LOCUS       NM_001414946            5159 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus bromodomain containing 1 (Brd1), transcript
            variant 1, mRNA.
ACCESSION   NM_001414946 XM_006242194
VERSION     NM_001414946.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5159)
  AUTHORS   Sanchez,R., Meslamani,J. and Zhou,M.M.
  TITLE     The bromodomain: from epigenome reader to druggable target
  JOURNAL   Biochim Biophys Acta 1839 (8), 676-685 (2014)
   PUBMED   24686119
  REMARK    Review article
REFERENCE   2  (bases 1 to 5159)
  AUTHORS   Christensen,J.H., Elfving,B., Muller,H.K., Fryland,T., Nyegaard,M.,
            Corydon,T.J., Nielsen,A.L., Mors,O., Wegener,G. and Borglum,A.D.
  TITLE     The Schizophrenia and Bipolar Disorder associated BRD1 gene is
            regulated upon chronic restraint stress
  JOURNAL   Eur Neuropsychopharmacol 22 (9), 651-656 (2012)
   PUBMED   22341945
  REMARK    GeneRIF: study found a significant 2-fold upregulation of long exon
            7 splice variants of the Brd1 gene in hippocampus in both groups of
            Chronic Restrain Stress rats compared to controls.
REFERENCE   3  (bases 1 to 5159)
  AUTHORS   Fryland,T., Elfving,B., Christensen,J.H., Mors,O., Wegener,G. and
            Borglum,A.D.
  TITLE     Electroconvulsive seizures regulates the Brd1 gene in the frontal
            cortex and hippocampus of the adult rat
  JOURNAL   Neurosci Lett 516 (1), 110-113 (2012)
   PUBMED   22675730
  REMARK    GeneRIF: These findings indicate that regulation of the Brd1 gene
            is part of the biological response to ECS and that splice variants
            are induced differentially in different brain regions.
REFERENCE   4  (bases 1 to 5159)
  AUTHORS   Qin,S., Jin,L., Zhang,J., Liu,L., Ji,P., Wu,M., Wu,J. and Shi,Y.
  TITLE     Recognition of unmodified histone H3 by the first PHD finger of
            bromodomain-PHD finger protein 2 provides insights into the
            regulation of histone acetyltransferases monocytic leukemic
            zinc-finger protein (MOZ) and MOZ-related factor (MORF)
  JOURNAL   J Biol Chem 286 (42), 36944-36955 (2011)
   PUBMED   21880731
REFERENCE   5  (bases 1 to 5159)
  AUTHORS   Mishima,Y., Miyagi,S., Saraya,A., Negishi,M., Endoh,M., Endo,T.A.,
            Toyoda,T., Shinga,J., Katsumoto,T., Chiba,T., Yamaguchi,N.,
            Kitabayashi,I., Koseki,H. and Iwama,A.
  TITLE     The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation
            of H3K14 and required for fetal liver erythropoiesis
  JOURNAL   Blood 118 (9), 2443-2453 (2011)
   PUBMED   21753189
REFERENCE   6  (bases 1 to 5159)
  AUTHORS   Kushima,I., Aleksic,B., Ikeda,M., Yamanouchi,Y., Kinoshita,Y.,
            Ito,Y., Nakamura,Y., Inada,T., Iwata,N. and Ozaki,N.
  TITLE     Association study of bromodomain-containing 1 gene with
            schizophrenia in Japanese population
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (3), 786-791 (2010)
   PUBMED   19908236
REFERENCE   7  (bases 1 to 5159)
  AUTHORS   Bjarkam,C.R., Corydon,T.J., Olsen,I.M., Pallesen,J., Nyegaard,M.,
            Fryland,T., Mors,O. and Borglum,A.D.
  TITLE     Further immunohistochemical characterization of BRD1 a new
            susceptibility gene for schizophrenia and bipolar affective
            disorder
  JOURNAL   Brain Struct Funct 214 (1), 37-47 (2009)
   PUBMED   19763615
  REMARK    GeneRIF: These results suggest a general role of BRD1 in the cell
            and stress that the two BRD1 variants may play different roles in
            the etiology of psychiatric disease.
REFERENCE   8  (bases 1 to 5159)
  AUTHORS   Severinsen,J.E., Bjarkam,C.R., Kiaer-Larsen,S., Olsen,I.M.,
            Nielsen,M.M., Blechingberg,J., Nielsen,A.L., Holm,I.E.,
            Foldager,L., Young,B.D., Muir,W.J., Blackwood,D.H., Corydon,T.J.,
            Mors,O. and Borglum,A.D.
