LOCUS       NM_001108317            4437 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus BOC cell adhesion associated, oncogene regulated
            (Boc), mRNA.
ACCESSION   NM_001108317 XM_001060215 XM_006221137 XM_006248353 XM_340986
VERSION     NM_001108317.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4437)
  AUTHORS   Beachy,P.A., Hymowitz,S.G., Lazarus,R.A., Leahy,D.J. and Siebold,C.
  TITLE     Interactions between Hedgehog proteins and their binding partners
            come into view
  JOURNAL   Genes Dev 24 (18), 2001-2012 (2010)
   PUBMED   20844013
  REMARK    Review article
REFERENCE   2  (bases 1 to 4437)
  AUTHORS   Fabre,P.J., Shimogori,T. and Charron,F.
  TITLE     Segregation of ipsilateral retinal ganglion cell axons at the optic
            chiasm requires the Shh receptor Boc
  JOURNAL   J Neurosci 30 (1), 266-275 (2010)
   PUBMED   20053908
REFERENCE   3  (bases 1 to 4437)
  AUTHORS   Jones,S., Zhang,X., Parsons,D.W., Lin,J.C., Leary,R.J.,
            Angenendt,P., Mankoo,P., Carter,H., Kamiyama,H., Jimeno,A.,
            Hong,S.M., Fu,B., Lin,M.T., Calhoun,E.S., Kamiyama,M., Walter,K.,
            Nikolskaya,T., Nikolsky,Y., Hartigan,J., Smith,D.R., Hidalgo,M.,
            Leach,S.D., Klein,A.P., Jaffee,E.M., Goggins,M., Maitra,A.,
            Iacobuzio-Donahue,C., Eshleman,J.R., Kern,S.E., Hruban,R.H.,
            Karchin,R., Papadopoulos,N., Parmigiani,G., Vogelstein,B.,
            Velculescu,V.E. and Kinzler,K.W.
  TITLE     Core signaling pathways in human pancreatic cancers revealed by
            global genomic analyses
  JOURNAL   Science 321 (5897), 1801-1806 (2008)
   PUBMED   18772397
REFERENCE   4  (bases 1 to 4437)
  AUTHORS   Okada,A., Charron,F., Morin,S., Shin,D.S., Wong,K., Fabre,P.J.,
            Tessier-Lavigne,M. and McConnell,S.K.
  TITLE     Boc is a receptor for sonic hedgehog in the guidance of commissural
            axons
  JOURNAL   Nature 444 (7117), 369-373 (2006)
   PUBMED   17086203
REFERENCE   5  (bases 1 to 4437)
  AUTHORS   Zhang,W., Kang,J.S., Cole,F., Yi,M.J. and Krauss,R.S.
  TITLE     Cdo functions at multiple points in the Sonic Hedgehog pathway, and
            Cdo-deficient mice accurately model human holoprosencephaly
  JOURNAL   Dev Cell 10 (5), 657-665 (2006)
   PUBMED   16647303
REFERENCE   6  (bases 1 to 4437)
  AUTHORS   Kang,J.S., Mulieri,P.J., Hu,Y., Taliana,L. and Krauss,R.S.
  TITLE     BOC, an Ig superfamily member, associates with CDO to positively
            regulate myogenic differentiation
  JOURNAL   EMBO J 21 (1-2), 114-124 (2002)
   PUBMED   11782431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1 and CB324285.1.
