LOCUS       NM_001024250            2587 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus BOP1 ribosomal biogenesis factor (Bop1), mRNA.
ACCESSION   NM_001024250 XM_216969
VERSION     NM_001024250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2587)
  AUTHORS   Henras,A.K., Plisson-Chastang,C., O'Donohue,M.F., Chakraborty,A.
            and Gleizes,P.E.
  TITLE     An overview of pre-ribosomal RNA processing in eukaryotes
  JOURNAL   Wiley Interdiscip Rev RNA 6 (2), 225-242 (2015)
   PUBMED   25346433
  REMARK    Review article
REFERENCE   2  (bases 1 to 2587)
  AUTHORS   Sloan,K.E., Bohnsack,M.T. and Watkins,N.J.
  TITLE     The 5S RNP couples p53 homeostasis to ribosome biogenesis and
            nucleolar stress
  JOURNAL   Cell Rep 5 (1), 237-247 (2013)
   PUBMED   24120868
REFERENCE   3  (bases 1 to 2587)
  AUTHORS   Sloan,K.E., Mattijssen,S., Lebaron,S., Tollervey,D., Pruijn,G.J.
            and Watkins,N.J.
  TITLE     Both endonucleolytic and exonucleolytic cleavage mediate ITS1
            removal during human ribosomal RNA processing
  JOURNAL   J Cell Biol 200 (5), 577-588 (2013)
   PUBMED   23439679
REFERENCE   4  (bases 1 to 2587)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2587)
  AUTHORS   Maggi,L.B. Jr., Kuchenruether,M., Dadey,D.Y., Schwope,R.M.,
            Grisendi,S., Townsend,R.R., Pandolfi,P.P. and Weber,J.D.
  TITLE     Nucleophosmin serves as a rate-limiting nuclear export chaperone
            for the Mammalian ribosome
  JOURNAL   Mol Cell Biol 28 (23), 7050-7065 (2008)
   PUBMED   18809582
REFERENCE   6  (bases 1 to 2587)
  AUTHORS   Rohrmoser,M., Holzel,M., Grimm,T., Malamoussi,A., Harasim,T.,
            Orban,M., Pfisterer,I., Gruber-Eber,A., Kremmer,E. and Eick,D.
  TITLE     Interdependence of Pes1, Bop1, and WDR12 controls nucleolar
            localization and assembly of the PeBoW complex required for
            maturation of the 60S ribosomal subunit
  JOURNAL   Mol Cell Biol 27 (10), 3682-3694 (2007)
   PUBMED   17353269
REFERENCE   7  (bases 1 to 2587)
  AUTHORS   Grimm,T., Holzel,M., Rohrmoser,M., Harasim,T., Malamoussi,A.,
            Gruber-Eber,A., Kremmer,E. and Eick,D.
  TITLE     Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and
            cell proliferation via incorporation into the PeBoW-complex
  JOURNAL   Nucleic Acids Res 34 (10), 3030-3043 (2006)
   PUBMED   16738141
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2587)
  AUTHORS   Holzel,M., Rohrmoser,M., Schlee,M., Grimm,T., Harasim,T.,
            Malamoussi,A., Gruber-Eber,A., Kremmer,E., Hiddemann,W.,
            Bornkamm,G.W. and Eick,D.
  TITLE     Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is
            required for ribosome biogenesis and cell proliferation
  JOURNAL   J Cell Biol 170 (3), 367-378 (2005)
   PUBMED   16043514
REFERENCE   9  (bases 1 to 2587)
  AUTHORS   Lapik,Y.R., Fernandes,C.J., Lau,L.F. and Pestov,D.G.
  TITLE     Physical and functional interaction between Pes1 and Bop1 in
            mammalian ribosome biogenesis
  JOURNAL   Mol Cell 15 (1), 17-29 (2004)
   PUBMED   15225545
REFERENCE   10 (bases 1 to 2587)
  AUTHORS   Strezoska,Z., Pestov,D.G. and Lau,L.F.
  TITLE     Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and
            5. 8S RRNA processing and 60S ribosome biogenesis
  JOURNAL   Mol Cell Biol 20 (15), 5516-5528 (2000)
   PUBMED   10891491
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092594.1.