  TITLE     Evidence implicating BRD1 with brain development and susceptibility
            to both schizophrenia and bipolar affective disorder
  JOURNAL   Mol Psychiatry 11 (12), 1126-1138 (2006)
   PUBMED   16924267
REFERENCE   9  (bases 1 to 5159)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   10 (bases 1 to 5159)
  AUTHORS   McCullagh,P., Chaplin,T., Meerabux,J., Grenzelias,D.,
            Lillington,D., Poulsom,R., Gregorini,A., Saha,V. and Young,B.D.
  TITLE     The cloning, mapping and expression of a novel gene, BRL, related
            to the AF10 leukaemia gene
  JOURNAL   Oncogene 18 (52), 7442-7452 (1999)
   PUBMED   10602503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 15, 2022 this sequence version replaced XM_006242194.3.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR26643299.32784.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               JAXUCZ010000007.1  121701397-121701700 c
            305-1685            JAXUCZ010000007.1  121696883-121698263 c
            1686-1842           JAXUCZ010000007.1  121686146-121686302 c
            1843-1974           JAXUCZ010000007.1  121681256-121681387 c
            1975-2103           JAXUCZ010000007.1  121680750-121680878 c
            2104-2416           JAXUCZ010000007.1  121680002-121680314 c
            2417-2677           JAXUCZ010000007.1  121674530-121674790 c
            2678-3175           JAXUCZ010000007.1  121668002-121668499 c
            3176-3311           JAXUCZ010000007.1  121658341-121658476 c
            3312-3439           JAXUCZ010000007.1  121657771-121657898 c
            3440-3549           JAXUCZ010000007.1  121656684-121656793 c
            3550-3704           JAXUCZ010000007.1  121656350-121656504 c
            3705-5159           JAXUCZ010000007.1  121653859-121655313 c
FEATURES             Location/Qualifiers
     source          1..5159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..5159
                     /gene="Brd1"
                     /note="bromodomain containing 1"
                     /db_xref="GeneID:315210"
                     /db_xref="RGD:1311855"
     exon            1..304
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..1685
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..3888
                     /gene="Brd1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bromodomain-containing protein 1"
                     /codon_start=1
                     /product="bromodomain-containing protein 1 isoform 1"
                     /protein_id="NP_001401875.1"
                     /db_xref="GeneID:315210"
                     /db_xref="RGD:1311855"
                     /translation="MRRKGRCHRGSAARHPSSPCSIKHSPTRETLTYAQAQRMVEIEI
                     EGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNE
                     VLPSTHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDE
                     EDYAWLEIINEKRKGDCVSAVSQNMFEFLMDRFEKESYCENQKQGEHQSLIDEDAVCC
                     ICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPN
                     KGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKG
                     VGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGSTTFSVRKTAYCDVHTPPG
                     CTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAP
                     YIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRNTQQ
                     RENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQMAMELRLTP
                     LTVLLRSVLEQLQEKDPAKIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNL
                     HAFEEDFNLIVDNCMKYNAKDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMH
                     LPERPIAAPRRPFSWEEVDRLLDPANRAHMSLEEQLRELLDKLDLTCSMKSSGSRSKR
                     AKLLKKEIALLRNKLSQQHSQTPSIGAGTGGFEDDAAPLAPDTGEEGDKSPPKLEPSD
                     ALPLPSDPETNSEPPTLKPVELNPEQSKLFKRVTFDNESHSTCTQSALVSGHPPEPTL
