LOCUS       NM_001109432            1919 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus bone morphogenetic protein 8a (Bmp8a), mRNA.
ACCESSION   NM_001109432 XM_001059507
VERSION     NM_001109432.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1919)
  AUTHORS   Wu FJ, Wang YW and Luo CW.
  TITLE     Human BMP8A suppresses luteinization of rat granulosa cells via the
            SMAD1/5/8 pathway
  JOURNAL   Reproduction 159 (3), 315-324 (2020)
   PUBMED   31940275
  REMARK    GeneRIF: Human BMP8A suppresses luteinization of rat granulosa
            cells via the SMAD1/5/8 pathway.
REFERENCE   2  (bases 1 to 1919)
  AUTHORS   Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vazquez
            MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, Dale M,
            Virtue S, Villarroya F, Cannon B, Rahmouni K, Lopez M and
            Vidal-Puig A.
  TITLE     BMP8B increases brown adipose tissue thermogenesis through both
            central and peripheral actions
  JOURNAL   Cell 149 (4), 871-885 (2012)
   PUBMED   22579288
REFERENCE   3  (bases 1 to 1919)
  AUTHORS   Sautter NB, Delaney KL, Hausman FA and Trune DR.
  TITLE     Tissue remodeling in the acute otitis media mouse model
  JOURNAL   Int J Pediatr Otorhinolaryngol 75 (11), 1368-1371 (2011)
   PUBMED   21889218
REFERENCE   4  (bases 1 to 1919)
  AUTHORS   Cheng H, Jiang W, Phillips FM, Haydon RC, Peng Y, Zhou L, Luu HH,
            An N, Breyer B, Vanichakarn P, Szatkowski JP, Park JY and He TC.
  TITLE     Osteogenic activity of the fourteen types of human bone
            morphogenetic proteins (BMPs)
  JOURNAL   J Bone Joint Surg Am 85 (8), 1544-1552 (2003)
   PUBMED   12925636
  REMARK    Erratum:[J Bone Joint Surg Am. 2004 Jan;86-A(1):141]
REFERENCE   5  (bases 1 to 1919)
  AUTHORS   Ying Y, Liu XM, Marble A, Lawson KA and Zhao GQ.
  TITLE     Requirement of Bmp8b for the generation of primordial germ cells in
            the mouse
  JOURNAL   Mol Endocrinol 14 (7), 1053-1063 (2000)
   PUBMED   10894154
REFERENCE   6  (bases 1 to 1919)
  AUTHORS   Zhao GQ, Liaw L and Hogan BL.
  TITLE     Bone morphogenetic protein 8A plays a role in the maintenance of
            spermatogenesis and the integrity of the epididymis
  JOURNAL   Development 125 (6), 1103-1112 (1998)
   PUBMED   9463357
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001059507.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16093050,
                              SAMN16676806 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1919
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1919
                     /gene="Bmp8a"
                     /note="bone morphogenetic protein 8a"
                     /db_xref="GeneID:680931"
                     /db_xref="RGD:1585858"
     exon            1..440
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1315
                     /gene="Bmp8a"
                     /codon_start=1
                     /product="bone morphogenetic protein 8A precursor"
                     /protein_id="NP_001102902.1"
                     /db_xref="GeneID:680931"
                     /db_xref="RGD:1585858"
                     /translation="MAVRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQ
                     REILAVLGLPGRPRPRAPPAAARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLV
                     MSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPPNTTLHI
                     SMFEVVQERSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHNKDLGLRLYVE
                     TEDGHSLDPGLAGLLGQTAPRSRQPFMVTFFRASSSPVRTPRAVRPLKRRQPKKTNEL
                     PHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFP
                     LDSCMNATNHAILQSLVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMV
                     VKACGCH"
     exon            441..630
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
     exon            631..779
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
     exon            780..974
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1054
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1165
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1919
                     /gene="Bmp8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccgcgaca ggtgcgaact caagggatcc actgcgcggt ctggtcctcc ccatcggggc
       61 gtcgcacccg agccaggcca gctaccggtg gatgcgcatc tgctgaaagt ccgagatggc
      121 cgtacgtccc gggccactct ggctattggg cctggctctg tgcgcgctgg gaggaggcca
      181 cggtccgcgt cccccgcaca cctgtcccca gcgtcgcctg ggagcgcgcg agcgccgcga
      241 catgcagcgc gaaatcctgg cagtgctcgg gctacccggg agaccccgac cccgtgcgcc
      301 acccgccgct gctcggcagc cagcatccgc gcccctcttc atgttggacc tgtatcacgc
      361 catgaccgat gacgacgacg gcgggccacc gcaggctcac ttgggccgtg ccgacctggt
      421 catgagcttc gtcaacatgg tggagcgcga ccgtaccctg ggctaccagg agccgcactg
      481 gaaggaattc cactttgact taacccagat ccctgctggt gaggctgtca cagccgctga
      541 gttccggata tacaaagagc ccagcaccca cccgcccaac acaaccctcc acatcagcat
      601 gtttgaagtg gtccaggagc gctccaacag ggagtctgac ttgttctttt tggatcttca
      661 gacgctccgg tctggggacg agggctggct ggtgctggac atcacagcag ccagtgaccg
      721 atggctgctg aaccataaca aggacctggg actccgcctc tatgtggaaa ccgaggatgg
      781 gcacagcctg gatcctggcc tggctggtct gcttggacaa acagcaccac gctccagaca
      841 gcctttcatg gtcaccttct tcagagccag ctcgagtcct gtgcggaccc ctcgggcagt
      901 gagaccgctg aagaggaggc agccaaagaa aacaaacgag cttccacatc ccaacaaact
      961 cccagggatc tttgatgatg gccacggttc ccgaggcaga gaggtttgcc gcagacacga
     1021 gctgtacgtc agcttccgtg acctcggctg gctggactgg gtcatcgccc cccagggcta
     1081 ctccgcctat tactgtgagg gagagtgtgc tttcccactg gactcctgta tgaatgccac
     1141 caaccatgcc atcttgcagt ctctggtgca cctgatgaaa ccagatgtcg tccccaaggc
     1201 atgctgtgct cccaccaaac tgagtgccac ctctgtgctc tactatgaca gcagcaacaa
     1261 tgtcatcctg cggaagcacc gcaacatggt ggtcaaggcc tgcggctgcc actgaggccc
     1321 tgcccggcat cctgcttcta cgacggtacc atctggtcag gcccctctcc agaggcagga
     1381 aaccctctta tgttatcata gctcagacag ggacaacggg aggccatcac ttcccctggc
     1441 cacttcctgc taaatttttg gtcctttccc agtccccctg tcctcttcat ggggtttgtg
     1501 ggctatcgcc ctcccctctc catcccccta ccccaagcat agaccgaatg cacacagaat
     1561 cccagagctg tgctgactga gaggtctggg gtcggtgctg aagacccaca tgaggaagac
     1621 tcgtccttgg ccatcctcag tccacagttg caaactctgg acggtctaag aaggctctga
     1681 aatttgaaac tggctgatct gggctctgca ccactcatta tggtggtcag ggcatttgta
     1741 ggtataacgg acacacacat cagtgtattg ctgtactcct tgaaatcaga gcaatcctgt
     1801 tataaaaaga atcagagcca ggtataacgg tgcatgacat taatcccagc actagagaga
     1861 tggagacagg aggatctctg tgagttcaag gccacatagg aagatcttgt ctcagggga
//
