LOCUS       NM_012514               6651 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus BRCA1, DNA repair associated (Brca1), mRNA.
ACCESSION   NM_012514 XM_346407
VERSION     NM_012514.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6651)
  AUTHORS   Du,C., Peng,Y., He,Y., Chen,G. and Chen,H.
  TITLE     Low levels of BRCA1 protein expression predict a worse prognosis in
            stage I-II colon cancer
  JOURNAL   Int J Biol Markers 36 (1), 47-53 (2021)
   PUBMED   33583275
REFERENCE   2  (bases 1 to 6651)
  AUTHORS   Gupta,R., Somyajit,K., Narita,T., Maskey,E., Stanlie,A., Kremer,M.,
            Typas,D., Lammers,M., Mailand,N., Nussenzweig,A., Lukas,J. and
            Choudhary,C.
  TITLE     DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of
            NHEJ and PARP Inhibitor Sensitivity
  JOURNAL   Cell 173 (4), 972-988 (2018)
   PUBMED   29656893
REFERENCE   3  (bases 1 to 6651)
  AUTHORS   Al-Dhaheri,W., Hassouna,I. and Karam,S.M.
  TITLE     Genetic polymorphisms and protein expression of P53 and BRCA1 in
            preneoplastic and neoplastic rat mammary glands
  JOURNAL   Oncol Rep 39 (5), 2193-2200 (2018)
   PUBMED   29498408
  REMARK    GeneRIF: Study indicates that alterations in the localization of
            BRCA1 protein occur in preneoplastic lesions of the DMBA-rat model
            of mammary gland carcinogenesis. While no change in the level of
            BRCA1 protein was detected, its translocation from the cytoplasm to
            nucleus is blocked during breast cancer progression.
REFERENCE   4  (bases 1 to 6651)
  AUTHORS   Krishnan,A., Purdy,K., Chandrasekhar,A., Martinez,J., Cheng,C. and
            Zochodne,D.W.
  TITLE     A BRCA1-Dependent DNA Damage Response in the Regenerating Adult
            Peripheral Nerve Milieu
  JOURNAL   Mol Neurobiol 55 (5), 4051-4067 (2018)
   PUBMED   28585187
  REMARK    GeneRIF: BRCA1 offers prominent functional roles in neurons and
            glial cells including key support for their physical and molecular
            integrity.
REFERENCE   5  (bases 1 to 6651)
  AUTHORS   Fountzilas,G., Psyrri,A., Giannoulatou,E., Tikas,I., Manousou,K.,
            Rontogianni,D., Ciuleanu,E., Ciuleanu,T., Resiga,L.,
            Zaramboukas,T., Papadopoulou,K., Bobos,M., Chrisafi,S., Tsolaki,E.,
            Markou,K., Giotakis,E., Koutras,A., Psoma,E.,
            Kalogera-Fountzila,A., Skondra,M., Bamia,C., Pectasides,D. and
            Kotoula,V.
  TITLE     Prevalent somatic BRCA1 mutations shape clinically relevant genomic
            patterns of nasopharyngeal carcinoma in Southeast Europe
  JOURNAL   Int J Cancer 142 (1), 66-80 (2018)
   PUBMED   28857155
REFERENCE   6  (bases 1 to 6651)
  AUTHORS   .
  TITLE     Pathology of familial breast cancer: differences between breast
            cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases.
            Breast Cancer Linkage Consortium
  JOURNAL   Lancet 349 (9064), 1505-1510 (1997)
   PUBMED   9167459
REFERENCE   7  (bases 1 to 6651)
  AUTHORS   Wu,L.C., Wang,Z.W., Tsan,J.T., Spillman,M.A., Phung,A., Xu,X.L.,
            Yang,M.C., Hwang,L.Y., Bowcock,A.M. and Baer,R.
  TITLE     Identification of a RING protein that can interact in vivo with the
            BRCA1 gene product
  JOURNAL   Nat Genet 14 (4), 430-440 (1996)
   PUBMED   8944023
REFERENCE   8  (bases 1 to 6651)
  AUTHORS   Spillman,M.A. and Bowcock,A.M.
