LOCUS       NM_031542              10350 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus BRCA2, DNA repair associated (Brca2), mRNA.
ACCESSION   NM_031542 NM_001007717 XM_346422
VERSION     NM_031542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10350)
  AUTHORS   Riahi,A., Messaoudi,A., Mrad,R., Fourati,A., Chabouni-Bouhamed,H.
            and Kharrat,M.
  TITLE     Molecular characterization, homology modeling and docking studies
            of the R2787H missense variation in BRCA2 gene: Association with
            breast cancer
  JOURNAL   J Theor Biol 403, 188-196 (2016)
   PUBMED   27211102
REFERENCE   2  (bases 1 to 10350)
  AUTHORS   Linjawi,S.A., Khalil,W.K., Hassanane,M.M. and Ahmed,E.S.
  TITLE     Evaluation of the protective effect of Nigella sativa extract and
            its primary active component thymoquinone against DMBA-induced
            breast cancer in female rats
  JOURNAL   Arch Med Sci 11 (1), 220-229 (2015)
   PUBMED   25861310
REFERENCE   3  (bases 1 to 10350)
  AUTHORS   Yin,J., Liu,H., Liu,Z., Wang,L.E., Chen,W.V., Zhu,D., Amos,C.I.,
            Fang,S., Lee,J.E. and Wei,Q.
  TITLE     Genetic variants in fanconi anemia pathway genes BRCA2 and FANCA
            predict melanoma survival
  JOURNAL   J Invest Dermatol 135 (2), 542-550 (2015)
   PUBMED   25243787
REFERENCE   4  (bases 1 to 10350)
  AUTHORS   Shahid,T., Soroka,J., Kong,E., Malivert,L., McIlwraith,M.J.,
            Pape,T., West,S.C. and Zhang,X.
  TITLE     Structure and mechanism of action of the BRCA2 breast cancer tumor
            suppressor
  JOURNAL   Nat Struct Mol Biol 21 (11), 962-968 (2014)
   PUBMED   25282148
REFERENCE   5  (bases 1 to 10350)
  AUTHORS   Moran,A., O'Hara,C., Khan,S., Shack,L., Woodward,E., Maher,E.R.,
            Lalloo,F. and Evans,D.G.
  TITLE     Risk of cancer other than breast or ovarian in individuals with
            BRCA1 and BRCA2 mutations
  JOURNAL   Fam Cancer 11 (2), 235-242 (2012)
   PUBMED   22187320
REFERENCE   6  (bases 1 to 10350)
  AUTHORS   Sharan,S.K., Morimatsu,M., Albrecht,U., Lim,D.S., Regel,E.,
            Dinh,C., Sands,A., Eichele,G., Hasty,P. and Bradley,A.
  TITLE     Embryonic lethality and radiation hypersensitivity mediated by
            Rad51 in mice lacking Brca2
  JOURNAL   Nature 386 (6627), 804-810 (1997)
   PUBMED   9126738
REFERENCE   7  (bases 1 to 10350)
  AUTHORS   Milner,J., Ponder,B., Hughes-Davies,L., Seltmann,M. and
            Kouzarides,T.
  TITLE     Transcriptional activation functions in BRCA2
  JOURNAL   Nature 386 (6627), 772-773 (1997)
   PUBMED   9126734
REFERENCE   8  (bases 1 to 10350)
  AUTHORS   Miyakawa,T., Yagi,T., Kagiyama,A. and Niki,H.
  TITLE     Radial maze performance, open-field and elevated plus-maze
            behaviors in Fyn-kinase deficient mice: further evidence for
            increased fearfulness
  JOURNAL   Brain Res Mol Brain Res 37 (1-2), 145-150 (1996)
   PUBMED   8738145
REFERENCE   9  (bases 1 to 10350)
  AUTHORS   Jensen,R.A., Thompson,M.E., Jetton,T.L., Szabo,C.I., van der
            Meer,R., Helou,B., Tronick,S.R., Page,D.L., King,M.C. and Holt,J.T.
  TITLE     BRCA1 is secreted and exhibits properties of a granin
  JOURNAL   Nat Genet 12 (3), 303-308 (1996)
   PUBMED   8589722
REFERENCE   10 (bases 1 to 10350)
  AUTHORS   Wooster,R., Bignell,G., Lancaster,J., Swift,S., Seal,S.,
            Mangion,J., Collins,N., Gregory,S., Gumbs,C. and Micklem,G.