                     ASSGDVPAAAASAVAEPSSDVNRRTSVLFCKSKSVSPPKSAKNTETQPTSPQLGTKTF
                     LSVVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDTGLTNGFGGTRSEQEPGSGPG
                     RKAAPRRRCASESSICSSNSPLCDSSFSTPKCGRGKPALVRRHTLEDRSELISCIENG
                     NYAKAARIAAEVGQNSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPG
                     HHNGVTIPAPPLDVLKIGEHMQTKSEEKLFLVLFFDNKRSWQWLPKSKMVPLGVDETI
                     DKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPASDLSDID"
     exon            1686..1842
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1974
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2103
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2416
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2677
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..3175
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3311
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3439
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3549
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3704
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..5159
                     /gene="Brd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgtttg cttcgctggg gagcgagcag cgcctcggca ggcgtccgag cagctccgcg
       61 ttcgcgtcct ccgcccggcc gggccccgag ccggccttag ccggctgtgc cggcgccgcc
      121 gaccccgccc gagccgtggc gccctgcggg tccggagccg ctggccgagc gcgccccgga
      181 gcccggcggg gcacggctgc gcggccgttg gcggaggagc cgcggcgcca ttagcgccgc
      241 ctcggccgcg ccggcccccg cgcccgcccg cccgccgggc tcccgcggcc gcggcgcccc
      301 gaaggtaatc attgccaaat gaggaggaaa ggacgatgtc atcgaggttc tgcagcgagg
      361 catccttctt ccccgtgcag tattaaacac tcccccactc gtgaaacatt gacatacgca
      421 caagctcaaa ggatggtgga gatagaaatc gaagggcgtt tgcatcggat cagtattttc
      481 gatcccttgg agatcattct agaagatgac ctcactgctc aagaaatgag tgaatgcaac
      541 agtaataaag aaaacagtga gaggccacct gtttgcttaa gaactaagcg tcacaaaaac
      601 aacagagtca aaaagaaaaa tgaagtcttg cccagcaccc atggcacacc ggcttcagcc
      661 agtgcccttc ctgagcccaa ggtgcggatt gtggagtata gtcctccatc tgcacccagg
      721 aggccccctg tgtactacaa gttcatcgag aagtcagccg aggagctgga caacgaggta
      781 gagtacgaca tggatgagga agattacgcc tggttagaga tcatcaatga gaagcggaag
      841 ggcgactgtg tctctgccgt gtcacagaac atgtttgagt tcctgatgga ccgctttgag
      901 aaggagtcct actgtgagaa ccagaagcag ggtgaacacc agtccttgat agacgaggac
      961 gctgtgtgct gcatctgcat ggatggcgaa tgccagaaca gcaacgttat actcttctgt
     1021 gacatgtgca acctggctgt gcaccaggag tgctacgggg tgccctacat ccctgagggc
     1081 cagtggcttt gccgccactg cctgcagtct cgggcccgcc ctgcggattg cgtgctgtgc
     1141 ccgaataagg gtggtgcctt caaaaagaca gacgatgacc gctggggcca tgtggtatgt
     1201 gcactgtgga tcccagaggt tggctttgcc aacacggtat tcattgagcc catcgatggt
     1261 gtgaggaaca tacctcctgc ccggtggaaa ctgacgtgct acctctgtaa gcagaaaggc
     1321 gtgggtgcct gcattcagtg ccacaaagca aattgctaca cagcattcca tgtgacgtgt
     1381 gcccagaagg ctggtctgta catgaagatg gagcctgtga aggagctgac tggaggcagc
     1441 accaccttct ctgtcagaaa gactgcttac tgtgatgtcc acacacctcc aggctgtacc
     1501 cggaggcctc tgaacattta tggagatgtt gaaatgaaaa atggtgtgtg tcgaaaagaa
     1561 agctcagtca aaacggtcag gtctacatcc aaggtcagga aaaaagcaaa aaaggctaag
     1621 aaagcactgg ctgagccctg cgcggtcctg ccgaccgtgt gtgctccata tatcccccct
     1681 cagagattaa ataggattgc gaatcaggtg gccattcagc ggaagaagca gtttgtggag
     1741 cgagcccaca gctactggtt actcaaaagg ctgtctagga atggtgctcc cctgctgcgg
     1801 cggctccagt ccagcctgca gtcccagaga aacacgcagc agagagaaaa tgatgaagag
     1861 atgaaagctg ccaaagagaa gctgaagtac tggcagcggc tacggcatga cctagagcgt
     1921 gcccgcctgc tgatcgagct gctgcgcaag cgggagaaac tcaaacggga gcaggtgaag
     1981 gtggagcaga tggctatgga gctccggttg acacctctga ctgtgctgct acgctcagtc
     2041 ctggagcagc tacaggagaa ggaccctgca aagatctttg cccagcccgt gagtctcaag