  TITLE     BRCA1 and BRCA2 mRNA levels are coordinately elevated in human
            breast cancer cells in response to estrogen
  JOURNAL   Oncogene 13 (8), 1639-1645 (1996)
   PUBMED   8895509
REFERENCE   9  (bases 1 to 6651)
  AUTHORS   Holt,J.T., Thompson,M.E., Szabo,C., Robinson-Benion,C.,
            Arteaga,C.L., King,M.C. and Jensen,R.A.
  TITLE     Growth retardation and tumour inhibition by BRCA1
  JOURNAL   Nat Genet 12 (3), 298-302 (1996)
   PUBMED   8589721
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   10 (bases 1 to 6651)
  AUTHORS   Ford,D., Easton,D.F., Bishop,D.T., Narod,S.A. and Goldgar,D.E.
  TITLE     Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage
            Consortium
  JOURNAL   Lancet 343 (8899), 692-695 (1994)
   PUBMED   7907678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jun 4, 2021 this sequence version replaced NM_012514.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036760.1, SRR26360181.712417.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               JAXUCZ010000010.1  86977457-86977581   c
            126-224             JAXUCZ010000010.1  86974978-86975076   c
            225-278             JAXUCZ010000010.1  86965278-86965331   c
            279-356             JAXUCZ010000010.1  86960961-86961038   c
            357-445             JAXUCZ010000010.1  86959186-86959274   c
            446-585             JAXUCZ010000010.1  86957137-86957276   c
            586-688             JAXUCZ010000010.1  86956155-86956257   c
            689-734             JAXUCZ010000010.1  86954783-86954828   c
            735-811             JAXUCZ010000010.1  86953170-86953246   c
            812-4129            JAXUCZ010000010.1  86948244-86951561   c
            4130-4200           JAXUCZ010000010.1  86947395-86947465   c
            4201-4372           JAXUCZ010000010.1  86942588-86942759   c
            4373-4502           JAXUCZ010000010.1  86937889-86938018   c
            4503-4681           JAXUCZ010000010.1  86935413-86935591   c
            4682-4968           JAXUCZ010000010.1  86932110-86932396   c
            4969-5056           JAXUCZ010000010.1  86929711-86929798   c
            5057-5134           JAXUCZ010000010.1  86926321-86926398   c
            5135-5175           JAXUCZ010000010.1  86925781-86925821   c
            5176-5256           JAXUCZ010000010.1  86924793-86924873   c
            5257-5311           JAXUCZ010000010.1  86920996-86921050   c
            5312-5385           JAXUCZ010000010.1  86919661-86919734   c
            5386-5446           JAXUCZ010000010.1  86919346-86919406   c
            5447-6651           JAXUCZ010000010.1  86917693-86918897   c
FEATURES             Location/Qualifiers
     source          1..6651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..6651
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /note="BRCA1, DNA repair associated"
                     /db_xref="GeneID:497672"
                     /db_xref="RGD:2218"
     exon            1..125
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..224
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..5598
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /EC_number="2.3.2.27"