  TITLE     Identification of the breast cancer susceptibility gene BRCA2
  JOURNAL   Nature 378 (6559), 789-792 (1995)
   PUBMED   8524414
  REMARK    Erratum:[Nature 1996 Feb 22;379(6567):749]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Sep 27, 2011 this sequence version replaced NM_031542.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89653.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               JAXUCZ010000012.1  4895447-4895607
            162-245             JAXUCZ010000012.1  4895700-4895783
            246-473             JAXUCZ010000012.1  4898807-4899034
            474-582             JAXUCZ010000012.1  4900643-4900751
            583-632             JAXUCZ010000012.1  4901256-4901305
            633-673             JAXUCZ010000012.1  4901597-4901637
            674-779             JAXUCZ010000012.1  4901823-4901928
            780-829             JAXUCZ010000012.1  4903446-4903495
            830-941             JAXUCZ010000012.1  4904214-4904325
            942-2036            JAXUCZ010000012.1  4904941-4906035
            2037-6908           JAXUCZ010000012.1  4907479-4912350
            6909-7004           JAXUCZ010000012.1  4913700-4913795
            7005-7074           JAXUCZ010000012.1  4915934-4916003
            7075-7403           JAXUCZ010000012.1  4916605-4916933
            7404-7585           JAXUCZ010000012.1  4918781-4918962
            7586-7773           JAXUCZ010000012.1  4920296-4920483
            7774-7944           JAXUCZ010000012.1  4921013-4921183
            7945-8299           JAXUCZ010000012.1  4922432-4922786
            8300-8455           JAXUCZ010000012.1  4923874-4924029
            8456-8600           JAXUCZ010000012.1  4924105-4924249
            8601-8722           JAXUCZ010000012.1  4925310-4925431
            8723-8915           JAXUCZ010000012.1  4927052-4927244
            8916-9079           JAXUCZ010000012.1  4927471-4927634
            9080-9218           JAXUCZ010000012.1  4927728-4927866
            9219-9460           JAXUCZ010000012.1  4933507-4933748
            9461-9619           JAXUCZ010000012.1  4934366-4934524
            9620-10350          JAXUCZ010000012.1  4935464-4936194
FEATURES             Location/Qualifiers
     source          1..10350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p12"
     gene            1..10350
                     /gene="Brca2"
                     /note="BRCA2, DNA repair associated"
                     /db_xref="GeneID:360254"
                     /db_xref="RGD:2219"
     exon            1..161
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            162..245
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..10210
                     /gene="Brca2"
                     /note="breast cancer 2, mutation 1, University of
                     Wisconsin-Madison; breast cancer susceptibility protein 2;
                     fanconi anemia group D1 protein homolog; breast cancer 2,
                     early onset"
                     /codon_start=1
                     /product="breast cancer type 2 susceptibility protein
                     homolog"
                     /protein_id="NP_113730.2"
                     /db_xref="GeneID:360254"
                     /db_xref="RGD:2219"
