LOCUS       NM_030849               3150 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein receptor type 1A
            (Bmpr1a), mRNA.
ACCESSION   NM_030849
VERSION     NM_030849.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Rasoulian,B., Almasi,A., Hoveizi,E., Bagher,Z., Hayat,P.,
            Joghataei,M.T., Rezayat,S.M. and Tavakol,S.
  TITLE     Strong binding active constituents of phytochemical to BMPR1A
            promote bone regeneration: In vitro, in silico docking, and in vivo
            studies
  JOURNAL   J Cell Physiol 234 (8), 14246-14258 (2019)
   PUBMED   30656682
  REMARK    GeneRIF: It is worthy to note that Aloin has the highest affinity
            to BMPR1A, whereas there are no reports regarding the impact of
            Aloenin, Aloesin, and gamma-sitosterol on osteogenesis.
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Li,S.F., Zhu,C.S., Wang,Y.M., Xie,X.X., Xiao,L.L., Zhang,Z.C.,
            Tang,Q.Q. and Li,X.
  TITLE     Downregulation of beta1,4-galactosyltransferase 5 improves insulin
            resistance by promoting adipocyte commitment and reducing
            inflammation
  JOURNAL   Cell Death Dis 9 (2), 196 (2018)
   PUBMED   29415997
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Tang,X.B., Zhang,J., Wang,W.L., Yuan,Z.W. and Bai,Y.Z.
  TITLE     The expression analysis of Bmpr1a and Bmp2 during hindgut
            development in rat embryos with anorectal malformations
  JOURNAL   Exp Mol Pathol 101 (1), 143-149 (2016)
   PUBMED   27477499
  REMARK    GeneRIF: downregulation of Bmpr1a and Bmp2 at the time of cloacal
            separation into the primitive rectum and UGS might be related to
            the development of anorectal malformations.
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Wu,X.G., Wang,Y., Wu,Q., Cheng,W.H., Liu,W., Zhao,Y., Mayeur,C.,
            Schmidt,P.J., Yu,P.B., Wang,F. and Xia,Y.
  TITLE     HFE interacts with the BMP type I receptor ALK3 to regulate
            hepcidin expression
  JOURNAL   Blood 124 (8), 1335-1343 (2014)
   PUBMED   24904118
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Howe,J.R., Bair,J.L., Sayed,M.G., Anderson,M.E., Mitros,F.A.,
            Petersen,G.M., Velculescu,V.E., Traverso,G. and Vogelstein,B.
  TITLE     Germline mutations of the gene encoding bone morphogenetic protein
            receptor 1A in juvenile polyposis
  JOURNAL   Nat Genet 28 (2), 184-187 (2001)
   PUBMED   11381269
REFERENCE   7  (bases 1 to 3150)
  AUTHORS   Liu,F., Pouponnot,C. and Massague,J.
  TITLE     Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible
            transcriptional complexes
  JOURNAL   Genes Dev 11 (23), 3157-3167 (1997)
   PUBMED   9389648
REFERENCE   8  (bases 1 to 3150)
  AUTHORS   Namiki,M., Akiyama,S., Katagiri,T., Suzuki,A., Ueno,N., Yamaji,N.,
            Rosen,V., Wozney,J.M. and Suda,T.
  TITLE     A kinase domain-truncated type I receptor blocks bone morphogenetic
            protein-2-induced signal transduction in C2C12 myoblasts
  JOURNAL   J Biol Chem 272 (35), 22046-22052 (1997)
   PUBMED   9268344
REFERENCE   9  (bases 1 to 3150)
  AUTHORS   Takeda,K.
  TITLE     Expression of serine/threonine kinase receptors during ectopic bone
            formation induced by bone morphogenetic protein (BMP)
  JOURNAL   Kokubyo Gakkai Zasshi 61 (4), 512-526 (1994)
   PUBMED   7897267
REFERENCE   10 (bases 1 to 3150)
  AUTHORS   Takeda,K., Oida,S., Ichijo,H., Iimura,T., Maruoka,Y., Amagasa,T.
            and Sasaki,S.