                     /note="breast cancer 1, early onset; RING-type E3
                     ubiquitin transferase BRCA1"
                     /codon_start=1
                     /product="breast cancer type 1 susceptibility protein
                     homolog"
                     /protein_id="NP_036646.2"
                     /db_xref="GeneID:497672"
                     /db_xref="RGD:2218"
                     /translation="MDLSAVRIQEVQNVLHAMQKILECPICLELIKEPVSTKCDHIFC
                     KFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSARFSQLVEELLKIIDAFELDTGMQCA
                     NGFSFSKKKNSSSELLNEDASIIQSVGYRNRVKKLRQIESGSATLKDSLSVQLSNLGI
                     VRSMKKNRQTQPQNKSVYIALESDSSEERVNAPDGCSVRDQELFQIAPGGAGDEGKLN
                     SAKKAACDFSEGIRNIEHHQCSDKDLNPTENHATERHPEKCPRISVANVHVEPCGTDA
                     RASSLQRGTRSLLFTEDRLDAEKAEFCDRSKQSGAAVSQQSRWADSKETCNGRPVPRT
                     EGKADPNVDSLCGRKQWNHPKSLCPENSGATTDVPWITLNSSIQKVNEWFSRTGEMLT
                     SDNASDRRPASNAEAAVVLEVSNEVDGCFSSSKKIDLVAPDSDNAVMCTSGRDFSKPV
                     ENIINDKIFGKTYQRKGSRPHLNHVTEIIGTFTTEPQIIQEQPFTNKLKRKRSTCLHP
                     EDFIKKADLTVVQRISENLNQGTDQMEPNDQAMSITSNGQENRATGNDLQRGRNAHPI
                     ESLRKEPAFTAKAKSISNSISDLEVELNVHSSKAPKKNRLRRKSTRCVLPLEPISRNP
                     SPPTCAELQIESCGSSEETKKNNSNQTPAGHIREPQLIEDTEPAADAKKNEPNEHIRK
                     RSASDAFPEEKLMNKAGLLTSCSSPRKPQGPVNPSPERKGIEQLEMCQMPDNNKELGD
                     LVLGGEPSGKPTEPSEESTSVSLVPDTDYDTQNSVSILEANTVRYARTGSVQCMTQFV
                     ASENPKELVHGSNNAGSGSECFKHPLRHELNHNQETIEMEDSELDTQYLQNTFQVSKR
                     QSFALFSKLRSPQKDCTLVGARSVPSREPSPKVTSRGEQKERQGQEESEISHVQAVTV
                     TVGLPVPCQEGKPGAVTMCADVSRLCPSSHYRSCENGLNTTDKSGISQNSHFRQSVSP
                     LRSSIKTDNRKTLTEGRFEKHTERGMGNETAVQSTIHTISQNNRGDACQEASSGSVIE
                     VHSTGENVQGQLDRNRGPTVNTVSLLDSTQPGVSKQSAPVSDKYLEIKQESKAVSADF
                     SPCLFSDHLEKPMRSDKIFQVCSETPDDLLDDVEIQENASFGEGGITEKSAIFNGSVL
                     RRESSRIPSPVTHASKSRSLHRGSRKLEFSEESDSTEDEDLPCFQHLLSRVSSTPELT
                     RCSSVVTQRVPEKAKGTQAPRKSSISDCNNEVILVEASQEYQFSEDAKCSGSMFSSQH
                     SAALGSPANALSQDPDFNPPSKQRRHQAENEEAFLSDKELISDHEDMAACLEEASDQE
                     EDSIIPDSVASGYESEANLSEDCSQSDILTTQQRATMKDNLIKLQQEMAQLEAVLEQH
                     GSQPSGHPPCLPADPCALEDLPDPEQNRSGTAILTSKNINENPVSQNPKRACDDKSQP
                     QPPDGLPSGDKESGMRRPSPFKSPLTSRRCSARGHSRSLQNRNSTSQEELLQPVELEK
                     SCEPHNLTGRSCLPRQDLEGTPYLESGISLFSSRDPDSESPKVPALVCTAPASTSALK
                     ISQGQVAGSCRSPAAGGADTAVVEIVSKIKPEVTSSKERAERDISMVVSGLTPKEVMI
                     VQKFAEKYRLALTDVITEETTHVIIKTDAEFVCERTLKYFLGIAGGKWIVSYSWVIKS
                     IQERKLLSVHEFEVKGDVVTGSNHQGPRRSRESQEKLFEGLQIYCCEPFTNMPKDELE
                     RMLQLCGASVVKELPLLTRDTGAHPIVLVQPSAWTEDNDCPDIGQLCKGRLVMWDWVL
                     DSISVYRCRDLDAYLVQNITCGRDGSEPQDSND"
     exon            225..278
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..356
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..445
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..585
