LOCUS       NM_001127300            2568 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus BRCA1/BRCA2-containing complex subunit 3 (Brcc3),
            mRNA.
ACCESSION   NM_001127300 XM_001059392 XM_237593
VERSION     NM_001127300.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Huang,X., Gan,H., Tan,J., Wang,T., Zhao,J. and Zhao,Y.
  TITLE     BRCC3 promotes activation of the NLRP6 inflammasome following
            cerebral ischemia/reperfusion (I/R) injury in rats
  JOURNAL   Neurosci Lett 756, 135954 (2021)
   PUBMED   33979701
  REMARK    GeneRIF: BRCC3 promotes activation of the NLRP6 inflammasome
            following cerebral ischemia/reperfusion (I/R) injury in rats.
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Wang,C.Y., Deneen,B. and Tzeng,S.F.
  TITLE     BRCA1/BRCA2-containing complex subunit 3 controls oligodendrocyte
            differentiation by dynamically regulating lysine 63-linked
            ubiquitination
  JOURNAL   Glia 67 (9), 1775-1792 (2019)
   PUBMED   31184779
  REMARK    GeneRIF: BRCC3 expressed in oligodendrocyte precursor cells in
            vitro is required for the oligodendrocyte lineage progression
            toward the mature stage. Lack of BRCC3 function could deteriorate
            demyelination at the lesion site. An increase in Lys63-linked
            ubiquitination levels induced by the deregulation of BRCC3
            expression promotes the endosomal/lysosomal processing of myelin
            proteins.
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Li,Y., Li,P., Yu,S., Zhang,J., Wang,T. and Jia,G.
  TITLE     miR-3940-5p associated with genetic damage in workers exposed to
            hexavalent chromium
  JOURNAL   Toxicol Lett 229 (1), 319-326 (2014)
   PUBMED   24973494
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Belle,J.I. and Nijnik,A.
  TITLE     H2A-DUBbing the mammalian epigenome: expanding frontiers for
            histone H2A deubiquitinating enzymes in cell biology and physiology
  JOURNAL   Int J Biochem Cell Biol 50, 161-174 (2014)
   PUBMED   24647359
  REMARK    Review article
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Zheng,H., Gupta,V., Patterson-Fortin,J., Bhattacharya,S.,
            Katlinski,K., Wu,J., Varghese,B., Carbone,C.J., Aressy,B.,
            Fuchs,S.Y. and Greenberg,R.A.
  TITLE     A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates
            interferon responses
  JOURNAL   Cell Rep 5 (1), 180-193 (2013)
   PUBMED   24075985
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Cooper,E.M., Cutcliffe,C., Kristiansen,T.Z., Pandey,A.,
            Pickart,C.M. and Cohen,R.E.
  TITLE     K63-specific deubiquitination by two JAMM/MPN+ complexes:
            BRISC-associated Brcc36 and proteasomal Poh1
  JOURNAL   EMBO J 28 (6), 621-631 (2009)
   PUBMED   19214193
REFERENCE   7  (bases 1 to 2568)
  AUTHORS   Shao,G., Lilli,D.R., Patterson-Fortin,J., Coleman,K.A.,
            Morrissey,D.E. and Greenberg,R.A.
  TITLE     The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes
            RNF8-Ubc13-dependent ubiquitination events at DNA double strand
            breaks
  JOURNAL   Proc Natl Acad Sci U S A 106 (9), 3166-3171 (2009)
   PUBMED   19202061
REFERENCE   8  (bases 1 to 2568)
  AUTHORS   Sato,N., Sugimura,Y., Hayashi,Y., Murase,T., Kanou,Y., Kikkawa,F.
            and Murata,Y.
  TITLE     Identification of genes differentially expressed in mouse fetuses
            from streptozotocin-induced diabetic pregnancy by cDNA subtraction
  JOURNAL   Endocr J 55 (2), 317-323 (2008)
   PUBMED   18323671
REFERENCE   9  (bases 1 to 2568)
  AUTHORS   Sobhian,B., Shao,G., Lilli,D.R., Culhane,A.C., Moreau,L.A., Xia,B.,
            Livingston,D.M. and Greenberg,R.A.
  TITLE     RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage
            sites
  JOURNAL   Science 316 (5828), 1198-1202 (2007)
   PUBMED   17525341
REFERENCE   10 (bases 1 to 2568)
  AUTHORS   Dong,Y., Hakimi,M.A., Chen,X., Kumaraswamy,E., Cooch,N.S.,
            Godwin,A.K. and Shiekhattar,R.