                     /translation="MTVEYKRRPTFWEIFKARCSTADLGPISLNWFEELSSEAPPYNT
                     EPPEESEYKPQGHEPQLFKTPQRNPSYHQFASTPIMFKEQSQTLPLDQSPFKELGNVV
                     ANSKRKHHSKKKARKDPVVDVASLPLKACPSESPCTPRCTQVAPQRRKPVVSGSLFYT
                     PKLEETPKHISESLGVEVDPDMSWTSSLATPPTLSSTVLIARDEEAHRNAFPADSPAS
                     LKSYFSNHNESLKKNDRFIPSVSDSENKSQQEAFSQGLEKMLGDSSSKINRFRDCLRK
                     PIPNVLEDGETAVDTSGEDSFSLCFPKRRTRNLQKTRMGKMKKKIFSETRTDGLSEEA
                     RGQADDKNSFALEIEPRDSEPLDPSVTNQKPLYSQSGDISSEAGQCSDSIWSQPDPSG
                     LNGTQTRKIPLLHISSHKQSILEDFIDMKKEGTGSITFPHISSLPEPEKMFSEETLVD
                     KEHEGQHLESLEDSISGKQMVSGTSQTACLSPSIRKSIVKMREPLEETLDTVFSDSMT
                     SSAFTEELDASAGGLEIHTACSQREDSLCPSSVDTGSWPTTLTDTSATVKNAGLITTL
                     KNKRRKFIYSVSDDASHQGKKLQTQRQSELTNLSAPFEASAFEVPFPFTNVDSGIPDS
                     SIKRSNLPNDPEEPSLSLTNSFVTAASKEISYIHALISQDLNDKEAILSEEKPQPYTA
                     LEADFLSCLPERSCENDQKSPKVSDRKEKVLVSACRPSGRLAAAVQLSSISFDSQENP
                     LGSHNVTSTLKLTPSPKTPLSKPVVVSRGKMCKMPEKLQCKSCKDNIELSKNIPLGVN
                     EMCVLSENSETPELLPPLEYITEVSSSVKSQFNQNTKIAVVQKDQKDSTFISEVTVHM
                     NSEELFPEKENNFAFQVTNESNKPNIGSTVEFQEEDLSHTKGHSLKNSPMTVDRDLDD
                     EQAGQVLITEDSDSLAVVHDCTKKSRNTIEQHQKGTADKDFKSNSSLYLKSDGNNDYL
                     DKWSEFLDPLMNHKFGGSFRTASNKEIKLSEDNVKKSKMFFKDIEEQYPTSLDCIDTV
                     STLQLANKKRLSEPHTFDLKSGTTVSTQCHSQSSVSHEDTHTAPQMLSSKQDFHSSHN
                     LTPSQKAEITELSTILEESGSQFEFTQFKNPSHIAQNNTSAVLGNQMAVVRTASEEWK
                     DVDLHLPLNPSSVGQIDHNKKFECLVGVKQSSSHLLEDTCNQNTSCFLPIKEMEFGGF
                     CSALGTKLSVSNEALRKAMKLFSDIENISEEPSTKVGPRGFSSCAHHDSVASVFKIKK
                     QNTDKSFDEKSSKCQVTVQNNKEMTTCILVDENPENYVKNIKQDNNYTGSQRNAYKLE
                     NSDVSKSSTSGTVYINKGDSDLPFAAEKGNKYPESCTQYVREENAQIKESVSDLTCLE
                     VMKAEETCHMKSSDKEQLPSDKMEQNMKEFNISFQTASGKNIRVSKESLNKSVNILDQ
                     ETEDLTVTSDSLNSKILCGINKDKMHISCHKKSINIKKVFEEHFPIGTVSQLPALQQY
                     PEYEIESIKEPTLLSFHTASGKKVKIMQESLDKVKNLFDETQYVRKTTNFGHQESKPL
                     KDREDYKERLTLAYEKIEVTASKCEEMQNFVSKQTEMLPQQNDHMYRQTENLTSNGSS
                     PKVHGNIENKIEKNPRICCICQSSYFVTEDSALACYTGDSRKTCVGESSLSKGKKWLR
                     EQSDKLGTRNTIEIQCVKEHTEDFAGNALYEHSLVIIRTEIDTSHVSENQASTLFSDP
                     NVCHSYLSHSSFCHHDDMHNDSGYFLKDKIDSDVQPDMKNTEGNAIFPKISATKEIKL
                     HPQTVNEECVQKLETNASPYANKNIAIDSAMLDLRNCKVGSPVFITTHSQETVRMKEI
                     FTDNCSKIVEQNRESKPDTCQTSCHKALDNSEDFICPSSSGDVCINSPMAIFYPQSEQ
                     ILQHNQSVSGLKKAATPPVSLETWDTCKSIRGSPQEVHPSRTYGIFSTASGKAVQVSD
                     ASLEKARQVFSEIDGDAKQLASMVSLEGNEKSHHSVKRESSVVHNTHGVLSLRKTLPG
                     NVSSSVFSGFSTAGGKLVTVSESALHKVKGMLEEFDLIRTEHTLQHSPTPEDVSKIPP
                     QPCLESRTPEYSVSSKLQKTYNDKSRSPSNYKESGSSGNTQSLEVSPQLSQMERKQET
                     QSVLGTKVSQRKTNILEKKQNLPQNIKIESNKMETFSDVSMKTNVGEYYSKEPENYFE
                     TEAVEIAKAFMEDDELTDSEQTHAKCSLFACPQNEALLNSRTRKRGGMAGVAVGQPPI
                     KRSLLNEFDRIIESKGKSLTPSKSTPDGTIKDRRLFTHHMSLEPVTCGPFCSSKERQE
                     TQSPHVTSPAQGLQSKGHPSRHSAVGKSSSNPTVSALRSERTRHSVSDKSTKVFVPPF
