LOCUS       NM_053420               1641 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Rattus norvegicus BCL2 interacting protein 3 (Bnip3), mRNA.
ACCESSION   NM_053420
VERSION     NM_053420.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Wang,F., Zhou,T., Zhou,C.X., Zhang,Q.B., Wang,H. and Zhou,Y.
  TITLE     The worsening of skeletal muscle atrophy induced by immobilization
            at the early stage of remobilization correlates with
            BNIP3-dependent mitophagy
  JOURNAL   BMC Musculoskelet Disord 24 (1), 632 (2023)
   PUBMED   37542244
  REMARK    GeneRIF: The worsening of skeletal muscle atrophy induced by
            immobilization at the early stage of remobilization correlates with
            BNIP3-dependent mitophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Chi,R., Chai,C., Liu,G., Cao,H. and Yang,B.
  TITLE     Chronic intermittent hypoxia-induced BNIP3 expression mitigates
            contractile dysfunction and myocardial injury in animal and cell
            model via modulating autophagy
  JOURNAL   Hum Cell 36 (2), 631-642 (2023)
   PUBMED   36627546
  REMARK    GeneRIF: Chronic intermittent hypoxia-induced BNIP3 expression
            mitigates contractile dysfunction and myocardial injury in animal
            and cell model via modulating autophagy.
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   Wang,F., Han,J., Wang,X., Liu,Y. and Zhang,Z.
  TITLE     Roles of HIF-1alpha/BNIP3 mediated mitophagy in mitochondrial
            dysfunction of letrozole-induced PCOS rats
  JOURNAL   J Mol Histol 53 (5), 833-842 (2022)
   PUBMED   35951252
  REMARK    GeneRIF: Roles of HIF-1alpha/BNIP3 mediated mitophagy in
            mitochondrial dysfunction of letrozole-induced PCOS rats.
REFERENCE   4  (bases 1 to 1641)
  AUTHORS   Zhu,Y., Han,X.Q., Sun,X.J., Yang,R., Ma,W.Q. and Liu,N.F.
  TITLE     Lactate accelerates vascular calcification through NR4A1-regulated
            mitochondrial fission and BNIP3-related mitophagy
  JOURNAL   Apoptosis 25 (5-6), 321-340 (2020)
   PUBMED   31993850
  REMARK    GeneRIF: Lactate accelerates vascular calcification through
            NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy.
REFERENCE   5  (bases 1 to 1641)
  AUTHORS   Ulamek-Koziol,M., Czuczwar,S.J., Kocki,J., Januszewski,S.,
            Bogucki,J., Bogucka-Kocka,A. and Pluta,R.
  TITLE     Dysregulation of Autophagy, Mitophagy, and Apoptosis Genes in the
            CA3 Region of the Hippocampus in the Ischemic Model of Alzheimer's
            Disease in the Rat
  JOURNAL   J Alzheimers Dis 72 (4), 1279-1286 (2019)
   PUBMED   31707369
  REMARK    GeneRIF: Dysregulation of Autophagy, Mitophagy, and Apoptosis Genes
            in the CA3 Region of the Hippocampus in the Ischemic Model of
            Alzheimer's Disease in the Rat.
REFERENCE   6  (bases 1 to 1641)
  AUTHORS   Vande Velde,C., Cizeau,J., Dubik,D., Alimonti,J., Brown,T.,
            Israels,S., Hakem,R. and Greenberg,A.H.
  TITLE     BNIP3 and genetic control of necrosis-like cell death through the
            mitochondrial permeability transition pore
  JOURNAL   Mol Cell Biol 20 (15), 5454-5468 (2000)
   PUBMED   10891486
REFERENCE   7  (bases 1 to 1641)
  AUTHORS   Ohi,N., Tokunaga,A., Tsunoda,H., Nakano,K., Haraguchi,K., Oda,K.,
            Motoyama,N. and Nakajima,T.
  TITLE     A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis
            induced by Nip3 by forming a heterodimer through the C-terminal
            hydrophobic region
  JOURNAL   Cell Death Differ 6 (4), 314-325 (1999)
   PUBMED   10381623
REFERENCE   8  (bases 1 to 1641)
  AUTHORS   Yasuda,M., Han,J.W., Dionne,C.A., Boyd,J.M. and Chinnadurai,G.
  TITLE     BNIP3alpha: a human homolog of mitochondrial proapoptotic protein
            BNIP3
  JOURNAL   Cancer Res 59 (3), 533-537 (1999)
   PUBMED   9973195
REFERENCE   9  (bases 1 to 1641)
  AUTHORS   Chen,G., Ray,R., Dubik,D., Shi,L., Cizeau,J., Bleackley,R.C.,
            Saxena,S., Gietz,R.D. and Greenberg,A.H.
