LOCUS       NM_001024259            5386 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein receptor type 1B
            (Bmpr1b), mRNA.
ACCESSION   NM_001024259 XM_039102479 XM_227759
VERSION     NM_001024259.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5386)
  AUTHORS   Zhao YY, Li XX, Wang W, Chen X, Yu P, Wang JJ and Xu YX.
  TITLE     Effect of BMPRIB gene silencing by siRNA on apoptosis and
            steroidogenesis of porcine granulosa cells
  JOURNAL   Genet Mol Res 13 (4), 9964-9975 (2014)
   PUBMED   25501208
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5386)
  AUTHORS   Graul-Neumann LM, Deichsel A, Wille U, Kakar N, Koll R, Bassir C,
            Ahmad J, Cormier-Daire V, Mundlos S, Kubisch C, Borck G, Klopocki
            E, Mueller TD, Doelken SC and Seemann P.
  TITLE     Homozygous missense and nonsense mutations in BMPR1B cause
            acromesomelic chondrodysplasia-type Grebe
  JOURNAL   Eur J Hum Genet 22 (6), 726-733 (2014)
   PUBMED   24129431
REFERENCE   3  (bases 1 to 5386)
  AUTHORS   Degenkolbe E, Konig J, Zimmer J, Walther M, Reissner C, Nickel J,
            Ploger F, Raspopovic J, Sharpe J, Dathe K, Hecht JT, Mundlos S,
            Doelken SC and Seemann P.
  TITLE     A GDF5 point mutation strikes twice--causing BDA1 and SYNS2
  JOURNAL   PLoS Genet 9 (10), e1003846 (2013)
   PUBMED   24098149
REFERENCE   4  (bases 1 to 5386)
  AUTHORS   Miyagi M, Mikawa S, Hasegawa T, Kobayashi S, Matsuyama Y and Sato
            K.
  TITLE     Bone morphogenetic protein receptor expressions in the adult rat
            brain
  JOURNAL   Neuroscience 176, 93-109 (2011)
   PUBMED   21185359
  REMARK    Erratum:[Neuroscience. 2011 Jun 2;183:278. Sho, K [corrected to
            Kobayashi, S]]
REFERENCE   5  (bases 1 to 5386)
  AUTHORS   Tsujii M, Akeda K, Iino T and Uchida A.
  TITLE     Are BMPs involved in normal nerve and following transection?: a
            pilot study
  JOURNAL   Clin Orthop Relat Res 467 (12), 3183-3189 (2009)
   PUBMED   19669850
  REMARK    GeneRIF: The upregulation in BMP/BMPR expression after nerve
            transection suggests that they may play a role in the healing
            response of the peripheral nerve.
REFERENCE   6  (bases 1 to 5386)
  AUTHORS   Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD,
            Laping NJ and Hill CS.
  TITLE     SB-431542 is a potent and specific inhibitor of transforming growth
            factor-beta superfamily type I activin receptor-like kinase (ALK)
            receptors ALK4, ALK5, and ALK7
  JOURNAL   Mol Pharmacol 62 (1), 65-74 (2002)
   PUBMED   12065756
REFERENCE   7  (bases 1 to 5386)
  AUTHORS   Yi SE, LaPolt PS, Yoon BS, Chen JY, Lu JK and Lyons KM.
  TITLE     The type I BMP receptor BmprIB is essential for female reproductive
            function
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7994-7999 (2001)
   PUBMED   11416163
REFERENCE   8  (bases 1 to 5386)
  AUTHORS   Visser JA, Olaso R, Verhoef-Post M, Kramer P, Themmen AP and
            Ingraham HA.
  TITLE     The serine/threonine transmembrane receptor ALK2 mediates Mullerian
            inhibiting substance signaling
  JOURNAL   Mol Endocrinol 15 (6), 936-945 (2001)
   PUBMED   11376112
REFERENCE   9  (bases 1 to 5386)
  AUTHORS   Baur ST, Mai JJ and Dymecki SM.
  TITLE     Combinatorial signaling through BMP receptor IB and GDF5: shaping
            of the distal mouse limb and the genetics of distal limb diversity
  JOURNAL   Development 127 (3), 605-619 (2000)
   PUBMED   10631181
REFERENCE   10 (bases 1 to 5386)
  AUTHORS   Astrom AK, Jin D, Imamura T, Roijer E, Rosenzweig B, Miyazono K,
            ten Dijke P and Stenman G.