  TITLE     Molecular cloning of rat bone morphogenetic protein (BMP) type IA
            receptor and its expression during ectopic bone formation induced
            by BMP
  JOURNAL   Biochem Biophys Res Commun 204 (1), 203-209 (1994)
   PUBMED   7945360
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 26, 2020 this sequence version replaced NM_030849.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2365697.1,
                                           SRR26643290.47435.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840106 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000016.1  9786784-9786861     c
            79-291              JAXUCZ010000016.1  9773295-9773507     c
            292-454             JAXUCZ010000016.1  9768992-9769154     c
            455-557             JAXUCZ010000016.1  9766517-9766619     c
            558-654             JAXUCZ010000016.1  9761199-9761295     c
            655-754             JAXUCZ010000016.1  9760967-9761066     c
            755-899             JAXUCZ010000016.1  9757562-9757706     c
            900-1092            JAXUCZ010000016.1  9754050-9754242     c
            1093-1390           JAXUCZ010000016.1  9750700-9750997     c
            1391-1566           JAXUCZ010000016.1  9745470-9745645     c
            1567-1697           JAXUCZ010000016.1  9744413-9744543     c
            1698-3150           JAXUCZ010000016.1  9742875-9744327     c
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p15"
     gene            1..3150
                     /gene="Bmpr1a"
                     /note="bone morphogenetic protein receptor type 1A"
                     /db_xref="GeneID:81507"
                     /db_xref="RGD:70989"
     exon            1..78
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            79..291
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1823
                     /gene="Bmpr1a"
                     /EC_number="2.7.11.30"
                     /note="ALK-3; activin receptor-like kinase 3; bone
                     morphogenetic protein 4 receptor; BMPR-1A; bone
                     morphogenetic protein receptor, type IA; BMP type-1A
                     receptor"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1A
                     precursor"
                     /protein_id="NP_110476.1"
                     /db_xref="GeneID:81507"
                     /db_xref="RGD:70989"
                     /translation="MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDVDQKKP
                     ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMK
                     YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSVRWLAVLISM
                     AVCIVAMIVFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGS
                     GSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE
                     IYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKL
                     AYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTN
                     EVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYIMADIYSFGLIIWEMARRCITGGIV
                     EEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNP
                     ASRLTALRIKKTLAKMVESQDVKI"
     exon            292..454
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            455..557
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            558..654
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            655..754
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            755..899
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1092
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1390
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1566
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1697
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..3150
                     /gene="Bmpr1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaattcatga gatggaaaca taggtcaaag ctgtttggag aaattggaac tacagtttta