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..688
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..734
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..811
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..4129
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4200
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4201..4372
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4373..4502
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4503..4681
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4682..4968
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4969..5056
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5057..5134
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5135..5175
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5176..5256
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5311
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5312..5385
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5386..5446
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5447..6651
                     /gene="Brca1"
                     /gene_synonym="BRCA-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agattgtaat tgcggctgcg cggtggccgc tggtgcaact cgaagaccta tctccttccc
       61 gggggggctt ctccggcatt taggcctcgg cgtttggaag tacggaggtt tttctcggaa
      121 gaaagttcac tggaagtgga agaaatggat ttatctgctg ttcgaattca agaagtacaa
      181 aatgtccttc atgctatgca gaaaatcttg gagtgtccaa tctgtttgga actgatcaaa
      241 gaaccggttt ccacaaagtg cgaccacata ttttgcaaat tttgtatgct gaaactcctt
      301 aaccagaaga aaggaccttc ccagtgtcct ttgtgtaaga atgagataac caaaaggagc
      361 ctacaaggaa gtgcaaggtt tagtcaactt gttgaagagc tgctgaaaat cattgatgct
      421 tttgagcttg acaccggaat gcagtgtgca aatggtttta gtttttcaaa aaagaaaaat
      481 agttcttctg agcttctgaa tgaggacgct tctatcatcc agagtgtggg ctaccgaaac
      541 cgcgtcaaaa aacttcgaca gattgagtct ggaagtgcca ccttgaagga cagtctcagt
      601 gtccagttgt ctaaccttgg gattgtgaga tcaatgaaga aaaataggca gacacaacct
      661 caaaacaaat ctgtctacat tgctttagaa tctgattctt ctgaggagag agtaaatgca
      721 cccgatggct gcagtgtgag agatcaggaa ttgtttcaga tcgcccctgg aggagctgga
      781 gatgaaggca agttgaactc tgcaaaaaag gctgcttgtg acttttctga gggcataaga
      841 aacattgaac atcatcaatg cagtgataaa gatttgaacc ccactgagaa tcatgcaact
      901 gaaaggcatc cagaaaaatg tccgcgtatt tctgttgcaa acgtgcacgt ggagccgtgt
      961 ggcacagatg ctcgtgccag ctcattacag cgtgggaccc gcagtttatt gttcactgag
     1021 gacagactgg atgcagaaaa ggctgaattc tgtgatagaa gcaaacagtc tggcgcagca
     1081 gtgagccagc agagcagatg ggctgacagt aaagaaacat gtaatggcag gccggttccc
     1141 cgcactgagg gaaaggcaga tccaaatgtg gattccctct gtggtagaaa gcagtggaat
     1201 catccgaaaa gcctgtgccc tgagaattct ggagctacca ctgacgttcc ttggataaca
     1261 ctgaatagca gcattcagaa agtgaatgag tggttttcca gaactggtga aatgttaact
     1321 tctgacaatg catctgacag gaggcctgcg tcaaatgcag aagctgctgt tgtgttagaa
     1381 gtttcaaatg aagtggatgg atgtttcagt tcttcaaaga aaatagactt agttgcccct
     1441 gattccgata atgctgtaat gtgtacaagt ggaagagact tctccaagcc agtagagaat
     1501 attatcaacg ataaaatatt tgggaaaacc tatcagagaa agggaagccg ccctcacttg
     1561 aaccatgtga ctgaaattat aggcacattt actacagaac cacagattat acaagagcag
