LOCUS       NM_001106835            1514 bp    mRNA    linear   ROD 16-MAR-2025
DEFINITION  Rattus norvegicus BCL2 interacting protein 2 (Bnip2), transcript
            variant 3, mRNA.
ACCESSION   NM_001106835 XM_001055775 XM_217191
VERSION     NM_001106835.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Cho,B., Choi,S.Y., Park,O.H., Sun,W. and Geum,D.
  TITLE     Differential expression of BNIP family members of BH3-only proteins
            during the development and after axotomy in the rat
  JOURNAL   Mol Cells 33 (6), 605-610 (2012)
   PUBMED   22639046
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Lu,M. and Krauss,R.S.
  TITLE     N-cadherin ligation, but not Sonic hedgehog binding, initiates
            Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4212-4217 (2010)
   PUBMED   20160094
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Oh,J.E., Bae,G.U., Yang,Y.J., Yi,M.J., Lee,H.J., Kim,B.G.,
            Krauss,R.S. and Kang,J.S.
  TITLE     Cdo promotes neuronal differentiation via activation of the p38
            mitogen-activated protein kinase pathway
  JOURNAL   FASEB J 23 (7), 2088-2099 (2009)
   PUBMED   19244314
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Sonn,S., Jeong,Y. and Rhee,K.
  TITLE     Nip2/centrobin may be a substrate of Nek2 that is required for
            proper spindle assembly during mitosis in early mouse embryos
  JOURNAL   Mol Reprod Dev 76 (6), 587-592 (2009)
   PUBMED   19117032
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121. PMID: 8001138]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474041.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217191.4, XM_001055775.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1514
                     /gene="Bnip2"
                     /note="BCL2 interacting protein 2"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
     exon            1..191
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..298
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1229
                     /gene="Bnip2"
                     /note="isoform 3 is encoded by transcript variant 3; Bcl-2
                     and E1B 19 kDa interacting protein; BCL2/adenovirus E1B
                     19kDa-interacting protein 1, NIP2; BCL2/adenovirus E1B
                     interacting protein 2; BCL2/adenovirus E1B 19 kDa
                     protein-interacting protein 2"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 2 isoform 3"
                     /protein_id="NP_001100305.1"
                     /db_xref="GeneID:300811"
                     /db_xref="RGD:1308944"
                     /translation="MEGVELKEEWQDEDFPIPLPEDDSIEADILDVTDPDRQPGSLEV
                     NGNKVRKKLVAPDISLTLDPGEDSLWSDDLDEGGEVDLDGLDTPSENSDEFEWEDDLP
                     KPKTTEVIRKGSITEYAATEEKEDGRRWRMFRIGEQDHRVDMKAIEPYKKVISHGGYY
                     GDGLNAIVVFAVCFMPESGQPNYRYLMDNLFKYVIGTLELLVAENYMIIYLNGATTRR
                     KMPSLGWLRRCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVF
                     NLAELAELVPMEYVGIPECIKQCVSLLCFSSWIWARGLLLCLTVLKNTGL"
     exon            299..366
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            367..543
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..720
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..823
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..955
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1042
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1514
                     /gene="Bnip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcactgaatc cgggtcagct gctgcctccg ggactgcagc tgagaccgtc cgggaaaagc
       61 tgggccccgt ctccacagcc gaccaagggc agcgggctct gcccggcgcc actttctgcg
      121 acctggccgt cagccccacg tcgccggcct ggaggggcaa agaggacgag ggggccgcgg
      181 cttcctccgg ggacctcggc tgcctggatt gccaggagct ggaagttgac attgagtcta
      241 ggctgaggat ggaaggtgtg gaactgaaag aagaatggca ggatgaagac ttcccaatac
      301 ctttaccaga agatgacagc attgaagcag atatactaga tgtaactgat ccagacagac
      361 agcctggctc gttagaagtt aatggaaaca aagtacggaa gaaactggtg gccccagaca
      421 tcagcctgac cttggatcct ggtgaagact ctctgtggtc agatgatttg gatgaaggtg
      481 gagaagttga cctggatggc ttagacaccc cctcagagaa cagtgatgag tttgagtggg
      541 aagatgatct tcccaaaccc aaaactactg aagtcattag gaaaggctca attactgaat
      601 atgcagctac agaagaaaag gaagatggac gccgctggcg catgttcagg attggagagc
      661 aggaccatag agtggacatg aaggcaatcg aaccctacaa aaaagttatt agccatggag
      721 gctattatgg ggatggctta aatgccattg ttgtatttgc tgtctgtttc atgcctgaga
      781 gtggtcagcc taactataga tatttgatgg acaatctctt taaatatgtt attggcactt
      841 tagagctgtt ggtagcagag aactacatga tcatttactt aaatggtgcg acaacgcgaa
      901 ggaaaatgcc cagtctggga tggctcagga gatgctacca gcaaatcgac agacgattaa
      961 ggaaaaacct aaagtctcta atcattgtgc acccctcttg gtttatccga acacttctgg
     1021 ctgttacaag accatttatc agttcaaaat tcagtcagaa gattagatac gtctttaatt
     1081 tggctgaact ggcggagctt gttcccatgg agtacgtcgg cataccagag tgcatcaaac
     1141 agtgcgtctc cctcctttgt ttctcttcct ggatctgggc aagagggctg cttctctgtc
     1201 tcactgtgct caagaacaca gggctgtaag gaagaggtag aggaggaacc tgtttgtccc
     1261 acagccttcc ctcacagctt ccccttgcag caccaggttt gcataaccgg aggggactgt
     1321 gctcatgagt ccttctgtac cttacgtgct gtttaagtct gagagatgac gtcctgagga
     1381 ggcagtcctg tagagtcgct tctctacttg acatgttact ctcacgagtt tatcgtgtta
     1441 ctgtgttact gaaggaactc ctattgctaa agaaacaagt tgttgtttaa agcagcctgg
     1501 tcttaatatt ttcc
//
