LOCUS       NM_013107               3390 bp    mRNA    linear   ROD 25-MAR-2024
DEFINITION  Rattus norvegicus bone morphogenetic protein 6 (Bmp6), mRNA.
ACCESSION   NM_013107 XM_341514
VERSION     NM_013107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   McColl,L.F., Chen,X., Solga,M.D., Schlegel,K., Haughey,S.P.,
            Lobo,P.I., Fread,K., Zunder,E., Cha,R., Park,S., Christophel,J.J.,
            Cui,Q. and Dighe,A.S.
  TITLE     BMP-6 promotes type 2 immune response during enhancement of rat
            mandibular bone defect healing
  JOURNAL   Front Immunol 14, 1064238 (2023)
   PUBMED   36845161
  REMARK    GeneRIF: BMP-6 promotes type 2 immune response during enhancement
            of rat mandibular bone defect healing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Guo,Q., Wang,W., Abboud,R. and Guo,Z.
  TITLE     Impairment of maturation of BMP-6 (35 kDa) correlates with delayed
            fracture healing in experimental diabetes
  JOURNAL   J Orthop Surg Res 15 (1), 186 (2020)
   PUBMED   32448307
  REMARK    GeneRIF: Impairment of maturation of BMP-6 (35 kDa) correlates with
            delayed fracture healing in experimental diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Ayala-Pena,V.B., Armiento,M.N., Fernandez Bell Fano,P.M.,
            Santillan,G.E. and Scolaro,L.A.
  TITLE     Infection of Rat Osteoblasts with Junin Virus Promotes the
            Expression of Bone Morphogenetic Protein 6, an Osteogenic
            Differentiation Inducer
  JOURNAL   Intervirology 62 (1), 1-8 (2019)
   PUBMED   31121597
  REMARK    GeneRIF: Junin virus infection of osteoblasts upregulated the
            expression of BMP6
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Rico-Llanos,G.A., Becerra,J. and Visser,R.
  TITLE     Insulin-like growth factor-1 (IGF-1) enhances the osteogenic
            activity of bone morphogenetic protein-6 (BMP-6) in vitro and in
            vivo, and together have a stronger osteogenic effect than when
            IGF-1 is combined with BMP-2
  JOURNAL   J Biomed Mater Res A 105 (7), 1867-1875 (2017)
   PUBMED   28256809
  REMARK    GeneRIF: study revealed that only BMP-6 was able to induce bone
            formation at the used dose and that the addition of IGF-1
            contributed to an increase of the mineralization in the implants.
            Hence, the combination of BMP-6 with IGF-1 might be a better
            alternative than BMP-2 for orthopedic surgery or bone tissue
            engineering approaches.
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Benn,A., Bredow,C., Casanova,I., Vukicevic,S. and Knaus,P.
  TITLE     VE-cadherin facilitates BMP-induced endothelial cell permeability
            and signaling
  JOURNAL   J Cell Sci 129 (1), 206-218 (2016)
   PUBMED   26598555
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Boden,S.D., Hair,G., Titus,L., Racine,M., McCuaig,K., Wozney,J.M.
            and Nanes,M.S.
  TITLE     Glucocorticoid-induced differentiation of fetal rat calvarial
            osteoblasts is mediated by bone morphogenetic protein-6
  JOURNAL   Endocrinology 138 (7), 2820-2828 (1997)
   PUBMED   9202223
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Knittel,T., Fellmer,P., Muller,L. and Ramadori,G.
  TITLE     Bone morphogenetic protein-6 is expressed in nonparenchymal liver
            cells and upregulated by transforming growth factor-beta 1
  JOURNAL   Exp Cell Res 232 (2), 263-269 (1997)
   PUBMED   9168801
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Gazit,D., Ebner,R., Kahn,A.J. and Derynck,R.
  TITLE     Modulation of expression and cell surface binding of members of the
            transforming growth factor-beta superfamily during retinoic
            acid-induced osteoblastic differentiation of multipotential
            mesenchymal cells
  JOURNAL   Mol Endocrinol 7 (2), 189-198 (1993)
   PUBMED   8385738
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Sauermann,U., Meyermann,R. and Schluesener,H.J.
