LOCUS       NM_052808                962 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus BPI fold containing family A, member 2 (Bpifa2),
            mRNA.
ACCESSION   NM_052808
VERSION     NM_052808.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   Abdolhosseini,M., Sotsky,J.B., Shelar,A.P., Joyce,P.B. and
            Gorr,S.U.
  TITLE     Human parotid secretory protein is a lipopolysaccharide-binding
            protein: identification of an anti-inflammatory peptide domain
  JOURNAL   Mol Cell Biochem 359 (1-2), 1-8 (2012)
   PUBMED   21833535
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Ekstrom,J., Murakami,M., Inzitari,R., Khosravani,N., Fanali,C.,
            Cabras,T., Fujita-Yoshigaki,J., Sugiya,H., Messana,I. and
            Castagnola,M.
  TITLE     RP-HPLC-ESI-MS characterization of novel peptide fragments related
            to rat parotid secretory protein in parasympathetic induced saliva
  JOURNAL   J Sep Sci 32 (17), 2944-2952 (2009)
   PUBMED   19642100
  REMARK    GeneRIF: Results suggest that at least two pathways--granular and
            vesicular--are responsible for the generation of the two peptides,
            PSPFr-A and PSPFr-B, from rat parotid secretory protein.
REFERENCE   4  (bases 1 to 962)
  AUTHORS   Bingle,L., Barnes,F.A., Lunn,H., Musa,M., Webster,S., Douglas,C.W.,
            Cross,S.S., High,A.S. and Bingle,C.D.
  TITLE     Characterisation and expression of SPLUNC2, the human orthologue of
            rodent parotid secretory protein
  JOURNAL   Histochem Cell Biol 132 (3), 339-349 (2009)
   PUBMED   19499239
REFERENCE   5  (bases 1 to 962)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   6  (bases 1 to 962)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 962)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   8  (bases 1 to 962)
  AUTHORS   Cowley,D.J., Chu,M. and Gorr,S.U.
  TITLE     Sorting of an exocrine secretory protein to the regulated secretory
            pathway in endocrine cells
  JOURNAL   Biochem Biophys Res Commun 299 (1), 98-101 (2002)
   PUBMED   12435394
  REMARK    GeneRIF: PSP co-fractionates with chromogranin A but not with
            secreted alkaline phosphatase; its sorting is not cell-type
            specific but the precise mechanism of its sorting is unknown
REFERENCE   9  (bases 1 to 962)
  AUTHORS   Mirels,L., Miranda,A.J. and Ball,W.D.
  TITLE     Characterization of the rat salivary-gland B1-immunoreactive
            proteins
  JOURNAL   Biochem J 330 (Pt 1) (Pt 1), 437-444 (1998)
   PUBMED   9461541
REFERENCE   10 (bases 1 to 962)
  AUTHORS   Mirels,L. and Ball,W.D.
  TITLE     Neonatal rat submandibular gland protein SMG-A and parotid
            secretory protein are alternatively regulated members of a salivary
            protein multigene family
  JOURNAL   J Biol Chem 267 (4), 2679-2687 (1992)
   PUBMED   1370829
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M83209.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M83209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..962
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /note="BPI fold containing family A, member 2"
                     /db_xref="GeneID:50585"
                     /db_xref="RGD:3431"
     exon            1..38
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            39..167
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..754
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /note="neonatal submandibular gland protein; short palate,
                     lung and nasal epithelium carcinoma-associated protein 2;
                     BPI fold containing family A, member 2E; parotid secretory
                     protein"
                     /codon_start=1
                     /product="BPI fold-containing family A member 2 precursor"
                     /protein_id="NP_434695.1"
                     /db_xref="GeneID:50585"
                     /db_xref="RGD:3431"
                     /translation="MFQLGSLVVLCGLLIGTSESLLGDVANAVNNLDILNSPSEAVAQ
                     NLNLDVGSLQQATTWPSAKDSILETLNKVELGNSNGFTPLNGLLLRVNKFRVLDLQAG
                     LSSNGKDIDLKLPLVFEISFSLPVIGPTLDVAVSLDLLNSVSVQTNAQTGLPGVTLGK
                     CSGNTDKISISLLGRRLPFVNRILDGVSGLLTGAVSILLQNILCPVLQYLLSTMSGSA
                     IQGLLSNVLTGQLAVPL"
     exon            168..309
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            310..417
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            418..570
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            571..652
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            653..716
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            717..795
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
     exon            796..962
                     /gene="Bpifa2"
                     /gene_synonym="Bpifa2e; Psp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaaacaag gctttcctgt ccttccttct ccaaaccaaa ccaaagatgt tccaacttgg
       61 gagccttgtg gtcttgtgtg gcctgcttat tgggacctca gaatcacttc ttggtgacgt
      121 tgccaatgct gtgaataatt tggacattct taattctccc tctgaagctg tcgctcagaa
      181 tctgaatctg gatgtggggt cacttcagca agccacaact tggccatcag ccaaggacag
      241 cattcttgaa acattgaaca aagtggagct tggcaattca aatggcttta cacctttgaa
      301 tggtttattg ttgcgagtca ataaatttag agtcctggat cttcaagctg ggctgtcttc
      361 caatggcaag gacatcgacc tgaaactgcc cctggttttt gaaatttctt tttctctgcc
      421 tgtcattggc cctacgctcg acgttgctgt ttccttggac ctcctaaact cagtcagtgt
      481 tcaaaccaat gcccagactg gcctccctgg ggtgacccta ggaaaatgct ccggtaatac
      541 agacaaaatc tccatttcct tgttgggcag acgacttccc ttcgtcaacc gtattctgga
      601 tggtgtatct ggcctcctca caggtgcagt gtcaatcctg ctgcaaaaca tcctatgccc
      661 agtgctccag tacctcctca gcacaatgag tggaagtgct attcagggtc tcctctctaa
      721 tgtactaaca ggacagctag cagtccctct ctgaagagga agaacagaag gaggaagcca
      781 tgacaacccc tgctggttag tctccactgg ctttatttta cttccggtgg catttctttc
      841 tgggaagttc tactatcatc cacacaaagt ctacctgata ccaacggaag gactttccca
      901 gattcccttc tttcctgagt agtctccaca cctgtcacca ccatcattaa aatcctaact
      961 gc
//
