LOCUS       NM_001108575            3133 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus bromodomain containing 3 (Brd3), mRNA.
ACCESSION   NM_001108575 XM_001075609 XM_342396
VERSION     NM_001108575.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3133)
  AUTHORS   Li,Y., Sabari,B.R., Panchenko,T., Wen,H., Zhao,D., Guan,H., Wan,L.,
            Huang,H., Tang,Z., Zhao,Y., Roeder,R.G., Shi,X., Allis,C.D. and
            Li,H.
  TITLE     Molecular Coupling of Histone Crotonylation and Active
            Transcription by AF9 YEATS Domain
  JOURNAL   Mol Cell 62 (2), 181-193 (2016)
   PUBMED   27105114
REFERENCE   2  (bases 1 to 3133)
  AUTHORS   Sanchez,R., Meslamani,J. and Zhou,M.M.
  TITLE     The bromodomain: from epigenome reader to druggable target
  JOURNAL   Biochim Biophys Acta 1839 (8), 676-685 (2014)
   PUBMED   24686119
  REMARK    Review article
REFERENCE   3  (bases 1 to 3133)
  AUTHORS   Filippakopoulos,P., Picaud,S., Mangos,M., Keates,T., Lambert,J.P.,
            Barsyte-Lovejoy,D., Felletar,I., Volkmer,R., Muller,S., Pawson,T.,
            Gingras,A.C., Arrowsmith,C.H. and Knapp,S.
  TITLE     Histone recognition and large-scale structural analysis of the
            human bromodomain family
  JOURNAL   Cell 149 (1), 214-231 (2012)
   PUBMED   22464331
REFERENCE   4  (bases 1 to 3133)
  AUTHORS   LeRoy,G., Rickards,B. and Flint,S.J.
  TITLE     The double bromodomain proteins Brd2 and Brd3 couple histone
            acetylation to transcription
  JOURNAL   Mol Cell 30 (1), 51-60 (2008)
   PUBMED   18406326
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474001.2.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001108575.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001075609.1, XM_342396.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..3133
                     /gene="Brd3"
                     /note="bromodomain containing 3"
                     /db_xref="GeneID:362092"
                     /db_xref="RGD:1308925"
     exon            1..104
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            105..412
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2377
                     /gene="Brd3"
                     /codon_start=1
                     /product="bromodomain-containing protein 3"
                     /protein_id="NP_001102045.1"
                     /db_xref="GeneID:362092"
                     /db_xref="RGD:1308925"
                     /translation="MSTTTAAAPTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQN
                     VVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECM
                     QDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPA
                     AGAQNAGAQQMGAVSSVSPAPPFQNIPPTVSQTPVIAATPVPTITANVTSVPVPPPAA
                     PPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSEPKQAKVV
                     ARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPF
                     YKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNP
                     PDHEVVAMARKLQDVFEMRFAKMPDEPMEVPALPAPTAPIVSKGAESSRSSEESSSDS
                     GSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEK
                     EKHKAKSEEEKKAKAAPAAKQAQQKKAPTKKANSTTTASRQLKKGGKQASASYDSEEE
                     EEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPT
                     TLRELERYVKSCLQKKQRKPLSTSGKKQAAKSKEELAQEKKKELEKRLQDVSGQLNSK
                     KPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSDSE"
     exon            413..550
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..698
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..913
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1285
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1414
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1606
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1842
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2135
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2261
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..3133
