LOCUS       NM_001271194            3563 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus BRCA1 associated protein (Brap), mRNA.
ACCESSION   NM_001271194 XM_001075972
VERSION     NM_001271194.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3563)
  AUTHORS   Kang,T., Qin,X., Lei,Q. and Yang,Q.
  TITLE     BRAP silencing protects against neuronal inflammation, oxidative
            stress and apoptosis in cerebral ischemia-reperfusion injury by
            promoting PON1 expression
  JOURNAL   Environ Toxicol 38 (11), 2645-2655 (2023)
   PUBMED   37647369
  REMARK    GeneRIF: BRAP silencing protects against neuronal inflammation,
            oxidative stress and apoptosis in cerebral ischemia-reperfusion
            injury by promoting PON1 expression.
REFERENCE   2  (bases 1 to 3563)
  AUTHORS   Fatima,S., Wagstaff,K.M., Loveland,K.L. and Jans,D.A.
  TITLE     Interactome of the negative regulator of nuclear import
            BRCA1-binding protein 2
  JOURNAL   Sci Rep 5, 9459 (2015)
   PUBMED   25820252
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3563)
  AUTHORS   Matheny,S.A., Chen,C., Kortum,R.L., Razidlo,G.L., Lewis,R.E. and
            White,M.A.
  TITLE     Ras regulates assembly of mitogenic signalling complexes through
            the effector protein IMP
  JOURNAL   Nature 427 (6971), 256-260 (2004)
   PUBMED   14724641
REFERENCE   4  (bases 1 to 3563)
  AUTHORS   Li,S., Ku,C.Y., Farmer,A.A., Cong,Y.S., Chen,C.F. and Lee,W.H.
  TITLE     Identification of a novel cytoplasmic protein that specifically
            binds to nuclear localization signal motifs
  JOURNAL   J Biol Chem 273 (11), 6183-6189 (1998)
   PUBMED   9497340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Sep 6, 2012 this sequence version replaced XM_001075972.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.318325.1,
                                           SRR23984936.798555.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               JAXUCZ010000012.1  40561535-40561726   c
            193-354             JAXUCZ010000012.1  40560090-40560251   c
            355-550             JAXUCZ010000012.1  40558650-40558845   c
            551-740             JAXUCZ010000012.1  40557008-40557197   c
            741-854             JAXUCZ010000012.1  40550011-40550124   c
            855-1003            JAXUCZ010000012.1  40547621-40547769   c
            1004-1079           JAXUCZ010000012.1  40544436-40544511   c
            1080-1218           JAXUCZ010000012.1  40543916-40544054   c
            1219-1328           JAXUCZ010000012.1  40543336-40543445   c
            1329-1418           JAXUCZ010000012.1  40540108-40540197   c
            1419-1522           JAXUCZ010000012.1  40538750-40538853   c
            1523-3563           JAXUCZ010000012.1  40535232-40537272   c
FEATURES             Location/Qualifiers
     source          1..3563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3563
                     /gene="Brap"
                     /note="BRCA1 associated protein"
                     /db_xref="GeneID:687346"
                     /db_xref="RGD:1586551"
     exon            1..192
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1886
                     /gene="Brap"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="BRCA1-associated protein"
                     /protein_id="NP_001258123.1"
                     /db_xref="GeneID:687346"
                     /db_xref="RGD:1586551"
                     /translation="MSVSLVVIRLELAGHSPVPADFGFSAAAGEMSNEEIKKKTLASA
                     AACLEGKSPGEKAAIIHQHLGRREMTDVIIETMKASADEFRDTSEEKTSSAAPSSAQR
                     SREQSESVNTVPDSPSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSA
                     MLCVLTVPATMTSHDLMKFVAPFNDVIEQMKIIRDSTPNQYMVLVKFSAQADADSFYM
                     ACNGRQFNSIEDDVCQLVYVERAEVLKSEDGASLPVMDLTELPKCTVCLERMDESVNG
                     ILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPVEENKCFECGVQENLWICLICGHI
                     GCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECEG
                     DTCQEEKIDALQLEYSYLLTSQLESQRVYWENKIVRIEKDTAEEINNMKSKFKETIEK
                     CDSLELRLSDLLKEKQSVERKCTQLSTRVAKLSTELQEEQELNKCLRANQLLLQNKLK
                     EEERLLKETCAQKDLQITEIQEQLRDVMFYLETQQQISHLPAETRQEIQEGQINIAMA
                     SAPNPPSSGAGGKLQSRKGRSKRGK"
     exon            193..354
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            355..550
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            551..740
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            741..854
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1003
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1079
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1218