  TITLE     Chromosomal localization of three human genes encoding bone
            morphogenetic protein receptors
  JOURNAL   Mamm Genome 10 (3), 299-302 (1999)
   PUBMED   10051328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000079.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001024259.4.
            
            On or before Feb 25, 2022 this sequence version replaced
            XM_039102479.1, NM_001024259.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00155329, SAMD00155332
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JACYVU010000079.1  17970502-17970606   c
            106-173             JACYVU010000079.1  17876877-17876944   c
            174-267             JACYVU010000079.1  17784247-17784340   c
            268-427             JACYVU010000079.1  17683261-17683420   c
            428-530             JACYVU010000079.1  17674673-17674775   c
            531-633             JACYVU010000079.1  17674088-17674190   c
            634-730             JACYVU010000079.1  17667492-17667588   c
            731-869             JACYVU010000079.1  17666203-17666341   c
            870-1062            JACYVU010000079.1  17661119-17661311   c
            1063-1360           JACYVU010000079.1  17660117-17660414   c
            1361-1536           JACYVU010000079.1  17648135-17648310   c
            1537-1667           JACYVU010000079.1  17643447-17643577   c
            1668-5386           JACYVU010000079.1  17637792-17641510   c
FEATURES             Location/Qualifiers
     source          1..5386
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..5386
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /note="bone morphogenetic protein receptor type 1B"
                     /db_xref="GeneID:310914"
                     /db_xref="RGD:1595863"
     exon            1..105
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            106..173
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            174..267
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            268..427
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1793
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /EC_number="2.7.11.30"
                     /note="bone morphogenetic protein binding serine/threonine
                     kinase receptor; bone morphogenetic protein receptor, type
                     IB"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1B"
                     /protein_id="NP_001019430.2"
                     /db_xref="GeneID:310914"
                     /db_xref="RGD:1595863"
                     /translation="MLLRSSGKLNVGTKKEDGESTAPTARPKVLRCKCHHHCPEDSVN
                     NICSTDGYCFTMIEEDDSGTPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNEC
                     NKDLHPTLPPLKDRDFVDGPIHHKALLISVTVCSLLLVLIILFCYFRYKRQEARPRYS
                     IGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEV
                     WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLY
                     LITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLK
                     SKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRTHF
                     QSYIMADMYSFGLILWEIARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCMKKLR
                     PSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL"
     exon            428..530
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            531..633
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            634..730
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            731..869
