LOCUS       NM_080888               3200 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus BCL2 interacting protein 3 like (Bnip3l), mRNA.
ACCESSION   NM_080888
VERSION     NM_080888.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Nie P, Wang H, Yu D, Wu H, Ni B, Kong J and Zhang Z.
  TITLE     NIX Mediates Mitophagy in Spinal Cord Injury in Rats by Interacting
            with LC3
  JOURNAL   Cell Mol Neurobiol 42 (6), 1983-1994 (2022)
   PUBMED   33779883
  REMARK    GeneRIF: NIX Mediates Mitophagy in Spinal Cord Injury in Rats by
            Interacting with LC3.
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Yu X, Sun Y, Cai Q, Zhao X, Liu Z, Xue X and Fu J.
  TITLE     Hyperoxia exposure arrests alveolarization in neonatal rats via
            PTEN-induced putative kinase 1-Parkin and Nip3-like protein
            X-mediated mitophagy disorders
  JOURNAL   Int J Mol Med 46 (6), 2126-2136 (2020)
   PUBMED   33125104
  REMARK    GeneRIF: Hyperoxia exposure arrests alveolarization in neonatal
            rats via PTENinduced putative kinase 1Parkin and Nip3like protein
            Xmediated mitophagy disorders.
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Ouyang S, Chen W, Zeng G, Lei C, Tian G, Zhu M, Liu Y and Yang M.
  TITLE     MicroRNA-183-3p up-regulated by vagus nerve stimulation mitigates
            chronic systolic heart failure via the reduction of BNIP3L-mediated
            autophagy
  JOURNAL   Gene 726, 144136 (2020)
   PUBMED   31629817
  REMARK    GeneRIF: VNS treatment benefited CSHF via the up-regulation of
            miRNA-183-3p, which reduced the BNIP3L-mediated autophagy.
REFERENCE   4  (bases 1 to 3200)
  AUTHORS   Duval N, Sumner WA, Andrianakos AG, Gray JJ, Bouchard RJ, Wilkins
            HM and Linseman DA.
  TITLE     The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and
            BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant
            SOD1 Mouse Spinal Cord
  JOURNAL   Front Cell Neurosci 12, 15 (2018)
   PUBMED   29440992
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3200)
  AUTHORS   Liu W, Wang X, Mei Z, Gong J, Huang L, Gao X, Zhao Y, Ma J and Qian
            L.
  TITLE     BNIP3L promotes cardiac fibrosis in cardiac fibroblasts through
            [Ca2+]i-TGF-beta-Smad2/3 pathway
  JOURNAL   Sci Rep 7 (1), 1906 (2017)
   PUBMED   28507335
  REMARK    GeneRIF: BNIP3L is a novel mediator of pressure overload-induced
            cardiac fibrosis through the [Ca(2+)]i-TGF-beta-Smad2/3 pathway in
            CFs.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3200)
  AUTHORS   Nakamura H, Honda H, Tashiro M, Taguchi M, Yoshikawa H and Otsuki
            M.
  TITLE     Increased expression of 19-kD interacting protein-3-like protein
            and the relationship to apoptosis in the lung of rats with severe
            acute pancreatitis
  JOURNAL   Crit Care Med 31 (10), 2527-2534 (2003)
   PUBMED   14530762
REFERENCE   7  (bases 1 to 3200)
  AUTHORS   Itoh T, Itoh A and Pleasure D.
  TITLE     Bcl-2-related protein family gene expression during
            oligodendroglial differentiation
  JOURNAL   J Neurochem 85 (6), 1500-1512 (2003)
   PUBMED   12787069
REFERENCE   8  (bases 1 to 3200)
  AUTHORS   Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K,
            Motoyama N and Nakajima T.
  TITLE     A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis
            induced by Nip3 by forming a heterodimer through the C-terminal
            hydrophobic region
  JOURNAL   Cell Death Differ 6 (4), 314-325 (1999)
   PUBMED   10381623
REFERENCE   9  (bases 1 to 3200)
  AUTHORS   Yasuda M, Han JW, Dionne CA, Boyd JM and Chinnadurai G.