     1621 cccttcacaa ataaattaaa acgcaaaaga agtacatgcc ttcatcctga ggactttatc
     1681 aagaaagcag atttaacagt tgttcaaagg atttctgaaa atttaaatca gggaactgac
     1741 caaatggagc caaatgacca agcaatgagt attaccagta acggtcagga gaacagagca
     1801 acaggtaatg atcttcagag agggagaaat gctcatccaa tagaatcatt gagaaaggaa
     1861 cctgctttca cagctaaagc caaatctata agcaacagta taagtgattt ggaggtagaa
     1921 ttaaatgttc acagttcaaa agcacctaag aaaaataggc tgaggaggaa gtctaccagg
     1981 tgtgttcttc cactcgaacc aatcagtaga aatccgagcc cacctacttg tgctgaactt
     2041 cagatcgaga gttgtggtag cagtgaagaa acaaagaaaa acaattccaa ccaaacccca
     2101 gccgggcaca ttagagagcc tcaactcatc gaagacacag aacccgcagc tgatgccaag
     2161 aagaacgagc caaatgaaca tataaggaag agaagtgcca gtgatgcgtt cccagaagag
     2221 aaattaatga acaaagctgg tttattaact agctgttcaa gtcctaggaa gcctcaagga
     2281 cctgtcaatc ctagccctga gagaaaagga atagagcaac ttgaaatgtg ccagatgcct
     2341 gataataaca aagaactcgg ggatttggtc ctgggaggag agcccagtgg gaaacctact
     2401 gaaccatctg aggagagcac cagtgtgtcc ttggtacccg acacagacta cgacacccag
     2461 aacagtgtct caatactgga agcgaacact gtcagatatg caagaacagg atcagttcag
     2521 tgtatgactc agtttgtcgc aagtgaaaac cccaaggaac ttgtccatgg ttctaacaat
     2581 gctggaagtg gctcggagtg cttcaagcac ccattgagac atgaacttaa ccacaatcaa
     2641 gagacaatag aaatggaaga cagtgaactt gatactcagt atttgcagaa tacatttcaa
     2701 gtttcaaagc gtcagtcatt tgctttattt tcaaaactta gaagtcccca aaaggactgt
     2761 actctggtag gtgcccgctc tgtgccctca agggaaccaa gtccaaaggt gacttctaga
     2821 ggtgaacaaa aagaacgtca gggacaagaa gagtctgaaa tcagtcatgt acaggcagtc
     2881 acagtcacag taggcttacc tgtgccctgt caggaaggta agccaggtgc tgttacaatg
     2941 tgtgctgatg tttctaggct ttgtccgtca tctcattata gaagctgtga gaatggactc
     3001 aacaccacag ataaatctgg aatttcacaa aactcacatt ttagacaatc agtttctccc
     3061 ctcaggtcat ctataaaaac tgacaataga aaaactctga cagagggacg atttgagaaa
     3121 catactgaaa ggggaatggg aaatgagact gctgttcaaa gtacaataca cacaattagt
     3181 caaaataaca gaggagatgc ttgtcaagaa gccagctcag gcagtgttat tgaagtacat
     3241 tccactggtg aaaacgtcca ggggcaacta gatagaaaca gagggcctac ggtaaacacc
     3301 gtgtctctat tagatagtac acagcctggt gtctctaagc agagtgctcc tgtaagtgat
     3361 aagtatcttg aaataaagca ggagagtaag gctgtcagtg cagacttctc tccatgtctg
     3421 ttctcagatc atcttgaaaa acctatgaga agtgataaga tttttcaggt ttgctctgag
     3481 acacctgatg acctgttgga tgatgttgaa atacaggaaa atgctagctt cggtgaaggt
     3541 ggcataacgg aaaagtctgc tatttttaat ggaagtgtcc tgagaagaga gtccagtagg
     3601 atccctagcc ctgtaaccca tgcatcgaag tcgcggagtc tccacagagg gtctaggaaa
     3661 ttagaattct cagaagagag cgactccact gaggatgaag accttccctg cttccagcac
     3721 ttgctgagca gagtaagcag cacacccgaa cttaccagat gcagcagtgt ggtgacacag
     3781 cgtgtgccag agaaagcgaa ggggacccaa gcaccccgga agagtagcat cagtgactgc
     3841 aataatgagg tgatcttggt agaggcatct caggaatatc agtttagtga ggatgcaaaa
     3901 tgctctggca gcatgttctc ctcacagcac agtgctgccc taggttcacc tgcaaatgca
     3961 ctctcccagg atcccgattt taatccacct tccaaacaaa ggcgtcacca ggctgagaat
     4021 gaggaagcct ttctaagtga taaggaattg atttcagatc atgaggacat ggcagcttgc
     4081 ctagaagagg ctagcgatca agaagaggac agtataatcc cggactcagt ggcgtctgga