  TITLE     The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial
            protein that activates apoptosis
  JOURNAL   J Exp Med 186 (12), 1975-1983 (1997)
   PUBMED   9396766
REFERENCE   10 (bases 1 to 1641)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121. PMID: 8001138]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO403082.1 and BC070958.1.
            
            On Mar 19, 2010 this sequence version replaced NM_053420.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212788.1, FQ216807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                CO403082.1         37-78
            43-1641             BC070958.1         1-1599
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1641
                     /gene="Bnip3"
                     /note="BCL2 interacting protein 3"
                     /db_xref="GeneID:84480"
                     /db_xref="RGD:620800"
     exon            1..152
                     /gene="Bnip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..685
                     /gene="Bnip3"
                     /note="BCL2/adenovirus E1B interacting protein 3;
                     BCL2/adenovirus E1B 19 kDa-interacting protein 3"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3"
                     /protein_id="NP_445872.1"
                     /db_xref="GeneID:84480"
                     /db_xref="RGD:620800"
                     /translation="MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDA
                     QHESGRSSSKSSHCDSPPRSQTPQDTNRAEIDTHSFGEKNSTLSEEDYIERRREVESI
                     LKKNSDWIWDWSSRPENVPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSADFLKVFLP
                     SLLLSHLLAIGLGIYIGRRLTTSTSTF"
     exon            153..300
                     /gene="Bnip3"
                     /inference="alignment:Splign:2.1.0"
     exon            301..382
                     /gene="Bnip3"
                     /inference="alignment:Splign:2.1.0"
     exon            383..489
                     /gene="Bnip3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..639
                     /gene="Bnip3"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1618
                     /gene="Bnip3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtcccctca atcccgtgtc gcctggcctc agagctgagc ggcgcaagct gccctgctac
       61 ctctcagtgg tcacttccca ggcctgtcgc agttgggctc cggctccttt gcggagccac
      121 catgtcgcag agcggggagg agaacctgca gggctcctgg gtagaactgc acttcagcaa
      181 tgggaatggg agcagcgttc cagcttccgt ctctatttat aatggtgaca tggaaaaaat
      241 actgctggat gcgcagcatg aatctggacg aagcagctcc aagagctctc actgtgacag
      301 cccacctcgc tcccagacac cacaagatac caacagagct gaaatagaca cccacagctt
      361 tggtgagaaa aacagcactc tgtctgagga agattatatt gagagaagaa gagaagttga
      421 aagtatcctg aagaaaaact cagattggat atgggattgg tcaagtcggc cagaaaatgt
      481 tccccccaag gagttccttt ttaaacaccc gaagcgcaca gctactctca gcatgagaaa
      541 cacaagcgtt atgaagaaag ggggtatttt ctcagcagac tttctgaagg ttttccttcc
      601 atctctgtta ctgtctcatc tgttagccat tggattgggg atctacattg gaaggcgtct
      661 gacaacttcc actagtacct tttgatgaga cttggatctg ccttctgctc acacagtgag
      721 gattcacgct gagctgtgac agctaattga agagctagca tgatccttgg gtgtctgcac
      781 tatgtgtgtt tatttgtttt gtaaatgcgg tgttcctgat ttagtgagac agaatagact
      841 cttaccacga cctataatta tacctatggg atcaattaat aagcatgtca gactgatgcc
      901 tattgtagca tttattagta aatttctttg aatatattag atataaatag tataaataat
      961 tttaatatag tagcaatagt gtatttaaaa atgatctgta attgtaatcc agttaagaca
     1021 ccttacactt caaaagaatg acttaagtga tattaaaatc attaaagggt tttccccaaa
     1081 ggaattctgt ggccttataa tcctattatg tagtagaaaa ttaaagggtg tgggttattt
     1141 gtaaaggcct cttactttat gaattcagta gcaaggagag actaaggtta cccacaaact
     1201 ccactttgca gtccccctct tcttgcttgc aggatgagga ttccagcctt gctgtccacc
     1261 attaccttgg gtgggcagtt gtgttacgcc tttatctctc tgctgagtga agttctacgg
     1321 tttgtactta aattttgtgt gcttttaaaa tcagctgtat tgtaagcaaa tctgtctact
     1381 ttaaaagact ggaaatgaaa aaaatctttg ccaaattctt tggagaatac tggatttgca
     1441 tatgaattaa tcagtatcca gcacttgtgt taaatcaggc gtcctcccag tcttctcttt
     1501 tctatagcat ggctttaaag cctgcctcct tgacatgctg tatatattct attgtatttg
     1561 tttcattgtc ccacacttaa ctcaggtgtg ctaaaaataa aagtaaattt taacagtcaa
     1621 aaaaaaaaaa aaaaaaaaaa a
//