  TITLE     BNIP3alpha: a human homolog of mitochondrial proapoptotic protein
            BNIP3
  JOURNAL   Cancer Res 59 (3), 533-537 (1999)
   PUBMED   9973195
REFERENCE   10 (bases 1 to 3200)
  AUTHORS   Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L,
            Dubik D and Greenberg A.
  TITLE     Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial
            proteins
  JOURNAL   J Biol Chem 274 (1), 7-10 (1999)
   PUBMED   9867803
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000270.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_080888.3.
            
            On Nov 27, 2020 this sequence version replaced NM_080888.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB077364.1, BC098658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JACYVU010000270.1  7768206-7768308     c
            104-287             JACYVU010000270.1  7759802-7759985     c
            288-360             JACYVU010000270.1  7753807-7753879     c
            361-464             JACYVU010000270.1  7749352-7749455     c
            465-614             JACYVU010000270.1  7749081-7749230     c
            615-3200            JACYVU010000270.1  7745172-7747757     c
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3200
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /note="BCL2 interacting protein 3 like"
                     /db_xref="GeneID:140923"
                     /db_xref="RGD:621354"
     exon            1..103
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..663
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /note="BCL2/adenovirus E1B 19 kDa-interacting protein
                     3-like; BCL2/adenovirus E1B interacting protein 3-like"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3-like"
                     /protein_id="NP_543164.2"
                     /db_xref="GeneID:140923"
                     /db_xref="RGD:621354"
                     /translation="MSHLVEPPPPLHNNNNNCEEGEQSLPPPAGLNSSWVELPMNSSN
                     GNGNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQ
                     IMFDVEMHTSRDHSSQSEEEVVDGEKEVEALKKSADWVSDWSSRPENIPPKEFLFRHP
                     KRAASLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY
                     "
     exon            104..287
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /inference="alignment:Splign:2.1.0"
     exon            288..360
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /inference="alignment:Splign:2.1.0"
     exon            361..464
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /inference="alignment:Splign:2.1.0"
     exon            465..614
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /inference="alignment:Splign:2.1.0"
     exon            615..3200
                     /gene="Bnip3l"
                     /gene_synonym="Nix; UV93"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgaccatgt ctcacttagt cgagccgccg ccgcccctgc acaacaacaa caacaactgc
       61 gaggaagggg agcagtccct gccgccgccc gctggcctca acagttcctg ggtggagcta
      121 cccatgaaca gcagcaatgg caacggtaat ggaaatggga agaatggggg cctggagcac
      181 gttccttcct cgtcttccat ccacaatgga gacatggaga agatccttct ggatgcgcag
      241 catgagtcgg gacagagcag ctcaagaggc agttctcact gtgacagccc ttcaccacaa
      301 gaagacgggc aaataatgtt tgatgttgag atgcacacca gcagggacca cagctctcag
      361 tcagaagaag aagttgtaga tggagaaaaa gaagttgagg ctttgaagaa aagtgcagac
      421 tgggtatcag actggtccag tagacccgaa aacatcccac ccaaagagtt ccttttcaga