                     KVKSRFHRDEHFDSKNVNLEGKNQKSADGVSEDGNDSDFPQFNKDLMSSLQNARDLQD
                     IRIKNKERHHLCPQPGSLYLTKSSTLPRISLQAAVGDSVPSACSPKQLYMYGVSKACI
                     SVNSKNAEYFQFAIEDHFGKEALCAGKGFRLADGGWLIPSDDGKAGKEEFYRALCDTP
                     GVDPKLISSVWVSNHYRWIVWKLAAMEFAFPKEFANRCLNPERVLLQLKYRYDVEIDN
                     SSRSALKKILERDDTAAKTLVLCVSDIISLSTNVSETSGSKASSEDSNKVDTIELTDG
                     WYAVKAQLDPPLLALVKSGRLTVGQKIITQGAELVGSPDACAPLEAPDSLRLKISANS
                     TRPARWHSKLGFFHDPRPFPLPLSSLFSDGGNVGCVDVIVQRVYPLQWVEKTVSGSYI
                     FRNEREEEKEALRFAEAQQKKLEALFTKVHTELKEHEEDIAQRRVLSRALTRQQVHAL
                     QDGAELYAAVQDASDPEHLETCFSEEQLRALNNYRQMLSDKKQARIQSEFRKALEAAE
                     KEEGLSRDVSTVWKLRVTSYKKREKSALLSIWRPSSDLPSLLTEGQRYRIYHLSVSKS
                     KNKFEWPSIQLTATKRTQYQQLPVSSETLLQLYQPRELLPFSKLSDPAFQPPCSEVDV
                     VGVVVSVVKPIGLAPLVYLSDECLHLLVVKFGIDLNEDIKPRVLIAASNLQWRPESTS
                     RVPTLFAGNFSVFSASPKEAHFQERVTNMKHAIENIDTFYKEAEKKLIQVLKGDSPKW
                     STPNKDPTREPYPASTCSASDLASGGQLPRSSPTDQQSYRSPLSCCTPTGKSTPLAHS
                     AWMAAKSCSGENEIEDPKTCRKKRALDLLSRLPLPPPLSPVCTFVSPAAQKAFQPPRS
                     CGTKYPTPLKKEGPSSPWSRAPFQKASGVSLLDCDSVADEELALLSTQALVPHSVGGS
                     EQVFPSDSTRTEGPSASTEARPANRSKRESLRDCRDDSDGKLAAETVPDYS"
     exon            246..473
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            474..582
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..632
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..673
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..779
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..829
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..941
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..2036
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..6908
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            6909..7004
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            7005..7074
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            7075..7403
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            7404..7585
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            7586..7773
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            7774..7944
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            7945..8299
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            8300..8455
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            8456..8600
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            8601..8722
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            8723..8915
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            8916..9079
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            9080..9218
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            9219..9460
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            9461..9619
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
     exon            9620..10350
                     /gene="Brca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtaattag ttaacgtgaa tacttttaaa tgacgttaag tttttctggt tattggctcc
