcttgg ggctgctttt cccaccatgc
     6181 ttgcctctac ctaactccta atttgattta agctcagggt taaccacata ctcttaggta
     6241 atgtacgttc cctccaaata ggatctctgt atccctacac atgaacacat ttccactgag
     6301 aaagccccca gatggcttcc ttaccttgtg cccacttgtt cacacatgtc ctggccccca
     6361 agaacagtct ctgtgatgta agataagtaa ttctacataa gcagagacac gttgactcaa
     6421 agtttctagc actcttaatc cgtatctccc ccctcaacca gaaaggccga acctcagagt
     6481 acagggcaca gttcaggtac ccagccaatg ctccctccct tcccttaagg tcctgtcctg
     6541 ctccaggcga ttcgtacata actgtgctgg agcaatggca ggtttagtcc tctgaggcgg
     6601 cttttaccac atccgaccct cacagtcttc tcttgagata cttccccacg ctgggcccca
     6661 cttctgaggt ggggagatca tttcagctgt accttcttgc tggagttttg aatggcctcc
     6721 gcaccttcct catgggtgtt cctctaactg ggttgtaatt agaactggga tctatttaat
     6781 ttctctgacc attttcaaat ccttcctgca gtactagaca tcttagtcct atacaagagt
     6841 aagaggtgtg tacaagcccc cactgtactg tatgcacggg tcgctcggcc aataattatg
     6901 tcagtgaatc tgagacttgt attaaaatac tttagacatt tgtagaaggg aattcataga
     6961 cttttcactt atatacttaa agggggtttt ttttgtgcag ttctcattgc aaaaataaac
     7021 atttgtactg aatataa
//
