LOCUS       NM_001135799            3785 bp    mRNA    linear   ROD 28-DEC-2023
DEFINITION  Rattus norvegicus BMP-binding endothelial regulator (Bmper), mRNA.
ACCESSION   NM_001135799 XM_001053312 XM_235962
VERSION     NM_001135799.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3785)
  AUTHORS   Esser JS, Saretzki E, Pankratz F, Engert B, Grundmann S, Bode C,
            Moser M and Zhou Q.
  TITLE     Bone morphogenetic protein 4 regulates microRNAs miR-494 and
            miR-126-5p in control of endothelial cell function in angiogenesis
  JOURNAL   Thromb Haemost 117 (4), 734-749 (2017)
   PUBMED   28124060
REFERENCE   2  (bases 1 to 3785)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 3785)
  AUTHORS   Lu CC, Appler JM, Houseman EA and Goodrich LV.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   4  (bases 1 to 3785)
  AUTHORS   Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib
            A, Augustin H, Bode C, Patterson C and Moser M.
  TITLE     BMPER is an endothelial cell regulator and controls bone
            morphogenetic protein-4-dependent angiogenesis
  JOURNAL   Circ Res 103 (8), 804-812 (2008)
   PUBMED   18787191
REFERENCE   5  (bases 1 to 3785)
  AUTHORS   Yu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA and
            Gelernter J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
REFERENCE   6  (bases 1 to 3785)
  AUTHORS   Caruana G, Cullen-McEwen L, Nelson AL, Kostoulias X, Woods K,
            Gardiner B, Davis MJ, Taylor DF, Teasdale RD, Grimmond SM, Little
            MH and Bertram JF.
  TITLE     Spatial gene expression in the T-stage mouse metanephros
  JOURNAL   Gene Expr Patterns 6 (8), 807-825 (2006)
   PUBMED   16545622
REFERENCE   7  (bases 1 to 3785)
  AUTHORS   Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL,
            Conlon FL and Patterson C.
  TITLE     BMPER, a novel endothelial cell precursor-derived protein,
            antagonizes bone morphogenetic protein signaling and endothelial
            cell differentiation
  JOURNAL   Mol Cell Biol 23 (16), 5664-5679 (2003)
   PUBMED   12897139
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from CH474007.2.
            
            On or before Oct 16, 2008 this sequence version replaced
            XM_001053312.1, XM_235962.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..3785
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /note="BMP-binding endothelial regulator"
                     /db_xref="GeneID:300455"
                     /db_xref="RGD:1563373"
     exon            1..679
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     CDS             547..2604
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /note="BMP-binding endothelial regulator protein"
                     /codon_start=1
                     /product="BMP-binding endothelial regulator protein
                     precursor"
                     /protein_id="NP_001129271.1"
                     /db_xref="GeneID:300455"
                     /db_xref="RGD:1563373"
                     /translation="MLWFSGVRALAERPCRRSPGITCCVLLLLNCSGVPMSLASSFLT
                     GSVAKCENEGEVLQIPFITDNPCIMCVCSNKEVTCKREKCPVLSRDCALAIKQRGACC
                     ERCKGCTHEGRTYNSSFKWQSPAEPCALRQCQEGVVTESEVRCVVHCKNPAEHPGACC
