LOCUS       NM_001004079            1936 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus bactericidal/permeability-increasing protein
            (Bpi), mRNA.
ACCESSION   NM_001004079 XM_230800
VERSION     NM_001004079.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1936)
  AUTHORS   Kong,S.L., Chui,P., Lim,B. and Salto-Tellez,M.
  TITLE     Elucidating the molecular physiopathology of acute respiratory
            distress syndrome in severe acute respiratory syndrome patients
  JOURNAL   Virus Res 145 (2), 260-269 (2009)
   PUBMED   19635508
REFERENCE   2  (bases 1 to 1936)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1936)
  AUTHORS   Klein,W., Tromm,A., Folwaczny,C., Hagedorn,M., Duerig,N.,
            Epplen,J., Schmiegel,W. and Griga,T.
  TITLE     A polymorphism of the bactericidal/permeability increasing protein
            (BPI) gene is associated with Crohn's disease
  JOURNAL   J Clin Gastroenterol 39 (4), 282-283 (2005)
   PUBMED   15758620
REFERENCE   4  (bases 1 to 1936)
  AUTHORS   Lennartsson,A., Pieters,K., Vidovic,K. and Gullberg,U.
  TITLE     A murine antibacterial ortholog to human
            bactericidal/permeability-increasing protein (BPI) is expressed in
            testis, epididymis, and bone marrow
  JOURNAL   J Leukoc Biol 77 (3), 369-377 (2005)
   PUBMED   15590754
REFERENCE   5  (bases 1 to 1936)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   6  (bases 1 to 1936)
  AUTHORS   Takahashi,M., Horiuchi,Y. and Tezuka,T.
  TITLE     Presence of bactericidal/permeability-increasing protein in human
            and rat skin
  JOURNAL   Exp Dermatol 13 (1), 55-60 (2004)
   PUBMED   15009116
  REMARK    GeneRIF: bactericidal/permeability-increasing protein BPI could
            exist in the inner root sheath cells of human and rat hair
            follicles, and might play a role as a barrier against anaerobic
            bacteria.
REFERENCE   7  (bases 1 to 1936)
  AUTHORS   Fang,W.H., Yao,Y.M., Shi,Z.G., Yu,Y., Wu,Y., Lu,L.R. and Sheng,Z.Y.
  TITLE     Effect of recombinant bactericidal/permeability-increasing protein
            on endotoxin translocation and lipopolysaccharide-binding
            protein/CD14 expression in rats after thermal injury
  JOURNAL   Crit Care Med 29 (7), 1452-1459 (2001)
   PUBMED   11445707
REFERENCE   8  (bases 1 to 1936)
  AUTHORS   Dentener,M.A., Von Asmuth,E.J., Francot,G.J., Marra,M.N. and
            Buurman,W.A.
  TITLE     Antagonistic effects of lipopolysaccharide binding protein and
            bactericidal/permeability-increasing protein on
            lipopolysaccharide-induced cytokine release by mononuclear
            phagocytes. Competition for binding to lipopolysaccharide
  JOURNAL   J Immunol 151 (8), 4258-4265 (1993)
   PUBMED   8409400
REFERENCE   9  (bases 1 to 1936)
  AUTHORS   Wasiluk,K.R., Skubitz,K.M. and Gray,B.H.
  TITLE     Comparison of granule proteins from human polymorphonuclear
            leukocytes which are bactericidal toward Pseudomonas aeruginosa
  JOURNAL   Infect Immun 59 (11), 4193-4200 (1991)
   PUBMED   1937776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Apr 12, 2023 this sequence version replaced NM_001004079.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079318.1, SRR26360186.464776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               JAXUCZ010000003.1  167329552-167329873
            323-437             JAXUCZ010000003.1  167332602-167332716
            438-566             JAXUCZ010000003.1  167332906-167333034
            567-725             JAXUCZ010000003.1  167333910-167334068
            726-789             JAXUCZ010000003.1  167334914-167334977
            790-853             JAXUCZ010000003.1  167338786-167338849
            854-945             JAXUCZ010000003.1  167339936-167340027
            946-1122            JAXUCZ010000003.1  167343108-167343284
            1123-1182           JAXUCZ010000003.1  167344217-167344276
            1183-1350           JAXUCZ010000003.1  167345836-167346003
            1351-1418           JAXUCZ010000003.1  167346950-167347017
            1419-1461           JAXUCZ010000003.1  167347993-167348035
            1462-1525           JAXUCZ010000003.1  167352205-167352268
            1526-1602           JAXUCZ010000003.1  167352940-167353016
            1603-1936           JAXUCZ010000003.1  167355798-167356131
FEATURES             Location/Qualifiers
     source          1..1936
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1936
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /note="bactericidal/permeability-increasing protein"