      481 caccctaagc gtgcagcctc tctaagcatg aggaagagtg gagccatgaa gaaagggggc
      541 attttctctg cagagttcct gaaggtcttc atcccatctc tcttcctctc tcacgtgttg
      601 gctttggggc tgggcatcta tatcggaaaa cgactgagca caccttctgc cagcacctac
      661 tgagggagac gaaaagcccc tgggaatccg tgtggcctgt gaagtggtgt attgtagttt
      721 gaatttgaga cctattgtaa gcatgatccc cacctacaac cctattttta catgcccaat
      781 tccaagtaac tctcaaatcc agtattttac tcaaactctg ttggggcatt ttactaacct
      841 tgttcccttt ttggcctgta aaacacttta gagattccta acagagttta ctgttgttta
      901 gaaatttgca agggcttttt tcagcaacgc caccagcaga ttataatctt gtcaacagtg
      961 catcgtctcc tcttagtacc actagtcaca cctgcatcat tcatgctaga agctgtgttc
     1021 tagccatgca attacatctc tttctaaatg aggtcaggtt tgcaaataat actatgaaag
     1081 ctttgtttag tctttgtttt gttttccagg acaaaaacaa gcttccctga gcttgagttt
     1141 ataaaatgaa aacaaaccaa aaaaaggaaa aaaaaaaaaa aaaaaaaaaa aaaaaagaag
     1201 gcaaaacaca aggaaaaaaa aaatcctggg caataaaaat tactttaaag cagctctgga
     1261 gcccctcttt cctcatcctc ctgccgccct gaatgggtag gagacagctg tgtgagggac
     1321 agacaggaga gaggagagga gagcatgctc gcaggtttaa catcagtata ttgcaatgct
     1381 gtcttttcta tggtagagaa tctttatttg taaggagtgt ctcaggccta gacatacatg
     1441 aaacttactt ttgagatttt catgcgtttg gtattttcat gtgttaactg catgtgaatt
     1501 tttcatgact ttctttgttt ttctagtttc tttttttcta agaagagact tggaacgagt
     1561 ctgattcatg gtgttaatag aggcttcttg ttttaggaag ctttgcttac actctggagc
     1621 ctttacactc tgaagaataa cttcagagtt attccaagta cttgtgtaac ttggaaaagt
     1681 agacttgggt tgtgggaaca gttgataaag ttctggaaag atgccattca ctctctttgg
     1741 gtccttactt cctgttgttg gctacagtct tcccaaggtc tccttagtct ctcccaggcc
     1801 cctgtgactg tcttacgtaa gtgtcttctc agttctgtca aattcctgat gctctatagc
     1861 actcagaaaa ttctttgaat ggcagacttt cttctgtctg tttctaaaat gtgaagcttt
     1921 aggaccaaat tgctagtatc aggattgcag attatctcaa gtagattttg ttagatttca
     1981 gagcacagca tcactctgag ggaatctgtg tcttatatat aaataattac tgttaatgat
     2041 gtacactttg ctgaagttat agaaccattg tgaatttcaa ggctagcaac ctacacggtg
     2101 caccaggttg acttgaataa atttggcaac caggtttgcc agcatgcaga aactcactct
     2161 tctctcacat aaagggttat aaaattggtg tgttatatgg aaatggaaag gaaggtagat
     2221 aagacatttc tgtcattttt caagaacatg gctgtttatc tttaaggcag ataatatatc
     2281 caaaatagtt ttgtgagtta ttttctttct ggcatttaat gtctacctga tttgagggca
     2341 acttctgccc ttttcctttc ttgctcttaa acctggtgat gcttgatctg ccttctcacc
     2401 tattacttca agtgtttata attgagtttc ttaggaagaa agcaaatctg gtggcctgtt
     2461 gttttgttgt tgtttttcaa attgtcagga ctgctgaggc taacctgcag cacagtttgc
     2521 agcactgacg tgtgagcaga gcagaatcac tctttaatgc tcttataggc ggacatcacc
     2581 tctctaaatt cagtagcagt ttcatcggca gtgccattga actgtgggaa catttatgat
     2641 tttgtctcaa cattaaaact aaatttagtt ttgccagttt ttgaaagtat caataaaatc
     2701 atggaatatg tcccagagca actgtccatc agtgagcatg tacgatgtcg atttgcggtt
     2761 ccaacataca ggatgttcat gctcctacac agattcttgt tgagtgaaaa cagattgtcc
     2821 tatcacaaag caggattcaa cagagttgaa atttaagata aggtttaaaa agctttattc
     2881 ctgtttacaa tttgggatga aaagcaggct tcgttctaag tttattgaaa cctggctcag
     2941 atgtttgtag gtcaagagaa aagcggcaca gagacagcac agtgagtcac tcaattgcag
     3001 taaagagtga aatggagaca gcccgtgaga cgaatctcac agtgaagcgt ttgttggacc
     3061 tcctggtatt aatggagcca gagtgacatg catccttcgt ctgtctcttc gtcagcactg
     3121 gcgtcattcc tttcagttta cagaacacat gtaacttgta gctataaaca ttttgtgcca
     3181 ttaaagctct cacaaaactt
//