     2101 gaggtaccag attatttgga tcacattaaa catcccatgg actttgctac aatgaggaaa
     2161 cggctagaag ctcaagggta taaaaacctc catgcgtttg aggaggattt taatctcatt
     2221 gtagataact gcatgaagta caatgccaag gacaccgtgt tttatagagc tgcagtgagg
     2281 ctgcgagatc agggaggtgt tgtcttgagg caggcccggc gtgaggtgga tagcatcggc
     2341 ctggaagagg cctcgggaat gcacctgcct gagcgaccca tcgcagcccc tcggcggccc
     2401 ttctcctggg aagaggtgga caggttgctg gacccagcca acagggccca catgagcttg
     2461 gaggagcagc tgagagaact actggacaag ttggacctga cctgctccat gaagtccagc
     2521 ggctcacgga gtaaacgggc aaagctgctc aaaaaagaga ttgctcttct ccgaaacaag
     2581 ctgagccagc agcacagcca gaccccatcc ataggggcag gcacaggagg ctttgaagac
     2641 gatgctgctc cactggcgcc agacacaggg gaggaaggag ataaatctcc ccctaaactt
     2701 gaaccatcag atgcattacc tcttccttca gacccggaga ctaattcaga accaccaacc
     2761 ctcaaaccag tagaactcaa ccccgagcag agtaagctat tcaaaagagt cacatttgat
     2821 aatgaatcac atagcacttg cactcagagc gcactggtaa gcggacaccc tccagagccc
     2881 accctcgcca gtagtggcga tgtgccggcg gcggcggcct ccgcagtggc ggagccatca
     2941 agcgatgtaa acagacgcac ttctgttctc ttctgcaaat cgaaaagtgt aagcccccca
     3001 aagtctgcca agaacactga aacccagcca acttctcctc agctagggac caaaaccttt
     3061 ttgtctgtag tccttccgag gttggagact ctactgcagc caaggaaaag gtcgaggagc
     3121 acatgtggag actccgaagt ggaggaggag tccccgggaa agcgcctgga tacaggtctc
     3181 accaatggct ttgggggtac tagaagcgag caggagccag gcagcggccc agggaggaaa
     3241 gctgcgcccc gacggcgctg tgcatctgag tccagcattt gttccagcaa cagcccactg
     3301 tgtgactcaa gctttagtac acccaagtgt ggccgaggga agcctgcgct tgtacgaagg
     3361 cacacactgg aagaccgcag tgagctgata tcttgtattg aaaatggaaa ctacgccaag
     3421 gcggccagga ttgcagctga ggtgggacag aacagcatgt ggatttccac cgatgccgct
     3481 gcctccgtcc tggagcccct gaaggtggtg tgggccaagt gtagcggcta tccctcctac
     3541 ccagcactga ttattgaccc caagatgcca cgagtgcctg gccaccacaa tggtgtcacc
     3601 atccccgccc cgcccctgga tgtgctgaag atcggtgaac acatgcagac caagtctgag
     3661 gagaagctgt tccttgtttt gttctttgac aataagagaa gctggcagtg gcttcccaag
     3721 tccaagatgg ttcctcttgg tgtggatgag accattgaca aactgaaaat gatggaaggg
     3781 aggaactcta gcatccggaa ggctgtgcgg attgcatttg atcgagccat gaatcatctg
     3841 agccgagtcc atggggagcc agccagtgac ctcagtgaca ttgactgagg tggcttccag
     3901 caaaaggcag tggctaaagc cacagccaac caggagccct gtcaatagtg ttgataagct
     3961 gtacatgttt gtatattgtt cagaacttaa cttattctga ttttctaggt gtagttcttt
     4021 aattcttttt cccccccccg ggaggggagg tttcacttcc aagttttcta tgaaaccatc
     4081 tggtcttggc tttgcaggtg aggagggtct gttccgagca gtgtggtgtg gggtcccact
     4141 gcaggtgccg agtgccgagg cctcacttac ttctaatctg tagggttttt ttttttaaag
     4201 acttttgaat gtttaataat tttgtagatc atgctcttta cacagagtac cgcttattta
     4261 ataagacggg gtgtaaattt acaatgacaa atgtgtattt taagaaagaa aatgacatta
     4321 ttttgaatgg tactttgtgc aaagagggaa taaatttatg ctgtgtgcat cacttgcaaa
     4381 tcaccaaaaa atgtcccgcc agctgctgcc ggccagggcc cgttctcacc gttctgactg
     4441 ccctgagtct cctgttctgc cctggctcct gcaggcgtgc ctcccagcgg gttatttatt
     4501 gtagaaagtg tactcatttg ctttataatg aaaaaataaa tttgcaaagg tatattgata
     4561 tgcattttta tacaggcaca taaaaactca acttggtgtg ggagcagaat gtgttgcgag
     4621 gttatataca tgatgggcct gtgtgtactt tgatttttgt aacttgtaat cttttgttta
     4681 caatgaggag ctttctgtaa cttgttttaa tttagaacac tttggtagca atagaccttt
     4741 ggatacattt ttgtatggta catgtgatgt atatagaatt agtactttat ttttatttct
     4801 aagaggtaaa gcattatgtt aggggaaaag gcagggtggg tttccaaatt tgcattttta
     4861 tattaaaaat aaagtgaaga tttggacagt gtggccctct cattcctgca tcactaggag
     4921 gctgggtgag ctgtagcctg aggtacatgt gggagcactg aggccttgag tgggtggtgt
     4981 gaccaggtgt gacacacttg atctaacagc tgacctgggg tggcattatt tattattttg
     5041 cctaatcata tttttatttt aaagctaaat agttactaaa aattttaaat gttcttttaa
     5101 gtctacatgt ttgtaatatc tccatagaaa cttgaaaaat aaaaagtctt cctttggta
//