  TITLE     Regulation of BRCC, a holoenzyme complex containing BRCA1 and
            BRCA2, by a signalosome-like subunit and its role in DNA repair
  JOURNAL   Mol Cell 12 (5), 1087-1099 (2003)
   PUBMED   14636569
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166833.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_237593.3, XM_001059392.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC166833.1, EV764664.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..2568
                     /gene="Brcc3"
                     /gene_synonym="Brcc3l1"
                     /note="BRCA1/BRCA2-containing complex subunit 3"
                     /db_xref="GeneID:316794"
                     /db_xref="RGD:1588543"
     exon            1..2543
                     /gene="Brcc3"
                     /gene_synonym="Brcc3l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..890
                     /gene="Brcc3"
                     /gene_synonym="Brcc3l1"
                     /EC_number="3.1.2.15"
                     /note="BRISC complex subunit BRCC36; BRCA1-A complex
                     subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36;
                     BRCA1/BRCA2-containing complex, subunit 3 like 1"
                     /codon_start=1
                     /product="lys-63-specific deubiquitinase BRCC36"
                     /protein_id="NP_001120772.1"
                     /db_xref="GeneID:316794"
                     /db_xref="RGD:1588543"
                     /translation="MAVPVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELND
                     DVRSESKFAHAGSDVCTVPEKVDSIRVVHIHSVIILRRSDKRKDRVEISPEQLSAAST
                     EAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIED
                     KNTKTGRVLYTCFQSVQAQKSSDYERIEIPVHVVPHVTIGKVCLESAVELPKILCQEE
                     QDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLREL
                     QREKEELMAELRSLE"
ORIGIN      
        1 tgaacgggga gacgatggcg gtgccggtgg ttcaggccgt gcaggctgtc catctggagt
       61 cggacgcctt tctggtttgt ctgaaccacg ccctgagtac ggagaaagag gaggtgatgg
      121 gtctgtgcat cggggagctg aacgacgacg taaggagtga gtccaaattc gcacacgccg
      181 gaagtgacgt gtgcacggtt ccggagaagg tggattcgat cagagtcgtc cacatccact
      241 cggtcatcat cctgcgccgt tctgacaaga ggaaggaccg cgtggagatt tccccagagc
      301 agctgtctgc agcctcgact gaggcggaaa ggttggcgga actcactggc cgtcccatga
      361 gagtcgtcgg ctggtaccat tcgcaccctc acataacggt gtggccttca cacgtggatg
      421 ttcgcacgca agccatgtac caaatgatgg accaaggctt cgtgggactt attttctcct
      481 gtttcataga agacaagaac acaaagaccg gacgtgtcct ctacacttgc ttccaatccg
      541 tacaagccca gaaaagctca gactatgaga gaatcgaaat ccccgtccac gtcgttcccc
      601 acgtcaccat cgggaaagtt tgcctggagt ccgcggtgga gctgccgaag atcctgtgtc
      661 aggaggagca ggacgcgtac aggcggatcc atagcctcac acatctggac tcggtgacca
      721 agatccacaa tggctcggtc ttcaccaaga atctgtgcag ccagatgtcg gcggtgagtg
      781 ggcctctgct gcagtggtta gaggacagat tggagcaaaa ccagcagcat ctgcgggagc
      841 tgcagcggga gaaggaggag ctcatggcgg agctgcgttc gctcgaataa atcgagggag
      901 cagcaaaaaa aaatccgggc ggggggacgt ggagtgaacg gaaatacctc gagtacaatt
      961 tattaaacaa aaatcaattt tgaaaaagat aaagtcggag ggcctacatt aacataactt
     1021 caagatttat tattgtaaag ctacagtgat caagatacga tgatatttgc agaagaatca
     1081 atgcaacagg gaagaaaatc cggaaataaa cccaacaata atgtgcttaa ctacgtttga
     1141 aaaagtacaa atgtgattca aagaggaaaa gacagtcatt tatttcaaca aatcaaacct
     1201 tctcaagcta acaaaatata tacaataaat aaatatgtaa aagagtctct gaatgtatca
     1261 cggatttaaa tccaatatgg aagacttagg gaaaaaagtt attccaaaaa agttttcagg
     1321 acttaaggac ttaacatttt caactccaaa gcacaatatc acaagaaaac aaagtagaga
     1381 gattggactt tgttaaaatt aaagctgttt attctgcaga aagatgaaga ggaaaccgtc
     1441 ggtgaaaaag atgtgtctga aactcgaaag taaatagcac cagtagaaat gaaaagagac
     1501 gtaaacattg tcactaaaaa tggtgaaaat agcaaatcct gttgaggggg caaatgagat
     1561 tcctcaccag tgacgggaat gtaaaaattc atcgactggg tagaaaagtt tggaaatttt
     1621 ttttaagtta aacatacact tagcatgacc cagccaccaa gctgcactgt cttggtacaa
     1681 aaacttttac aaaatttttc ttggtagttt tatctgtgga agctgcaaat cagaaacagc
     1741 ccagattttc tacagtgagt ccacagctaa agaaaccgtt cttatggtgg aatattactg
     1801 tgtaggaaaa aggaacatac cgcctaatgg ttttgtcact gaactacatc tcagcctgac
     1861 ttaactggat ttggaatcat gtaaatacaa cgtgtacatg aaggtgtttt caaaaaagtt
     1921 ttaagtgggg agagaagact gatctttaac gtaggtgaca ccattccatg gggtagggcc
     1981 ccagactgaa taaaaagaag ggaatgatca gatcatcagg tctgtcaaac atggaatata
     2041 tgccttcaaa ttgtgagcca agataaaccc taccttacat aagttgcttt tagcaggtct
     2101 tttgtcaaag aaataaaaaa gtaaaaaagc agtgacagtg acctgtcatc taagatggct
     2161 ctacccatca aaactacctt ttaaaattga caaaaatacg tatgccagtt ccagttttca
     2221 tgtgcttagc agattgatgt tcattttctt ttgctggtga aaagtggctc ctttaaaaca
     2281 aataccctaa agatagttgg atcttgattt ttaatccagc aagcaagttt tcatttcttc
     2341 attggtaaat caggtttatt tgcatttaag attatacatg gaagatgatt acttatttta
     2401 actactttgt tcattgattt tctggttgac tgtttattgt tttctttctc tccatttggg
     2461 gtttgcttgt ttacttagaa atcacctgat cattgcaaaa tagaagactt tttaaaatta
     2521 aaaataaaaa aaaaatcaat attaaaaaaa aaaaaaaaaa aaaaaaaa
//