     4141 tatgagagtg aagcaaacct ctctgaagac tgctcacaga gtgatattct aaccactcag
     4201 cagagggcga ccatgaagga taacctgata aagctccagc aggaaatggc tcagctggaa
     4261 gctgtgctag agcagcatgg gagccagccg tctggccacc ccccttgcct cccagctgac
     4321 ccttgtgccc tagaagacct gccagatcca gaacaaaaca gatcaggaac agcaatttta
     4381 acttcaaaga acattaatga gaatcctgta agccagaatc caaagcgcgc ctgtgatgac
     4441 aaatcccaac cacaacctcc ggacggtctc cccagtggag ataaggagtc aggaatgaga
     4501 aggccttccc cttttaaatc tccactgacc agcagaaggt gctctgcacg aggccactcc
     4561 aggagtcttc agaatagaaa ctccacctct caagaggagc tccttcagcc tgttgaattg
     4621 gagaagtcat gtgaaccaca caacttaaca gggcggtctt gcttgccaag gcaagatctc
     4681 gaaggaaccc catacctgga atctggaatc agccttttct ccagtagaga ccccgattct
     4741 gaatccccta aagtgccagc ccttgtttgc actgcaccag cttcaacctc tgcactgaaa
     4801 atatcccaag gtcaagttgc tgggtcttgc aggagtccag ctgctggtgg tgctgatact
     4861 gcagtggtag aaattgtgag caagataaag ccggaagtga cgtcttcaaa agaacgagcg
     4921 gagagagata tatccatggt ggtgtcaggc ttgaccccta aagaagtaat gattgtgcaa
     4981 aagtttgctg aaaaataccg ccttgcttta actgatgtaa ttactgagga aactacgcat
     5041 gtaattataa aaacagatgc tgagtttgtg tgtgaacgga cactgaaata ttttctgggc
     5101 attgcaggag gaaagtggat agttagctat tcttgggtga tcaagtctat ccaagaaaga
     5161 aaacttctga gtgtgcatga atttgaagtc aaaggagacg ttgtgactgg aagcaaccac
     5221 caaggtccaa ggcgatccag agaatcccag gaaaagctct ttgaaggcct acagatctat
     5281 tgttgtgagc ccttcaccaa catgcccaaa gatgagctgg agaggatgct gcagctgtgt
     5341 ggggcttctg tggtgaagga gcttccattg ctcacccgtg acacaggtgc tcatccaatt
     5401 gtgctcgtgc agccaagtgc ctggacagaa gacaacgact gccctgatat tgggcagctg
     5461 tgcaagggac gtctagtgat gtgggactgg gtgttggaca gtatatccgt ctaccggtgt
     5521 cgggatctgg atgcctacct ggtacagaat atcacctgtg gccgtgatgg tagcgagcca
     5581 caagactcca atgattaatt taagaaatgg tcttcccgtc ccgggagcat ctctcagtct
     5641 tcggtgcttc tacgccctac ttactaagtc ttttacatgc atcggcctgg acaaaacagc
     5701 ttctaccttt gcgtgggtgc cttaaaggtt ttctaattaa gtctctcttt gaaatccgtc
     5761 ttgagcacaa aaagttttca catgagaaga ctccaagact atttaaatcc caccaattga
     5821 gcaagatgct cactcattat atatcgttct tggagagacg gtagagtagc tcggctggtc
     5881 tgagctgggc atggtggtac ttgcctctaa tcacagctct tggtggaaaa agtcaggagt
     5941 gtcatgagtt caaggccaac ctgggctata taagactgaa gaacatataa ctagtggttc
     6001 taattttttc cttataaaat cacatgttca taatggccaa gagtcgagtt cttcaaggag
     6061 atggcttgaa atctgtgatt tcacttaaga ttagtgctcc tcaaggcttc aggtttaata
     6121 ctcagcacca aacaataccc atttccctcc cccaacaaca cccagaatag ggcttgtgca
     6181 ggtcttagag ggcactgagg aaattcagag gcagattatg tatttgatgt gaatgtgaag
     6241 tttttcaagt gccagtgtca aggagagcct tctaattccc cataactgat gagcagcgtg
     6301 tctgttgtag tagctctaag taacccattc ctctttaaat acaaggtctc tggtatgaat
     6361 attgcatgtc tgtaaaatga tggattccac cggaaaggag ctgttgcttt ctttgaagta
     6421 attttttccc ttttactccc tgttgctgaa ccatactact ttataaataa ttttgctcgc
     6481 tgaaggaaga gaacatattt tttatgaact cataatcttg gactgtttat agatattggg
     6541 ggagtgggtc ttccctggca ccccagtgtg caaggacagt ggagacctga ttatacaggt
     6601 atgtttataa tgctgtactg ttaatgctgc aaataaacgg aatagcaatc a
//