                     /db_xref="GeneID:296321"
                     /db_xref="RGD:1303179"
     exon            1..322
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1641
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /note="BPI fold containing family D, member 1"
                     /codon_start=1
                     /product="bactericidal permeability-increasing protein
                     precursor"
                     /protein_id="NP_001004079.1"
                     /db_xref="GeneID:296321"
                     /db_xref="RGD:1303179"
                     /translation="MAWGPDNVRKWSSLALLAIVGTALTAATDPGFVARISQKGLDFV
                     CQESMVELQKELLAISIPDFSGDFKIKHLGKGTYEFYSMAVEGFHIPDPQIKLLPSDG
                     LQLSITSASIKISGRWKYRKNILKASGNFQLSIQGVSIIADLILGNDPSGRITITCST
                     CDSHINSVRIKVSGSMLGWLIQLFHRKIETSLKKTIYKKICKIVRNSVSAKLQPYVKT
                     LPVVAKVDDITSIDYSLLAPPMTTDKFLEGQLRGEFFWRGHHGPFPAVPPVMNILPNN
                     NYMVCMGISDYFFNTAEFAYQESETLKITLRDQLLAKDARYHLNTDFLKTFLPEVAKK
                     FPSMGLQLLISAPLFAHLNIQPSGLSLSPNLETRAFVVLPNSSLIPLFLLGMKTNASL
                     EVNAMKNRLIGEMKLGRLLLELKQSNFGSFKVELLEDVINYLMSTMVLPKINEKLRRG
                     FPLPLPAGIQLINSILYSSQNFLLLEADLHRT"
     exon            323..437
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..566
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..725
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..789
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..853
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..945
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1122
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1182
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1350
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1418
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1461
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1525
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1602
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1936
                     /gene="Bpi"
                     /gene_synonym="Bpifd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctccact ggggcagccc ctggactggt ccccaacgtt gatggggaac cgcagctgcc
       61 ctccccctcc cgcccccacg gttgccttcc tccttcctct ttctactact gccctgccct
      121 tccccagaag gcttttttat aggtctcaag ttcccatccg aggccttgag gtttggggct
      181 gccctggagg acatggcctg gggccctgac aacgtgcgga aatggtcaag cctggcactg
      241 ctggccatcg tgggcacagc tttgacagcg gccaccgacc ctggcttcgt ggccagaatc
      301 tcccagaagg gtctggactt cgtgtgccag gagagtatgg ttgagttgca gaaggagctc
      361 ctagccatca gcattcctga cttctctgga gactttaaga taaagcacct gggaaagggt
      421 acctatgaat tctacagcat ggccgtggaa ggatttcata ttcctgatcc ccagatcaag
      481 ctgctaccca gtgatggcct ccagctgtcc atcaccagtg ccagcatcaa gataagtgga
      541 agatggaaat ataggaagaa catcctcaaa gccagcggca attttcagct gagcattcag
      601 ggtgtctcta tcatcgctga cctgatcctg ggcaatgacc cctcaggtcg catcaccatc
      661 acctgttcta cttgcgacag tcacatcaac agcgtccgca tcaaagtctc tggcagcatg
      721 ctggggtggc tgatccaact gttccacagg aaaattgaga cttccttgaa aaagaccatt
      781 tacaaaaaga tctgcaagat cgtgagaaac tccgtgtccg ccaagcttca gccttatgtg
      841 aagactcttc cagtggtagc caaagtggat gatataacct cgattgacta cagtctgctg
      901 gctcctccga tgaccacgga caagttcctg gaggggcagc taagggggga gtttttctgg
      961 cggggacacc acggcccatt tcccgctgtc ccaccagtaa tgaatatttt gcccaacaat
     1021 aactacatgg tatgcatggg catctctgac tacttcttca acactgcaga gtttgcgtac
     1081 caagagtctg aaaccttgaa aataaccctg agggaccaat tgttagcaaa ggatgccaga
     1141 taccacctga acactgactt ccttaagacc ttcctgcccg aggtggccaa gaagttcccc
     1201 agcatggggt tgcagctact gatctcagcg cccttgtttg cacacctgaa catacagccc
     1261 tcaggccttt cgctcagtcc taacctggag acccgggcct ttgtggtcct ccccaactcc
     1321 tccctgatcc ctctcttcct gcttggcatg aaaacaaatg cctctctgga agtgaatgct
     1381 atgaaaaaca ggcttattgg cgagatgaag ctaggcaggc tgttgctgga actgaagcaa
     1441 tccaactttg gctcctttaa ggtggagtta ctggaggatg tcataaacta cctcatgtcc
     1501 acaatggtgc tgcccaagat caacgagaag ctgcgtcgag gctttcctct ccctttgcct
     1561 gccgggattc agctcatcaa ctcgattctt tactcctccc agaatttcct gttgcttgag
     1621 gcggatttac accggacctg agatcacctc agaccctgag ccaggaagct ctgcagctgc
     1681 ttccaagggg ccatcacact caccggctgt cctgctcaag aatcctttag tctttgaccc
     1741 tgacctgcag cccctgcttg cttccccgtg ctcagctcta gaaataaccc aagccactgg
     1801 aagttgagca ccggaaagcg agaggtctgt gtaccggggc tccgggcctc tttcagagca
     1861 gcccctccag caccggcatt tctgcggcag ctgtgacatt attttggact ttacaaaaac
     1921 accccttttc tcccca
//