            
            On or before Aug 27, 2019 this sequence version replaced
            XM_006248353.3, XM_006221137.3, NM_001108317.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is based on
            transcript alignments from orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.38107.1,
                                           SRR26643298.66703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               JAXUCZ010000011.1  69628703-69629114
            413-589             JAXUCZ010000011.1  69666133-69666309
            590-868             JAXUCZ010000011.1  69667101-69667379
            869-1015            JAXUCZ010000011.1  69684397-69684543
            1016-1159           JAXUCZ010000011.1  69686234-69686377
            1160-1453           JAXUCZ010000011.1  69687327-69687620
            1454-1726           JAXUCZ010000011.1  69688314-69688586
            1727-2031           JAXUCZ010000011.1  69692073-69692377
            2032-2194           JAXUCZ010000011.1  69695316-69695478
            2195-2305           JAXUCZ010000011.1  69695922-69696032
            2306-2512           JAXUCZ010000011.1  69696456-69696662
            2513-2694           JAXUCZ010000011.1  69697010-69697191
            2695-2800           JAXUCZ010000011.1  69697704-69697809
            2801-2923           JAXUCZ010000011.1  69698132-69698254
            2924-3145           JAXUCZ010000011.1  69700390-69700611
            3146-3381           JAXUCZ010000011.1  69701257-69701492
            3382-3461           JAXUCZ010000011.1  69701676-69701755
            3462-3652           JAXUCZ010000011.1  69702237-69702427
            3653-4419           JAXUCZ010000011.1  69703242-69704008
            4420-4437           CB324285.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4437
                     /gene="Boc"
                     /note="BOC cell adhesion associated, oncogene regulated"
                     /db_xref="GeneID:360715"
                     /db_xref="RGD:1304550"
     exon            1..412
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            413..589
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..3840
                     /gene="Boc"
                     /note="brother of CDO; biregional cell adhesion
                     molecule-related/down-regulated by oncogenes (Cdon)
                     binding protein"
                     /codon_start=1
                     /product="brother of CDO precursor"
                     /protein_id="NP_001101787.2"
                     /db_xref="GeneID:360715"
                     /db_xref="RGD:1304550"
                     /translation="MVTCRGEQPMLTLLWFLLAIAGCLADLNEVPQVTVQPMSTVQKL
                     GGTVILGCVVEPPWVNVTWRFNGKELNGSDDALGVLITRGTLVIAALNNHTVGRYQCV
                     ARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSV
                     KQEWLEASRDNYLIMPSGNLQIVNASQEDEGTYKCAAYNPVTQEVKTSGSSDRLRVRR
                     STAEAARIIYPLEAQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAAYNKTRFLL
                     SNLLIDTTSEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPPEVTVELSQLVIPWGQS
                     AKLTCEVRGNPPPSVLWLRNAVPLSSNQRLRLSRKALRVVSVRPEDEGVYQCMAENAV
                     GSAHAVVQLRTARPDTTLRPGRDTKPIAATPPMPPSRPNRPDQMLREQPGLVKPPTSV
                     QPTSLKCLGEEQVAPAEAPVILSSPRTSKTDSYELVWRPRHEGSSRAPILYYVVKHRK
                     QVTNSSDDWIISGIPANQHHLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRP
                     KPEIVASKEQQIQRDDPGASLQSSSQPDHGRLSPPEAPDRPTISTASETSVYVTWIPR
                     GNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNML
                     GESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPASNNNTPI
                     HGFYIYYRPTDSDNDSDYKKDMVEGDRYWHSISHLQPETSYDIKMQCFNEGGESEFSN
                     VMICETKARKFSGQPGRPPPLTLAPPQPPPLEAMERPMGTGAMVARASDLPYLIVGVV
                     LGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALLSSSCQYTMVPLGGLPGHQANG
                     QPYLSGIGGRACVSRLHGSRGYPAATVGCPGRKLQQHCPGELAQQREDSNSLLRQPIV
                     SNGYDLQNQQVARGTKSGSEEGSFLYTLPDDSTHQLLQPQDCCHLQKQPVTTCQTAVR
                     RAPEGPGLEASWDPQYHSGPRCCLGLVPVEEVDSSDSCQVGGGDCCPQHPSGTYTGQE
                     LGVRLSPSPSVHVSFETPPPTI"
     exon            590..868
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1015
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1159
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1453
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1726
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..2031
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2194
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2305
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2512
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2694
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2800
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2923
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3145
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3381
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3461
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3652
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..4420
                     /gene="Boc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttgcaagt tcagtcatcc aaaaaagcgt cttccatatg gaggggttgg gtgcgctggg
       61 cgcggcgtcc cctgccttgt ccgcctgctg ccgccgctgc caccacggct ccggcttctt
      121 gcagtgggga ccctgagctg ggtctcgctg gtgtcagctc cgaccacact cgcacactct
      181 cgcacctcgt accctccgcg gccacacaag cccttcctcc tcgggccgca acttctgggt
      241 cctgggctcc tttgttgctc tggctgcggc cactctcccg tggtgtgtgt ccccgtgtgt
      301 catcgcgccg tgcgtgtgtg tcggtgtgcg cggggccgtg tggccctctc cgcttcacca
      361 cgcgggaccc ggagtcccgg ccccctcttc cccggctccg gctgcaggag aggattgcag
      421 gggaaggcag tatctccacg agggtcacgc gtggcttatg ggacttcggc ttggatccct
      481 ctgtgacaca ccatacttcg tgggaagatg gtaacgtgcc gaggagagca gcctatgctc
      541 acactgcttt ggttcctctt agccatagca ggctgcctgg ctgatttgaa tgaggttcct
      601 caggtcacgg tccagcccat gtccactgtc cagaagctcg gaggaactgt gatcctgggc
      661 tgtgtggtgg agccaccatg ggtgaacgtg acttggcgct tcaacgggaa ggagctaaat
      721 ggctcggatg atgctctagg tgtcctcatc acccgtggga ccctggtcat tgctgccctc
      781 aacaaccaca ctgtgggacg ataccagtgt gtggctcgga tgcctgcggg agctgtggcc
      841 agtgtgccag ccacggtgac actagccaat ctccaggact ttaagttaga tgtgcagcat
      901 gtgattgaag tagatgaggg gaacacagct gtcattgcct gccacctgcc tgagagtcac
      961 ccaaaagccc aggtccggta cagcgtcaaa caggagtggc tggaggcctc tagagacaac
     1021 tacctgatca tgccatcggg gaatctccaa attgtcaatg ccagccagga ggatgagggc
     1081 acgtacaagt gtgctgccta caacccagtg acccaggaag tgaaaacctc tggctccagt
     1141 gacaggctgc gcgtgcgccg gtccaccgct gaggctgccc gcatcatcta cccactagaa
     1201 gctcagactg tcattgtcac caaaggccag agtctcatac tggagtgtgt ggccagtgga
     1261 atcccgccac ctcgagtcac gtgggccaag gatgggtcca gcattgctgc ctacaacaag
     1321 actcgcttcc tgctgagtaa cttgctcatt gacaccacca gtgaggagga ctcaggcacc
     1381 taccgctgta tggccagcaa tggggttgga gatcccggtg cagctgtcat tctctacaac
     1441 gtccaggtgt ttgaaccccc tgaggtcacc gtggagctat cccagctcgt catcccatgg
     1501 ggccagagtg caaagctcac ctgtgaggtt cgaggaaacc ccccaccctc tgtactgtgg