  TITLE     Cloning of a novel TGF-beta related cytokine, the vgr, from rat
            brain: cloning of and comparison to homologous human cytokines
  JOURNAL   J Neurosci Res 33 (1), 142-147 (1992)
   PUBMED   1453478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Sep 27, 2022 this sequence version replaced NM_013107.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY184240.1, SRR22399481.1710225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1447              JAXUCZ010000017.1  26673815-26675261   c
            1448-1640           JAXUCZ010000017.1  26554441-26554633   c
            1641-1789           JAXUCZ010000017.1  26538547-26538695   c
            1790-1987           JAXUCZ010000017.1  26537635-26537832   c
            1988-2064           JAXUCZ010000017.1  26526450-26526526   c
            2065-2175           JAXUCZ010000017.1  26525006-26525116   c
            2176-3390           JAXUCZ010000017.1  26523704-26524918   c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..3390
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /note="bone morphogenetic protein 6"
                     /db_xref="GeneID:25644"
                     /db_xref="RGD:2214"
     exon            1..1447
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             805..2325
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /note="BMP-6; VGR-1; VG-1-related protein"
                     /codon_start=1
                     /product="bone morphogenetic protein 6 precursor"
                     /protein_id="NP_037239.1"
                     /db_xref="GeneID:25644"
                     /db_xref="RGD:2214"
                     /translation="MPGLGRRAQWLCWWWGLLCSCGPPPLRPPLPVAAAAAGGQLLGA
                     GGSPVRAEQPPPQSSSSGFLYRRLKTHEKREMQKEILSVLGLPHRPRPLHGLQQPQSP
                     VLPQQQQSQQTAREEPPPGRLKSAPLFMLDLYNSLSKDDEEDGVSEGEGLEPESHGRA
                     SSSQLKQPSPGAAHSLNRKSLLAPGPGGSASPLTSAQDSAFLNDADMVMSFVNLVEYD
                     KEFSPRQRHHKEFKFNLSQIPEGEAVTAAEFRVYKDCVVGSFKNQTFLISIYQVLQEH
                     QHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGLHINP
                     RAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVSRGSS
                     ASDYNSSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATN
                     HAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH"
     exon            1448..1640
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1789
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1987
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2064
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2175
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..3390
                     /gene="Bmp6"
                     /gene_synonym="VGR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagccca cgttggcggc ggccgggagc gcagcacgca caggcgggag actgcgaatt
       61 cccgagccga cgccgcagcc tgtgttccgc gctcggctcc tcggctctcc catcgccctg
      121 gagagccgga tccttcggga acccgagaga cggccgagag gaaagtcaga tcgtggccgc
      181 ctccacttgg ggaggcgcgc ggagattgcg agggggagcg acggtgcccg agggcggagg
      241 ggcgctgagt ttcgggccag agggaagttt aaagcgacgc gaagaaaatt ggctttttag
      301 gacgcggggt cgccctgccc gggacccgga gaggagtaaa ctccacgatt gtcctacaag
      361 ccaggagagg agtgtccgag gatggtgcca ggcatcgacc ccatctcttg atctgtggtc
      421 tccgattccc ctcggccagc ctcctgcggg gtctcagggc agcgcacgtg tgcagacagc
      481 aagtgaccgt gccgtgaccc gccagggaac gccggctgca gcgcagtcct gtctcggaca
      541 cacctggctc agctcgtgcg cctccagaga cctgcgggag agtgggggat cctggccgtc