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1328
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1418
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1522
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..3563
                     /gene="Brap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggctctga ggcggtggcg gggctgccga ccgcgggccg ctcggcctct gggctcggcc
       61 cgcagccttc cgtcagccag ccggagccca cgccgaccag cgcctatcct atgagtgtgt
      121 cactggtggt catccgactg gagctcgcgg gtcactcgcc ggtccccgcc gatttcggct
      181 tcagcgctgc cgctggagag atgtccaatg aggagatcaa aaagaagacg ttggcttcag
      241 cagccgcctg cctcgaaggg aagtcgccag gggaaaaagc agcaatcatc caccagcacc
      301 ttggccgtcg ggaaatgact gacgtgatca ttgagaccat gaaggccagt gcagatgagt
      361 ttcgagacac gtcggaagaa aagacgtctt cagcagcccc cagctctgca cagagaagta
      421 gagagcagag tgagtctgtg aacacggtcc cggattctcc gtccaaacag ctcccagacc
      481 agatttcctt cttcagtggc aacccttccg ttgaaatagt ccacggcatt atgcacctgt
      541 acaagacaaa taagatgacc tccctaaaag aagacgtgcg gcgcagtgcc atgctgtgtg
      601 tcctcaccgt cccggccacc atgaccagcc atgaccttat gaagtttgtt gccccgttta
      661 atgacgtaat tgaacaaatg aaaattatca gggactcaac tccgaatcag tacatggtgc
      721 tggtcaagtt cagtgcacag gctgatgctg atagtttcta catggcatgc aacggccgcc
      781 agttcaactc aatcgaagat gacgtgtgcc agctggtcta tgtggagagg gccgaagtgc
      841 tcaagtccga agatggcgcc agccttcctg tgatggacct gacggagctc cccaagtgca
      901 ctgtgtgtct ggagcgaatg gacgagtctg tgaatggcat cctcaccacc ctatgcaacc
      961 acagcttcca tagtcagtgt ctgcagcggt gggatgacac aacgtgtcct gtgtgccggt
     1021 actgtcaaac gccagagcca gtggaagaaa acaagtgttt cgagtgtggt gttcaggaaa
     1081 acctctggat ttgtttaata tgcggccaca taggctgtgg gcggtacgta agccgacatg
     1141 cgtacaagca ctttgaggag acccagcaca catacgccat gcagctcacc aaccatcggg
     1201 tctgggacta tgctggagat aattatgtcc atcgactggt ggccagcaag acggatggga
     1261 agattgttca gtacgagtgt gagggcgata cctgccaaga agaaaagatt gatgccttac
     1321 aattagagta ttcatacctg ctgacgagcc agctggaatc gcagcgggta tactgggaaa
     1381 acaaaattgt gcgcatagag aaggacacgg cagaggagat taataacatg aagagcaagt
     1441 ttaaagagac cattgaaaag tgtgacagcc tggagctcag gctcagtgac ctcctgaagg
     1501 agaagcagtc tgtggaaagg aagtgcactc agctgagcac cagagtggcc aagctgagca
     1561 cggagctcca ggaggagcag gagctgaaca agtgtctgcg cgccaaccag ctgctgctgc
     1621 agaacaagct gaaggaggag gagaggctgc tgaaggagac ctgtgcccag aaggacctgc
     1681 agatcacaga gatccaggag cagctgcgtg acgtcatgtt ctacctggag acgcagcagc
     1741 aaatcagcca tctgcctgca gagacgaggc aggagatcca ggaagggcag atcaacattg
     1801 ccatggcctc agcccccaac ccaccctctt caggtgccgg tgggaagctg cagtctagga
     1861 agggccgcag caaaaggggc aagtgacctt gagagacttg tcccagagac ttcctgggca
     1921 ccacagggtg tgctgggacc tttgctgagt gggagggtgg gccctaataa gtacgtctga
     1981 ggacgaactg cggtcggtcg tgtggctcct tcatttgttg cgtgtggtgt gaggagacta
     2041 aaagtggggg agacgctggc agcatttcac aagggcaagc cacagcttgc cattctgcct
     2101 tccagctggg tagcctccgg cctgtgcaat tttccgtgta tttattcagt tggagcactt
     2161 gcagttgggt tccagggtaa atctatgaca tgatgcgacc ttcctagcac taaaggaatt
     2221 ccagcattac ttagcactaa agcacagtgc ctccctgagg ccctagctgc cttcaggaga
     2281 ggagcctgcc gcccactgca gaggatctcc cctccatccc tccctccctt cccctgcagg
     2341 gttgaagagc tgcttgcatg tcagagcgaa aggggctaag ttgtaaacca ggcataggct
     2401 tgtcctcagc agcctgactt ggggacagga agaacgagca gctggggcag atggggtaga
     2461 ctcagtttag ggaagatggt gacagctctc ttcatttttg atgactccat acgaaatgtg
     2521 cctgtcatgt aagaaaagcc ttactggctc ctcctctgct cgctggggta actgagtgtc
     2581 ctccacctag caggagtcag gcaagcctgg tgagaggcct cggtggcgag ctgacgtgtg
     2641 gctgggtcag tgtgtactga ctgttacagg ccgaatgttc aggtcgcagc tagagggagc
     2701 ttgggcagat ttcagttgct cttttctgat agtttcaaag gctgcttcac actccagaaa
     2761 atggcttcag caggccctct ttcaaacagc catacaatac ttactgtgac caacagaggg
     2821 gctgtgtgcc tctctctaga gccaggaacg tcaggtaact tgtaacaaat taattgaaca
     2881 aaattgcggg acaccatgtt gggatttagc ttttagtaga gcctgggcac ttggcagcgg
     2941 tgtgtgctgt agtttaattt tttgctttat catcagccaa aggtttaaaa tgtcatactt
     3001 tagggacttt ttttttccaa ctgactggac ctcgtccttt gaccggagtg tctgacatgt
     3061 caccacgttg cctgtgttgc tgatcaccat ccagttctgt ggaacgggct gtggcatttc
     3121 ccaaaatccc cacctgtggc tgcagactga gtgctggcct gctcagaccc ctcggctctc
     3181 agcaggctgt actccaccct caggcctgag ccacacagga gcttctagaa ccgttttaca
     3241 ctgtcacggt cttgccggct cagccctgct tgtcttgcac atctgaccta gcagaggctg
     3301 gggtgggtgg tagcatgcta actaagagaa tcggaagaag ttcccaaagc tggcccctca
     3361 ctccagtaca atccagagca gccctcctgc ccagacgaga gcagcgctcc acagcacagg
     3421 ttggggaaac gcctgcgaag gccgtggccg gaggaagcag ccgatgggca gaggtttcca
     3481 aactacttga aggtctttaa aaaaatgtcc caggacaaca aaaatcaaga tgtgtaaata
     3541 aaatgttatt ttaaaaggtc aaa
//