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1062
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1360
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1536
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1667
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..5386
                     /gene="Bmpr1b"
                     /gene_synonym="CFK-43a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggcggcg gcggcggcgg cagcggcagc ggcggaggct gaagttgccg gcgtggtgct
       61 cggagtgcgg gcgccgagga cccgggacca ggggcgcggc ggcgggttgg agttcaaggt
      121 actcgttacg tgtgacgagg aagtgaagcc cattccatgc cttgctgaga aaggttcaaa
      181 cttcggctga atcacaacca tttggcgctg agctatgaca agagagcaaa caaaaagtta
      241 aaggagcaac tcggccataa gtgacagaga agttcgttga taacatgctc ttacgaagct
      301 ctggaaaatt aaatgtgggc accaagaagg aggatggtga gagtacagcc cccactgctc
      361 ggcccaaggt cctgcgttgt aaatgccacc accactgtcc tgaagactca gtcaacaata
      421 tctgcagcac agatgggtac tgcttcacga tgatagaaga agacgactct ggaacgcctg
      481 ttgtcacctc cggatgccta ggactagaag ggtcagattt tcaatgtcgc gacacgccca
      541 tccctcatca gagaaggtca attgaatgct gcacagaaag gaacgaatgt aataaagatc
      601 tccaccccac gctgcctccc ctgaaggaca gagattttgt tgatggaccc atacaccaca
      661 aagccttact catatctgtg actgtctgta gtttactctt ggtcctcatt attttattct
      721 gttacttcag gtataaaaga caagaagcca gacctcggta cagcattggg ctggagcagg
      781 atgaaacgta cattcctcct ggagaatccc tgagagactt gattgagcaa tcgcagagct
      841 cgggaagtgg ctcaggactc cctctgctgg tccaaaggac aatagctaag caaattcaga
      901 tggtgaagca aattggaaaa ggtcgctatg gcgaagtgtg gatgggaaag tggcgtggag
      961 aaaaggtagc tgtgaaagtg ttcttcacca cggaggaagc cagctggttc cgagagactg
     1021 agatatatca gacggtcctg atgaggcacg agaacattct ggggttcatt gcagcagata
     1081 tcaaagggac tgggtcttgg actcagttat acctcatcac agactatcat gaaaacgggt
     1141 ctctttatga ctatctgaaa tccaccacct tagatgccaa gtccatgctg aagctagcct
     1201 actcgtctgt cagcggcctg tgccatctac acacggaaat cttcagcact caaggcaagc
     1261 cagccattgc ccatcgggac ttgaaaagta aaaacatcct ggtgaagaaa aatggaactt
     1321 gctgcatagc agacctgggc ctggctgtca agttcattag tgacacaaat gaggttgaca
     1381 ttccacccaa cacccgggtt ggcaccaagc gctatatgcc tccagaagtg ctggacgaga
     1441 gcttgaatag aactcatttc cagtcctaca tcatggctga catgtacagc tttggactca
     1501 tcctctggga gattgcaagg agatgtgttt ctggaggtat agtggaagaa taccagcttc
     1561 catatcacga cctggtgccc agtgaccctt cttatgagga catgagagaa attgtgtgta
     1621 tgaagaagtt acggccttca ttccccaatc gatggagcag tgacgagtgc ctcaggcaaa
     1681 tggggaagct tatgacagag tgctgggcgc ataatcctgc ctccaggctg acggccctga
     1741 gagttaagaa aacacttgcc aaaatgtcag agtcccagga cattaaactc tgacgtcagg
     1801 tacttgtgga cagagcaagg aattacacag aagcatcctt agcccaagcc ttgaacgttg
     1861 atctactgcc cagtgagttc agactttcct ctaagagagc aagctggaca gacacagagg
     1921 aacccagaaa cacggattca ccatggcttt ctgaggaggg gaaaccattt gggtaacttg
     1981 ttcaagatat gatgcatgtt gctttctaag aaagccctgt attttgggat taccattttt
     2041 tttaaagaag aaagatactt taatttttac caaaataaaa caaatattgt agatgttttg
     2101 aggtttatac agtcatagtt taaataataa caaaagttct tcctagaaac gttcctggaa
     2161 gtcaaaatgt tttttccatt ggcaaattac tcttgcactc tagaaaacag agcagactgt
     2221 gaacataaat tagaattcaa cttacctgct tccctgctcc aggcacctca gactgtttgg
     2281 gccagccctg ctatgagctg ccagtgcagt gtgaatgcac atgcatacaa gtcccaaatg
     2341 cctgggacca cagtttgaaa tcctcttgca gcttcagcca gagtggaaca aatgaagggt
     2401 ttatgtcact gataggatta tgtgtgggtg gcttcttcag aaccactcct gcttctgggt
     2461 gtgttaggca gctcttttag gcaattccag cccctccccc ccaacccctg ctttcattaa