      601 accccgtcgt ctcttctccg cccgggcttc tgggggcgcc gcggatgacc atgagagata
      661 aggactgagt gccaggatcg ggaagagagc ccgccgagag gtggcggggg ctgcccactc
      721 caagggccac agccgccgcg ctcgggcctc gctccgccgc tcgacgcctc gcggggcccg
      781 cggggacagc cgggccgggc ggcgatgccc gggctggggc ggagggcgca gtggctgtgc
      841 tggtggtggg ggttactgtg cagctgcggc cccccgccac tgcggccccc tctgccggta
      901 gccgcggccg ccgccggggg gcagctgctg ggagccggcg ggagccctgt gcgcgccgag
      961 cagccaccgc cgcaatcctc ctcttcgggc ttcctctatc ggcggctcaa gacccacgag
     1021 aagcgggaga tgcaaaagga gatcctgtcg gtgttggggc tgcctcacag gccgcggccc
     1081 ctgcacggtc tccagcagcc tcaatccccc gtgctcccgc agcagcaaca atcgcaacag
     1141 acggcccgcg aggagccccc tccagggcgg ctgaagtccg ctccgctctt catgctggat
     1201 ctctacaact ccctgtccaa ggacgacgaa gaggatgggg tgtcagaggg agagggactg
     1261 gagcccgagt cccacggaag ggccagctcg tcccagctca aacagccatc tcccggggct
     1321 gcacactccc tgaaccgcaa gagtctcctg gccccgggac ccggcggcag tgcgtcccca
     1381 ctgaccagcg cgcaggacag cgctttcctc aacgacgcgg acatggtcat gagctttgtg
     1441 aacctggtgg agtacgacaa ggagttctcc ccacgccagc gacaccacaa ggagttcaag
     1501 ttcaacttat cccagattcc cgagggtgag gcagtgacgg ctgcagagtt ccgcgtctac
     1561 aaggactgtg tggtggggag ttttaaaaac caaacttttc ttatcagcat ttaccaagtc
     1621 ttacaggagc atcagcacag agactctgac ctatttttgt tggacacccg ggtggtgtgg
     1681 gcctctgaag aaggctggct ggaattcgac atcacagcaa ctagcaatct gtgggtggtg
     1741 acaccgcagc acaacatggg actccagctg agtgtggtga ctcgggacgg actccacatc
     1801 aacccccgtg cggcgggcct ggtgggcaga gacggccctt acgacaagca gcccttcatg
     1861 gtggccttct tcaaggtgag cgaggtccac gtgcgcacca ccaggtcagc ctccagtcgg
     1921 cgtcgacagc agagtcgcaa tcggtccacc cagtcgcagg acgtgtcccg gggctccagt
     1981 gcttcagact acaacagcag tgagttaaaa acagcttgca agaagcatga gctttacgtg
     2041 agcttccagg acctgggatg gcaggactgg atcatcgcac ccaaaggcta cgctgccaac
     2101 tattgtgacg gagagtgttc cttccctctc aatgcacaca tgaatgccac caaccacgcc
     2161 attgtacaga ccttggtcca ccttatgaat cccgagtacg tccccaaacc atgctgcgca
     2221 ccaaccaaac tgaatgccat ctcggttctt tacttcgacg acaactccaa tgtcatcttg
     2281 aaaaaataca ggaacatggt tgtgagagct tgtggatgtc attgagtgga agccagttgc
     2341 aggggctgtg attctgcctc ggattcctaa catctgcctt aaaacacggg aagcagcaca
     2401 gtgcagcggg acgatgacac tcaaagcatc tcctgctggt gccttagccc aaggaggatt
     2461 ttacgaggac cttgtcgatg gctttcccag ttgagcagtt gctggtctgt aggaagctgt
     2521 aatgcttgta gcacaggcct ggaaactaca gaaacatagt gttctcctcc cccagtccca
     2581 cccagactag ccttagcttt tagatctagc tgtttgtggt gtaagtagga gataaacttg
     2641 aaggaatatt aaatatccct ggttgaaaga cagatctagt ggttctacag cacccatccc
     2701 agggagattt tgcagatagc cgaatggagg agaggagaac actctattag attccattcc
     2761 cagcaaaggg cagctcccac agaacctgca gcctggccat cacagggctt tgtggaggtg
     2821 ccttctgtct actgttagtt acccgtttta tgttgactct tggtggtgtg aaaatgtact
     2881 aatttcggtc aaaacaaact atagcattcc cacgccatac tcctccctta ctcacagaat
     2941 tccttactag aaccaaagta gatggactgt actttgtggt agagccctga agcatctgca
     3001 gtagccttca tttaaaccac ggaacagcag aatgtgattc tgcgtctctc gggcagactg
     3061 gctggacatg tacgttacca tcaggaacac tggccccaac acatcagctc tctctctcct
     3121 aactctgctt tttccctttt ccctacatta gcattccacg gttcagggct agagtctaaa
     3181 gcagaagtcc acaaacagaa gggccctgac tctaagaatg ggtttgttga ggtgagcatg
     3241 ctgtttgtaa accaaaacca ccatttcctc ttgtagaaag taagactcag actgaatctt
     3301 agaatatttt ttaaatgtct ttttcacaat catgtactgg gaaaccaatt tcatactaaa
     3361 ctgattaaat aatgcattta caatctgtaa
//
