LOCUS       NM_001191856            2448 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 7 (Bmp7), transcript
            variant 1, mRNA.
ACCESSION   NM_001191856 XM_342591
VERSION     NM_001191856.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2448)
  AUTHORS   Song,S.H., Han,D., Park,K., Um,J.E., Kim,S., Ku,M., Yang,J.,
            Yoo,T.H., Yook,J.I., Kim,N.H. and Kim,H.S.
  TITLE     Bone morphogenetic protein-7 attenuates pancreatic damage under
            diabetic conditions and prevents progression to diabetic
            nephropathy via inhibition of ferroptosis
  JOURNAL   Front Endocrinol (Lausanne) 14, 1172199 (2023)
   PUBMED   37293506
  REMARK    GeneRIF: Bone morphogenetic protein-7 attenuates pancreatic damage
            under diabetic conditions and prevents progression to diabetic
            nephropathy via inhibition of ferroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2448)
  AUTHORS   Zhang,H., Gao,L., Zhang,W. and Li,K.
  TITLE     Differentiation of rat bone marrow mesenchymal stem cells into
            neurons induced by bone morphogenetic protein 7 in vitro
  JOURNAL   Neurol Res 45 (5), 440-448 (2023)
   PUBMED   36542543
  REMARK    GeneRIF: Differentiation of rat bone marrow mesenchymal stem cells
            into neurons induced by bone morphogenetic protein 7 in vitro.
REFERENCE   3  (bases 1 to 2448)
  AUTHORS   Yu,X.J., Wang,Y.G., Lu,R., Guo,X.Z., Qu,Y.K., Wang,S.X., Xu,H.R.,
            Kang,H., You,H.B. and Xu,Y.
  TITLE     BMP7 ameliorates intervertebral disc degeneration in type 1
            diabetic rats by inhibiting pyroptosis of nucleus pulposus cells
            and NLRP3 inflammasome activity
  JOURNAL   Mol Med 29 (1), 30 (2023)
   PUBMED   36858954
  REMARK    GeneRIF: BMP7 ameliorates intervertebral disc degeneration in type
            1 diabetic rats by inhibiting pyroptosis of nucleus pulposus cells
            and NLRP3 inflammasome activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2448)
  AUTHORS   Kim,Y., Yu,N., Jang,Y.E., Lee,E., Jung,Y., Lee,D.J., Taylor,W.R.,
            Jo,H., Kim,J., Lee,S. and Kang,S.W.
  TITLE     Conserved miR-370-3p/BMP-7 axis regulates the phenotypic change of
            human vascular smooth muscle cells
  JOURNAL   Sci Rep 13 (1), 2404 (2023)
   PUBMED   36765143
  REMARK    GeneRIF: Conserved miR-370-3p/BMP-7 axis regulates the phenotypic
            change of human vascular smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2448)
  AUTHORS   Manzano-Lista,F.J., Sanz-Gomez,M., Gonzalez-Moreno,D.,
            Vega-Martin,E., Gil-Ortega,M., Schulz,A., Rubio,M.A.,
            Ruiz-Hurtado,G., Ruilope,L.M., Aranguez,I., Kreutz,R. and
            Fernandez-Alfonso,M.S.
  TITLE     Imbalance in Bone Morphogenic Proteins 2 and 7 Is Associated with
            Renal and Cardiovascular Damage in Chronic Kidney Disease
  JOURNAL   Int J Mol Sci 24 (1), 40 (2022)
   PUBMED   36613483
  REMARK    GeneRIF: Imbalance in Bone Morphogenic Proteins 2 and 7 Is
            Associated with Renal and Cardiovascular Damage in Chronic Kidney
            Disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2448)
  AUTHORS   Onishi,T., Ishidou,Y., Nagamine,T., Yone,K., Imamura,T., Kato,M.,
            Sampath,T.K., ten Dijke,P. and Sakou,T.