            
            On May 27, 2005 this sequence version replaced XM_216969.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092594.1, SRR8487230.41509.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2587
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2587
                     /gene="Bop1"
                     /note="BOP1 ribosomal biogenesis factor"
                     /db_xref="GeneID:300050"
                     /db_xref="RGD:1310589"
     exon            1..100
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..2203
                     /gene="Bop1"
                     /note="block of proliferation 1 protein"
                     /codon_start=1
                     /product="ribosome biogenesis protein BOP1"
                     /protein_id="NP_001019421.1"
                     /db_xref="GeneID:300050"
                     /db_xref="RGD:1310589"
                     /translation="MAGACGKHHMSPGSLPGKRRLEPDQEPQIQEPLLLSDPDSSLSD
                     SEESVFSGLEDSGSDTSDEDTEEVARAGCDKDNRTEKTSEEQEQAVPPCPRAEEAGAL
                     TRDEYEEDSSDEEDIRNTVGNVPLAWYDDFPHVGYDLDGKRIYKPLRTRDELDQFLDK
                     MDDPDFWRTVQDKMTGSDLRLTDEQVALVHRLQRGQFGDSGFDPYEPAVDFFSGDIMI
                     HPVTNRPADKRSFIPSLVEKEKVSRLVHAIKMGWIKPRRPPDSTPSFYDLWAQEDPNA
                     VLGRHKMHVPAPKLALPGHAESYNPPPEYLPTEEERLAWMQQEPIERKLNFLPQKFPS
                     LRTVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPVCQAL
                     VYRGHSDLVRCLSVSPGGQWLASGSDDGTLRLWEVATARCMKTVRVGGVIRSIAWNPN
                     PTICLVAAAMDDAVVLLNPALGDRLLVGSTDQLLETFTPPEEPTLQPAHWLEVSEEER
                     QRGLRLRICHSKPVTQVTWHGRGDYLAVVLSSQGHTQVLIHQLSRRRSQSPFRRSHGQ
                     VQCVAFHPTRPFLLVASQRSIRIYHLLRQELTKKLMPNCKWVSSMAVHPAGDNIICGS
                     YDSKLVWFDLDLSTKPYKVLRHHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYND
                     LLQNPLLVPVKVLKGHSLTRDLGVLDVAFHPTQPWVFSSGADGTIRLFS"
     exon            101..271
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..352
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..507
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..625
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..727
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..940
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1102
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1183
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1253
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1386
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1567
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1856
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1941
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2049
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2483
                     /gene="Bop1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcagcatg gcgggggcgt gtggtaagca ccacatgtca ccgggatcgc tgccagggaa
       61 acggcgtttg gaacctgatc aggagccaca gatacaagag cctcttctcc tcagcgaccc
      121 tgactccagt ctctctgaca gcgaggagag tgtgttttca ggccttgaag attctggcag
      181 tgacacgagt gacgaggaca ctgaagaagt ggccagagct ggttgtgaca aagacaatag
      241 aacagagaag acctctgagg agcaggaaca ggctgtgccc ccttgcccaa gggcagagga
      301 agcaggtgct ctgaccagag atgagtatga agaggacagc tctgatgagg aggacattcg
      361 gaacaccgtg ggcaatgtgc ccctggcgtg gtatgacgat ttcccacatg tgggctatga
      421 cctggacggc aaacgtatct ataagcccct gcggacacga gatgagctgg accagtttct
      481 ggacaaaatg gatgacccag atttctggcg cactgtgcaa gacaagatga cagggagtga
      541 tcttcggctg actgatgagc aggttgccct ggtacatcgg cttcagagag gccagtttgg
      601 agattcaggc tttgacccct atgagccagc tgtggatttc ttcagtggtg acatcatgat
      661 ccaccccgtg accaaccgcc cagctgacaa acgtagtttc atcccgtccc tagttgagaa
      721 ggagaaggtg tctcgattgg tgcatgccat caagatgggt tggatcaagc ctcgacggcc
      781 ccccgactcc actcctagct tctatgacct gtgggcccag gaggatccaa atgctgtgtt
      841 ggggcgccac aagatgcacg tgcctgcacc caagctggcc ctgcccggcc atgcggagtc
      901 ttacaaccca cctcccgagt acctgcccac tgaggaggag cgcttggcat ggatgcagca
      961 ggagcccatt gagaggaagc ttaacttctt accacagaag ttccccagcc tgaggacagt
     1021 gcctgcttat ggccgcttca tccaggagcg ttttgaacgc tgtcttgatt tgtatctgtg
     1081 cccacggcag cgcaagatga gggtgaatgt ggatcccgaa gacctcatcc ccaagctccc
     1141 tcggccaaga gaccttcagc ctttccctgt gtgccaggcc cttgtctaca ggggccacag
     1201 cgaccttgtc cgttgcctca gtgtctcccc agggggccag tggctagctt caggttcaga
     1261 cgacggcaca ttgaggcttt gggaggtggc cactgcccgc tgcatgaaga cggtgcgtgt
     1321 tggaggtgtg atacggagca ttgcttggaa ccccaatccc accatatgct tagtagccgc
     1381 tgccatggat gatgccgtgg tgctgctgaa cccagccctg ggggaccggc tgctggtggg
     1441 cagcacagac cagctgctgg aaaccttcac tccccctgaa gagccaactt tgcagcctgc
     1501 ccactggctg gaggtctcag aggaagaacg ccagaggggc cttcgactac gtatctgcca
     1561 cagtaaacca gtgacacagg tgacctggca tgggcgaggg gactacctgg ctgtggtgct
     1621 gtccagccaa gggcacactc aagtgctgat ccaccagctg agcagaaggc gcagccagag
     1681 cccattccgc cgcagccacg gacaggtgca gtgtgtggct ttccatccca cgcggccctt
     1741 cctgcttgtg gcctcccagc gcagcatccg catttaccac ctgctacgcc aggagcttac
     1801 gaagaagctg atgcctaact gcaagtgggt gtctagcatg gctgtgcatc cagcaggtga
     1861 caacatcatc tgtggcagct atgacagcaa actggtgtgg tttgacctgg atctttccac
     1921 caagccatac aaagtgctga ggcaccacaa gaaggccttg cgggctgtgg ccttccaccc
     1981 ccgataccca ctctttgcat ccggctcaga cgacggcagc gttatcgttt gccatggcat
     2041 ggtgtacaat gacctgctgc agaacccatt gctggtgccc gtcaaggtgc ttaagggaca
     2101 cagcctgacc cgagatctgg gtgtactgga tgtggccttc caccccacac agccatgggt
     2161 cttctcctcc ggggcagatg gcaccattcg actcttcagc taagctgaca cactacttca
     2221 ggaggcctgg agagggtgcg tgtccctcac acagaatcga tagagaggac ccttgattgc
     2281 cactgtcctt gccttcttga ttggaacttc cggcagctgc ccagccttga ccttatgtgg
     2341 caccccagaa cccagcttaa gccagaagga aaggtggtat tgatacactg tcacccactg
     2401 aggtgtaact ggctttattg ggcaataaat tggggcaccg cagtcttggc cctgtctggc
     2461 agcagagagt cctctaggca gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2581 aaaaaaa
//