       61 tctagccaca tctctgagaa gtctgaagaa agcagcaggt gaaagtcatt gtcaagtgat
      121 tttgttcttc tgtaaggaaa cctcgttcag taaggccgtt tacttcagtg aaacagcagg
      181 accagtaatc aaggtggccg gacaggacac gtgcgaattg gacaatgact cagctataca
      241 cttacatcag attactggga gcctgtctgt tcatcatttc tcatgttcaa gggcagaatc
      301 tagatagtat gctccatggt actggtatga aatcagacgt ggaccagaag aagccggaaa
      361 atggagtgac gttagcacca gaggacacct tacctttctt aaaatgctat tgctcaggac
      421 actgcccaga tgacgctatt aataacacat gcataactaa tggccattgc tttgccatta
      481 tagaagaaga tgatcaggga gaaaccacgt taacttctgg gtgtatgaag tatgaaggct
      541 ctgattttca atgcaaggat tcaccaaaag cccagctacg caggacaata gaatgttgtc
      601 ggaccaattt gtgcaaccaa tatttgcagc ctacactgcc ccctgtcgtt ataggcccat
      661 tctttgatgg cagcgtccga tggctggctg tgctcatctc tatggctgtc tgtattgtcg
      721 ccatgatcgt cttctccagc tgcttctgtt acaaacatta ctgtaagagt atctcaagca
      781 gaggtcgtta caaccgtgac ttggaacagg atgaagcatt tattccagta ggagaatcac
      841 tgaaagacct gattgaccag tcacaaagct ctggtagtgg atctggatta cctttattgg
      901 ttcagcgaac tattgccaaa cagattcaga tggttcggca ggttggtaag ggccggtatg
      961 gagaagtatg gatgggtaaa tggcgtggtg aaaaagtggc tgtcaaagtg ttttttacca
     1021 ctgaagaagc tagctggttt agagaaacag aaatctacca gacggtgtta atgcgtcatg
     1081 aaaatatact tggttttata gctgcagaca ttaaaggcac cggttcctgg actcagctgt
     1141 atttgattac tgattaccat gagaatgggt ctctctatga cttcctgaaa tgtgccaccc
     1201 tggacaccag agccctactc aagttagctt attctgctgc ctgtggtctg tgccacctcc
     1261 acacagaaat ttatggcacg caaggcaagc ctgcaattgc tcatcgagac ctgaagagca
     1321 aaaacatcct tattaagaaa aatggtagtt gctgtattgc tgacctgggc ctagctgtta
     1381 aattcaacag tgacacaaat gaagttgaca tacccttgaa caccagggtg ggcaccaggc
     1441 ggtacatggc tccagaagtg ctggacgaga gcctgagtaa aaaccatttc cagccctaca
     1501 tcatggctga catctacagc tttggtttga tcatttggga gatggcccgt cgctgtatta
     1561 caggaggaat cgtggaggaa tatcaattac catattacaa catggtgcct agtgacccat
     1621 cttatgaaga catgcgtgag gtcgtgtgtg tgaaacgctt gcggccaatc gtctctaacc
     1681 gctggaacag tgatgaatgt cttcgagccg ttttgaagct gatgtcagaa tgctgggccc
     1741 ataatccagc atccagactc acagctttga gaatcaagaa gacgctcgca aagatggttg
     1801 aatcccagga tgtaaagatt tgacaaacag ttttgagaaa gaatttagac tgcaagaaat
     1861 tcacccaagg aagggtggag ttagcatgga ctaggatgtc ggcttggttt ccagactctc
     1921 tcctctacat cttcacaggc tgctaacagt aaacctttca ggactctgca gaatgcaggg
     1981 ttggagcttc agacatagga cttcagacat gttgttcttt gcgtatggac agctttgttt
     2041 taaatgtggg cttttgatgc ctttttggtt tttatgaatt gcatcaagac tccaatcctg
     2101 ataagaagtc tctggtcaaa ctctggttac tcactatcct gtccataaag tggtgctttc
     2161 tgtgaaagcc ttaaggaaat tagtgagctc agcagagatg gagaaaggca tatttgccct
     2221 ctacagagaa aatatctgtc tgtgttctgt ctctgtaaac agcctggact atgatctctt
     2281 tgggatgctg cctggttgat gatggtgcat catgcctctg atatgcatac cagacttcct
     2341 ctgctgccat gggcttacaa gacaagaatg tgaaggttgc acaggacggt atttgtggcc
     2401 agtggtttaa atatgcaata tctaatcgac attcgccaat ctcataaaag ccatctacct
     2461 tgtaactgaa gtaacttctc taccaacttt atttttagca taatagttgt aaaggccaaa
     2521 ctatgtataa agtgtccata gactcgaact gttttcctcc agtcaccatt ttgttttcct
     2581 tttggtaatt atttttgtta tataattcct cctatccaga attggcgctc actgtcttga
     2641 accatacttt gaaagaaatg cctcttcctg gagtctgcct tactgcatct gatcaccatg
     2701 tgcatacctc tgatcaaatt ctggagtctt tgttctcggt acctcttaaa aagggaaatt
     2761 gtgtatcatg tgtagtgtgc ttttattttc aaaatcttca tagcctttat tctagccatt
     2821 tttacctaca tactcattct gtacaaaaca gctcactcgg gtctcacggc tgatcctcag
     2881 tggaaatgat ttaaagtaga gctgtgtacg aatttcagaa ttcatgtatt taaaaacttc
     2941 acactaacac tttactaaga tattgtctca tatcttttat gaggatgtca gctgattttt
     3001 caatgactat aaatgtatct tagctatcta aatcttttga aatttggttt tataatttct
     3061 ggtccctaac ttgtgaagac aaagaggcag aagtacccag tctacccaca tttacactga
     3121 acattattaa ataaaaaaat gtatatttta
//