       61 caccatatcc gctttcgggt gcagtttggt tcgaagcaca attataatct ctccccatct
      121 tcatgataag ttctgttctt gccccaaaag atgggcctaa gacttcttta ccaagaacat
      181 gaccgttgaa tacaaaagga gaccaacttt ttgggaaatt tttaaagcga gatgcagcac
      241 agcagattta ggaccaataa gcctcaattg gtttgaagaa ctttcttcag aagccccacc
      301 atataatact gaacctccag aagaatctga atataaaccc caaggccatg aaccacagct
      361 atttaaaaca ccacagagga atccctctta ccatcagttt gcttcaactc caataatgtt
      421 caaagaacaa agtcaaactc taccactaga ccagtcacct ttcaaagaat tagggaatgt
      481 tgttgcaaat agtaaacgta aacatcacag caaaaagaag gccagaaagg accctgtggt
      541 agatgttgcc agtctgccgc tgaaagcttg tcccagtgaa agcccttgta ctccgcgatg
      601 cacacaggtg gcaccgcagc gaagaaagcc agtggtatct ggaagtttat tctatacacc
      661 aaaacttgag gagacaccaa aacatatttc tgaaagtctg ggagttgaag tggatccgga
      721 tatgtcttgg acaagttcat tagctacacc accaaccctt agttccactg tgctcatagc
      781 ccgagatgaa gaagcacaca gaaatgcatt tccagccgac tctcctgcta gtttgaaaag
      841 ctatttttct aaccacaatg aaagtctgaa aaagaatgat agatttattc cctctgtgtc
      901 tgacagtgaa aacaaaagcc agcaagaagc ttttagtcag ggactggaga aaatgttagg
      961 ggattcatct agcaaaataa atcgcttcag agactgcctt agaaaaccaa taccaaatgt
     1021 tctagaagat ggggagacag ctgtagatac ttcaggagaa gatagtttct cgttatgttt
     1081 tcctaaacgt agaaccagaa atctacagaa aacgagaatg ggcaagatga agaagaaaat
     1141 cttcagtgaa acaaggactg atggattaag tgaagaagcc agaggacaag ctgatgataa
     1201 aaactcattt gcacttgaaa ttgaaccaag agatagtgag cccttagatc catctgtaac
     1261 aaaccagaag cccctttaca gccagagtgg ggacatctcc agtgaagctg gccagtgttc
     1321 agacagtata tggtctcagc cagatccctc tggtctaaat ggaacccaga caagaaaaat
     1381 acccctactc catatttctt ctcataagca aagtatttta gaagacttca tagatatgaa
     1441 gaaggaaggt actggctcta ttacttttcc tcatatttct agtcttccag aaccagaaaa
     1501 gatgttcagt gaggaaactc tggtagacaa ggaacatgaa ggacagcatc ttgagtcact
     1561 tgaagactcc atctcaggga aacaaatggt gtctggaacg agtcaaacag cctgtctctc
     1621 tccgagtatc aggaagtcta tagtcaagat gagagagcca cttgaagaga ctttggatac
     1681 tgttttctca gacagtatga ccagctcagc ctttacagaa gaacttgacg cctctgcagg
     1741 gggactggaa atacatactg catgctcaca gagagaggat tctttatgtc ctagttcagt
     1801 ggacactgga agctggccaa ccactctcac tgacacttct gcaactgtga aaaatgcagg
     1861 tttaataacc actctcaaaa ataaaagaag aaagtttatt tactctgtaa gtgatgatgc
     1921 atctcatcaa ggaaaaaaac tacagacaca gagacagtca gagcttacta acctttcagc
     1981 cccgtttgaa gcaagtgctt ttgaagtacc attccccttt acaaatgtag attcaggtat
     2041 accagattct tcaatcaaaa gaagcaattt accaaatgat cctgaagagc catctttgtc
     2101 cttgaccaac tcttttgtga ctgctgccag taaagaaatt agttatattc atgcattgat
     2161 atctcaggat ctaaatgaca aagaagcaat actcagtgaa gaaaagccac agccatatac
     2221 agccctagaa gctgactttc tgtcgtgctt gccagaaaga tcatgtgaaa atgatcaaaa
     2281 aagtccaaaa gtttccgacc gaaaagaaaa agtcttagtc tcagcatgtc gtccttcagg
     2341 aaggcttgca gcagcagtgc agctcagcag cattagcttt gactctcagg aaaaccctct
     2401 tggtagccac aacgtaacaa gtactcttaa attaactccc agcccgaaga cacctctgtc
     2461 aaagccagtt gtggtttcta gagggaaaat gtgtaaaatg ccagagaaac tgcaatgtaa
     2521 gagttgtaaa gataatattg aattaagcaa aaacatccct ctgggggtta atgaaatgtg
     2581 tgtcttaagt gaaaattctg aaacacctga gcttctgcca cctctagaat atataacaga