                     PTCPGCVFEGVQYREGEEFQPEANKCIKCSCVGGRTQCVREVCPILSCPQHLSHTPSG
                     QCCPKCLGQRKVFDLPFGSCLFRSDVYDNGASFVYDNCTVCTCKDSTMVCKKKCSHPG
                     VCNTDEDACCEECLLRVPPEDVKVCKFGSKIFRDGEMWSSVNCSICACVKGKTECRKK
                     QCVPVSSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTK
                     DCSSPASPFQVLVKNDARRTRSFSWTKSVELVLGESTVSLQQHLTVRWNGSRIALPCH
                     TPHFHIDLDGYLLKVTTRAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDL
                     IGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSW
                     EFQTCHSTVDYTTFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQSC
                     AATQCKHGAVYDTCGPGCVKTCDNWNEIGPCNKPCIAGCHCPANLVLHKGRCIKPVLC
                     PQR"
     exon            680..765
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            766..865
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            866..948
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1039
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1122
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1222
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1332
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1473
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1578
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1624
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1954
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2291
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2422
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..3785
                     /gene="Bmper"
                     /gene_synonym="RGD1563373"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcggctg ggcgttcgag tgcgccactg tcgctcctga gccggcatag ctccagcgcc
       61 gggatcacag tccctcgtgc gaccctgcgg attccgcaca gagctcagtg ccccgttgtg
      121 tcccgcacgg agcaagcgcg ccggccggac accgagcccg gggacccggc cggagctgtg
      181 cttgcgggag ccggagccca gtggggctcc agagcggcga gcgcactcgg cagtcgctgc
      241 agccgcttcc cagatctcgc tgtccgccac ccctcctccc ggcccagatc tggcgcggag
      301 gggctgacgg ctaacccgct gcgagcaact cccttagaaa aaagccgccg cattggccga
      361 ggctggccgc aggacccctc ctcccggggc gcccccactc ctcccccgcc gctcggggcg
      421 cccgcctccc tcagccgact gtctcccggc acgccggccc acagcccttt tgactgcgag
      481 cagcggccgc cgagcagagg cggcgacgcg ggacctgcag tcgcccggga ttccctccag
      541 gtgacgatgc tctggttctc cggcgtcagg gctctggctg agcgtccttg ccgacgctcg
      601 cctgggatta cctgctgcgt cttgctgctg ctcaattgct ccggggtccc catgtctctg
      661 gcttcctcct tcctgacagg gtctgttgca aaatgtgaaa atgaagggga ggtcctccaa
      721 attccattta tcacagacaa cccttgcata atgtgtgtgt gctcgaacaa agaggtgact
      781 tgtaagaggg agaagtgccc tgtgctgtcc cgggactgtg cgctggccat taagcagagg
      841 ggcgcctgct gtgagcgatg caaaggttgt actcatgaag gaagaaccta caacagctcc
      901 ttcaagtggc aaagcccagc tgagccttgt gcccttagac agtgccagga gggcgtggtc
      961 acagagtctg aggtgcgttg tgttgttcat tgtaaaaatc ccgcagagca tccaggagcc
     1021 tgctgcccta cctgtccagg ctgtgtgttt gaaggtgtgc agtaccggga aggagaagaa
     1081 tttcagccag aagcaaacaa atgtatcaag tgctcctgtg ttggaggcag gacacagtgc
     1141 gtgagagaag tctgtcccat tctctcttgt ccccagcacc ttagtcacac accctcagga
