LOCUS       NM_001109016            2984 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus BMX non-receptor tyrosine kinase (Bmx), mRNA.
ACCESSION   NM_001109016 XM_001071364 XM_346302
VERSION     NM_001109016.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Ying WZ, Aaron KJ and Sanders PW.
  TITLE     Sodium and potassium regulate endothelial phospholipase C-gamma and
            Bmx
  JOURNAL   Am J Physiol Renal Physiol 307 (1), F58-F63 (2014)
   PUBMED   24785188
  REMARK    GeneRIF: The effects of dietary K(+) on Bmx were more pronounced
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Wu JC, Chen KY, Yu YW, Huang SW, Shih HM, Chiu WT, Chiang YH and
            Shiau CY.
  TITLE     Location and level of Etk expression in neurons are associated with
            varied severity of traumatic brain injury
  JOURNAL   PLoS One 7 (6), e39226 (2012)
   PUBMED   22723969
  REMARK    GeneRIF: Location and level of Etk expression in neurons are
            associated with varied severity of traumatic brain injury
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Chen KY, Wu CC, Chang CF, Chen YH, Chiu WT, Lou YH, Chen YH, Shih
            HM and Chiang YH.
  TITLE     Suppression of Etk/Bmx protects against ischemic brain injury
  JOURNAL   Cell Transplant 21 (1), 345-354 (2012)
   PUBMED   21929872
  REMARK    GeneRIF: data suggest that Etk/Bmx is activated after neuronal
            injury; suppressing Etk activity protects against neurodegeneration
            in ischemic brain
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y
            and Qiu Y.
  TITLE     Regulation of the PH-domain-containing tyrosine kinase Etk by focal
            adhesion kinase through the FERM domain
  JOURNAL   Nat Cell Biol 3 (5), 439-444 (2001)
   PUBMED   11331870
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Tsai YT, Su YH, Fang SS, Huang TN, Qiu Y, Jou YS, Shih HM, Kung HJ
            and Chen RH.
  TITLE     Etk, a Btk family tyrosine kinase, mediates cellular transformation
            by linking Src to STAT3 activation
  JOURNAL   Mol Cell Biol 20 (6), 2043-2054 (2000)
   PUBMED   10688651
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474014.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_346302.3, XM_001071364.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351,
                              SAMN06680413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..2984
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /note="BMX non-receptor tyrosine kinase"
                     /db_xref="GeneID:367786"
                     /db_xref="RGD:1565643"
     exon            1..141
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2106
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /EC_number="2.7.10.1"
                     /codon_start=1
                     /product="cytoplasmic tyrosine-protein kinase BMX"
                     /protein_id="NP_001102486.1"
                     /db_xref="GeneID:367786"
                     /db_xref="RGD:1565643"
                     /translation="MDNNMDSKSILEELLLKKSQQKKKMSPINYKERLFVLTKTSLSY
                     YEYDKMKRGSRKGSIEVKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEES
                     RCQWLKALQKEIRGNPHLLIKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYADLHIAI
                     SDEKHRAPTFPERILKIPRAVPILKMDASSSSAIPPQYDSHLKKSYDSQPTVNIRYIP
                     REDCPDWWQIRKPKSEEDIARSNQLERNIVSHSPSKMSWGFPESSSSEEEENLDAYDW
                     FAGNISRSQSEQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDKKGTVKHYHVHTN
                     AENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGIWEL
                     KREEIALLKELGSGQFGVVQLGKWKGQYSVAVKMIKEGAMSEDEFFQEAQTMMKLSHP
                     KLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKNHGKGLESSQLLEMCYDVCEGMAFLE
                     SHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHY
                     FKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQI
                     MYSCWHELPEKRPTFQQLLSAIEPLREQDKP"
     exon            142..288
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            289..393
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            394..475
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            476..595
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            596..660
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            661..836
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            837..908