     2641 agtgtcctca tcagtgaagt cacagttcaa tcaaaataca aaaatagcag tcgtacaaaa
     2701 ggaccaaaaa gactcaactt ttatttcaga agtaacagtc catatgaatt ctgaagaact
     2761 tttcccagaa aaggagaata attttgcttt tcaagtaacc aatgaaagca ataaacccaa
     2821 tataggaagt actgtggaat tccaggaaga agacctcagc cacacaaaag ggcatagtct
     2881 caagaactct cccatgacag tagatagaga cctagatgat gagcaagcag gccaagtgtt
     2941 gattacagag gactcagatt cattagcagt agtccatgat tgtacaaaga agagcagaaa
     3001 tactatagag cagcatcaga aaggaactgc agacaaagac ttcaagtcaa attcctcctt
     3061 gtatttgaaa tcagatggga acaatgatta tttagacaaa tggtcagagt tcttggatcc
     3121 actcatgaac cataaatttg gaggtagctt cagaacagct tccaataaag aaataaaact
     3181 ttcagaggat aatgtcaaga aaagcaaaat gttcttcaaa gatatcgaag aacagtatcc
     3241 tactagttta gattgtattg acactgttag taccctacaa ttagcaaaca agaagagact
     3301 aagtgaacct catacatttg atttgaagtc aggtactact gtatctacac agtgtcatag
     3361 tcaatcatct gtttctcatg aagatactca cacagcacct cagatgttat cttcaaagca
     3421 agattttcat tcaagtcata acttaacgcc cagccaaaaa gcagaaatta cagaactgtc
     3481 tactatcttg gaagaatcag gaagtcagtt tgaattcaca cagttcaaaa atccaagcca
     3541 catagcacag aataatacat ctgcagtgct tggaaaccag atggctgttg taaggaccgc
     3601 ttctgaggag tggaaagatg ttgatcttca tctcccactg aatccctcct ctgtaggtca
     3661 gatagatcac aacaagaaat tcgaatgttt ggttggagtt aagcaaagct cttctcacct
     3721 gttagaagac acttgtaacc aaaatacatc ttgtttttta ccgataaaag aaatggagtt
     3781 tggaggattt tgttctgctc ttggcacaaa acttagtgtg tctaatgagg ctctgagaaa
     3841 ggctatgaaa ctgttcagtg acattgaaaa tattagtgag gagccttcta caaaagtagg
     3901 accaagagga ttctcttcat gtgcacatca tgattctgtt gcttccgtgt ttaagataaa
     3961 gaaacaaaac actgataaaa gttttgatga gaaatctagt aagtgccagg taacagtaca
     4021 aaataataag gaaatgacta cctgtattct tgttgatgaa aatcctgaaa attatgtaaa
     4081 gaatataaaa caagataaca actatactgg ctctcaaaga aatgcttata aattagaaaa
     4141 ctctgatgtt agtaaatcaa gtacaagtgg cacagtttat attaataaag gtgacagtga
     4201 tttacctttt gctgctgaaa aaggcaataa gtatcctgag tcatgtaccc aatatgtgag
     4261 ggaagaaaat gcacaaatta aggaaagtgt atcagattta acatgtttgg aagtcatgaa
     4321 agctgaggaa acatgtcata tgaaatcttc agataaagaa caattacctt cagataagat
     4381 ggaacaaaat atgaaagagt ttaatatatc ttttcagact gcaagcggga aaaatatcag
     4441 agtctccaaa gagtcactaa ataaaagtgt gaatatttta gatcaggaaa cagaagactt
     4501 gactgtcact tcagattctt tgaattctaa aattctttgt ggcataaata aggacaaaat
     4561 gcatatttca tgtcacaaga aatcaatcaa tattaaaaag gtatttgaag aacatttccc
     4621 aattggaact gtcagtcaat taccagctct tcagcagtat cctgaatatg aaatagaaag
     4681 tatcaaagaa cctactctgt tgagttttca tacagctagt gggaaaaaag tcaaaattat
     4741 gcaggaatct ttggacaaag tgaaaaatct ttttgatgag acacagtatg ttaggaaaac
     4801 caccaatttt ggtcatcaag aatcaaaacc cctgaaggac agagaggact ataaagaaag
     4861 acttacatta gcatatgaga aaattgaagt aactgcctca aaatgtgaag aaatgcagaa
     4921 ctttgtctct aagcagactg aaatgctacc ccagcaaaat gatcatatgt ataggcaaac
     4981 tgaaaatctc acatcaaatg gtagctctcc caaagtacat ggaaacatag aaaataaaat
     5041 agaaaagaat cctagaattt gctgtatttg tcagtcctca tactttgtca ctgaagattc
     5101 tgctttggca tgttatacgg gggacagtag aaaaacttgt gtcggagagt cttctctgtc
     5161 caaaggcaaa aaatggctta gagaacaaag tgataagctt ggaacaagaa atactattga