     2521 acaccagcaa agccttctca tgagcggaga atcaatcgac acgggcatgc ttttgttctt
     2581 gtaaatcaga agatcaatat taaataaaac tgtcgcgagt gtggtagaaa gagggaggga
     2641 gggagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagagaga
     2701 gagacagaca gacagacaga caagggactc ttaaatggaa gtgattggag cttgtgtcat
     2761 aagaaagaca taccagtgag gcagagccga ggctgaaggt gcagcagatg tagatggctt
     2821 gtttcctccc tgtgcctaaa cccatcacag caccccagga gagaagtatg gatgccacag
     2881 cttgtgtaca tatgtatagt ttcatattgc tgtgttttct aagtctccaa cttcagagac
     2941 agagaggaag tttctgttgg gttaacgtca ctagccttta ctttaaaaat aagcagagga
     3001 aagtgaatgg gggacatcca acatcatggc tgttgtgatt tctactagaa cagatatgag
     3061 tccagtatgg acctcttacc tggtatttca caccttaggt aggactcatt tactcttgta
     3121 tgcatttcac tactaactta cagtgtttct gtacaaaaca tcttgtgatt cggtcctgtg
     3181 aggtcttaac ccttgactct ctgtgcaaaa tcactgatac gaccattatt ccatagaaac
     3241 agaactgcaa caaagtgtaa tgacacacgg ccctcctctc aactttattc atgtagtccc
     3301 ttactgtgtt tcttccataa tgattagaaa ctgcctactg gttgttaaga aagtggaaga
     3361 acttgctgtg ccttagagaa cggcaattcc ttccagaatc ctccaggggt cactgttgtc
     3421 ctatgcatct caccgctggg tgcttgaaag catggagacc ttaggaaaaa ttgacagctg
     3481 caggagaaat gagcaaatgt ttgactcttt ttctcgagta gatgttcagc cggtgggctg
     3541 ttcatctgga aaaaaaaaat cctgagctca atatttttga gctgtacctg gagtttagga
     3601 gaagtgtaaa gagaagcgct cctctgcgtt gtaattcact gtgcggtgct gcagggccac
     3661 taagataggt tttctcagtt cttgaatttg aaaagataaa aacaactggt tgttaattta
     3721 acagtcatca cattttggtc ttactgagtc cagggcaagc taagccacgg gagagccttt
     3781 tctctgttaa attatatttg ccacagacag attttccata tatttctacc taacacgtgc
     3841 cagtcatctg agcctgggag gaaaacatta tcgcctctag acagatctgt ctaccgacac
     3901 ctatgtaagc attttgccag ttaagtgggt acgctttggt tttcgttatc ttaggtttga
     3961 gtgaggttgt ggggaacctc ttagctcaga ctgtgttttc ctattggtag attttttttc
     4021 ttttttaatt gtgggcaact ttaaatcaga atgttttgga tgaggctgtt gatgatgtaa
     4081 agtgttctag atttccaggg ttcctgtgaa gaacgggggg gggatttaag tgtccaaatt
     4141 ccatctatat gtttcgtttt actgctttgg gggaaaaaaa atcagccgtt tatttgctaa
     4201 ctatcaacct tatttattca gtatgaaaat cttgaaatta tggagatcct ttaaaagatc
     4261 cactcagtta ttatgaattt tcagtaagaa tttataattt atttatgaat ataatttctg
     4321 tcttagtaga gcctaattga gacaactaag ttgttgttaa ggactacctg ttatcttcgc
     4381 ggtaatccat gataacattt aaacttctag catctcagaa aatatgcatt tattttatcc
     4441 tttgcttcaa cttcctgcac gttaataata taactgactg ctgctgaccc tcaggactct
     4501 ttcaaagagc aagatttcct tctaactcct ctcccccaaa ggaatcctaa attattaatt
     4561 gttagatgaa ctttgcgtat ccaagtttat ggttgatgtg cgtgtgtgta tatattatat
     4621 aaatatagag atgtatatgt aaataaatat gttcattctg gagtctggca caaccctagt
     4681 atgtggatta gaaagtaaaa tattatggat gataaagtcc tagatgaaac ctaatattta
     4741 tttatggaag catgaacatt gttaactcac agatgaagag cagtaaacaa tatgtctgac
     4801 tcagacagag caccgtgacg tcactactgc ctgttcttta tattccccca gtgggaagct
     4861 tcttgggggg acatgccggg ttttacttcc attggtactt agtaatgacc aggtttcttg
     4921 ttcctcctcg ggccaccctc attcatcagg ggctttctgt tttctgtctg ttgtcactct
     4981 tcttggtttg tgggttgaaa ggtagtgaga atacattttt ttttaagctt gaacatgttt
     5041 tccatctaag aaaaccccag tctcataaag aacacaagaa gggggctgca tcaaaagtga
     5101 tacaattgaa cagtttgaac taattgttat agaaactaat gccatagaaa catattaaca
     5161 gaaaaattgg taatattggg tggcggggtg gggtgggggg agggcgttct tttctgtctg
     5221 tttcaaaaca agactcgttt gtgtactttt ggggaaccag tgccttaggg aatttgtata
     5281 tactgtaatt attcacggtt agggaacaaa cagttgttat ttgttaaaaa ttgtgtatga
     5341 ttttgttttc ttatttccat caataaaaca gtgtcattct ccccat
//
