LOCUS       NM_001109221            1335 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus S-adenosylmethionine sensor upstream of mTORC1
            (Samtor), mRNA.
ACCESSION   NM_001109221 XM_001057511 XM_001060838
VERSION     NM_001109221.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Gu,X., Orozco,J.M., Saxton,R.A., Condon,K.J., Liu,G.Y.,
            Krawczyk,P.A., Scaria,S.M., Harper,J.W., Gygi,S.P. and
            Sabatini,D.M.
  TITLE     SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
  JOURNAL   Science 358 (6364), 813-818 (2017)
   PUBMED   29123071
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 5, 2021 this sequence version replaced NM_001109221.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.15342.1,
                                           SRR26643291.11849.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000004.1  42911270-42911546   c
            278-419             JAXUCZ010000004.1  42897290-42897431   c
            420-590             JAXUCZ010000004.1  42866228-42866398   c
            591-705             JAXUCZ010000004.1  42849927-42850041   c
            706-1335            JAXUCZ010000004.1  42847720-42848349   c
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1335
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /note="S-adenosylmethionine sensor upstream of mTORC1"
                     /db_xref="GeneID:500034"
                     /db_xref="RGD:1588441"
     exon            1..277
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1335
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /note="probable methyltransferase BTM2 homolog; base
                     methyltransferase of 25S rRNA 2 homolog"
                     /codon_start=1
                     /product="S-adenosylmethionine sensor upstream of mTORC1"
                     /protein_id="NP_001102691.1"
                     /db_xref="GeneID:500034"
                     /db_xref="RGD:1588441"
                     /translation="MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRR
                     LRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCR
                     EYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPEFITELLQA
                     SGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAID
                     AFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITP
                     DSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPG
                     MLYIPQDFNSVEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPF
                     YELEDPILLLS"
     exon            278..419
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..590
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..705
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..1335
                     /gene="Samtor"
                     /gene_synonym="Bmt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttagctgt ggctcctcgg cctcctccgg ctgctgcctc tgctgctgcc tcctccttcc
       61 ccacctcctc cgtccgggga gagaccgcgg ggcccgaggg gcggcggcag cggcggcagc
      121 gctatggagc cggggccggg tggccgaggc gcagcgcgcg gacagcggcc cccgaacgcc
      181 gcgcagcccc gggagcagga gcggaagctg gagcaggaga agctgtccgg ggtggtgaag
      241 agcgtccacc ggcggctccg caagaaatac cgcgaagtgg gagactttga taagatttgg
      301 cgagaacact gtgaagatgc agaaacactt tgtgaatatg ctgttgcaat gaaaaatttg
      361 gcagataatc actgggcaaa aacttgcgag ggtgaaggtc gcattgaatg gtgttgtagt
      421 gtatgcagag agtatttcca aaatggtggg aagagaaaag cacttgagaa agatgaaaaa
      481 cgagctgtcc tcgccactaa gaccactcca gccttaaacg ttcacgagtc ttctaaactt
      541 gaaggtcctt taacaaacct cagctttaca agccctgagt ttataactga gttgcttcag
      601 gcctcaggaa agataagatt acttgacgtt ggcagctgct ttaatccgtt tttgaagttt
      661 gaagaatttc taactgttgg catagatatt gtacctgctg tagagagtgt gtataagtgt
      721 gacttcctga acttgcagct gcagcagccg ctccaacttg cacaagacgc tatagacgct
      781 tttctgaagc aactgaaaaa tcctattgat tctcttccag gagaactttt tcatgtggtt
      841 gttttctctc tcctcctttc ctattttcca tcaccctacc agcgatggat ttgctgtaag
      901 aaagcccatg agctgttagt gctgaatggc ttactgctca tcatcacccc cgactcctcc
      961 catcagaacc ggcacgccat gatgatgaag agctggaaga ttgctataga atccctgggc
     1021 tttaagcgct tcaagtattc aaaattttct catatgcatc tcatggcttt tagaaaaacc
     1081 tcccttaaaa ccacgagtga cttggttagt aggaactatc cagggatgtt atatattcct
     1141 caagatttca acagtgtaga agatgaggag tattctaacc cttcctgcta tgtccgatca
     1201 gatatagaag atgaacaact agcgtacggt ttcacagagc tccctgatgc tccttatgat
     1261 tcagattctg gagaaagtca agccagctct atcccattct atgagctaga ggatcccatc
     1321 ttacttttaa gctaa
//
