LOCUS       NP_001102679             617 aa            linear   ROD 02-APR-2024
DEFINITION  BPI fold-containing family B member 4 precursor [Rattus
            norvegicus].
ACCESSION   NP_001102679 XP_001063904 XP_575269
VERSION     NP_001102679.2
DBSOURCE    REFSEQ: accession NM_001109209.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 617)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   2  (residues 1 to 617)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   3  (residues 1 to 617)
  AUTHORS   Dear,T.N., Boehm,T., Keverne,E.B. and Rabbitts,T.H.
  TITLE     Novel genes for potential ligand-binding proteins in subregions of
            the olfactory mucosa
  JOURNAL   EMBO J 10 (10), 2813-2819 (1991)
   PUBMED   1915264
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Sep 9, 2010 this sequence version replaced
            XP_575269.3, XP_001063904.2, NP_001102679.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1590438.1,
                                           SRR22582424.1709440.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..617
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     Protein         1..617
                     /product="BPI fold-containing family B member 4 precursor"
                     /note="long palate, lung and nasal epithelium
                     carcinoma-associated protein 4; ligand-binding protein
                     RY2G5; potential ligand-binding protein"
                     /calculated_mol_wt=63859
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1739
     mat_peptide     18..617
                     /product="BPI fold-containing family B member 4.
                     /id=PRO_0000089160"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05704.2)"
                     /calculated_mol_wt=63859
     Region          124..149
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q05704.2)"
     Region          221..391
                     /region_name="BPI1"
                     /note="BPI/LBP/CETP N-terminal domain; smart00328"
                     /db_xref="CDD:214622"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q05704.2)"
     Region          417..617
                     /region_name="BPI2"
                     /note="BPI/LBP/CETP C-terminal domain; smart00329"
                     /db_xref="CDD:128624"
     Site            order(425,430,433,437,440,499,532,534,543,579,583,587,613)
                     /site_type="active"
                     /note="apolar binding pocket [active]"
                     /db_xref="CDD:238164"
     CDS             1..617
                     /gene="Bpifb4"
                     /gene_synonym="Lplunc4; RY2G5"
                     /coded_by="NM_001109209.2:1..1854"
                     /db_xref="GeneID:499925"
                     /db_xref="RGD:1561174"
ORIGIN      
        1 mwtawcvaal svaavcgirq dtttvlrvtk dvlgdaisgt iqksdafrsa lrevpvgvgg
       61 vpyndfhvre pppkytngrq lggnykyghi eandntaqlg gkyrygeild sdgslrdlrh
      121 edyrpsdsay hrgpgryrsa adpssagrlh rrelrpgeip agvatgalgp ggllgtggil
      181 anegilagqg gllggggllg dggllggggv lgvlgeggil stvqgitglr iveltlprvs
      241 vrllpgvgvy lslytrvain gksligfldi avevnitakv rltmdrtgyp rlviercdtl
      301 lggikvkllr gllpnlvdnl vnrvlanvlp dllcpivdvv lglvndqlgl vdslvplgil
      361 gsvqytfssl plvtgeflel dlntlvgeag gdlidyplgr pamlprpqmp elppmgdntn
      421 sqlaisanfl ssvltmlqkq galdiditdg mfedlppltt stlgalipkv fqqypesrpl
      481 tiriqvpnpp tvtlqkdkal vkvfatsevv vsqpndvett iclidvdtdl lasfsvegdk
      541 lmidakldkt slnlrtsnvg nfdvfileml vekifdlafm pamnailgsg vplpkilnid
      601 fsnadidvle dllvlst
//