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            909..962
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1017
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1097
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1225
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1300
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1472
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1689
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1754
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1873
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2031
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2984
                     /gene="Bmx"
                     /gene_synonym="RGD1565643"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagccatttc tgacccaaca gccagaaaaa atgtgacaca attcactgct gctggagaga
       61 agacagcccg aagttgagtt cttgcaggag cagcttcgct tcaccgtggt gaaccccagg
      121 gaggcagaag aagcctaaat ggacaacaat atggatagta aatccatttt ggaagaactg
      181 cttctcaaaa agtcacagca aaagaagaaa atgtcaccta ttaattacaa ggagcggctt
      241 tttgttctaa ccaaaacaag cctttcctac tatgaatatg acaaaatgaa acgaggaagc
      301 agaaaaggat cgatagaagt taagaaaatc cgatgtgtgg aaaaagtcaa ccttgaggag
      361 cagacacccg tggagagaca gtatccattt cagattgtgt acaaagatgg gcttctttat
      421 gtctatgcgt cgaatgaaga gagccgatgt cagtggttga aagcgctgca aaaagagata
      481 cggggcaacc cccacctgtt gatcaagtat cacagtggct tctttgtgga tgggaagttc
      541 ctgtgttgcc agcagagctg caaagcagcc ccaggatgca ctctctggga agcatatgct
      601 gatctgcaca ttgcaatcag tgatgagaaa cacagagccc ccacttttcc agagaggata
      661 ctgaagatcc caagggcagt tcccattctc aaaatggatg catcatcctc aagtgccatt
      721 ccaccccaat atgacagcca cttaaagaaa agttatgact cccagccaac cgtcaacata
      781 cgctatattc caagggaaga ctgccctgac tggtggcaaa taaggaaacc gaaaagtgag
      841 gaagacattg cccgcagtaa ccaattggaa agaaatattg tatctcacag cccctcaaag
      901 atgtcatggg gattccctga gtcaagttca tctgaagaag aggaaaatct ggatgcttat
      961 gactggtttg ctgggaatat ctccaggtca caatctgagc agttactgag acaaaaggga
     1021 aaagaaggcg cattcatggt gaggaattcc agccagatgg ggatgtacac cgtgtcctta
     1081 ttcagcaagg ctgtaaatga caaaaaagga actgtcaaac attatcacgt gcataccaat
     1141 gctgaaaata aattatactt ggctgaaaac tactgctttg attctattcc aaagctcatt
     1201 cactatcacc aacataattc agcaggcatg atcacaaggc tccgccaccc agtgtcaacc
     1261 aaggccaaca aggtcccggt gtctgtggct ctgggaagtg gaatttggga actgaaaaga
     1321 gaagagatcg ccttgttgaa ggagctgggc agtggccagt ttggagtggt ccagctgggc
     1381 aagtggaagg ggcagtattc tgtggctgta aagatgatca aggagggcgc catgtcagaa
     1441 gatgaattct ttcaggaggc ccagaccatg atgaaactca gccatcccaa gctggtgaaa
     1501 ttctatggcg tatgctcaaa gaaatacccc atctatatag taacagagta tataacgaat
     1561 ggttgcttgc ttaattacct gaagaatcat gggaaaggac tagaaagctc ccagctctta
     1621 gaaatgtgct atgatgtctg tgaaggcatg gccttcttgg agagccatca gttcatacat
     1681 cgggatttgg ctgctcggaa ctgtttggtg gacagtgatc tctccgtgaa agtctcagac
     1741 tttggaatga cgagatatgt ccttgatgac cagtatgtca gttcagtagg aaccaagttt
     1801 ccagtcaagt ggtcggcccc agaggtgttt cactatttca aatacagcag caagtcggac
     1861 gtatgggcgt ttgggatcct gatgtgggag gtgtttagcc taggcaagca gccctatgac
     1921 ttatatgata actctgaagt ggttgtgaag gtctcccagg gccacagact ctaccggccc
     1981 caactagcat cagacactat ctaccagata atgtacagct gctggcatga gcttccagaa
     2041 aagcgcccca catttcagca actcctatct gccatagaac cactccggga acaagataag
     2101 ccatgaagag aaatttcaga atggtgatga aaatgaatat aaacattgac caacactctc
     2161 attgtttgta aggggagtag aaagacgcca tgtattatag ctagttctta ataatggtct
     2221 gtgtattgtt taactgttat attacctacc aagaaaagca aggtaggaaa caaggtattt
     2281 ctttgaaatt tagcttaaat tggtcatttt tgtttgtgct gcttttaatg tactacttcc
     2341 cagactatgg tagaagttca tttttagatt acactttcca aagggtgtgt actgtgtata
     2401 aagggagagc gggattgaaa aggtaatttg ttgggagttc agtttttttc tattggcact
     2461 tgtgtggtaa ttaaatatct tttcaagaac agaaatgtgt atgtttgctt ctgtatgaga
     2521 aatgtctcag gcatttgaat atttgttctc cagtttgtgg cactgtttgt agaggtttag
     2581 gaagaatggc ctcgatggag gaattatgtc aatagggcag gctttgagag cttaaggctt
     2641 caccctacct gtagtttact tcttgcatgc agttcaagat gtgagctctc agaagctgaa
     2701 gaagtggctt agtggttaag aacactggct gttcctccag aggacacagg ttcaattccc
     2761 agaactgcac agtggcttac aacttgtcta tgaatccagt tctaaagaat attatggctt
     2821 cttctagcct tcacgcgtac ctagtacaca tgtggtacac caacatatat acaagcaaag
     2881 aagaaaacta aagggtggga gctctcagca tcctgctctg tctgccatgt ctgcaagtag
     2941 cctttgacct gccattttga actctctctc tggaactata agca
//