  TITLE     Distinct and overlapping patterns of localization of bone
            morphogenetic protein (BMP) family members and a BMP type II
            receptor during fracture healing in rats
  JOURNAL   Bone 22 (6), 605-612 (1998)
   PUBMED   9626398
REFERENCE   7  (bases 1 to 2448)
  AUTHORS   Nakao,A., Imamura,T., Souchelnytskyi,S., Kawabata,M., Ishisaki,A.,
            Oeda,E., Tamaki,K., Hanai,J., Heldin,C.H., Miyazono,K. and ten
            Dijke,P.
  TITLE     TGF-beta receptor-mediated signalling through Smad2, Smad3 and
            Smad4
  JOURNAL   EMBO J 16 (17), 5353-5362 (1997)
   PUBMED   9311995
REFERENCE   8  (bases 1 to 2448)
  AUTHORS   Dudley,A.T. and Robertson,E.J.
  TITLE     Overlapping expression domains of bone morphogenetic protein family
            members potentially account for limited tissue defects in BMP7
            deficient embryos
  JOURNAL   Dev Dyn 208 (3), 349-362 (1997)
   PUBMED   9056639
REFERENCE   9  (bases 1 to 2448)
  AUTHORS   Takahashi,H. and Ikeda,T.
  TITLE     Transcripts for two members of the transforming growth factor-beta
            superfamily BMP-3 and BMP-7 are expressed in developing rat embryos
  JOURNAL   Dev Dyn 207 (4), 439-449 (1996)
   PUBMED   8950518
REFERENCE   10 (bases 1 to 2448)
  AUTHORS   Dudley,A.T., Lyons,K.M. and Robertson,E.J.
  TITLE     A requirement for bone morphogenetic protein-7 during development
            of the mammalian kidney and eye
  JOURNAL   Genes Dev 9 (22), 2795-2807 (1995)
   PUBMED   7590254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001191856.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.17453.1,
                                           SRR26643287.9947.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-839               JAXUCZ010000003.1  182134308-182135146 c
            840-1032            JAXUCZ010000003.1  182108899-182109091 c
            1033-1181           JAXUCZ010000003.1  182085184-182085332 c
            1182-1379           JAXUCZ010000003.1  182069245-182069442 c
            1380-1456           JAXUCZ010000003.1  182065197-182065273 c
            1457-1567           JAXUCZ010000003.1  182063185-182063295 c
            1568-2448           JAXUCZ010000003.1  182059318-182060198 c
FEATURES             Location/Qualifiers
     source          1..2448
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2448
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /note="bone morphogenetic protein 7"
                     /db_xref="GeneID:85272"
                     /db_xref="RGD:620743"
     exon            1..839
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1717
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; bone moorphogenic protein-7"
                     /codon_start=1
                     /product="bone morphogenetic protein 7 isoform 1
                     precursor"
                     /protein_id="NP_001178785.1"
                     /db_xref="GeneID:85272"
                     /db_xref="RGD:620743"
                     /translation="MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHR
                     RLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEESGPDGQGF
                     SYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLS
                     KIPEGEAVTAAEFRIYKDYIRERFDNETFQITVYQVLQEHSGRESDLFLLDSRTIWAS
                     EEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFM
                     VAFFKATEVHLRSIRSTGGKQRSQNRSKTPKNQEALRMASVAENSSSDQRQACKKHEL
                     YVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPDTVPK
                     PCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH"
     exon            840..1032
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1181
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1379
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1456
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1567
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..2448
                     /gene="Bmp7"
                     /gene_synonym="BMP-7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttc ccgctggtgc ccgcgggccc gagcgcgagc agagtgggag gagggagcga
       61 gggttcgccc agcgccctgc tgcctccccg gcactcgctc tccggacttg aaggtctgca
      121 aactgctgct cctcccaccc cggcccgcct cctcgctctc ttgctctctc tctggagttg
      181 ctgtgctagc cttgcggtgc gtcctggcga gtgcgggccg aggggccccg ggccagaact
      241 gagtagagga ctggggcgtc tcgggcagag cgcagcgggc cagggagtgg ccatgagtgg
      301 cgaggccacg gtgaagctcg tctgcagcaa gtgacctcgg gtcgtggacc gctgccctgc
      361 cccctccgct gccacctggg gcggcgcggg cccggtgccc cggatcgcgc gtagagccgg
      421 cgcgatgcac gtgcgctcgc tgcgcgctgc ggcgccacac agcttcgtgg cgctctgggc
      481 gcctctgttc ttgctgcgct ctgccttggc cgacttcagc ctggacaacg aggtgcactc
      541 cagtttcatc caccggcgcc tccgcagtca ggagcggcgg gagatgcagc gggaaatcct
      601 gtccatcttg ggcttgcccc atcgtccgcg cccgcacctc cagggaaaac ataattcggc
      661 gcccatgttc atgttggacc tgtacaacgc catggcggtg gaggagagtg ggccggacgg
      721 acagggcttc tcctacccct acaaggccgt cttcagtacc cagggtcccc ctttggccag
      781 cctgcaggac agccacttcc tcaccgacgc cgacatggtc atgagcttcg tcaacctagt
      841 ggagcacgac aaggaattct tccaccctcg ataccaccat cgagagttcc ggtttgatct
      901 ttccaagatc cccgagggag aggcggtgac cgcagccgag ttcaggatct ataaggacta
      961 catccgggag cggtttgaca acgagacctt ccagatcaca gtctatcagg tgctccagga
     1021 gcactcaggc agggagtccg acctcttctt gctggacagc cgtaccatct gggcttctga
     1081 ggagggctgg ttggtatttg acatcacagc caccagcaac cactgggtgg tcaaccctcg
     1141 gcacaacctg ggcttacagc tctccgtgga gaccctggat gggcagagca tcaaccccaa
     1201 gttggcaggc ctgattggac ggcatggacc ccagaacaag caacccttca tggtggcctt
     1261 cttcaaggcc acggaggttc atctccgtag catccggtcc acggggggca aacaacgcag
     1321 ccagaaccgc tccaagactc caaagaacca agaggcactg aggatggcca gtgtggcaga
     1381 aaacagcagc agtgaccaga ggcaggcctg caagaaacac gagctgtatg ttagcttccg
     1441 agaccttggc tggcaggact ggatcatcgc acctgaaggc tatgctgcct actactgtga
     1501 gggagagtgt gccttccctc tgaactccta catgaacgcc accaaccatg ctatcgtcca
     1561 gacactggtt cacttcatca acccagacac cgtacccaag ccctgctgtg cccccaccca
     1621 gctcaacgcg atatctgtcc tctacttcga cgacagctcc aacgtcatcc tgaagaagta
     1681 cagaaacatg gtggtccggg cctgtggctg ccactaggtc ttcctgagac cctgaccttt
     1741 tgggaccgca ttttttccag atccccaatg tctcaccacc taggtctctc actgcccacc
     1801 ttggcgagga gccaacagac caagcacctc tcctgagcct tcccctcacc tccccagctg
     1861 gaagcgtgca aggcattaga aacctgagca caccgtggtt gataagcagc atactttcat
     1921 tccggcacat tccgcttgag atcctacaca ctgcctctgg aaacgactag caggaaaaat
     1981 gtcttccaag aaagaatccg ttggccatgt tggtccctgg cgctcggaac ctttgagggg
     2041 taattacaag cacctccttc ggctgcagca ggaggaaggg cataaccagg gtgggcgctt
     2101 acgtctgtgc tgaaggaaaa ccaagcagaa gtccctgtaa taaaatgtca caataaaacc
     2161 aaaccatgac tgaaaatggt taggatgtta cagatatatt ttcccaaaca gtttatcccc
     2221 atttcttggt ttattctgac ttcgtaaaca gaagcccggg ctgtggagga tggagaggcc
     2281 cttcctttcc gttctatttc ttcctgaggc tgcagggctg tgtgtgtgtg tttacccaga
     2341 cctgcccaaa tctgccctgt ggggagggaa ggaggatgtc tgctcagaag aggtcggtga
     2401 gggatgtggc cttaaggggt gttggggtga aggtggaggg aggcgtgt
//