     5221 aatccaatgt gtaaaggaac acactgaaga ttttgcagga aatgccttat atgaacatag
     5281 tttagtcatt atcagaactg aaattgatac aagtcatgtc tctgaaaacc aagcttcaac
     5341 cctctttagt gaccctaatg tgtgtcacag ctatctatcc cattctagtt tttgtcatca
     5401 tgatgatatg cataatgatt caggatattt cttaaaagat aaaattgatt ctgatgtcca
     5461 gccagacatg aagaatactg aaggcaatgc cattttccct aaaatatctg ctacaaaaga
     5521 aataaaacta cacccacaaa ctgtaaatga agagtgtgtt caaaaactgg agactaatgc
     5581 ttcaccatat gcaaataaaa atatagccat tgactcagct atgctggatt taaggaattg
     5641 taaggtaggc tcacctgtat tcattacaac tcattcacaa gaaactgtaa gaatgaaaga
     5701 gatattcaca gataactgta gtaaaatagt cgaacaaaac agggagagta aaccagacac
     5761 ttgccagaca agctgtcata aagcattgga taattcagag gattttatat gtcctagctc
     5821 ttcaggtgat gtctgcataa actcacctat ggctattttt tatcctcaaa gtgaacaaat
     5881 tttacagcat aaccaaagtg tgtctggact gaagaaagct gcaacaccac ctgttagttt
     5941 ggaaacttgg gatacatgta aatctataag aggatctcct caggaagtcc atccttcacg
     6001 cacttatgga atttttagca cagcaagtgg aaaagctgta caagtatctg atgcttcatt
     6061 ggaaaaggca cggcaagtgt tttctgagat agatggtgat gctaaacagt tagcttccat
     6121 ggtgtcactg gaaggtaatg aaaaatcaca tcactctgtg aaaagagaaa gctctgtggt
     6181 gcataacacc catggtgtat tgtcactccg aaaaaccctc ccaggcaatg tcagttcatc
     6241 tgtattctct ggatttagca ccgcaggtgg aaaactggtc acagtttcag aaagtgcttt
     6301 acataaagtt aaaggaatgt tagaggaatt tgatttgatc agaactgaac atactctcca
     6361 gcattcacct acacctgaag acgtatcaaa aatacctcct caaccttgtc ttgaaagcag
     6421 aaccccagaa tactctgtaa gctctaaatt gcagaaaacc tacaatgata aatccaggtc
     6481 accaagtaat tataaagaaa gtggttcttc aggcaatact caatctcttg aagtttctcc
     6541 ccaactctct cagatggaga gaaagcaaga aacacagtcg gtattaggaa caaaagtgtc
     6601 ccagaggaag actaatatct tggaaaaaaa acaaaactta ccccaaaaca taaaaataga
     6661 aagtaataaa atggaaacat tttctgatgt ttccatgaaa acaaatgtag gagagtacta
     6721 ctccaaagag ccagagaact attttgaaac agaagcagtg gaaattgcca aagcttttat
     6781 ggaagatgat gagctgacgg attctgaaca gactcatgcc aaatgctcac tgtttgcatg
     6841 cccccaaaac gaggctttat taaattcgag aactagaaaa agaggaggaa tggctggtgt
     6901 tgcagttgga caacccccaa ttaaaaggag cttattaaat gaatttgaca ggataataga
     6961 aagtaaagga aaatccttaa cgccttcaaa aagcactcca gatggcacaa taaaagacag
     7021 acgattgttc acacaccaca tgtctttaga gccggttacc tgtggaccct tctgctcaag
     7081 taaagaaagg caagaaaccc agagcccaca tgttacctca cctgctcaag gacttcagtc
     7141 taaggggcat ccttcaagac actcagctgt gggaaagtct tcaagcaatc ctacagtttc
     7201 tgccctaaga tctgaaagga ccagacactc agtctcagac aaatccacca aagtctttgt
     7261 cccacctttc aaggtgaaat cacggtttca cagagatgaa cattttgata gcaagaatgt
     7321 taatttggag ggaaaaaacc aaaagagcgc agatggagtc agtgaagatg ggaacgacag
     7381 tgactttcct cagtttaaca aagatttaat gtcaagcctt cagaatgcca gagacctaca
     7441 ggatatacga attaaaaaca aagaaaggca tcatctctgt ccgcagccag gcagtctgta
     7501 tcttacaaaa tcatccaccc tgccccggat ttctctgcag gccgcagtag gagacagcgt
     7561 tccttctgcc tgttctccta agcagctcta tatgtatggc gtttctaaag catgcataag
     7621 cgttaacagc aaaaacgctg agtattttca gtttgccatt gaggatcact ttggtaaaga
     7681 agctctgtgc gctggcaaag gctttcggtt ggcagatggt ggatggctaa tcccctccga
     7741 tgacgggaag gctgggaaag aagaatttta cagggctctg tgtgacactc caggtgtgga