     1201 cagtgctgcc ctaaatgttt gggccagagg aaagtatttg accttccttt tgggagctgc
     1261 ctgtttcgca gtgatgttta tgacaatgga gcctcatttg tctatgataa ctgcacagta
     1321 tgcacttgca aggactctac aatggtttgt aagaaaaaat gttcccaccc gggtgtctgt
     1381 aatactgatg aggatgcctg ttgtgaagag tgtctcctcc gggtgccccc tgaagatgtc
     1441 aaagtatgca agttcggtag caagattttc agggatggag agatgtggtc ctcggtcaac
     1501 tgcagcatct gcgcttgcgt gaaggggaag acggagtgtc gaaagaagca gtgtgtccct
     1561 gttagcagct gcccacaggg taaaattctc aacagaaaag gatgctgccc tatttgtact
     1621 gaaaagcctg gtgtgtgcac agtattcgga gatcctcact acaacacttt tgatggacgg
     1681 acatttaact tccagggaac gtgtcagtat gttctgacaa aagactgctc ctcccctgcc
     1741 tcaccctttc aggtgctggt gaagaacgat gcccggagga cccgctcctt ctcctggacc
     1801 aaatctgtgg agttggtgct gggtgagagc acggtcagcc tgcagcagca cctcacggtg
     1861 cgctggaatg gctctcgcat tgcgctgccc tgccacacgc ctcacttcca cattgacctg
     1921 gacggctacc ttttgaaagt gactaccagg gcaggtttgg agatatcgtg ggatggagac
     1981 agttttgtgg aggtcatggc tgcccctcat ctcaagggca agctctgtgg tctttgtggc
     2041 aattacaatg gtcataaacg cgatgacttg attggtggag atggaaactt caagtttgat
     2101 gtggatgact ttgctgaatc atggagggtg gaatccaatg aattctgcaa cagaccacag
     2161 agaaaaccag tgcctgagct atgtcagggc acagtgaagg tgaagcttcg agcccatcga
     2221 gagtgccaga aactcaagtc ctgggagttc cagacctgcc actcaacagt ggactatacc
     2281 actttctacc ggtcctgtgt aacagacatg tgcgaatgtc cagtccataa aaactgctat
     2341 tgtgagtcat ttctggcgta cacccgtgcc tgccagagag agggcatcaa agtgcactgg
     2401 gaacctcagc agagctgtgc agctacccag tgcaagcatg gtgctgtgta tgatacctgc
     2461 ggcccagggt gtgtgaagac gtgtgacaac tggaatgaga ttggcccctg taataaaccg
     2521 tgcatcgcag ggtgccactg cccagcaaat ctggtccttc ataagggaag gtgcatcaag
     2581 ccagtcctct gtcctcagcg atgacctttg ttctagtcca taagactttg aaatccagtg
     2641 tctttgacac agacacggaa gagccaatga aggactgtag tatttgtgtg cctgattctg
     2701 caaatacaca gagtatatac gtgtacatat atatagatat atagatatat tcaaaacatt
     2761 tcatcattta tataaactac aggtggatta ttatatgtat attttttgct ataagacatg
     2821 tattatttct agaatcctaa tgtgtaagcc attggatgca tcgtataaat acacaggtgc
     2881 ttttaattta atgagacggc atgtagactc atcgggtacc tttaacaagt gcattcatgt
     2941 gtcattctgg ggacatttcc taggagccct catgcctgcc tgcactaatt taagatttgc
     3001 gtcaggacct ttgagtgaga ttgtctcgga ggagggtgct ttatctaggg gtatttcata
     3061 tttccaaaga ctggaatgta tgccagaaaa agatggcgtg atatcgggga tgggccctag
     3121 ttagtgcaaa ccaaggggag tccatcagac ttccctgggt cagagctgga tatggcttcc
     3181 aaaactggat agttgccaag gaatgtgtat ttttcactag catactgcca aattatttct
     3241 tttcattttc acatatctcc tgagtctcct cattatttgt gtgtgcgatg gatatgacca
     3301 tttgtacgtc gtgcactgaa gtcaaaggat gtctggatga catttttatt aaacacgaaa
     3361 agctatttgg aggaatcatt gcacaacatg taaagaattt cggagcaatt taggattggc
     3421 aaatccattg agtggctagg ggccatctac gttttgtcac tatctcatga tgtataaaat
     3481 ggaagccttc agcaattttg tccctttcct gtctggggtt gtttggtggc tattcatatg
     3541 ttgtgggtat tgggcaagag agaagggtct gctgaccagt tgttttagcc tcgttccaaa
     3601 cgagatttga ttttgtacgt gttctaattc actgatgtta ctaacagtta ttggttcttg
     3661 tattctgttg gatacattaa aaagaaatgt caaaaagcga aaacagaaag ccccacccgc
     3721 aactcactga aattgaaaag taaaatgttc tgcgttgtag taaataaagg gcttaagatt
     3781 taagc
//