                     /gene="Brd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgagttctg gaccagcctg agctgtagag tgagactgtc ttgagccaga ataaggaagg
       61 aagggagggc cgcctctgac ctgcaggctg tgagcattgc aaaggtgcct gattgggccc
      121 agaaatggga tgccaagcct tcccgaggag cgcctctttg agctgctgct gtgacagcaa
      181 gtgactaagc tgccagagga tgtccactac tacagcggct gcccccacgg ggatcccggc
      241 agtcccgggc cccgtgaacc ctcccccacc tgaggtctcc aaccccagca agcccggccg
      301 aaagactaac cagctgcagt acatgcagaa cgtagtggtg aagacactct ggaaacatca
      361 gtttgcctgg cctttctacc agcctgtgga tgcaatcaag ctgaacctgc ctgattatca
      421 taaaataata aaaaacccaa tggacatggg gactatcaag aagagactag aaaataatta
      481 ttattggagt gccagtgagt gtatgcagga cttcaacacc atgtttacaa actgttatat
      541 ttataataag cccacagatg acatagtgct aatggcccag gccttagaga aaatctttct
      601 gcagaaagtg gcccagatgc ctcaggagga agttgaacta ttgccccctg ctccaaaggg
      661 caaaggccgg aagccagctg caggagccca gaatgcaggt gcacaacaaa tgggagctgt
      721 gtcctcggtc tccccagcac cccccttcca gaacataccc cccaccgtat cccagacacc
      781 cgtcattgcc gccacccctg taccaaccat cactgcaaac gtcacgtcag ttccagtccc
      841 cccacccgcc gcaccgcctc ctcctgcgac acccatcgtc ccagtggtcc ctcccacacc
      901 gcctgtagtc aagaaaaagg gcgtgaagcg gaaagcagac acaaccacac ccacaacgtc
      961 cgccatcact gccagccgga gtgagtctcc cccgccactt tcagagccca agcaagccaa
     1021 ggtagtagcc cgaagagaga gcgggggtcg ccccatcaaa cctcccaaga aggacctgga
     1081 agatggtgag gtcccacagc acgcgggtaa aaagggaaaa ctgtccgagc acctgcggca
     1141 ttgtgacagc atcctccggg agatgctgtc caagaagcac gctgcctatg cgtggccctt
     1201 ttacaagcca gtggatgccg aggcactgga gctgcatgac taccatgaca taatcaaaca
     1261 ccccatggac cttagcacag tcaaaaggaa aatggacagc cgtgagtacc cagatgcaca
     1321 gggcttcgct gccgatatcc ggttaatgtt ctccaattgt tataagtaca accctccaga
     1381 ccacgaagtg gtagccatgg ccaggaagct ccaggatgtg tttgagatga ggtttgccaa
     1441 gatgcccgat gagcccatgg aggtgcctgc gctgcctgct cccacagccc ccatcgtgag
     1501 caaaggggct gagagcagcc gtagtagcga ggagagctct tcggactcag gcagctcaga
     1561 ctctgaagag gagcgagcca ctcggctggc agagctgcag gagcagctga aagccgtgca
     1621 cgaacagctg gccgccttgt ctcaggcccc agtgaacaaa ccaaagaaga agaaggagaa
     1681 gaaggaaaag gagaagaaga agaaagacaa ggagaaggag aaggagaagc acaaggccaa
     1741 gtccgaggag gagaagaagg ccaaggcagc cccagcagcc aagcaggccc agcagaagaa
     1801 ggctcccacc aagaaggcca atagcacaac cacagccagc agacagctca agaagggcgg
     1861 caagcaggca tctgcatcct atgactcgga ggaagaggag gagggcctgc ccatgagcta
     1921 cgatgagaag cggcaactca gcctcgacat caaccggctg cctggcgaga agctaggtcg
     1981 tgtggtgcac atcattcagt cccgggagcc ttcccttcgg gactcgaacc cagacgagat
     2041 tgagattgac tttgagaccc tgaagccaac cacacttcgg gaactggaga gatatgtcaa
     2101 gtcttgttta cagaaaaagc agaggaaacc attgtcaaca agcgggaaga agcaggcagc
     2161 caaatcgaaa gaggagctag ctcaggagaa gaaaaaggag ctggagaagc ggctacagga
     2221 tgtcagcgga caactgaaca gcaagaaacc cactaagaaa gagaagtccg gctcagctcc
     2281 ctcaggaggc ccatcaaggc tcagcagtag cagctcctcc gagtctgcga gtagcagctc
     2341 cagtgggtca agctctgaca gcagtgactc agagtgaagt tggactggaa cagagctgga
     2401 caaatggacg tggcgcacgc cgactgcagt gtcccctcct atggttaata tactttcgtt
     2461 ccatggtgtg caggttttct tttacttcag tgttatgatc tcttccagct gtgctccagt
     2521 agggcggaga gcctcgcaca tgcgtgcacc agaccccaca agagggccga gctctgcagg
     2581 gatccctgca gctcgggttt agttgtgtgg agactgcgcc tgggatgcta acctgatggc
     2641 catagacagg gtgggctgga ggcggggctg gacctgccca atccctcctc aggcccagcc
     2701 tctctccctt cataaattga aggaagcttt tcaagggtat ttctctggaa tgggttctgt
     2761 gtttcaaagg tattagaaca ctaaccagca ggttacttct ctccgcaggg gctgaagaca
     2821 tgtgtcagcc catggggacc tacccgggcc ctagtggagg gtcctggtag ctgcaaacca
     2881 gagcctcatg cctgtgggtt gggcatggag gaaaaggggt gctgagtttt ctggtccttt
     2941 ggctgtgtgt gcagcgtgca gatttcggaa caccgaaact tttacctcaa cttaagggaa
     3001 taaaaacaaa caaaaaaaga ttaaaaaaaa aaactttttt gtaaattcat ccattttcta
     3061 cagaagtcca gcccagcgtc cccactttgc tagcgctgcc cggctgtcgt cgcctaacgc
     3121 tctgaaccac ttc
//