     7801 tccaaagctg atttctagcg tctgggtctc taaccactac aggtggattg tatggaaact
     7861 ggcagctatg gaatttgctt ttcctaagga attcgcgaat agatgtctaa acccagagcg
     7921 agtgctgctt caactaaaat acagatacga tgtggaaatt gacaatagca gcagatcagc
     7981 tctcaagaag atactggaaa gggatgatac agcagcaaaa acgcttgtcc tctgtgtttc
     8041 tgatatcatt tcactaagca caaatgtgtc tgaaacttca ggcagtaaag ctagcagtga
     8101 ggacagtaac aaagtagaca cgatcgaact cacagatggg tggtatgctg tcaaggccca
     8161 gctagaccct ccactcctgg ctctcgtaaa gagtgggaga ctcactgtgg gtcagaagat
     8221 cattactcag ggagcagagc tggtgggctc tcccgatgcc tgtgcacctc tggaagcccc
     8281 agactccctt aggctaaaga tttctgcaaa cagcacgcgg cctgctcgct ggcacagcaa
     8341 gctggggttc tttcatgacc ccaggccctt ccctctgccc ttgtcctcac tgttcagtga
     8401 tggaggaaat gttggttgtg tggatgtcat cgttcagaga gtgtaccctc tacagtgggt
     8461 ggagaagacg gtgtctggat cgtacatatt tcgtaatgag agagaggagg agaaggaagc
     8521 gctgagattt gcagaggccc agcagaagaa actagaggcc ttgttcacca aagtccacac
     8581 agagcttaaa gagcatgaag aagacatagc ccagcggcgt gtgctgtccc gggcactcac
     8641 acggcagcag gtccacgctc tgcaggacgg tgcagagctc tatgcagcag tgcaggatgc
     8701 atcagaccca gagcacctgg agacttgttt cagcgaagag cagctgagag ccttgaacaa
     8761 ctacagacaa atgctgagcg ataagaaaca agcgcggatc cagtcagagt tccggaaggc
     8821 cctggaggcc gctgagaaag aagagggttt atcaagggac gtctcaactg tgtggaagct
     8881 tcgtgttaca agctacaaga aaagagaaaa atcagctctg ttgagtatct ggcgtccatc
     8941 ttcagacttg ccctccctgt taacagaagg acagagatac agaatctatc atctttcggt
     9001 gtcaaaatcg aagaataaat ttgagtggcc cagcatccag ttaacagcca caaagagaac
     9061 tcagtatcaa cagctgccgg tttccagtga gaccctgctc cagctttacc agcccaggga
     9121 gctccttccc ttcagcaaac tgtcagatcc agccttccag ccaccttgtt ctgaagtgga
     9181 tgtagtagga gttgtagttt ctgttgtaaa accaataggt cttgctcctt tggtctactt
     9241 gtcagacgag tgccttcatt tattagtggt gaaatttgga atagacctta atgaagacat
     9301 aaagccacgt gtgcttattg ctgcgagcaa cctccagtgg cggccggagt ccacgtcacg
     9361 agtgccaact ttatttgctg ggaacttttc cgtattctct gccagtccaa aggaggccca
     9421 ctttcaggag agggtcacga acatgaagca tgctattgag aacatcgaca cattttacaa
     9481 ggaggcagaa aagaagctta tacaggtgct gaagggagac agtccaaagt ggtccacccc
     9541 gaacaaagac cccacccgag aaccctaccc agcctccact tgctctgctt cagaccttgc
     9601 ttcaggaggt cagttaccga ggagttcacc tactgatcag caaagttatc gaagtccttt
     9661 atcatgctgc acaccgacgg ggaaatctac acccctggcc cactcagcct ggatggcagc
     9721 caagtcttgt agtggggaga atgagattga ggaccccaag acctgtcgaa aaaaaagggc
     9781 cttggatctc ctaagtcggc tgcccttacc gccaccgctc agtcctgtct gcacctttgt
     9841 ctctccggct gcacagaagg cctttcagcc accacggagc tgtggcacca aatacccaac
     9901 acctctaaaa aaagagggac ccagttcccc ttggagcagg gcgccatttc agaaggccag
     9961 tggcgtttct ctcctggact gtgattcagt agctgatgaa gaacttgcct tgctcagtac
    10021 ccaagccctt gtgcctcact cagtgggagg aagtgaacaa gtgtttccca gtgattccac
    10081 aaggacagaa ggaccctcag ccagcacaga ggccagacca gcaaatagat ccaagaggga
    10141 gtctctgagg gactgtagag atgacagcga tgggaaattg gctgctgaga cagttccaga
    10201 ctactcataa gtgtccgtgt gtccagacag gaatacactt attgacgcat ttgtttactc
    10261 tacagatgct ctacctggta actctttagg attagacttg atcaccacaa gaattatttt
    10321 gcatacaaaa taaacatagc tttgctttta
//