     1561 ttgaggaatg ctgtgcctct cagctccaac cagcgcctcc ggctgtctcg caaagccctt
     1621 cgtgtggtca gtgtcaggcc tgaggatgaa ggcgtgtacc agtgcatggc tgagaatgct
     1681 gttgggagtg cccatgctgt ggttcaactg aggactgccc ggccagacac aaccctgaga
     1741 cccgggaggg atactaagcc gattgctgcc acacctccca tgccgccctc ccgacccaac
     1801 agacctgacc agatgcttcg ggaacaaccg gggcttgtta agcccccaac atcagtacag
     1861 cctacttccc taaagtgcct gggagaggag caggtagccc ctgcggaggc acccgtcatc
     1921 ctcagctcac cccggacctc caagacggat tcatacgagc tggtgtggcg gcctcgccat
     1981 gagggcagca gccgggcacc catcctgtac tacgtagtga agcatcgtaa gcaggtcaca
     2041 aactcctctg atgactggat catttctggc attccagcca accagcacca ccttaccctg
     2101 accaggcttg atcctggaag cttgtacgaa gtggagatgg cagcctacaa ctgtgctggc
     2161 gagggtcaga cggccatggt caccttccga acaggacggc ggcccaaacc tgagatcgtg
     2221 gccagcaagg agcagcagat ccagagagat gaccctggtg ccagtctcca gagtagcagc
     2281 cagcctgacc acggccgcct ctctccccca gaagctccag acagacccac catctccaca
     2341 gcttctgaga cctcagtgta tgtaacctgg attccccgag ggaatggcgg cttcccaatt
     2401 cagtctttcc gtgtggagta caagaagcta aaaaaagtgg gagattggat actggccacc
     2461 agtgccatac ctccctcgag gctctctgtg gagatcacag gcctggagaa aggtatttct
     2521 tacaagttcc gagtccgtgc tttgaacatg ctaggggaaa gtgagcccag tgctccctcc
     2581 cggccttatg tggtatcagg ctacagtggc cgtgtgtatg agagacccgt ggcaggacct
     2641 tacatcactt tcaccgatgc agtcaatgag accaccatta tgctcaagtg gatgtatatc
     2701 cctgccagca acaacaacac cccaatccat ggcttctata tctactaccg acccacagat
     2761 agtgacaacg acagtgatta caagaaagac atggtggaag gggacaggta ctggcactcc
     2821 atcagccacc tgcagccaga gacctcctat gacattaaga tgcaatgctt caacgaagga
     2881 ggggagagcg agttcagcaa cgtcatgatc tgtgagacca aagctcggaa attttctggt
     2941 cagcctggaa gacccccacc cttaactctg gctccaccac aacctccgcc cctagaagcc
     3001 atggagcggc cgatgggcac tggagccatg gtggcccggg ccagcgacct gccctatctg
     3061 attgtcgggg tcgttctggg ctctatcgtc ctcatcatcg tcaccttcat ccccttctgc
     3121 ctatggaggg cctggtctaa gcagaagcat acaacagatc tgggttttcc tcggagtgcc
     3181 ctcctgtctt cttcctgcca gtacacaatg gtgccactgg gaggacttcc aggtcaccaa
     3241 gccaatggcc agccctacct cagtggtatt ggtggacggg cctgtgtcag cagactacac
     3301 ggaagcaggg gctaccctgc tgctacagtg ggctgcccag gcaggaagct tcaacagcac
     3361 tgcccagggg agcttgcaca gcagcgggaa gactccaaca gcctactgag gcagcccatt
     3421 gttagcaatg gatatgacct ccagaaccag caggttgcca gaggtaccaa gtctggttca
     3481 gaagaaggtt ctttcttata cacgctgcca gatgactcaa ctcaccagct gctccaacct
     3541 caagattgct gtcacctcca gaagcaacct gtcaccacgt gccagacagc agtgagaaga
     3601 gcaccggaag gtcctgggct agaagcttca tgggaccctc aatatcattc aggaccccgg
     3661 tgttgtttag gtcttgtacc agttgaagag gtagacagtt ctgactcctg ccaagtgggt
     3721 ggaggagact gctgtcccca gcacccttca gggacctaca caggacaaga acttggggtg
     3781 cgcctctctc ccagcccatc agttcatgtg tcctttgaaa caccacctcc cacaatttag
     3841 gccgacgcca atatgcccga aagactatat attatatgtt tgtttgtttg ttgacagaga
     3901 aaaattggta tttatttttc tattatagcc atatttatat atttatgtac ttgtaaataa
     3961 atgtatatgt gtttctataa ttctggagag atatggaatc ctccccgttc tggcacaaga
     4021 cagaaaacaa acagctgagt agctggagac cagtggaagt gagtgtcata gatagtcagg
     4081 ctgcagatgg accacagaac cagcagctcc aggggctccg ggaggcctca gaagctgcag
     4141 tcgagttggc ggaaggaccc taagcacact gttcaggaag aacgcaaggg ataaagcaaa
     4201 agccatggtg ctgcagactg acaccacccg gaagccactc aggtttggtg gcataggaca
     4261 ggtttccgag atgtcacgag aaaaacccca gatgtgtaca gcactctaag cattaacagt
     4321 ctcccagaac caataatcgg tggcaacata tctctgtaaa aacaaacact gtaacttcta
     4381 aataaatgtt tagtcttccc tgtaatcttc atcatagtca aaaaaaaaaa aaaaaaa
//
