LOCUS       NM_172031               1054 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus BPI fold containing family A, member 1 (Bpifa1),
            mRNA.
ACCESSION   NM_172031 XM_346665
VERSION     NM_172031.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Hobbs,C.A., Blanchard,M.G., Alijevic,O., Tan,C.D., Kellenberger,S.,
            Bencharit,S., Cao,R., Kesimer,M., Walton,W.G., Henderson,A.G.,
            Redinbo,M.R., Stutts,M.J. and Tarran,R.
  TITLE     Identification of the SPLUNC1 ENaC-inhibitory domain yields novel
            strategies to treat sodium hyperabsorption in cystic fibrosis
            airway epithelial cultures
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 305 (12), L990-L1001 (2013)
   PUBMED   24124190
  REMARK    Erratum:[Am J Physiol Lung Cell Mol Physiol. 2014 Apr
            1;306(7):L708]
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Liu,Y., Bartlett,J.A., Di,M.E., Bomberger,J.M., Chan,Y.R.,
            Gakhar,L., Mallampalli,R.K., McCray,P.B. Jr. and Di,Y.P.
  TITLE     SPLUNC1/BPIFA1 contributes to pulmonary host defense against
            Klebsiella pneumoniae respiratory infection
  JOURNAL   Am J Pathol 182 (5), 1519-1531 (2013)
   PUBMED   23499554
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   4  (bases 1 to 1054)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   5  (bases 1 to 1054)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   6  (bases 1 to 1054)
  AUTHORS   Sung,Y.K., Moon,C., Yoo,J.Y., Moon,C., Pearse,D., Pevsner,J. and
            Ronnett,G.V.
  TITLE     Plunc, a member of the secretory gland protein family, is
            up-regulated in nasal respiratory epithelium after olfactory
            bulbectomy
  JOURNAL   J Biol Chem 277 (15), 12762-12769 (2002)
   PUBMED   11821380
REFERENCE   7  (bases 1 to 1054)
  AUTHORS   Lindahl,M., Stahlbom,B. and Tagesson,C.
  TITLE     Identification of a new potential airway irritation marker, palate
            lung nasal epithelial clone protein, in human nasal lavage fluid
            with two-dimensional electrophoresis and matrix-assisted laser
            desorption/ionization-time of flight
  JOURNAL   Electrophoresis 22 (9), 1795-1800 (2001)
   PUBMED   11425234
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172031.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF393750.1, CF111213.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JAXUCZ010000003.1  163087965-163087994
            31-253              JAXUCZ010000003.1  163088796-163089018
            254-413             JAXUCZ010000003.1  163089190-163089349
            414-521             JAXUCZ010000003.1  163090014-163090121
            522-671             JAXUCZ010000003.1  163090402-163090551
            672-750             JAXUCZ010000003.1  163091332-163091410
            751-814             JAXUCZ010000003.1  163092128-163092191
            815-891             JAXUCZ010000003.1  163092525-163092601
            892-1054            JAXUCZ010000003.1  163093546-163093708
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1054
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /note="BPI fold containing family A, member 1"
                     /db_xref="GeneID:246238"
                     /db_xref="RGD:619818"
     exon            1..30
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            31..253
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..855
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /note="palate, lung, and nasal epithelium carcinoma
                     associated protein; protein Plunc; palate lung and nasal
                     epithelium clone protein; palate, lung, and nasal
                     epithelium expressed transcript; ES cell-related protein;
                     palate, lung and nasal epithelium associated"
                     /codon_start=1
                     /product="BPI fold-containing family A member 1 precursor"
                     /protein_id="NP_742028.1"
                     /db_xref="GeneID:246238"
                     /db_xref="RGD:619818"
                     /translation="MFLVGSLVVLCGLLAQSTAQLAGLPLPLGQGLPLPLGQGLPLPL
                     GQGLPLAVSPALPSNPTDLLAGNFANALSGGLLSGGLLGILENIPLLDVIKSGGGSSN
                     GLVGGLLGKLTSSVPLLNNILDIKITDPRLLELGLVQSPDGHRLYATIPLSLKLQVNM
                     PVVGSFLQLAVKLNITAEIVAMKDNQGRIHLVLGDCTHSPGSLQITLLNGVTPVQSSL
                     DSLTGILTKVLPELIQGKVCPLINGILSGLDVTLVHNIAELLIHGIQFVIKV"
     exon            254..413
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            414..521
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            522..671
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            672..750
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            751..814
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            815..891
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1054
                     /gene="Bpifa1"
                     /gene_synonym="Plunc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagacaccc actgagacct taagactcag acaccaagag agatgtttct agttgggagt
       61 cttgtcgtcc tctgtgggct gctggcccag agcacagccc agctagcagg cctgcctttg
      121 ccccttgggc agggtctgcc tttgcccctg gggcagggtc tgcctttgcc cctggggcag
      181 ggtctgcctt tggccgtgag cccagcactg ccttcaaatc ccacagatct tcttgctgga
      241 aacttcgcaa atgctctcag tggtggcctg ctctctgggg gactgctggg catcttggaa
      301 aatattccac tcctggatgt tataaagtct ggaggaggca gttccaatgg ccttgttggg
      361 ggcctgcttg gaaaactgac gtcatcagtc cctctcctga acaacatcct tgacataaaa
      421 atcactgatc ctcggctgct ggaacttggc cttgtgcaga gccctgatgg ccatcgtctc
      481 tacgccacca tccctctgag cttgaaactc caagtgaata tgcccgtggt tggaagtttt
      541 ttgcaacttg ctgtgaagct gaacatcacc gcagagattg tagccatgaa agacaatcag
      601 gggaggatcc atctggttct tggtgactgc acccactccc ctggcagcct gcaaatcacc
      661 ttgctcaatg gagtcactcc tgttcagagc tctttagaca gcctcacagg gatactgact
      721 aaagtccttc ctgagctgat ccagggcaag gtatgccctc tgatcaatgg gattctcagc
      781 ggtttggatg tcaccctggt gcataacatt gctgaattac tgatccatgg aatacaattt
      841 gtcatcaaag tttaggcttc ccaggaagga aggcccacct tggttgagct gaatcgtttc
      901 tcgatgctct ctcctgcctc ttgcccagtt tcccatggct cacagaaagg gacccacgtc
      961 ctggaaaatc atatgcctgc cttctcctca cagagtctgc tctcttttcc catcagacat
     1021 gattaatcct aaataaaata gttcttcatc tgca
//
